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Article
Infectious Diseases
Haidi Karam-Allah Ramadan et al.
Summary: This study evaluated AHUE cases in Egypt, with adenovirus identified as the common etiological agent. Among the 42 patients included, 24 cases had unknown causes of hepatitis, and adenovirus was detected in 20.8% of them. The prevalence of newly emerging viral hepatitis pathogens needs further investigation.
Correction
Biotechnology & Applied Microbiology
Han Hsi Wong et al.
Review
Oncology
Sophia Z. Shalhout et al.
Summary: This article summarizes the advantages of oncolytic viruses (OVs) as an emerging class of cancer therapeutics, including selective replication in tumor cells, delivery of multiple eukaryotic transgene payloads, induction of immunogenic cell death and promotion of antitumor immunity, and a tolerable safety profile that largely does not overlap with that of other cancer therapeutics. Although four OVs and one non-oncolytic virus have been approved for cancer treatment globally, only T-VEC has been widely approved. However, a better understanding of the biology and pharmacology of OVs is needed to fully exploit their therapeutic potential in patients with cancer.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Huijing Wang et al.
Summary: Chemically modified mRNA has shown potential as a versatile tool for treating cancers and infectious diseases, but a safe and effective delivery system is needed to overcome the complex barriers. Researchers have explored lipopolymers as novel transfection reagents, which demonstrated excellent biocompatibility, efficient delivery capabilities, and the ability to escape lysosomes, thus improving mRNA stability and promoting efficient gene translation in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Qing Wu et al.
Summary: This study describes a virus-concealed tumor-targeting strategy that enables the delivery of oncolytic viruses (OVs) to lung metastasis through systemic administration. The OVs can actively infect, be internalized, and cloak into tumor cells, which are subsequently treated to eliminate their pathogenicity. This Trojan Horse-like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor-targeted delivery with over 110-fold virus enrichment. Additionally, this strategy can function as a tumor vaccine and initiate endogenous adaptive antitumor effects by increasing memory T cells and modulating the tumor immune microenvironment.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yichen Zhong et al.
Acta Pharmaceutica Sinica B
(2023)
Article
Surgery
Anna M. Banc-Husu et al.
Summary: Investigation into a recent cluster of acute hepatitis in children from the southeastern United States found human adenovirus (HAdV) DNAemia in all 9 cases. HAdV type 41 was identified in all cases, and two children progressed to pediatric acute liver failure (PALF) and required liver transplantation. This report highlights the importance of early multidisciplinary medical management and the feasibility of liver transplantation in children with PALF and HAdV DNAemia.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Oncology
Rebecca L. Siegel et al.
Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Engineering, Environmental
Junyan Li et al.
Summary: Scientists have synthesized F-PEI nanovaccine for mRNA delivery, which can induce dendritic cell maturation and trigger effective antigen presentation, leading to strong anti-tumor immune responses. This research provides a new tool for mRNA delivery, promising for personalized cancer vaccines as well as other mRNA-based immunotherapies.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Lei Gu et al.
Summary: Emerging nanomedicines can eliminate cancer cells by promoting excessive intracellular reactive oxygen species (ROS) generation. However, tumor heterogeneity and poor penetration of nanomedicines often result in varying levels of ROS production, where low levels of ROS can actually promote tumor cell growth, reducing the effectiveness of these nanomedicines. In this study, a novel amphiphilic and block polymer-dendron conjugate-derived nanomedicine (GFLG-DP/Lap NPs) was developed, incorporating a photosensitizer (Ppa) for ROS therapy and Lapatinib (Lap) for molecular targeted therapy. By combining ROS therapy with Lap, the synergistic effect effectively kills cancer cells, even in deep tumor regions.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yu'e Liu et al.
Summary: Cancer immunotherapy utilizes immune checkpoints-targeted therapy and adoptive transfer of engineered immune cells to mobilize patients' own immune systems against cancer cells, revolutionizing the field of oncology. Phagocytosis checkpoints, including CD47, CD24, MHC-I, PD-L1, STC-1, and GD2, play essential roles in suppressing immune responses and linking innate and adaptive immunity in cancer immunotherapy. Genetic ablation and blockade of these checkpoints have shown promising results in enhancing phagocytosis and reducing tumor size. CD47 is the most extensively studied phagocytosis checkpoint and has emerged as a promising target for cancer treatment. However, challenges such as anemia and thrombocytopenia due to CD47's ubiquitous expression on erythrocytes need to be addressed. This review discusses the mechanisms, functions, clinical progress, challenges, and potential solutions of phagocytosis checkpoints in cancer immunotherapy, aiming to facilitate combined immunotherapeutic strategies involving both innate and adaptive immune responses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Lvqin Fu et al.
Summary: Tumor immunogenic cell death (ICD) is a death mode of tumor cells that can enhance tumor immune responses. The application of nanotechnology can improve drug delivery and enhance the efficacy of immunotherapy.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Physical
Weiyue Ban et al.
Summary: Oncolytic virotherapy (OVT) is a novel immunotherapy that utilizes selective self-replication within cancer cells and oncolytic virus (OV)-mediated immunostimulation to induce anti-tumor responses. Recent advancements in systemic delivery of OVs show promise in expanding the scope of cancer immunotherapy and improving OV delivery efficacy. This review summarizes the general characteristics of OVs, discusses the advantages and disadvantages of OVT, and highlights emerging systemic administration approaches and combination treatments with traditional therapies. The future prospects and challenges of OVT are also discussed.
Review
Oncology
Victor A. Naumenko et al.
Summary: This article summarizes the data on the infection of non-cancer cells by oncolytic viruses, with a focus on tumor microenvironment and secondary lymphoid tissues. The article aims to address two major questions: how attenuated viruses infect normal cells and whether it is important for oncolytic virotherapy.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Review
Oncology
Oriol Pich et al.
Summary: The translational challenges in the field of precision oncology are partly due to the complexity and diversity of cancer. Advances in genomics have enabled large-scale sequencing efforts and discoveries, impacting our understanding of cancer initiation, prevention, treatment, and other concepts. Key areas for improving cancer outcomes are discussed, along with the practical challenges of adopting molecular profiling in clinical settings and the need for robust translational infrastructure.
Article
Chemistry, Multidisciplinary
Aazam Shaikh et al.
Summary: Dendrimers have a wide range of applications in biomedical fields, including cargo delivery, nucleic acid delivery, and macromolecule delivery. They can also be used to crosslink synthetic and natural polymeric scaffolds and mimic the extracellular matrix. Dendrimers play a crucial role in regulating cell behavior and delivering bioactive molecules, and have shown significant results in stem cell survival, osteogenesis, and repair.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Lihong Wang et al.
Summary: Tumor cells manipulate the local environment to create a tumor microenvironment (TME) that promotes tumor survival and metastasis. Oncolytic viruses (OVs) are a promising therapeutic approach that can modify the TME to activate antitumor immune cells and overcome tumor therapeutic resistance and recurrence. This review discusses the tropism of OVs towards tumor cells and their interaction with immune cells, tumor stroma, vasculature, and the metabolic environment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Qing He et al.
Summary: mRNA vaccines are well-tolerated by patients and offer flexibility in the choice of encoded molecules. The approval of the first mRNA-based COVID-19 vaccine by the FDA in 2021 has sparked enthusiasm for mRNA vaccine research and development. mRNA cancer vaccines have become a hot topic and have undergone rapid development in recent years.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Hanwei Huang et al.
Summary: Intravenous delivery of oncolytic virus (OVs) is promising in cancer treatment, but its wide application has been impeded by fast clearance and severe cytokine release syndrome. Researchers have developed erythrocyte-lipid hybrid membrane vesicles to fully encapsulate OVs, leading to prolonged circulation and enhanced oncolytic efficacy.
Article
Oncology
Kimberly D. Miller et al.
Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Multidisciplinary Sciences
Jarrod Shilts et al.
Summary: In this study, we systematically mapped the direct protein interactions across a recombinant library that includes most of the surface proteins on human leukocytes, providing a high-confidence and quantitative view of the receptor wiring that connects human immune cells. By integrating our interactome with expression data, we identified trends in the dynamics of immune interactions and constructed a mathematical model that predicts cellular connectivity. We also developed an interactive multi-tissue single-cell atlas to infer immune interactions throughout the body and linked our receptor interactions to functional roles through protein stimulation and microscopy.
Article
Biochemistry & Molecular Biology
Victor A. Naumenko et al.
Summary: Hepatotoxicity is a problem in adenovirus cancer therapy, caused by Kupffer cell death and hepatocyte transduction. The interaction between adenovirus and liver cells is not well understood. This study used intravital microscopy to track the infection and immune response in mouse livers after adenovirus injection, and found that Ad5-RGD and Ad5/3 caused macrophage deformation and virus release, but neutrophils and CD8+ T cells did not affect the rate or dynamics of liver infection. Ad5-RGD failed to complete the replicative cycle in hepatocytes, but enhanced liver transduction during hepatic regeneration.
Article
Engineering, Biomedical
Xue Dong et al.
Summary: The study demonstrates a bioactive vaccine platform using hybrid M13 phage and personal tumor antigens for efficient delivery of antigens and activation of immune response. The vaccine not only prevents tumor occurrence but also delays tumor growth, showing potential synergy with immune checkpoint blockade therapy.
Review
Pharmacology & Pharmacy
Evalyne M. Jansen et al.
Summary: This literature study reviewed and evaluated the safety and efficacy of pulmonary administered mRNA vaccines. It found that frequent booster administrations are necessary post-vaccination, and pulmonary administration could provide a more convenient and effective approach. Future research should include head-to-head comparison studies and consider the tolerability of patients with respiratory diseases.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Nanoscience & Nanotechnology
Haonan Li et al.
Summary: Dendritic polymers with highly branched three-dimensional architectures and low viscosity have great potential in various biomedical applications. Despite most review articles focusing on drug or gene delivery, there is still a lack of discussion on their function as cancer diagnosis agents.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karuna Ganesh et al.
Summary: Improved understanding of metastases biology has led to advancements in targeting and treating both micro- and macrometastases. Recent studies have identified the unique biology of metastasis-initiating cells, providing new opportunities for developing more effective treatment strategies through cancer sequencing, mechanistic studies, and clinical trials. These insights offer potential for better outcomes in targeting metastatic relapse and improving patient survival.
Article
Engineering, Biomedical
Zongmin Zhao et al.
Summary: The study demonstrates that treatment with chemokine-encapsulating nanoparticles anchored onto the surface of injected erythrocytes leads to local and systemic tumor suppression in mouse models of lung metastasis.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Bo Xu et al.
Summary: Oncolytic herpes simplex virus-1 can lyse tumor cells and activate the immune system; oncolytic viruses expressing anti-CD47 antibodies can improve the survival of glioblastoma patients.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Tong Guo et al.
Summary: The study on using matrix metalloproteinase to enhance oncolytic virus (NDV-MMP8) spread in tumors showed that in vitro and in vivo experiments, NDV-MMP8 can effectively degrade extracellular matrix, promote virus spread, and reduce tumor growth.
CHINESE CHEMICAL LETTERS
(2021)
Review
Immunology
Jiayi Zeng et al.
Summary: The prognosis of malignant gliomas remains poor, with limited therapeutic options. Immunotherapy and oncolytic virotherapy are rapidly developing fields that hold promise for enhancing cancer treatment effectiveness.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Jamie E. Chaft et al.
Summary: The treatment goal for early-stage lung cancer patients is cure, with surgical resection or radiotherapy as definitive local treatments along with adjuvant therapy to improve the likelihood of cure. New therapies lag behind due to inefficient trial designs and lengthy follow-ups, despite efforts to study surrogate endpoints to shorten trial durations.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Oncology
Merry Jennifer Markham et al.
JOURNAL OF CLINICAL ONCOLOGY
(2020)
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Chemistry, Multidisciplinary
Hao Cai et al.
Review
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Nasser Hashemi Goradel et al.
PHARMACOLOGY & THERAPEUTICS
(2020)
Review
Oncology
Nicholas Macedo et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
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Materials Science, Biomaterials
Hao Kong et al.
BIOMATERIALS SCIENCE
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Review
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Kevin Harrington et al.
NATURE REVIEWS DRUG DISCOVERY
(2019)
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Multidisciplinary Sciences
Zongmin Zhao et al.
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Marie E. Killerby et al.
OPEN FORUM INFECTIOUS DISEASES
(2019)
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Manlio Fusciello et al.
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Neha N. Parayath et al.
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Cell Biology
Adel Samson et al.
SCIENCE TRANSLATIONAL MEDICINE
(2018)
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Jacob S. Brenner et al.
NATURE COMMUNICATIONS
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Freddie Bray et al.
CA-A CANCER JOURNAL FOR CLINICIANS
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Review
Oncology
Ibrahim Ragab Eissa et al.
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JOURNAL FOR IMMUNOTHERAPY OF CANCER
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EXPERT OPINION ON DRUG DELIVERY
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Correction
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EMERGING INFECTIOUS DISEASES
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Robert C. Carlisle et al.
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Daniel Stone et al.
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Olaf Boehm et al.
BIOLOGICAL CHEMISTRY
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