4.8 Article

Cell-Selective Binding Zwitterionic Polymeric Micelles Boost the Delivery Efficiency of Antibiotics

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Multidisciplinary

Advances in Drug Delivery Systems Based on Red Blood Cells and Their Membrane-Derived Nanoparticles e

Phuong Hoang Diem Nguyen et al.

Summary: Red blood cells (RBCs) and RBC membrane derived nanoparticles have been developed as bioinspired drug delivery systems to address the issues of synthetic nanocarriers. RBC-based delivery systems possess characteristics including biocompatibility, biodegradability, and long circulation time, which make them suitable for systemic administration. They have been employed in designing optimal drug formulations in various preclinical models and clinical trials to treat a wide range of diseases.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

Two-Tailed Dynamic Covalent Amphiphile Combats Bacterial Biofilms

Xiaowen Hu et al.

Summary: This research reports a novel class of antimicrobial molecules (T(2)A(2)) composed of nitric oxide (NO)-donor (DN) and various natural aldehydes, which self-assemble into nanoparticles and exhibit significant bactericidal efficacy. Cin-T(2)A(2) can kill multidrug-resistant staphylococci and eradicate their biofilms through multiple mechanisms. Furthermore, Cin-T(2)A(2) rapidly eradicates bacteria and alleviates inflammation in murine infection models.

ADVANCED MATERIALS (2023)

Article Chemistry, Multidisciplinary

Role of Micelle Size in Cell Transcytosis-Based Tumor Extravasation, Infiltration, and Treatment Efficacy

Wufa Fan et al.

Summary: Transcytosis-based active transport of cancer nanomedicine has been shown to enhance tumor extravasation and infiltration, but how the nanoproperties, particularly particle size, affect transcytosis is unknown. In this study, we used a transcytosis-inducing polymer, OPDEA, to fabricate stable OPDEA-based micelles of different sizes. The smallest micelles (30 nm) showed the fastest transcytosis and most efficient tumor extravasation and infiltration, leading to enhanced antitumor activity compared to larger micelles (140 nm).

NANO LETTERS (2023)

Article Chemistry, Multidisciplinary

Screening of Zwitterionic Liposomes with Red Blood Cell-Hitchhiking and Tumor Cell-Active Transporting Capability for Efficient Tumor Entrance

Zhihao Zhao et al.

Summary: A type of tertiary amine oxide (TAO)-containing zwitterionic liposomal nanocarriers has been developed to hitchhike red blood cells (RBCs) to tumor blood vessels and enter solid tumors through transcytosis. Two types of TAO liposomes (TAOLs) have been identified that can induce efficient tumor cell transcytosis through rapid macropinocytosis and endoplasmic reticulum/Golgi-involved exocytosis. These zwitterionic TAOLs can hitchhike RBCs to gain long blood circulation and effectively enter and infiltrate the whole tumor through transcytosis. Chemotherapeutic drug-loaded liposomes have shown superior antitumor activity compared to traditional liposomal drugs.

ADVANCED FUNCTIONAL MATERIALS (2023)

Article Chemistry, Multidisciplinary

Unraveling the Plasma Protein Corona by Ultrasonic Cavitation Augments Active-Transporting of Liposome in Solid Tumor

Guowei Wang et al.

Summary: This study reveals that ultrasonic cavitation can unravel the surface protein corona on liposomal nanoparticles, and develops transcytosis-targeting liposomes for efficient cancer therapy. This effective strategy tackles the biological barriers of the protein corona and provides a promising approach for active tumor transport and cancer treatment.

ADVANCED MATERIALS (2023)

Article Chemistry, Multidisciplinary

Mucus Penetrating and Cell-Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery

Wufa Fan et al.

Summary: The study introduces a novel polymeric micelle that can penetrate mucus layer and be absorbed by villi, efficiently delivering anticancer drugs to tumors with improved therapeutic efficacy.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Multipotent Poly(Tertiary Amine-Oxide) Micelles for Efficient Cancer Drug Delivery

Jiajia Xiang et al.

Summary: The cancer drug delivery process is hindered by biological barriers. This study presents a new type of nanomedicine that can exhibit multiple functions, including long circulation, tumor accumulation and penetration, fast cellular internalization, and mitochondrial targeting. The nanomedicine shows potent anticancer activity and holds promise as a generic platform for clinical translation.

ADVANCED SCIENCE (2022)

Article Pharmacology & Pharmacy

Red blood cell-hitchhiking mediated pulmonary delivery of ivermectin: Effects of nanoparticle properties

Jinpeng Zheng et al.

Summary: This study demonstrates that red blood cell hitchhiking strategy can effectively enhance the delivery of ivermectin to the lungs, improve its accumulation in lung tissue, and alleviate the progression of acute lung injury. The effects are dependent on the properties of nanoparticles, with cationic nanoparticles showing better results. Red blood cell hitchhiking provides an alternative strategy to improve the pharmacokinetics and bioavailability of ivermectin.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Multidisciplinary Sciences

Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism

Rong Cai et al.

Summary: The nanomaterial-protein corona plays a crucial role in the cellular uptake and subcellular distribution of nanomaterials. Understanding its biological and toxicological characteristics is essential for the development of nanomedicine and nanosafety. However, the dynamics of intracellular release and exchange of the protein corona from nanomaterials remains unclear, and the biological footprints of the nanoparticle-protein corona inside cells are not well understood. This study investigates the evolution of the intracellular protein corona along the endocytotic pathway and reveals its impact on cell metabolism.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Review Microbiology

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Jessa Marie V. Makabenta et al.

Summary: Nanomaterial-based therapies offer a promising approach to combat antibiotic-resistant bacterial infections by targeting biofilms and overcoming recalcitrant infections. Their unique size and physical properties enable them to evade existing mechanisms associated with acquired drug resistance.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Infectious Diseases

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

Cristina Uruen et al.

Summary: Multidrug resistant bacteria pose a global threat, but only partially contribute to antibiotic failure. Another factor is the formation of biofilms, which provide an environment that allows bacteria to develop tolerance and resistance to antibiotics.

ANTIBIOTICS-BASEL (2021)

Article Engineering, Biomedical

Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity

Siqin Chen et al.

Summary: Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and weak interaction with phospholipids can effectively eradicate large tumours and patient-derived tumour xenografts in mice by facilitating their transcytosis-mediated extravasation and infiltration into tumours, showcasing potential for translational anticancer nanomedicines.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Chemistry, Multidisciplinary

pH-Responsive Polymer-Drug Conjugate: An Effective Strategy to Combat the Antimicrobial Resistance

Mingzhou Ye et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

Gram-Negative Bacteria Targeting Mediated by Carbohydrate-Carbohydrate Interactions Induced by Surface-Modified Nanoparticles

Larissa Brentano Capeletti et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Review Chemistry, Multidisciplinary

Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Yong Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Chemistry, Multidisciplinary

A neutral water-soluble mitochondria-targeting polymer

Yu Geng et al.

CHEMICAL COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

Review Microbiology

Implant infections: adhesion, biofilm formation and immune evasion

Carla Renata Arciola et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Pharmacology & Pharmacy

Strategies to overcome the polycation dilemma in drug delivery

Andreas Bernkop-Schnuerch

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management

Can Yang Zhang et al.

ADVANCED MATERIALS (2018)

Article Chemistry, Multidisciplinary

Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections

Akash Gupta et al.

ACS NANO (2018)

Article Chemistry, Medicinal

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

Ma Su et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

Carlos H. Villa et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Review Microbiology

Biofilms: an emergent form of bacterial life

Hans-Curt Flemming et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Review Microbiology

Molecular mechanisms of antibiotic resistance

Jessica M. A. Blair et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Article Pharmacology & Pharmacy

Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

Carlos H. Villa et al.

THERAPEUTIC DELIVERY (2015)

Article Multidisciplinary Sciences

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

Song Lin Chua et al.

NATURE COMMUNICATIONS (2014)

Review Biotechnology & Applied Microbiology

Applying insights from biofilm biology to drug development - can a new approach be developed?

Thomas Bjarnsholt et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Biochemical Research Methods

Biofilm formation and dispersal in Gram-positive bacteria

Tjakko Abee et al.

CURRENT OPINION IN BIOTECHNOLOGY (2011)

Review Chemistry, Multidisciplinary

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Katrin Knop et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Microbiology

Clarithromycin

TUBERCULOSIS (2008)

Article Chemistry, Multidisciplinary

Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes

E Chambers et al.

JOURNAL OF CONTROLLED RELEASE (2004)

Review Biotechnology & Applied Microbiology

Understanding biofilm resistance to antibacterial agents

D Davies

NATURE REVIEWS DRUG DISCOVERY (2003)