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ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
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Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
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Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
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ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization
Fei Li et al.
EMBO JOURNAL (2019)
CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
Rubina Tuladhar et al.
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A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
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Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation
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JOURNAL OF CELL BIOLOGY (2018)
Determinants and clinical implications of chromosomal instability in cancer
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ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner
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FRONTIERS IN GENETICS (2018)
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Strong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter
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CELL (2017)
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S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation
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MOLECULAR CELL (2016)
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