期刊
JOURNAL OF NATURAL PRODUCTS
卷 86, 期 11, 页码 2529-2538出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.3c00742
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This study isolated four new macrolide glycosides from a marine cyanobacterium and determined their structures through spectroscopic analyses. These macrolides demonstrated moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense and showed no cytotoxicity against normal human cells at a certain concentration.
Akunolides A (1), B (2), C (3), and D (4), new macrolide glycosides, were isolated from a marine Okeania sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A-D (1-4) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A-D (1-4) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense, with IC50 values ranging from 11 to 14 mu M. Furthermore, akunolides A (1) and C (3) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 mu M.
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