☆ 4.6 Article

Site-specific antibody masking enables conditional activation with different stimuli

NEW BIOTECHNOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Functionally Masked Antibody to Uncouple Immune-Related Toxicities in Checkpoint Blockade Cancer Therapy

Seok Ho Song et al.

Summary: This study investigates the use of tumor microenvironment-responsive polymer chains to mask immune checkpoint antibodies, which can mitigate immune-related adverse events (irAEs) and selectively target tumors. The results support a strategy to separate toxicity from efficacy in antibody-based therapies and demonstrate the translational potential for cancer immunotherapy.

ACS NANO (2023)

添加到收藏夹

Review Pharmacology & Pharmacy

Current Strategies in Photodynamic Therapy (PDT) and Photodynamic Diagnostics (PDD) and the Future Potential of Nanotechnology in Cancer Treatment

Marta Olszowy et al.

Summary: Photodynamic diagnostics (PDD) and photodynamic therapy (PDT) are established medical technologies for the diagnosis and treatment of malignant neoplasms, utilizing photosensitizers, light, and oxygen. This review highlights recent advancements in nanotechnology, such as using quantum dots as photosensitizers or energy donors, liposomes, and micelles. Furthermore, it explores the combination of PDT with other treatment modalities and discusses the promising enhancements in PDD and PDT in the field of oncology.

PHARMACEUTICS (2023)

添加到收藏夹

Article Oncology

Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

Fiore Cattaruzza et al.

Summary: Schellenberger and colleagues have successfully engineered masked, conditionally active T-cell engagers (TCEs) that specifically target tumor antigens and CD3, effectively killing tumor cells in mouse models with the help of proteases. The TCEs, called XPAT proteins, are designed to be released in the tumor microenvironment by proteases, making them highly effective in vitro and proteolytically stable in healthy tissues. Non-human primate studies have shown that the XPAT proteins have a strong safety margin and their stability is similar in both healthy and diseased individuals, indicating their potential for clinical translation.

NATURE CANCER (2023)

添加到收藏夹

Article Biochemical Research Methods

Incorporation of a repeated polypeptide sequence in therapeutic antibodies as a universal masking procedure: A case study of T cell-engaging bispecific antibodies

Atsushi Maejima et al.

Summary: In this study, a universal masking sequence called PAS, composed of repeated Pro, Ala, and Ser residues, was proposed for reducing off-target effects of therapeutic antibodies. PAS effectively inhibited the binding of anti-CD3 single-chain variable fragment through steric hindrance caused by its large fluid dynamic radius and disordered structure. The masking effects of PAS could be adjusted by tuning its length, making it a valuable tool for the design of prodrug antibodies.

NEW BIOTECHNOLOGY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Efgartigimod: First Approval

Young-A Heo

Summary: Efgartigimod is a novel drug developed by argenx for the treatment of autoimmune diseases, including myasthenia gravis. It received its first approval in the USA in 2021 and is currently being evaluated and registered in other countries. Numerous clinical studies are also investigating the use of Efgartigimod in various other autoimmune diseases.

DRUGS (2022)

添加到收藏夹

Article Engineering, Biomedical

Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma

Tao Yang et al.

Summary: Monoclonal antibodies conjugated with multiple polymer chains, functionalized to target glucose transporter 1 and detaching in the reductive tumor microenvironment, can enhance the potency and safety of checkpoint blockade therapy for glioblastoma. This approach showed promising results in mouse models, reinvigorating antitumor immune responses and inducing protective immunological memory against tumor rechallenge.

NATURE BIOMEDICAL ENGINEERING (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

The Masking Game: Design of Activatable Antibodies and Mimetics for Selective Therapeutics and Cell Control

Roberta Lucchi et al.

Summary: Antibodies with high selectivity and affinity are widely used in therapy, diagnosis, and basic science. Chemogenetic approaches have enabled antibodies to respond to a variety of stimuli, leading to the development of new tools and therapeutics. Opportunities for further advancement exist in the development of more efficient masking strategies at the interface between chemistry and biotechnology.

ACS CENTRAL SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Programmable Bivalent Peptide-DNA Locks for pH-Based Control of Antibody Activity

Wouter Engelen et al.

ACS CENTRAL SCIENCE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Satralizumab: First Approval

Young-A Heo

DRUGS (2020)

添加到收藏夹

Article Engineering, Biomedical

Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery

Samagya Banskota et al.

BIOMATERIALS (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Ravulizumab: First Global Approval

Kate McKeage

DRUGS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Optical Control of Antibody Activity by Using Photocleavable Bivalent Peptide-DNA Locks

Simone F. A. Wouters et al.

CHEMBIOCHEM (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A coiled-coil masking domain for selective activation of therapeutic antibodies

Vivian H. Trang et al.

NATURE BIOTECHNOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

Paul J. Carter et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction

Benjami Oller-Salvia et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Review Oncology

The role of CD133 in cancer: a concise review

Paige M. Glumac et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2018)

添加到收藏夹

Article Rheumatology

Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation

Shimobi C. Onuoha et al.

ARTHRITIS & RHEUMATOLOGY (2015)

添加到收藏夹

Article Biology

Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1

H. Sun et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Localized In Vivo Activation of a Photoactivatable Doxorubicin Prodrug in Deep Tumor Tissue

Stuart Ibsen et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2013)

添加到收藏夹

Article Cell Biology

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

Luc R. Desnoyers et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Article Instruments & Instrumentation

Identification and characterization of a novel scFv recognizing human and mouse CD133

Suresh Kumar Swaminathan et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2013)

添加到收藏夹

Article Oncology

Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth doxorubicin with less toxicity

CF Albright et al.

MOLECULAR CANCER THERAPEUTICS (2005)

添加到收藏夹

Article Medicine, Research & Experimental

Novel antitumor prodrugs designed for activation by matrix metalloproteinases-2 and-9

Toni Kline et al.

MOLECULAR PHARMACEUTICS (2004)

添加到收藏夹

Article Chemistry, Medicinal

Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates

F Kratz et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.