Severe hepatic encephalopathy with mechanical ventilation may inform waitlist priority in acute liver failure: A UNOS database analysis

Article Gastroenterology & Hepatology

Outcomes of patients with acute liver failure listed for liver transplantation: A multicenter prospective cohort analysis

Constantine J. Karvellas et al.

Summary: Liver transplantation is a life-saving treatment for acute liver failure patients. This study evaluated the long-term outcomes of patients listed for liver transplantation for acute liver failure. The 1- and 3-year post-transplant patient survival rates were 91% and 90%, respectively. Factors associated with death without transplantation included age, drug-induced liver injury, requirement for vasopressors, severe hepatic encephalopathy, and Model for End-Stage Liver Disease scores. Post-transplant outcomes for acute liver failure patients were excellent.

LIVER TRANSPLANTATION (2023)

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Article Critical Care Medicine

Use of the Molecular Adsorbent Recirculating System in Acute Liver Failure: Results of a Multicenter Propensity Score-Matched Study*

Andrew J. MacDonald et al.

Summary: Treatment with molecular adsorbent recirculating system is associated with increased 21-day transplant-free survival in acute liver failure and improves biochemical variables and hemodynamics, particularly in acetaminophen-acute liver failure.

CRITICAL CARE MEDICINE (2022)

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Article Gastroenterology & Hepatology

Eight-Fold Increase in Dietary Supplement-Related Liver Failure Leading to Transplant Waitlisting Over the Last Quarter Century in the United States

Marwan Ghabril et al.

Summary: Over the past quarter century, there have been significant changes in the trends of drug-induced acute liver failure (DIALF) in the United States, including shifts in patient demographics, changes in implicated agents, and notably improved post-liver transplantation survival rates for patients with DIALF.

LIVER TRANSPLANTATION (2022)

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Article Surgery

Transplant center experience influences spontaneous survival and waitlist mortality in acute liver failure: An analysis of the UNOS database

Natalie Z. Wong et al.

Summary: This study examined outcomes of acute liver failure patients on waitlists at different transplant centers and found that greater center experience is associated with higher spontaneous survival rates and lower waitlist mortality. More focused management pathways are needed to improve outcomes at less-experienced centers and to identify opportunities for improvement at larger centers.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Surgery