Identification of UBFD1 as a prognostic biomarker and molecular target among estrogen receptor-positive breast cancer

Estrogen receptor (ER)-positive breast cancer (BRCA) is the most commonly diagnosed molecular subtype of BRCA. It is routinely treated with endocrine therapy; however, some patients relapse after therapy and develop drug resistance, resulting in treatment failure. In the present study, we identified markers of ER-positive BRCA and evaluated their putative function in immune infiltration as well as their clinicopathological significance. The ubiquitin family domain containing 1 (UBFD1) protein was associated with the prognosis of ER-positive BRCA patients. Its expression was higher in ER-positive BRCA tissues compared with adjacent nontumor tissues. Pa-tients with higher UBFD1 expression had a poorer prognosis. UBFD1 is an independent risk factor for ER-positive BRCA patients and its function was primarily associated with hormone activity and inflammation. Taken together, UBFD1 is a potential prognostic biomarker and candidate target of ER-positive BRCA.

Automated summary

This study identified a prognostic biomarker, UBFD1, associated with ER-positive breast cancer. Higher expression of UBFD1 was observed in ER-positive breast cancer tissues and correlated with poor prognosis. UBFD1 was found to be primarily associated with hormone activity and inflammation. These findings suggest that UBFD1 has the potential to be a prognostic biomarker and therapeutic target for ER-positive breast cancer.