期刊
JOURNAL OF MATHEMATICAL BIOLOGY
卷 87, 期 6, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00285-023-02019-y
关键词
Mutational meltdown; Muller's ratchet; Lethal mutagenesis; Extinction; Branching processes; Evolutionary rescue
In this study, the phenomenon of mutational meltdown is analyzed using a multi-type branching process model, where populations are doomed to extinction due to the accumulation of mutations.
Asexual populations are expected to accumulate deleterious mutations through a process known as Muller's ratchet. Lynch and colleagues proposed that the ratchet eventually results in a vicious cycle of mutation accumulation and population decline that drives populations to extinction. They called this phenomenon mutational meltdown. Here, we analyze mutational meltdown using a multi-type branching process model where, in the presence of mutation, populations are doomed to extinction. We analyse the change in size and composition of the population and the time of extinction under this model.
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