4.5 Article

Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

Meizeng Li et al.

Summary: In recent years, the role of potassium channels in tumors has been extensively studied. Potassium channel proteins are involved in various cellular processes, and their expression and dysfunction are closely related to tumor progression. Potassium channel blockers or activators have shown antitumor effects by directly inhibiting tumor growth or enhancing the efficacy of traditional antitumor drugs in combination therapy. This article reviews the mechanisms by which potassium channels contribute to tumor development in various tumors, discusses the potential of potassium channels as diagnostic targets and therapeutic agents, and provides insights for individualized treatment of tumors.

FRONTIERS IN ONCOLOGY (2023)

Review Biochemistry & Molecular Biology

2-Aminobenzothiazoles in anticancer drug design and discovery

Guang Huang et al.

Summary: Cancer is a leading cause of death and disease globally, and efforts have been made to develop new compounds with improved anticancer properties. 2-Aminobenzothiazole is a class of important heterocycles with various medical and pharmacological activities. Recent research has discovered potent and low-toxicity 2-aminobenzothiazole compounds as new anticancer agents. This article provides a comprehensive review of the activities, design strategies, mechanisms of action, and pre-clinical development of these compounds, highlighting their advantages over other heterocyclic systems.

BIOORGANIC CHEMISTRY (2023)

Review Oncology

The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology

Kazem Nejati-Koshki et al.

Summary: Epigenetic mechanisms control gene expression and cellular identity, with DNA methylation being an important epigenetic modification. Methyl-CpG-Binding Protein 2 (MeCP2) is a reader of DNA methylation and plays key roles in cellular identity and function. Recent studies have uncovered MeCP2's involvement in tumorigenesis of various human cancers, highlighting its potential oncogenic properties. This article provides an overview of the emerging role of MeCP2 as an oncogene in different types of human cancer.

CANCERS (2023)

Review Oncology

Focal adhesion kinase: from biological functions to therapeutic strategies

Ximin Tan et al.

Summary: Focal adhesion kinase (FAK) plays a crucial role in cellular functions and tumor microenvironment. Increased FAK expression and activity are strongly associated with unfavorable clinical outcomes and metastatic characteristics in cancer. Modulating FAK activity has potential as an effective approach in cancer therapy.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2023)

Article Chemistry, Medicinal

Design, synthesis, cytotoxicity, and molecular docking studies of novel thiazolyl-hydrazone derivatives as histone lysine acetyl-transferase inhibitors and apoptosis inducers

Eman M. H. Abbas et al.

Summary: Compounds containing both thiazole and arylsulfone moieties have potential for high biological activity, particularly in inhibiting histone lysine acetyl-transferase. Among the synthesized derivatives, compound 10b showed the strongest inhibitory effect on P300 and pCAF, as well as promising anticancer efficacy against leukemia cell lines.

ARCHIV DER PHARMAZIE (2022)

Article Biochemistry & Molecular Biology

Novel sulfonyl thiazolyl-hydrazone derivatives as EGFR inhibitors: Design, synthesis, biological evaluation and molecular docking studies

Thoraya A. Farghaly et al.

Summary: New hydrazonoyl-sulfonylthiazoles were designed and synthesized as EGFR inhibitors, exhibiting excellent anti-tumor activity and good safety profiles.

BIOORGANIC CHEMISTRY (2022)

Article Chemistry, Medicinal

Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives

Lele Zhang et al.

Summary: This article introduces the importance of human dihydroorotate dehydrogenase (hDHODH) in cancers, as well as the development and clinical applications of small molecular inhibitors targeting hDHODH.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Chemistry, Medicinal

Expedition of sulfur-containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

Kritika Laxmikeshav et al.

Summary: This review provides a comprehensive report on the design strategies of sulfur-bearing cytotoxic agents and their potential in anticancer therapy. The article discusses various sulfur-containing heterocyclic scaffolds and their cytotoxic effects through multiple mechanisms. The assessment of antiproliferative activities allows for a proficient evaluation of the structure-activity relationships of the synthesized molecules.

MEDICINAL RESEARCH REVIEWS (2022)

Article Chemistry, Medicinal

From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles

Milena Witkowska et al.

Summary: Mitochondrial targeting is crucial in anticancer therapy. The synthesis of novel substituted carbazole derivatives as mitochondria-disruptive agents shows potent oxidative activity, leading to DNA damage and dysfunction of mitochondria. These findings provide new leads for the treatment of colon cancer and osteosarcoma.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study

Manar G. Salem et al.

Summary: A novel set of 1,3-thiazole derivatives was designed and synthesized, among which compound 4 showed the most potent antiproliferative activity against breast cancer cells and significant inhibitory activity towards VEGFR-2, suggesting it as a promising lead compound for developing potent anti-breast cancer compounds.

MOLECULES (2022)

Review Cell Biology

Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression

Yanmei Chen et al.

Summary: Kynurenine-3-monooxygenase (KMO) plays a crucial role in the tryptophan metabolism pathway and its dysregulation may be involved in the pathogenesis of various diseases such as neurodegenerative diseases, psychosis, and cancer.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Review Biochemistry & Molecular Biology

An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives

Anca-Maria Borcea et al.

Summary: Thiazole, a key heteroaromatic ring, is a crucial scaffold in many synthetic compounds, with diverse pharmacological activities found in clinically approved molecules. Numerous biologically active thiazole and bisthiazole derivatives have been reported, encouraging further research on thiazole-containing drugs.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study

Omar A. El-Khouly et al.

Summary: The newly designed and synthesized benzofuran derivatives exhibited promising anticancer, PI3K inhibitory, and antimicrobial activities. Certain compounds showed significant antibacterial activity against specific bacteria, as well as effects on cell cycle arrest and induction of apoptosis.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Green chemistry approaches for thiazole containing compounds as a potential scaffold for cancer therapy

Diksha Sharma et al.

Summary: This article discusses the recent advancements in green chemistry-based synthesis of thiazole derivatives with anticancer potential. Thiazole scaffold is widely used in drug development, with a drug approved for breast cancer treatment.

SUSTAINABLE CHEMISTRY AND PHARMACY (2021)

Review Biochemistry & Molecular Biology

Control of the eIF4E activity: structural insights and pharmacological implications

Alice Romagnoli et al.

Summary: eIF4E plays a central role in controlling mRNA translation, with its interaction with eIF4G and 4E-BPs being crucial for the assembly of the translational machinery. Recent discoveries of non-canonical binding motifs could have implications for the development of new therapeutic strategies targeting eIF4E.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Chemistry, Medicinal

Recent contributions of quinolines to antimalarial and anticancer drug discovery research

Tim Van de Walle et al.

Summary: Quinoline, a privileged scaffold in medicinal chemistry, plays a central role in antimalarial and anticancer research, but established quinoline-containing antimalarial drugs are facing widespread resistance. On the other hand, there is a growing interest in quinoline compounds as potential anticancer agents.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders

Patrick D. Fischer et al.

Summary: The translation initiation factor eIF4E is a key regulator of cap-dependent protein synthesis, with overexpression implicated in diseases like cancer. A novel inhibitor, i4EG-BiP, has been shown to displace eIF4G and inhibit cancer cell proliferation. Efforts to design PROTACs targeting eIF4E for proteasomal degradation have faced challenges, such as competitive effects from 4E-BP1 binding.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Physical

Structural, antioxidant, antiproliferative and in-silico study of pyridine-based hydrazonyl-selenazoles and their sulphur isosteres

Jovana B. Araskov et al.

Summary: In this study, it was found that selenium compounds exhibit greater potency in antioxidant and antiproliferative activities compared to their sulfur isosteres. The pharmacokinetic profiles of the compounds were also assessed using insilico calculations.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Biochemistry & Molecular Biology

Thiazole Ring-A Biologically Active Scaffold

Anthi Petrou et al.

Summary: Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.

MOLECULES (2021)

Review Chemistry, Medicinal

Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

Juliana de Oliveira Carneiro Brum et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2020)

Editorial Material Oncology

Epigenetic Marks Repressing Gluconeogenesis in Liver and Kidney Cancer

Katharina Leithner

CANCER RESEARCH (2020)

Review Chemistry, Medicinal

Artemisinin-derived hybrids and their anticancer activity

Feng Gao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Thiazole-containing compounds as therapeutic targets for cancer therapy

Prabodh Chander Sharma et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro

Jun Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Oncology

MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents

Arnold Bolomsky et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Chemistry, Medicinal

Hydroxamic acid hybrids as the potential anticancer agents: An Overview

Wenhua Liu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Quinolone hybrids and their anti-cancer activities: An overview

Feng Gao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

An overview on the synthetic and medicinal perspectives of indenopyrazoles

Irfan Khan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Coumarin-containing hybrids and their anticancer activities

Longfei Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo

Liang-Liang Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Quinoline and quinolone dimers and their biological activities: An overview

Xue-Mei Chu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Chemistry, Medicinal

N-Acylhydrazones as drugs

Sreekanth Thota et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Medicinal

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

Temistocles Italo de Santana et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells

Dauren Alimbetov et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

Mehlika Dilek Altintop et al.

MOLECULES (2018)

Article Chemistry, Medicinal

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds

Jolanta Dyniewicz et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents

Romeo Romagnoli et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

An overview of quinoline as a privileged scaffold in cancer drug discovery

Robert Musiol

EXPERT OPINION ON DRUG DISCOVERY (2017)

Article Multidisciplinary Sciences

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Haley R. Pugsley

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

Review Biochemistry & Molecular Biology

Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer

Bojana Ristic et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2017)

Article Multidisciplinary Sciences

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

Claudia Manzoni et al.

SCIENTIFIC REPORTS (2016)

Review Chemistry, Medicinal

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

Adile Ayati et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Oncology

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity

Rita Morigi et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2015)

Article Chemistry, Multidisciplinary

ChemDes: an integrated web-based platform for molecular descriptor and fingerprint computation

Jie Dong et al.

JOURNAL OF CHEMINFORMATICS (2015)

Article Chemistry, Organic

PREDICTION OF THE BIOLOGICAL ACTIVITY SPECTRA OF ORGANIC COMPOUNDS USING THE PASS ONLINE WEB RESOURCE

D. A. Filimonov et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2014)

Review Chemistry, Medicinal

Acylhydrazone derivatives: a patent review

Rodolfo do Couto Maia et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

Article Chemistry, Medicinal

iLOGP: A Simple, Robust, and Efficient Description of n-Octanol/Water Partition Coefficient for Drug Design Using the GB/SA Approach

Antoine Daina et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)

Editorial Material Pharmacology & Pharmacy

How can attrition rates be reduced in cancer drug discovery?

Lucas Moreno et al.

EXPERT OPINION ON DRUG DISCOVERY (2013)

Article Cell Biology

The thiazole derivative CPTH6 impairs autophagy

Y. Ragazzoni et al.

CELL DEATH & DISEASE (2013)

Letter Pharmacology & Pharmacy

5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

Barbara Pardini et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)

Article Chemistry, Inorganic & Nuclear

Synthesis and Structure of Copper(II) Coordination Compounds with 8-Quinolinecarboxaldehyde Thio- and 4-Phenylthiosemicarbazones

M. D. Revenko et al.

RUSSIAN JOURNAL OF INORGANIC CHEMISTRY (2010)

Article Chemistry, Inorganic & Nuclear

Molecular and crystal structure of quinoline-2-aldehyde thiosemicarbazone

P. N. Bourosh et al.

JOURNAL OF STRUCTURAL CHEMISTRY (2009)

Article Biotechnology & Applied Microbiology

Relating protein pharmacology by ligand chemistry

Michael J. Keiser et al.

NATURE BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

DrugBank: a comprehensive resource for in silico drug discovery and exploration

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2006)

Review Biochemistry & Molecular Biology

Lysosomes in cell death

ME Guicciardi et al.

ONCOGENE (2004)

Letter Biochemistry & Molecular Biology

Announcing the worldwide Protein Data Bank

H Berman et al.

NATURE STRUCTURAL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Improved protein-ligand docking using GOLD

ML Verdonk et al.

PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)