The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors

Article Cell Biology

CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p

Jiaping Pei et al.

Summary: This study reveals that up-regulation of circFAM53B promotes the progression of glioma by regulating the miR-532-3p/c-MET/PI3K/AKT pathway.

CELL CYCLE (2022)

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Article Biochemistry & Molecular Biology

CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA

Simin Chen et al.

Summary: In this study, circCDK14 is identified as an overexpressed circRNA in glioma, and its high expression is associated with poor prognosis in glioma patients. CircCDK14 promotes glioma cell migration, invasion, and proliferation by sponging miR-3938 to upregulate PDGFRA expression. Additionally, circCDK14 reduces glioma cells' sensitivity to ferroptosis by regulating PDGFRA expression.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Yung-Hung Luo et al.

Summary: Lung cancer is the leading cause of death from cancer in Taiwan and worldwide. Immunotherapy has shown promising efficacy in non-small cell lung cancer (NSCLC) by blocking the PD-1/PD-L1 signaling pathway. Circular RNAs (circRNAs) have been identified as potential blood-based biomarkers to monitor the disease progression and immunotherapy efficacy. Hsa_ circ_0000190 was found to interfere with anti-PD-L1 antibody and T-cell activation, leading to immunotherapy resistance and poor prognosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Ziwen Pan et al.

Summary: This study reveals the significant role of circNEIL3 in promoting gliomagenesis and malignant progression, as well as in driving macrophage infiltration into the tumour microenvironment. CircNEIL3 may serve as a potential prognostic biomarker and therapeutic target for gliomas.

MOLECULAR CANCER (2022)

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Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Neurosciences

Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281

Jun Wang et al.

Summary: Circ_0001588 plays a crucial role in the progression of glioma by regulating the miR-1281/ERBB4 pathway, promoting malignant progression of glioma.

NEUROTOXICITY RESEARCH (2022)

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Review Immunology

IFNγ signaling integrity in colorectal cancer immunity and immunotherapy

Wan Du et al.

Summary: The majority of colorectal cancer patients do not respond to immune checkpoint blockade, with the IFN gamma signaling pathway playing a crucial role in antitumor immunity. Targeting IFN gamma signaling for novel clinical trials in treating patients with colorectal cancer is of significant importance.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Review Pharmacology & Pharmacy

Nanomedicine for brain cancer

Sabina Quader et al.

Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Neurosciences

CircPOSTN competes with KIF1B for miR-185-5p binding sites to promote the tumorigenesis of glioma

Yongchang Guan et al.

Summary: Background: The involvement of certain circular RNAs (circRNAs) in the development of glioma has been revealed. This study validated the positive association of circRNA periostin (circPOSTN) with glioma cell growth and metastasis. The mechanism of circPOSTN in glioma tumorigenesis, specifically its interaction with miR-185-5p/KIF1B axis, was elucidated.

BRAIN RESEARCH BULLETIN (2022)

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Article Neurosciences

Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma

Fanen Yuan et al.

Summary: The study demonstrated that hsa_circ_0072309 promotes autophagy through the p53 signaling pathway and enhances sensitivity to temozolomide in GBM. It may serve as a potential and promising target in designing treatment strategies for GBM.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

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Article Gastroenterology & Hepatology

Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription

Qinjunjie Chen et al.

Summary: The circular RNA circACTN4 was found to be highly expressed in intrahepatic cholangiocarcinoma and promoted tumor growth and metastasis through interaction with miR-424-5p and YBX1 to activate FZD7. This suggests that circACTN4 may serve as a prognostic marker and therapeutic target for intrahepatic cholangiocarcinoma.

JOURNAL OF HEPATOLOGY (2022)

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Article Biotechnology & Applied Microbiology

circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway

Yaming Li et al.

Summary: The protein-coding ability of circRNAs in TNBC has not been well understood. This study identified a circRNA called circ-EIF6, which was associated with poorer prognosis and clinicopathological characteristics in TNBC patients. Functional experiments showed that circ-EIF6 promoted proliferation and metastasis of TNBC cells, mediated by encoding a novel peptide called EIF6-224aa that interacted with MYH9, leading to activation of the Wnt/β-catenin pathway.

MOLECULAR THERAPY (2022)

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Review Clinical Neurology

Expression, prognostic significance and therapeutic implications of PD-L1 in gliomas

Gayaththri Vimalathas et al.

Summary: Checkpoint immunotherapy with PD-1 and PD-L1 inhibitors has shown groundbreaking results in several advanced cancers, but is facing challenges in gliomas due to poor clinical efficacy. Gliomas possess deep immunosuppressive properties and molecular heterogeneity, and PD-L1 as an important therapeutic target holds prognostic value.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Ashuai Du et al.

Summary: This study identified a new oncogenic circRNA, circMDK, that promotes the progression of HCC through the regulation of the miR-346/874-3p-ATG16L1 axis. The research team also developed poly (beta-amino esters)-based nanoparticles that effectively deliver siRNA targeting circMDK, inhibiting HCC proliferation and metastasis.

MOLECULAR CANCER (2022)

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Article Medicine, Research & Experimental

circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

Haibin Xia et al.

Summary: The high expression of circRNA-0002109 in glioma promotes the malignant development of the tumor by regulating the miR-129-5P/EMP2 axis, affecting the proliferation, invasion, and migration of glioma cells.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Article Biotechnology & Applied Microbiology

Circular RNA circRNA_0067934 promotes glioma development by modulating the microRNA miR-7/Wnt/β-catenin axis

Yunlong Pei et al.

Summary: This study found that circRNA_0067934 regulates the progression of glioma cells by targeting the miR-7/Wnt/β-catenin axis, which is of significant importance for understanding the development mechanism of glioma.

BIOENGINEERED (2022)

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Review Immunology

The Role of NcRNAs to Regulate Immune Checkpoints in Cancer

Yicun Jiang et al.

Summary: The treatment of cancer has always been a problem, and current conventional therapies are not effective enough. However, non-coding RNAs play crucial roles in various aspects of cancer biology, and targeting immune checkpoints through ncRNAs may provide a new strategy for cancer treatment.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

circCsnk1g3-and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment

Roberta Piras et al.

Summary: Circular RNAs circCsnk1g3 and circAnkib1 promote sarcoma growth by controlling the expression of interferon-related genes and pro-inflammatory factors in sarcoma cells. They may repress pro-inflammatory elements by buffering activation of the pathways mediated by RIG-I, the cytosolic viral RNA sensor.

NATURE COMMUNICATIONS (2022)

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Review Pharmacology & Pharmacy

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

Camilla Hald Albertsen et al.

Summary: The translation discusses the important role of lipid nanoparticles in mRNA vaccines against COVID-19, as well as the contributions of lipid components to the LNP delivery platform. Challenges and strategies related to LNPs in treating various diseases are also explored.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019

Quinn T. Ostrom et al.

Summary: The report provides the latest data on primary brain tumors in the United States, including incidence rates, mortality rates, and relative survival rates. The overall incidence rate is higher in females and non-Hispanic population, and glioblastoma is the most common malignant brain tumor, while meningioma is the most common non-malignant brain tumor. The relative survival rate is lower for malignant brain tumors and higher for non-malignant brain tumors.

NEURO-ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies

Hongjian Li et al.

Summary: In this study, we successfully improved the stability of RNA vaccines by circularizing linear RNA molecules to form highly stable circRNA molecules. We established a novel circRNA vaccine platform capable of triggering robust immune activation and showing superior anti-tumor efficacy in multiple tumor models. This provides a new prospect for the development of cancer RNA vaccines in hard-to-treat malignancies.

THERANOSTICS (2022)

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Article Oncology

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling

Yutian Wei et al.

Summary: This study revealed that circASAP1 is upregulated in recurrent GBM tissues and TMZ-resistant cell lines, promoting GBM cell proliferation and TMZ resistance by increasing NRAS expression through sponging miR-502-5p. The findings suggest that ceRNA-mediated microRNA sequestration may be a potential therapeutic strategy for GBM treatment.

NEURO-ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence

Wendi Huang et al.

Summary: TransCirc is a specialized database providing comprehensive evidences supporting the translation potential of circRNAs. It integrates seven types of evidences to predict the translation likelihood of circRNAs, offering a user-friendly interface and flexible tools for data retrieval and analysis. This resource can be expanded to include new evidences or additional species in the future.

NUCLEIC ACIDS RESEARCH (2021)

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Article Cell Biology

Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis

Wen Ge et al.

Aging-US (2021)

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Letter Clinical Neurology

Distinct circular RNA expression profiles in pediatric ependymomas

Ulvi Ahmadov et al.

Summary: The study revealed a significant downregulation of circRNAs in pediatric ependymomas, with different circRNA expression patterns correlated to clinical outcomes and characteristics. These findings suggest that circRNAs could potentially serve as diagnostic and prognostic biomarkers in the future.

BRAIN PATHOLOGY (2021)

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Article Oncology

CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p

Kebin Zheng et al.

Summary: The study revealed that overexpressed CircPIP5K1A in glioma tissues was associated with tumor volume and histopathological grade. Functional experiments showed that overexpressing CircPIP5K1A significantly promoted glioma cell proliferation, invasion, and epithelial-mesenchymal transition, while inhibiting apoptosis.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis

Binghong Chen et al.

Summary: Glioblastoma (GBM) is a highly aggressive cancer characterized by rapid cell proliferation. Legumain (LGMN), a specific protease, is associated with poor progression in GBM. CircRNAs are abnormally expressed in various cancers, and circLGMN derived from LGMN promotes GBM malignancy by sponging miR127-3p to upregulate LGMN expression. Targeting the circLGMN/miR-127-3p/LGMN axis may be a promising strategy for GBM treatment, and further research on LGMN self-regulation by circLGMN is warranted.

CANCER LETTERS (2021)

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Review Biotechnology & Applied Microbiology

Targeting Notch in oncology: the path forward

Samarpan Majumder et al.

Summary: The Notch pathway in cancer has multifaceted roles, acting as both an oncogene and a tumor suppressor depending on the context. Despite potential, developing safe and effective Notch-targeting agents for clinical use remains challenging.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Oncology

Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity

Yi Liu et al.

Summary: The study identified a novel EGFR variant, rtEGFR, encoded by circEGFR, which promotes GBM development by maintaining EGFR activation and inhibiting EGFR degradation, showing significant correlation with patient prognosis. Targeting rtEGFR could potentially enhance the efficacy of EGFR-targeting therapies in GBM treatment.

NEURO-ONCOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

Dong-Liang Chen et al.

Summary: The study highlights the upregulation of circDLG1 in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy, correlating with aggressive tumor phenotype and poor prognosis. Ectopic circDLG1 expression promotes proliferation, migration, invasion, and immune evasion of gastric cancer cells. Mechanistically, circDLG1 interacts with miR-141-3p as a miRNA sponge to increase CXCL12 expression, promoting gastric cancer progression and resistance to anti-PD-1 therapy.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Shi-Wei Chen et al.

Summary: In human non-small cell lung cancer (NSCLC) tissues, high expression levels of circUSP7 are associated with poor clinical prognosis and dysfunction of CD8(+) T cells. CircUSP7 found in NSCLC patient plasma is mainly secreted by NSCLC cells via exosomes, inhibiting CD8(+) T cell function by upregulating SHP2 expression. Additionally, circUSP7 may contribute to resistance to anti-PD1 immunotherapy in NSCLC patients.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation

Feng Yang et al.

Summary: The study identified a novel protein p113 encoded by CUX1 circular RNA that promotes tumorigenesis and aggressiveness of neuroblastoma cells through interaction with ZRF1 and BRD4 to form a transcriptional regulatory complex. Inhibiting the interaction between p113 and ZRF1 can suppress the invasion and growth of tumor cells.

MOLECULAR CANCER (2021)

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Article Oncology

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018

Quinn T. Ostrom et al.

Summary: The report from CBTRUS provides the most up-to-date population-based data on primary brain tumors in the United States, including incidence rates, mortality rates, and survival rates for both malignant and non-malignant tumors.

NEURO-ONCOLOGY (2021)

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Article Cell Biology

Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis

Chenlong Li et al.

Summary: This study identified the novel biomarker panel consisting of the circHECTD1/miR-296-3p/SLC10A7 axis, which is critical for glioma tumorigenesis and invasiveness, representing a potential therapeutic target for intervening in glioma progression.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Review Medicine, Research & Experimental

Circular RNA: an important player with multiple facets to regulate its parental gene expression

Tong Shao et al.

Summary: Circular RNAs, with covalently closed-loop structures, have emerged as a new research hotspot in the RNA world. They regulate parental gene expression through diverse mechanisms such as transcription and splicing regulation, microRNA sponges, mRNA traps, translational modulation, and post-translational modification.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Letter Clinical Neurology

Circular RNA profiling distinguishes medullobastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma

Daniel Rickert et al.

ACTA NEUROPATHOLOGICA (2021)

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Article Cell Biology

Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis

Ling Qi et al.

Aging-US (2021)

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Article Cell Biology

Exosomal circRNA 0001445 promotes glioma progression through miRNA-127-5p/SNX5 pathway

Yonggang Han et al.

Aging-US (2021)

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Article Genetics & Heredity

PBX2-Mediated circTLK1 Activates JAK/STAT Signaling to Promote Gliomagenesis via miR-452-5p/SSR1 Axis

Jing Li et al.

Summary: The study revealed that circTLK1 activates JAK/STAT signaling to promote glioma progression through the circTLK1/miR-452-5p/SSR1 axis. Additionally, the expression of circTLK1 in glioma cells is regulated by the transcription factor PBX2.

FRONTIERS IN GENETICS (2021)

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Article Oncology

The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells

Xuchen Dong et al.

Summary: The study demonstrates that circ_0001367 inhibits the proliferation and invasion of glioma cells by absorbing miR-545-3p to regulate the expression of leucine zipper protein (LUZP1). This axis may serve as a novel target for glioma therapy.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

Junshuang Zhao et al.

Summary: Our study identified a feedback loop involving SRSF1/circATP5B/miR-185-5p/HOXB5 in GSCs, which plays a crucial role in glioma proliferation. This feedback loop provides a potential biomarker for glioma diagnosis and prognosis evaluation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma

Chenyu Ding et al.

Summary: Exosomal circ_0072083 promotes TMZ resistance in glioma through increasing NANOG levels via regulating miR-1252-5p-mediated degradation and demethylation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Cell Biology

CircNFIX promotes progression of pituitary adenoma via CCNB1 by sponging miR-34a-5p

Jianhua Cheng et al.

Summary: This study identified that circNFIX regulates cell invasion, migration, and proliferation in pituitary adenomas by sponging miR-34a-5p through CCNB1. The expression of circNFIX and CCNB1 was upregulated in pituitary adenoma tissues, while miR-34a-5p expression was downregulated. Silencing of circNFIX or overexpression of miR-34a-5p inhibited cell invasion, migration, and proliferation, indicating the potential of circNFIX as a therapeutic target for pituitary adenomas.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

Tianlu Jiang et al.

Summary: The study identified that circMAPK1 is downregulated in gastric cancer tissues, and its lower expression predicts poor survival. CircMAPK1 exerts a tumor suppressive effect through the encoded protein MAPK1-109aa, inhibiting the proliferation and invasion of gastric cancer cells.

MOLECULAR CANCER (2021)

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Article Biochemistry & Molecular Biology

FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs

Yang Jiang et al.

Summary: A novel circRNA-CHAF1A was discovered to be overexpressed in glioma and associated with low survival rate. CircCHAF1A was found to regulate HOXC8 expression through miR-211-5p, promoting proliferation and tumorigenesis of GSCs. The feedback loop involving FMR1, circCHAF1A, miR-211-5p, and HOXC8 may play a role in the malignant transformation of glioma.

ONCOGENE (2021)

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Article Medicine, Research & Experimental

circMELK promotes glioblastoma multiforme cell tumorigenesis through the miR-593/EphB2 axis

Fengqi Zhou et al.

Summary: This study demonstrates that circMELK acts as an oncogene in GBM, regulating mesenchymal transition and GSC maintenance by sponging miR-593. EphB2 is involved in the circMELK/miR-593 axis induced GBM tumorigenesis. This finding suggests a potential novel therapeutic target for gliomas.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Chemistry, Multidisciplinary

HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein

Yan Li et al.

Summary: This study identified a novel oncogenic circRNA called circARHGAP35 originating from the tumor suppressor gene ARHGAP35, which has antithetical expression and functions with linear ARHGAP35. CircARHGAP35 encodes a truncated protein without the Rho GAP domain, promoting cancer cell progression by interacting with TFII-I protein in the nucleus. HNRNPL facilitates the formation of circARHGAP35, which is associated with poor survival in cancer patients.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation

Lingfei Jia et al.

Summary: Elevated circFAT1 in squamous cell carcinoma (SCC) unifies and regulates the positive association between cancer stemness and immune evasion by promoting STAT3 activation. Knockdown of circFAT1 reduces tumorsphere formation of SCC cells and tumor growth, while enhancing PD1 blockade immunotherapy. This study demonstrates that circFAT1 plays an important role in regulating cancer stemness and antitumor immunity.

ADVANCED SCIENCE (2021)

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Article Oncology

Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism

Zhiwei Zhou et al.

Summary: The study revealed that in glioma, the upregulation of circ_0080229 was associated with unfavorable clinicopathologic characteristics and mediated tumor progression through the miR-1827/MDM2 signaling pathway. This suggests that circ_0080229 may serve as a potential prognostic biomarker in gliomas.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Clinical Neurology

TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma

Kenji Fujimoto et al.

Summary: This study found that in IDH-wildtype lower grade gliomas, the pTERT mutation is a significant predictor of poor prognosis, while both EGFR amplification and PDGFRA gain also play important roles in prognosis.

ACTA NEUROPATHOLOGICA (2021)

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Article Cell Biology

Circular RNA ZNF609 enhances proliferation and glycolysis during glioma progression by miR-378b/SLC2A1 axis

Zhihuang Zhao et al.

Summary: The circular RNA ZNF609 plays a critical role in regulating glioma by affecting cell growth, invasion, apoptosis, and glycolysis. ZNF609 modulates cell survival and glycolysis by targeting the miR-378b/SLC2A1 axis in glioma cells. ZNF609 and miR-378b may serve as potential therapeutic targets in treating glioma.

AGING-US (2021)

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Article Cell Biology

Blocking hsa_circ_0006168 suppresses cell proliferation and motility of human glioblastoma cells by regulating hsa_circ_0006168/miR-628-5p/IGF1R ceRNA axis

Tuo Wang et al.

Summary: The oncogenic circular RNA hsa_circ_0006168 was found to promote cell proliferation and motility in glioblastoma, acting as a competitive endogenous RNA for miR-628-5p and regulating the IGF1R/Ras/Erk pathway.

CELL CYCLE (2021)

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Article Biology

Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis

Liang Di et al.

Summary: This study revealed that circ_0008344 played a crucial role in radioresistance of glioma, with its down-regulation enhancing glioma cell susceptibility to radiation. It was found to interact with miR-433-3p and regulate radiosensitivity of glioma cells by sponging miR-433-3p. Additionally, RNF2 was identified as a target of miR-433-3p and regulated by the circ_0008344/miR-433-3p axis, indicating circ_0008344 as a potential diagnostic biomarker and therapeutic target in glioma radiotherapy.

JOURNAL OF BIOSCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Circular RNA circ_0001588 sponges miR-211-5p to facilitate the progression of glioblastoma via up-regulating YY1 expression

Qian Wang et al.

Summary: The study revealed that circ_0001588 plays a crucial role in glioblastoma (GBM) by modulating the miR-211-5p/YY1 signaling pathway, which accelerates the proliferation, migration, and invasion of GBM.

JOURNAL OF GENE MEDICINE (2021)

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Article Oncology

Circ_CLIP2 promotes glioma progression through targeting the miR-195-5p/HMGB3 axis

Bing Xiao et al.

Summary: The study showed that Circ_CLIP2 and HMGB3 were upregulated while miR-195-5p was downregulated in glioma cells. Silencing of Circ_CLIP2 inhibited cell proliferation and promoted cell apoptosis. MiR-195-5p inhibited HMGB3 expression by directly targeting HMGB3, leading to the suppression of the Wnt/beta-catenin signaling pathway.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy

Wenxiao Jiang et al.

Summary: The focus of the study is on understanding the regulatory roles of long noncoding RNAs and circular RNAs in the PD-1/PD-L1 pathway, in hopes of driving more precise and effective cancer immune checkpoint therapies.

MOLECULAR CANCER (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Article Medicine, General & Internal

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

S. J. Thomas et al.

Summary: BNT162b2 vaccine remains highly effective and safe over the course of 6 months post-vaccination, with efficacy rates ranging from 86% to 100% across different demographics and risk factors for Covid-19. The vaccine also shows a high efficacy against severe disease, with particularly promising results observed in South Africa against the B.1.351 variant.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cell Biology

Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3

Liang Liu et al.

Summary: The study reveals that circ_0001367 functions as a suppressor in glioma by targeting the miR-431/NRXN3 axis, potentially serving as a promising therapeutic target against gliomas.

CELL DEATH & DISEASE (2021)

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Article Oncology

Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway

Deheng Li et al.

Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling

Senjie Du et al.

Summary: This study demonstrated that circ-ZNF609 is significantly upregulated in glioma and promotes tumor growth and metastasis by enhancing PLK1 expression through competitively binding miR-1224-3p. Inhibition of circ-ZNF609 could suppress glioma cell proliferation, migration and invasion, suggesting circ-ZNF609 as a potential therapeutic target for glioma.

JOURNAL OF CANCER (2021)

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Review Materials Science, Biomaterials

Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance

Peng Xie et al.

Summary: This paper summarizes the mechanisms of resistance to platinum drugs, the advantages of nanoparticles in drug delivery, and the recent strategies of nanoparticle-based platinum drug delivery. It also discusses how to design delivery platforms more effectively to overcome chemoresistance in cancers and improve the efficacy of platinum-based chemotherapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Oncology

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p

Jin Qian et al.

Summary: This study demonstrated that the upregulation of circular RNA hsa_circ_0091581 in glioma promotes proliferation, migration, and invasion of glioma cells by sponging miR-1243-5p to regulate RMI1. Knockdown of hsa_circ_0091581 was shown to inhibit glioma growth in vivo, suggesting a potential novel therapeutic target in glioma.

JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

Circ-VPS18 Knockdown Enhances TMZ Sensitivity and Inhibits Glioma Progression by MiR-370/RUNX1 Axis

Weimin Li et al.

Summary: This study revealed that circ-VPS18 functions as a sponge of miR-370 to downregulate the expression of RUNX1, thereby improving sensitivity to TMZ and inhibiting the progression of glioma.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Circ_101064 regulates the proliferation, invasion and migration of glioma cells through miR-154-5p/PIWIL1 axis

Hongjun Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Biotechnology & Applied Microbiology

The challenge and prospect of mRNA therapeutics landscape

Yuhua Weng et al.

BIOTECHNOLOGY ADVANCES (2020)

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Article Biochemistry & Molecular Biology

ncEP: A Manually Curated Database for Experimentally Validated ncRNA-encoded Proteins or Peptides

Haizhou Liu et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Hsa_circ_0008225 inhibits tumorigenesis of glioma via sponging miR-890 and promoting ZMYND11 expression

Xiaoliang Wang et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling

Jianxin Qiao et al.

LIFE SCIENCES (2020)

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Article Medicine, General & Internal

The circ_VCAN with radioresistance contributes to the carcinogenesis of glioma by regulating microRNA-1183

Chengbin Zhu et al.

MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Pan Wu et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Functions and clinical significance of circular RNAs in glioma

Jikui Sun et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Structure-Mediated RNA Decay by UPF1 and G3BP1

Joseph W. Fischer et al.

MOLECULAR CELL (2020)

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Review Neurosciences

Role of circular RNAs in brain development and CNS diseases

Suresh L. Mehta et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Article Oncology

Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p/NEK2 axis

Yongchang Guan et al.

CANCER CELL INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Jian Cheng et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin

Martina Ghetti et al.

MOLECULAR CANCER (2020)

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Article Neurosciences

Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development

Qiu Du et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Oncology

SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway

Xiaobai Liu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

Qiyi Zhao et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

CircMMP1promotes the progression of glioma throughmiR-433/HMGB3axis in vitro and in vivo

Kai Yin et al.

IUBMB LIFE (2020)

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Article Neurosciences

Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis

Xinyu Zhang et al.

NEUROSCIENCE LETTERS (2020)

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Review Neurosciences

Circular RNAs: The Brain Transcriptome Comes Full Circle

Akira Gokool et al.

TRENDS IN NEUROSCIENCES (2020)

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Article Cell Biology

The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway

Jie Wang et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-κB axis

Jinghan Yang et al.

CELL DEATH & DISEASE (2020)

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Article Genetics & Heredity

Circular RNA CircHIPK3 Elevates CCND2 Expression and Promotes Cell Proliferation and Invasion Through miR-124 in Glioma

Zengjin Liu et al.

FRONTIERS IN GENETICS (2020)

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Article Cell Biology

Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease

Dingding Mo et al.

CELLS (2020)

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Article Cell Biology

Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis

Yanyao Deng et al.

Aging-US (2020)

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Article Oncology

CircSKA3 Modulates FOXM1 to Facilitate Cell Proliferation, Migration, and Invasion While Confine Apoptosis in Medulloblastoma via miR-383-5p

Xinfang Wang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Noncoding RNAs: the shot callers in tumor immune escape

Lei Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Biochemistry & Molecular Biology

CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153/PI3K signaling

Fei Shi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Medical Laboratory Technology

Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis

Yuchen Li et al.

CLINICAL CHEMISTRY (2019)

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Article Genetics & Heredity

Circular RNA HIPK3 promotes glioma progression by binding to miR-124-3p

Daling Hu et al.

GENE (2019)

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Article Oncology

FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma

Zhenwei He et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Oncology

Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma

Xin Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

R. Alexander Wesselhoeft et al.

MOLECULAR CELL (2019)

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Article Multidisciplinary Sciences

Circular RNAs are temporospatially regulated throughout development and ageing in the rat

E. Mahmoudi et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, General & Internal

Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma

Jianxing Yin et al.

EBIOMEDICINE (2019)

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Article Oncology

CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1

Davide Barbagallo et al.

CANCERS (2019)

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Article Biochemistry & Molecular Biology

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity

Chu-Xiao Liu et al.

CELL (2019)

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Review Biochemistry & Molecular Biology

The role of m6A RNA methylation in human cancer

Xiao-Yu Chen et al.

MOLECULAR CANCER (2019)

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Article Biochemical Research Methods

IRESpy: an XGBoost model for prediction of internal ribosome entry sites

Junhui Wang et al.

BMC BIOINFORMATICS (2019)

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Article Cell Biology

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Jlenia Guarnerio et al.

CELL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma

Lan Zhan et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis

Chao Yi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Medicine, General & Internal

Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas A microarray analysis

Yu Hu et al.

MEDICINE (2019)

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Article Genetics & Heredity

circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells

Yaoyong Lu et al.

EPIGENOMICS (2019)

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Article Medicine, Research & Experimental

Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis

Qiang Meng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Cell Biology

circCPA4 acts as a prognostic factor and regulates the proliferation and metastasis of glioma

Hao Peng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Oncology

circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma

Jiansheng Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Gastroenterology & Hepatology

Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a

Qu Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

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Review Biochemistry & Molecular Biology

R Loops: From Physiological to Pathological Roles

Tatiana Garcia-Muse et al.

CELL (2019)

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Article Pharmacology & Pharmacy

Circular RNA circ-PITX1 promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-379-5p/MAP3K2 axis

Xinwen Lv et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Oncology

CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5

Shuai Zhang et al.

NEURO-ONCOLOGY (2019)

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Article Genetics & Heredity

CircCode: A Powerful Tool for Identifying circRNA Coding Ability

Peisen Sun et al.

FRONTIERS IN GENETICS (2019)

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Article Biochemistry & Molecular Biology

Circular RNA circ_0034642 elevates BATF3 expression and promotes cell proliferation and invasion through miR-1205 in glioma

Mengli Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression

Bingxi Lei et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Oncology

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change

Qianru He et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Oncology

CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis

Chenyu Ding et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Review Pharmacology & Pharmacy

The Prognostic and Therapeutic Value of PD-L1 in Gliomaa

Ruo Qiao Chen et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Cell Biology

Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis

Hua Li et al.

CELL DEATH & DISEASE (2019)

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Review Oncology

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

Katie L. Owen et al.

CANCERS (2019)

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Article Oncology

Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1-Survivin axis

Jun-Hai Tang et al.

CANCER COMMUNICATIONS (2019)

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Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Biochemistry & Molecular Biology

Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation

Lasse Sommer Kristensen et al.

RNA BIOLOGY (2018)

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Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Biochemistry & Molecular Biology

CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regulating miR-654/IGF2BP3 signaling

Pengcheng Jin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells

Guang-Feng Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Oncology

CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis

Renjie Wang et al.

CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma

Zhiqiang Chen et al.

DNA AND CELL BIOLOGY (2018)

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Article Genetics & Heredity

Decreased circular RNA hsa_circ_0001649 predicts unfavorable prognosis in glioma and exerts oncogenic properties in vitro and in vivo

Yu Wang et al.

GENE (2018)

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Review Oncology

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

Xinwei Huang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Oncology

Analyzing the interactions of mRNAs, miRNAs, lncRNAs and circRNAs to predict competing endogenous RNA networks in glioblastoma

Yang Yuan et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

New insights into long noncoding RNAs and their roles in glioma

Zixuan Peng et al.

MOLECULAR CANCER (2018)

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Review Oncology

Current state of immunotherapy for glioblastoma

Michael Lim et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Genetics & Heredity

A-to-I RNA editing - immune protector and transcriptome diversifier

Eli Eisenberg et al.

NATURE REVIEWS GENETICS (2018)

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Article Biochemistry & Molecular Biology

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

Maolei Zhang et al.

ONCOGENE (2018)

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Review Endocrinology & Metabolism

JAK/STAT - Emerging Players in Metabolism

David W. Dodington et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

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Article Multidisciplinary Sciences

Engineering circular RNA for potent and stable translation in eukaryotic cells

R. Alexander Wesselhoeft et al.

NATURE COMMUNICATIONS (2018)

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Article Neurosciences

NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway

Haiyang Xu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

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News Item Multidisciplinary Sciences

Gene-silencing drug approved

Heidi Ledford

NATURE (2018)

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Article Medicine, Research & Experimental

Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1

Aimiao Bian et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Biochemistry & Molecular Biology

Circular RNA hsa_circ_0074362 Promotes Glioma Cell Proliferation, Migration, and Invasion by Attenuating the Inhibition of miR-1236-3p on HOXB7 Expression

Xingbang Duan et al.

DNA AND CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Maolei Zhang et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes

Tao Lv et al.

CANCER MEDICINE (2018)

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Review Pharmacology & Pharmacy

Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Song Zhu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Oncology

The role of bevacizumab in the treatment of glioblastoma

Roberto Jose Diaz et al.

JOURNAL OF NEURO-ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

Ivano Legnini et al.

MOLECULAR CELL (2017)

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Article Biochemistry & Molecular Biology

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

Xiang Li et al.

MOLECULAR CELL (2017)

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Article Multidisciplinary Sciences

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

Tugce Aktas et al.

NATURE (2017)

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Article Oncology

Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis

Junle Zhu et al.

TRANSLATIONAL ONCOLOGY (2017)

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Editorial Material Neurosciences

Commentary: FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

Bert M. Verheijen et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Article Biochemical Research Methods

CircPro: an integrated tool for the identification of circRNAs with protein-coding potential

Xianwen Meng et al.

BIOINFORMATICS (2017)

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Article Plant Sciences

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation

Vanessa M. Conn et al.

NATURE PLANTS (2017)

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Article Cell Biology

Extensive translation of circular RNAs driven by N6-methyladenosine

Yun Yang et al.

CELL RESEARCH (2017)

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Article Oncology

MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints

Jun Wei et al.

NEURO-ONCOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223

Kun Wang et al.

EUROPEAN HEART JOURNAL (2016)

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Article Multidisciplinary Sciences

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

Qiupeng Zheng et al.

NATURE COMMUNICATIONS (2016)

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Article Oncology

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway

Ping Yang et al.

ONCOTARGET (2016)

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Review Cell Biology

Bioengineering of noncoding RNAs for research agents and therapeutics

Pui Yan Ho et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)

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Article Multidisciplinary Sciences

circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

Xiaoping Chen et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

The RNA Binding Protein Quaking Regulates Formation of circRNAs

Simon J. Conn et al.

CELL (2015)

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Article Biochemistry & Molecular Biology

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Agnieszka Rybak-Wolf et al.

MOLECULAR CELL (2015)

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Review Clinical Neurology

Prospects of immune checkpoint modulators in the treatment of glioblastoma

Matthias Preusser et al.

NATURE REVIEWS NEUROLOGY (2015)

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Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Oncology

A Genetic Platform to Model Sarcomagenesis from Primary Adult Mesenchymal Stem Cells

Jlenia Guarnerio et al.

CANCER DISCOVERY (2015)

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Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

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Article Cell Biology

Exon Circularization Requires Canonical Splice Signals

Stefan Starke et al.

CELL REPORTS (2015)

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Review Cell Biology

Biogenesis, identification, and function of exonic circular RNAs

Iju Chen et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2015)

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Review Oncology

Immunosuppressive mechanisms of malignant gliomas: parallels at non-CNS sites

Powell Perng et al.

FRONTIERS IN ONCOLOGY (2015)

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Article Oncology

Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients

Elizabeth Vera-Bolanos et al.

NEURO-ONCOLOGY (2015)

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Article Biochemistry & Molecular Biology

Complementary Sequence-Mediated Exon Circularization

Xiao-Ou Zhang et al.

CELL (2014)

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Review Biochemistry & Molecular Biology

The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones

Thomas R. Cech et al.

CELL (2014)

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Article Oncology

Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors

Derek A. Wainwright et al.

CLINICAL CANCER RESEARCH (2014)

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Article Biochemistry & Molecular Biology

circRNA Biogenesis Competes with Pre-mRNA Splicing

Reut Ashwal-Fluss et al.

MOLECULAR CELL (2014)

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Review Multidisciplinary Sciences

The multilayered complexity of ceRNA crosstalk and competition

Yvonne Tay et al.

NATURE (2014)

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Review Biotechnology & Applied Microbiology

Targeting RAS-ERK signalling in cancer: promises and challenges

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