4.3 Article

Acacetin protects against sepsis-induced acute lung injury by facilitating M2 macrophage polarization via TRAF6/NF-κB/COX2 axis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemical Research Methods

A signature of immune-related genes correlating with clinical prognosis and immune microenvironment in sepsis

Zhong-Hua Chen et al.

Summary: A 7 immune-related genes (IRGs) signature was developed to predict the 28-day survival of sepsis patients. The signature showed independent predictive value and strong clinical prediction performance in both validation and external datasets.

BMC BIOINFORMATICS (2023)

Article Cell & Tissue Engineering

MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Yaqi Zhang et al.

Summary: This study demonstrates that MSCs derived from human umbilical cords can protect renal function in rats with diabetic nephropathy by altering macrophage phenotype. UC-MSCs-derived miR-146a-5p promotes the anti-inflammatory phenotype of macrophages by inhibiting the TRAF6/STAT1 signaling pathway and effectively improves renal function.

STEM CELL RESEARCH & THERAPY (2022)

Article Immunology

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis

Jing Zhang et al.

Summary: YAP1 can inhibit ferroptosis and alleviate sepsis-induced acute lung injury (ALI) by disrupting ferritinophagy and regulating key genes and pathways.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells

Hao Zhang et al.

Summary: This study reveals that the production of Neutrophil Extracellular Traps (NETs) is a major strategy employed by polymorphonuclear neutrophils (PMNs) to fight against microbes. The study finds that there is an increased accumulation of NETs in sepsis-associated acute lung injury (SI-ALI) patients and mice, along with the upregulation of ferroptosis. The findings also demonstrate the critical role of METTL3-induced m(6)A modification of GPX4 in the induction of ferroptosis in ALI.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Review Plant Sciences

Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism

Jia-Li Zhang et al.

Summary: This review discusses the essential role of traditional Chinese medicine in treating COVID-19, exploring its mechanisms from anti-inflammatory, antioxidant, and anti-apoptotic perspectives. It highlights specific Chinese herbs commonly used for treating organ damages caused by COVID-19 and their effects on inflammation, oxidative stress, and apoptosis signaling pathways. The review suggests that TCM can protect COVID-19 patients from tissue injuries through its anti-inflammatory, antioxidant, and anti-apoptotic properties, providing evidence for clinical treatment and drug research.

PHYTOMEDICINE (2021)

Article Multidisciplinary Sciences

Study of the active ingredients and mechanism of Sparganii rhizoma in gastric cancer based on HPLC-Q-TOF-MS/MS and network pharmacology

Xiaona Lu et al.

Summary: The study used HPLC-Q-TOF-MS/MS combined with network pharmacology to identify the main active ingredients and hub genes of Sparganii rhizoma in the treatment of gastric cancer. The results suggest that Sparganii rhizoma may control biological processes in tumor cells such as proliferation, apoptosis, migration, and angiogenesis by regulating signaling pathways like PI3K-Akt.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Macrophages in Lung Injury, Repair, and Fibrosis

Peiyong Cheng et al.

Summary: Fibrosis progression in the lung can lead to impaired gas exchange, respiratory failure, or even death. Macrophages play a crucial role in response to lung injury, repair, and fibrosis, with their activation and polarization being key factors in the process. Targeting macrophages may offer potential benefits in alleviating pulmonary fibrosis.
Article Pharmacology & Pharmacy

A Systematic Study of the Mechanism of Acacetin Against Sepsis Based on Network Pharmacology and Experimental Validation

Yuanshuo Ouyang et al.

Summary: The study demonstrated that acacetin has potential protective effects on sepsis by suppressing pathological damage and pro-inflammatory cytokine expression, attenuating LPS-induced M1 polarization, and binding to multiple targets like EGFR, PTGS2, SRC, and ESR1. The network pharmacology approach also revealed gap junctions as a potential mechanism of action for acacetin in the treatment of sepsis. The findings suggest that acacetin may offer a novel therapeutic approach for sepsis treatment by targeting multiple pathways and multiple targets.

FRONTIERS IN PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Macrophage M1/M2 polarization

Chen Yunna et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Respiratory System

Immunopathogenesis and therapeutic potential of macrophage influx in diffuse parenchymal lung diseases

Ritu Kulshrestha et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2020)

Article Biochemistry & Molecular Biology

TRAF6 promotes IL-4-induced M2 macrophage activation by stabilizing STAT6

Chenchen Zhou et al.

MOLECULAR IMMUNOLOGY (2020)

Article Oncology

NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization

Chao Song et al.

EXPERIMENTAL CELL RESEARCH (2019)

Article Pathology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Massimo Locati et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

Article Respiratory System

Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury

Inwon Park et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Cell Biology

M2b macrophage polarization and its roles in diseases

Le-xun Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Review Medicine, General & Internal

Sepsis: The evolution in definition, pathophysiology, and management

Bishal Gyawali et al.

SAGE OPEN MEDICINE (2019)

Article Biochemistry & Molecular Biology

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

Yunjie Wang et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Pharmacology & Pharmacy

Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination

Depeng Zhang et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Cell Biology

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

Maude Liegeois et al.

CELLULAR IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

B-1a cells protect mice from sepsis-induced acute lung injury

Monowar Aziz et al.

MOLECULAR MEDICINE (2018)

Article Medicine, Research & Experimental

Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage

Guo-wei Tu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway

Xiang Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Editorial Material Medicine, General & Internal

Severe Sepsis and Septic Shock: Clinical Overview and Update on Management

Kelly A. Cawcutt et al.

MAYO CLINIC PROCEEDINGS (2014)

Article Biochemistry & Molecular Biology

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

Kari A. Sweeney et al.

NATURE MEDICINE (2011)

Article Biochemical Research Methods

Immunodesign of experimental sepsis by cecal ligation and puncture

Daniel Rittirsch et al.

NATURE PROTOCOLS (2009)

Article Critical Care Medicine

Mortality in sepsis versus non-sepsis induced acute lung injury

Jonathan E. Sevransky et al.

CRITICAL CARE (2009)

Article Physiology

Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury

James A. Frank et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)

Article Physiology

Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge

J Lomas-Neira et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)