☆ 4.5 Article

Shaoyao decoction alleviates TNBS-induced ulcerative colitis by decreasing inflammation and balancing the homeostasis of Th17/Treg cells

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Plant Sciences

Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway

Yin Wang et al.

Summary: This study evaluated the therapeutic effect of JWSMYA and investigated the mechanism of repair and anti-fibrosis on acute radiation-induced cutaneous wounds. The results showed that JWSMYA accelerated the repair of acute radiation-induced cutaneous wounds through the MAPK/ERK pathway and inhibited fibrosis through the PI3K/AKT pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cornus mas L. Extract Targets the Specific Molecules of the Th17/Treg Developmental Pathway in TNBS-Induced Experimental Colitis in Rats

Marta Szandruk-Bender et al.

Summary: Research suggests that cornelian cherry extract, rich in iridoids and polyphenols, has potential anti-inflammatory properties and can target specific molecules involved in the development of Th17/Treg cells. In an experimental colitis model, a dose of 100 mg/kg of cornelian cherry extract was effective in reducing inflammation and modulating immune factors related to Th17/Treg axis regulation. When administered with sulfasalazine, cornelian cherry extract showed even greater efficacy in reversing the pathological changes induced by colitis.

MOLECULES (2023)

添加到收藏夹

Article Oncology

Establishment of a gastric cancer cell line with high microsatellite instability, OCUM-13, derived from Borrmann type-2 primary tumor

Yurie Yamamoto et al.

Summary: In this study, a unique GC cell line OCUM-13 with MSI was established, which may be useful for analyzing the mechanisms of immunotherapy and cancer therapy for GC.

CANCER MEDICINE (2023)

添加到收藏夹

Article Plant Sciences

Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa

Shuguang Yan et al.

Summary: This study showed that Wu-Mei-Wan can inhibit intestinal inflammation and promote the repair of damaged intestinal mucosa, thus treating ulcerative colitis.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Chemistry, Medicinal

Integrated Metabonomics and Network Pharmacology to Reveal the Action Mechanism Effect of Shaoyao Decoction on Ulcerative Colitis

Jin Wu et al.

Summary: This study investigated the mechanism of Shaoyao decoction (SYD) in the treatment of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) using metabolomics and network pharmacology. The results showed that SYD effectively improved symptoms and ameliorated intestinal mucosal damage and metabolic disorder in DSS-induced UC mice. The mechanism of action mainly involves sphingolipid metabolism, PI3K/AKT-mTOR signaling pathway, and S1P3 pathway.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

添加到收藏夹

Article Plant Sciences

Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6/STAT3 signaling pathway

Xuan-qing Chen et al.

Summary: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Article Integrative & Complementary Medicine

The Effects of Sishen Wan on T Cell Responses in Mice Models of Ulcerative Colitis Induced by Dextran Sodium Sulfate

Ke Li et al.

Summary: The study found that Sishen Wan (SSW) could modulate T cell responses in mice models of ulcerative colitis (UC), including inhibiting the immune reaction of Th17 cells, promoting the transdifferentiation of Th17 cells into IL-10(+) Th17 cells in acute UC, inhibiting the excessive reaction of Th1 cells, facilitating Tregs development, and enhancing the anti-inflammatory effects in chronic UC.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Poly(ADP-ribose) polymerase-1 inhibitor ameliorates dextran sulfate sodium-induced colitis in mice by regulating the balance of Th17/Treg cells and inhibiting the NF-κB signaling pathway

Shuai Peng et al.

Summary: The PARP-1 inhibitor 5-AIQ demonstrates significant pharmacological effects in a mouse model of colitis by reducing tissue damage and inflammation, modulating immune balance, and downregulating key components of signaling pathways.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Baitouweng Decoction Ameliorates Ulcerative Colitis in Mice Partially Attributed to Regulating Th17/Treg Balance and Restoring Intestinal Epithelial Barrier

Zhiwei Miao et al.

Summary: The study found that BTW significantly suppressed intestinal inflammation in UC mice, potentially through regulating the balance of Th17/Treg cells and restoring the intestinal epithelial barrier.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Microbiology

Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium

Shruti Ahlawat et al.

Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.

CRITICAL REVIEWS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Plant Sciences

Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling

Yaxing Zhao et al.

Summary: The study demonstrated that Gegen Qinlian decoction (GQ) alleviated symptoms of ulcerative colitis (UC) in mice by modulating immune imbalance, reducing the production of inflammatory factors, improving dysregulation of Treg and Th17 cells, and suppressing IL-6/JAK2/STAT3 signaling pathway.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Root Extract of Lindera aggregata (Sims) Kosterm. Modulates the Th17/Treg Balance to Attenuate DSS-Induced Colitis in Mice by IL-6/STAT3 Signaling Pathway

Huimin Lai et al.

Summary: The root extract of Lindera aggregata can effectively treat ulcerative colitis by inhibiting IL-6 production and secretion, regulating the IL-6/STAT3 signaling pathway, and modulating the balance of Th17 and Treg cells.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Integrative & Complementary Medicine

Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis from the Perspective of Inflammation and Immunity Based on Systemic Pharmacology

Yan Jiang et al.

Summary: This study suggests that berberine may interfere with ulcerative colitis by regulating biological processes and signaling pathways related to inflammation and immunity. Experimental results show that berberine can improve colonic pathological changes in rats, reduce inflammatory markers, and increase levels of immune-related factors.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

添加到收藏夹

Article Immunology

Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation

Hao Xu et al.

Summary: TGF-beta signaling is crucial for differentiation of Th17 and Treg cells, with distinct requirements for downstream signaling components. Arkadia deficiency impairs Treg cell differentiation but is dispensable for Th17 cell responses. Genetic ablation of transcriptional corepressors SKI and SnoN rescues Arkadia-deficient iTreg cell differentiation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Plant Sciences

Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway

Yuan-Yuan Wei et al.

Summary: This study investigated the protective effects of Shaoyao decoction (SYD) against ulcerative colitis by inhibiting the MKP1/NF-kappa B/NLRP3 pathway. Through network pharmacology and molecular biology technology, it was found that SYD could alleviate inflammatory responses and pyroptosis in ulcerative colitis by regulating MAPK cascade and NF-kappa B signaling pathway.

PHYTOMEDICINE (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling

Lina Fan et al.

Summary: Inflammatory bowel disease (IBD) is an immune dysregulation disease with poor prognosis, and therapies based on gut microbe modulation have been proposed. The study showed that B. adolescentis has therapeutic effects on IBD, improving inflammation symptoms and promoting gut microbiota balance.

GUT MICROBES (2021)

添加到收藏夹

Article Oncology

Curcumin ameliorates DSS-induced colitis in mice by regulating the Treg/Th17 signaling pathway

Cheng Wei et al.

Summary: Curcumin effectively treats ulcerative colitis by regulating the re-equilibration of Treg/Th17, reducing inflammation, and potentially involving the IL-23/Th17 pathway.

MOLECULAR MEDICINE REPORTS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Upregulation of microRNA-219-5p relieves ulcerative colitis through balancing the differentiation of Treg/Th17 cells

Xinhua Li et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Article Oncology

The effect of 6-gingerol on inflammatory response and Th17/Treg balance in DSS-induced ulcerative colitis mice

Yingyue Sheng et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Genetics & Heredity

Close homolog of L1-deficient ameliorates inflammatory bowel disease by regulating the balance of Th17/Treg

Jun Yao et al.

GENE (2020)

添加到收藏夹

Review Immunology

The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease

Jun-bin Yan et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner

Yao-Jiang Liu et al.

THERANOSTICS (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Application of Herbaceous Medications for Inflammatory Bowel Disease as a Complementary and Alternative Therapy

Zili Lin et al.

INFLAMMATORY BOWEL DISEASES (2019)

添加到收藏夹

Article Immunology

Regulating effect of baicalin on IKK/IKB/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis

Jian Shen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

添加到收藏夹

Review Microbiology

Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome

Israr Khan et al.

PATHOGENS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17/Treg cell balance

Meng Xu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Immunology

Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice

Jingyun Xu et al.

IMMUNOBIOLOGY (2019)

添加到收藏夹

Editorial Material Integrative & Complementary Medicine

Herbal Medicines Useful to Treat Inflammatory and Ulcerative Gastrointestinal Disorders: Preclinical and Clinical Studies

Sergio Faloni de Andrade et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

添加到收藏夹

Editorial Material Immunology

TRIMming TGF-β signals in Th17 cells

Aaron S. Rapaport et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon

Huantian Cui et al.

FRONTIERS IN PHARMACOLOGY (2018)

添加到收藏夹

Article Oncology

Total glucosides of paeony ameliorates TNBS-induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines

Haihua Lin et al.

MOLECULAR MEDICINE REPORTS (2017)

添加到收藏夹

Article Immunology

CD11b regulates the Treg/Th17 balance in murine arthritis via IL-6

Mathias Stevanin et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.