Enabling translational geroscience by broadening the scope of geriatric care

Geroscience poses that core biological mechanisms of aging contribute to chronic diseases and disabilities in late life and that health span and longevity can be modulated by pharmacological and behavioral interventions. Despite strong evidence from studies in model organisms and great potentials for translation, most geriatricians remain skeptical that geroscience will help them in the day-by-day battle with the consequences of aging in their patients. We believe that a closer collaboration between gerontologists and geriatricians is the key to overcome this impasse. There is evidence that trajectories of health with aging are rooted in intrinsic and extrinsic exposures that occur early in life and affect the pace of molecular and cellular damage accumulation with aging, also referred to as the pace of biological aging. Tools that measure the pace of aging currently allow for the identification of individuals experiencing accelerated aging and at higher risk of multimorbidity and disability. What we term Translational Geroscience, i.e., the merger of fundamental and translational science with clinical practice, is thus poised to extend the action of geriatric care to a life course perspective. By targeting core mechanisms of aging, gerotherapeutics should be effective in treating patients with multimorbidity and disability, phenotypes that are all too common among geriatric patients nowadays. We call for initiatives that enhance the flow of ideas between gerontologists and geriatricians to facilitate the growth of translational geroscience. This approach can widen the scope of geriatric care, including a new role for geroscience in the promotion and operationalization of healthy longevity. Translational Geroscience poses that slowing down the underlying mechanisms of aging will result in prevention of most diseases and disabilities that affect older persons. To facilitate this transformation will require a closer collaboration and wider discussion between gerontologists who study aging in research laboratories (geroscience) and geriatricians who maintain life course records and care for older patients with complex multimorbidity and disability (geriatric care). Figure generated using Office suite and Biorender.image

Automated summary

Geroscience suggests that aging mechanisms contribute to chronic diseases and disabilities in old age, and interventions can modulate health span and longevity. Collaboration between gerontologists and geriatricians is key. Early life exposures affect the pace of aging and health trajectories. Tools measuring aging pace can identify individuals at higher risk of multimorbidity and disability. Translational Geroscience extends geriatric care to a life course perspective, targeting core aging mechanisms to treat patients with complex conditions.