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Photonic control of image-guided ferroptosis cancer nanomedicine

COORDINATION CHEMISTRY REVIEWS (2024)

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Article Chemistry, Multidisciplinary

Dynamic-Reversible MRI Nanoprobe for Continuous Imaging Redox Homeostasis in Hepatic Ischemia-Reperfusion Injury

Cheng Zhang et al.

Summary: A reversible redox-responsive magnetic nanoprobe was designed to monitor oxidative stress levels in liver injury. The nanoprobe showed high imaging sensitivity and could visualize tiny changes in oxidative stress in real time. Additionally, the nanoprobe provided molecular and anatomical information about the degree and location of liver injury.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Penetrative and Sustained Drug Delivery Using Injectable Hydrogel Nanocomposites for Postsurgical Brain Tumor Treatment

Taegyu Kang et al.

Summary: We present an injectable thermoresponsive hydrogel nanocomposite as a potential solution for postsurgical treatment of glioblastoma multiforme (GBM). The hydrogel nanocomposite acts as a soft, deep intracortical drug reservoir, with drug-loaded micelles targeting residual GBM cells. Alternating magnetic fields generated by water-dispersible ferrimagnetic iron oxide nanocubes facilitate penetrative drug delivery. In an orthotopic mouse GBM model, significant tumor growth suppression and improved survival rates are observed.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Trojan Horse Phototheranostics: Fine-Engineering NIR-II AIEgen Camouflaged by Cancer Cell Membrane for Homologous-Targeting Multimodal Imaging-Guided Phototherapy

Jie Cui et al.

Summary: This study successfully developed a versatile molecule DHTDP with aggregation-induced emission, which can simultaneously exhibit second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion. By camouflaging DHTDP nanoparticles with cancer cell membrane, the resultant biomimetic nanoparticles not only have facilitated delivery efficiency and homologous targeting capability, but also provide precise imaging guidance through NIR-II fluorescence imaging, photoacoustic imaging, and photothermal imaging. This study presents a new approach to explore superior phototheranostics for practical cancer theranostics using biomimetic multimodal phototheranostics loaded by homogeneity-targeting cell membrane.

ADVANCED MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Ultra-Small Nano-Assemblies as Tumor-Targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy

Dongsheng Zhang et al.

Summary: An ultra-small nano-photosensitizer 1a with excellent tumor-specific accumulation and renal clearance is reported. It is formed from the self-assembly of compound 1 bearing TEG arms and pyridinium groups in water. Nano-PS 1a exhibits an outstanding photodynamic therapy efficacy on tumor-bearing mouse models, providing a promising design strategy for renal clearable and tumor-targeting photosensitizers.

ADVANCED MATERIALS (2023)

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Review Chemistry, Inorganic & Nuclear

Recent advances in augmenting Fenton chemistry of nanoplatforms for enhanced chemodynamic therapy

Shu-Lan Li et al.

Summary: Chemodynamic therapy (CDT) has emerged as a promising strategy for suppressing malignant tumors in recent years. Nanoplatform-based CDT, which is highly effective, non-invasive, and independent of external energy input, shows great potential. However, its efficacy is still suboptimal, limiting its practical use in the clinic.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy

Van-Nghia Nguyen et al.

Summary: Due to the limitations of conventional antitumor agents, efforts are being made to develop advanced drug delivery systems using extracellular vesicles, particularly exosomes. These membrane-bound vesicles, secreted by various human cells, have unique features that make them promising nanocarriers for cancer therapy. This review provides knowledge on extracellular vesicles and highlights exosomes as potential nanocarriers for drug delivery. It also discusses recent developments of exosome-based nanotherapeutic agents for cancer treatment and presents challenges and prospects for the future development of exosomal drug delivery systems.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Tumor microenvironment-triggered intratumoral in-situ biosynthesis of inorganic nanomaterials for precise tumor diagnostics

Xueni Zhang et al.

Summary: Conventional chemotherapeutic drugs have severe side effects and low bioavailability, which hinders current clinical cancer treatments. Tumor microenvironment (TME)-responsive nanomedicine has emerged as a safe and effective approach for cancer diagnosis and therapy. In this review, the intratumoral biosynthesis of inorganic nanomaterials for cancer diagnosis and treatment, triggered by specific TME conditions, is systematically summarized. The review also discusses unresolved issues, potential solutions, perspectives, and future directions in this field.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

BODIPY-based probes for hypoxic environments

Lizhi Gai et al.

Summary: The hypoxic environment is a significant characteristic of solid tumors, resulting from an imbalance between oxygen supply and consumption. Recent progress has been made in designing hypoxia probes derived from BODIPY scaffolds. These probes have attracted particular attention and are closely related to tumor resistance to various therapies. This review focuses on the construction strategies, recognition mechanisms, and biological imaging applications of various BODIPY-based hypoxia probes, aiming to inspire novel approaches and innovations for designing fluorescent probes for imaging hypoxic environments and promoting the development of tumor diagnostics and hypoxia-responsive anti-cancer nanomedicines.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Coumarin-based near-infrared fluorogenic probes: Recent advances, challenges and future perspectives

Yufan Fan et al.

Summary: Coumarin-based fluorogenic probes are preferred imaging tools for real-time and noninvasive monitoring of target analytes in biological systems. They possess tunable optical properties, facile synthesis, excellent cell-membrane permeability, and favorable biocompatibility. The development and applications of coumarin-based near-infrared probes (CBNPs) have been reviewed, including their structure-fluorescence relationships, diverse high-performance CBNPs with various sensing mechanisms, and their biomedical applications in native living systems. Challenges and future perspectives in this field are also highlighted.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Recent developments on luminescent octahedral transition metal cluster complexes towards biological applications

Kaplan Kirakci et al.

Summary: Over the past decades, the luminescent octahedral molybdenum, tungsten, and rhenium cluster complexes with the general formula [{M6Li8}La6]n have gained significant attention for their potential applications in photofunctional materials design. These complexes exhibit red phosphorescence with high quantum yields, sensitivity to oxygen, and production of singlet oxygen, O2(1Dg). The wide range of ligands allows for precise tuning of their physico-chemical, photophysical, and biological properties for various applications such as photodynamic therapy and photoinactivation of bacteria.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Structure-activity of chlormethine fluorescent prodrugs: Witnessing the development of trackable drug delivery

Wenfang Jin et al.

Summary: Chlormethine, an important anticancer drug, has been used for more than 70 years. It has been integrated with trackable prodrugs for drug control and tumor targeting, thanks to its good efficacy and adaptable structure.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Metal halide perovskite nanocrystals for biomedical engineering: Recent advances, challenges, and future perspectives

Girum Getachew et al.

Summary: This article systematically summarizes the significance of halide perovskite quantum dots in biomedical applications, including bioimaging, light-activated therapeutics, and biosensing technologies. The optoelectronic properties, structural studies, and synthesis methodologies of halide perovskite quantum dots are highlighted, as well as their structural intolerance to polar environments and light exposure. Various encapsulation strategies for enhancing the structural and luminescence stability of halide perovskite quantum dots in aqueous solvents and under light illumination are thoroughly evaluated.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Zhaoyou Chu et al.

Summary: Due to the higher concentration of hydrogen peroxide (H2O2) in tumor cells compared to normal cells, it can be used as an effective target for tumor therapy to differentiate between normal tissues and produce differential therapeutic effects. This review focuses on modulating H2O2-related strategies through direct delivery of exogenous factors and amplifying endogenous genes, which show promising results in cancer treatment. The review also discusses the obstacles that need to be overcome and the bright future in H2O2 modulation.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Near infrared fluorescent probes for detecting and imaging active small molecules

Caiping Ding et al.

Summary: Near infrared (NIR) fluorescent probes have advantageous features including low background interference, strong tissue penetration, and minimal tissue damage. This paper provides a summary and discussion on the various types and properties of fluorophores used in the design of NIR fluorescent probes. It also discusses the latest research achievements in detecting and imaging reactive oxygen species, reactive nitrogen, and active sulfur in cells or in vivo. Additionally, a concise overview of the future development of NIR molecular fluorescence probes is proposed based on existing research, offering a reference for current research directions.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment

Huanhuan Fan et al.

Summary: Summary: The tumor microenvironment (TME) is an ideal target for cancer treatment. Manganese-based nanomaterials (Mn-based NMs) have unique characteristics and can modulate the TME. This review introduces different types of Mn-based NMs and discusses their strategies for TME modulation, as well as their broad applications in cancer therapies.

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Chemistry, Physical

Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy

Sol Shin et al.

Summary: A curvature-sensing antiviral peptide is repurposed to disrupt tumour-derived exosomes and used in combination with immune checkpoint blockade cancer therapy. The peptide inhibits T-EXOs from various cancer types and improves treatment outcomes in tumour-bearing mice.

NATURE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Photodynamic treatment of acute vascular occlusion by using an iron-nitrosyl complex

Jisu Choe et al.

Summary: A new strategy for treating retinal vascular occlusion by using a photoresponsive nitric oxide transporter has been reported. The results from animal models showed that this method effectively dilates the blocked blood vessels. This study provides a promising option for the treatment of vascular occlusive diseases.

CHEM (2023)

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Article Chemistry, Multidisciplinary

Protease-Activatable Nanozyme with Photoacoustic and Tumor-Enhanced Magnetic Resonance Imaging for Photothermal Ferroptosis Cancer Therapy

Wen Qin et al.

Summary: This study presents a novel activatable ferrous nanotheranostics for spatial-temporal control over antitumor ferroptosis responses. The nanotherapeutics can be guided by photoacoustic and magnetic resonance imaging (MRI), and it can effectively induce tumor cell death through photothermal therapy and Fenton reaction. This treatment not only suppresses tumor growth, but also promotes immune response against the tumor.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Chemistry, Multidisciplinary

A Photoacoustic Probe with Blood‐Brain Barrier Crossing Ability for Imaging Oxidative Stress Dynamics in the Mouse Brain

Yijing Cui et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Article Chemistry, Multidisciplinary

A Biocompatible Probe for the Detection of Neutrophil Elastase Free from the Interference of Structural Changes and Its Application to Ratiometric Photoacoustic Imaging In Vivo

Ling Huang et al.

Summary: Neutrophil elastase (NE) is crucial in chronic inflammation and acute responses to infection and injury. However, structural changes of NE interfere with its detection. This study introduces a biocompatible molecular probe, achieved through theoretical calculations and experimental studies, allowing for highly specific and sensitive detection of NE in cells and in vivo. The upregulated NE accumulation in inflammation was measured using ratiometric photoacoustic and near-infrared fluorescence imaging, providing a new method for developing more specific fluorogenic probes for other enzymes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

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Article Chemistry, Multidisciplinary

Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Yves S. S. Kafuti et al.

Summary: In this study, the fluorescent probe ER-Nap-NBD was developed to detect H2S levels in solution and living systems (cells and zebrafish) using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting.

CHEMICAL COMMUNICATIONS (2023)

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Review Chemistry, Multidisciplinary

Mechanical stimuli-driven cancer therapeutics

Jusung An et al.

Summary: Mechanical stimulation using deep tissue-penetrating and focusable energy sources like ultrasound and magnetic fields is seen as an emerging and effective therapeutic strategy for cancer treatment. This approach can provide direct therapeutic effects and intelligent control, while also utilizing mechanical forces such as compression, tension, shear force, and torque. Future research may focus on developing materials activated by ultrasound and magnetic fields for applications in this field.

CHEMICAL SOCIETY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Hongwei Xu et al.

Summary: Thanks to the development of nanotechnology, a polymer nano-material called polydopamine (PDA) inspired by mussels has been discovered. PDA possesses exceptional characteristics such as light absorption, reactivity, simplicity in preparation, and scavenging of free radicals. Various PDA-derived nanoplatforms have been developed for applications such as tumor treatment, imaging, antibacterials, and antioxidant. This review provides an overview of the advancements in PDA-derived nano-materials in photothermal therapy, theranostics, antibacterials, antioxidant, and delivery of active molecules, including preparation methods, polymerization mechanism, and different nanostructures of PDA. The limitations of PDA-derived nanoparticles are also discussed.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Selenium: From fluorescent probes to biomedical application

Junping Wang et al.

Summary: Selenium is essential for human health and its regulation of selenoproteins is crucial. However, the lack of tools for in situ monitoring of selenium species hinders its development in bio-analysis. Thus, fluorescent probes that can specifically recognize and respond to selenium species show promise for studying its biological actions.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Small molecule fluorescent probes for the detection of reactive nitrogen species in biological systems

Yongqing Zhou et al.

Summary: Reactive nitrogen species (RNS), including nitric oxide (NO or NO.), peroxynitrite anion (ONOO-) and nitroxyl (HNO), play important roles in physiological, pathological and pharmacological processes. Abnormal variations in RNS concentrations are closely associated with the occurrence and progression of numerous diseases. Therefore, it is significant to visualize RNS for a better understanding of their distribution, roles, functions, interactions and mechanisms in biological systems. Fluorescence imaging technique and small molecule fluorescent probes have been widely used for the detection and monitoring of RNS in living systems. In this review, recent advances in small molecule fluorescent probes for monitoring NO, ONOO- and HNO are summarized, including their design strategies, recognition mechanisms and biological applications.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

Ya-Lin Qi et al.

Summary: In recent years, there has been great interest in the development of organic near-infrared (NIR) ratiometric fluorescent probes. Traditional intensity-based probes lack an internal standard method, resulting in unreliable and inaccurate detection signals as well as an inability to achieve quantitative determination of analytes. Smart dual emission probes with built-in correction ability have overcome the limitations of single channel fluorescent probes and enable reliable quantitative image analysis. Moreover, fluorescent chemosensors in the NIR window offer advantages such as high signal-to-noise ratio, low tissue damage, and deep tissue penetration. The combination of the advantages of ratiometric fluorescent probes and single-intensity-based NIR probes in NIR ratiometric fluorescent probes has led to their widespread application in biomedical research and clinical practice. This review provides a systematic summary of the recent advances (2020-2022) in this field, discussing the design strategies, sensing mechanisms, and bioapplications of these intelligent fluorescent probes. The challenges and prospects in this promising field are also addressed, with the anticipation that this work will inspire the development of organic NIR ratiometric fluorescent probes.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Near-Infrared Fluorescence Probes for Monitoring and Diagnosing Nephron-Urological Diseases

Jing Wang et al.

Summary: Optical imaging is widely used as an emerging in vivo imaging technology in basic research and clinical follow-up, providing real-time physiological and pathological information that cannot be obtained from in vitro testing. NIR optical imaging offers advantages such as spatiotemporal resolution and a relatively high signal-to-noise ratio compared to traditional imaging strategies. This review focuses on the structure design of molecular NIR fluorescent probes and their applications in bioimaging and diagnosis of typical nephron-urological diseases, as well as the potential development and current difficulties in this field.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Reversible fluorescent probes for biological dynamic imaging: Current advances and future prospects

Jingting Zhan et al.

Summary: Reversible fluorescent probes have been widely used in biological research due to their ability to observe dynamic changes of biomolecules in real-time. This review categorizes reversible fluorescent probes into six groups based on the principles of reversible reactions and focuses on their interactions with physiological compounds and small molecule compounds or microenvironments. Representative examples of reversible processes, including complex reactions, addition reactions, redox reactions, and spiral cyclization, are reviewed to demonstrate the potential of reversible fluorescent probes for visualizing intracellular dynamic changes. Furthermore, the challenges and future directions of utilizing reversible fluorescent probes in biological applications are discussed.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Inorganic & Nuclear

Near-infrared manipulation of temperature-sensitive ion channel through photothermal nanotransducer brightens in vivo photomedicine

Mengyao Su et al.

Summary: Precisely regulating temperature-sensitive transient receptor potential ion channels (Thermo-TRPs) is crucial for understanding their biochemical effects and potential therapeutic applications. Current strategies, such as chemical perturbation and genetic engineering, face challenges in terms of invasiveness and low spatiotemporal resolution. The emerging optical control technology, utilizing near-infrared (NIR) photothermal nanomaterials, shows promise for noninvasive and deep-tissue operation of Thermo-TRPs. This review focuses on the recent developments in NIR photothermal nanotransducers for precise modulation of Thermo-TRPs, including biological classification, gating mechanisms, and neuronal activation.

COORDINATION CHEMISTRY REVIEWS (2023)

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Review Chemistry, Multidisciplinary

Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

Baode Chen et al.

Summary: With the advancement in MRI technology, traditional contrast agents struggle to meet accuracy imaging demands, but novel dual-mode contrast agents with T1-T2 ability provide better imaging applications and improved accuracy. Responsive MRI probes, unlike traditional agents, change signals in response to stimuli, leading to highly selective and excellent contrast effects. This review focuses on responsive and switchable MRI probe types, highlighting their mechanism, application in tumor imaging, and future development trends and challenges.

NANO TODAY (2023)

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Article Chemistry, Multidisciplinary

GSH/APE1 Cascade-Activated Nanoplatform for Imaging Therapy Resistance Dynamics and Enzyme-Mediated Adaptive Ferroptosis

Renye Yue et al.

Summary: This study discovered that persistent oxidative stress during ferroptosis can upregulate the APE1 protein, leading to therapeutic resistance. To address this issue, researchers developed a GSH/APE1 cascade activated therapeutic nanoplatform (GAN) that can induce efficient lipid peroxidation for ferroptosis therapy.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Smart Nanomedicine to Enable Crossing Blood-Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma

Hairong Wang et al.

Summary: In this study, a BBB-crossing copolymer was successfully fabricated using a choline analogue MPC, leading to efficient delivery of ICB therapy in a glioma model and significantly prolonging animal survival.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

A Closed-Loop Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

Yaqian Du et al.

Summary: This study reports a closed-loop therapy system based on photothermal enhancement of ferroptosis and immunotherapy. By combining mesoporous nanospheres with gold nanoparticles, researchers successfully enhanced tumor cell ferroptosis and triggered an immune response. The system is effective in both killing the primary tumor and inhibiting tumor metastasis.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Dynamic Ligand Screening by Magnetic Nanoassembly Modulates Stem Cell Differentiation

Hyunsik Hong et al.

Summary: This study investigates the modulation of stem cell differentiation in the microenvironment using nanoassembly-based magnetic screens. Different sizes of screens can affect the adhesion, mechanotransduction, and differentiation of stem cells by adjusting nanogaps. This regulation mechanism is shown to be effective in vivo, demonstrating the potential for diverse modalities of unscreening RGDs to modulate stem cell differentiation for tissue repair.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas

Sander J. Wezenberg et al.

Summary: Membrane transport proteins have important regulatory functions in biology and can respond to environmental stimuli. Using bis(thio)ureas derived from stiff-stilbene, photocontrol of transmembrane transport and electric potential has been demonstrated through UV-vis and H-1 NMR spectroscopy. The (Z)-isomers show stronger binding properties and are more active in transmembrane transport compared to the (E)-isomers.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Lisi Xie et al.

Summary: In this study, phototheranostic metal-phenolic networks were engineered for precise photo thermal therapy. This therapy could relieve exosomal suppression, restore T cells, and enhance ferroptosis. The synergy of photo thermal therapy with antiexosomal PD-L1 evoked potent antitumor immunity and immunological memory against metastatic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Pulmonary Delivery of Theranostic Nanoclusters for Lung Cancer Ferroptosis with Enhanced Chemodynamic/Radiation Synergistic Therapy

Yingbo Li et al.

Summary: Smart nanoclusters can enhance therapy efficacy of lung cancer by increasing drug penetration and providing superior antitumor effects. pH-sensitive superparamagnetic iron oxide nanoclusters disintegrate into smaller particles and release more iron ions in an acidic microenvironment, which enhance tumor ferroptosis and apoptosis with radiotherapy and chemodynamic therapy.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Junmin Lee et al.

Summary: Injectable shear-thinning biomaterials, specifically gelatin/LAPONITE (R) nanocomposites, have shown promising potential for efficiently delivering molecules like doxorubicin in response to different pH values. Among different compositions tested, STBs with lower LAPONITE (R) content (6NC25) demonstrated enhanced pH-responsiveness and localized drug release in acidic tumor microenvironments. Additionally, 6NC25 exhibited lower storage modulus and required lower injection forces, improving ease of administration.

NANOSCALE (2022)

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Article Chemistry, Multidisciplinary

NIR/MRI-Guided Oxygen-Independent Carrier-Free Anti-Tumor Nano-Theranostics

Di Gao et al.

Summary: The development of carrier-free nano-theranostic agents (AIBME@IR780-APM NPs) addresses the challenge of tumor hypoxia on PDT efficacy, utilizing alkyl radicals and heat effects to achieve synergistic cell death via MRI-guided photothermal therapy/thermodynamic therapy against cancer cells.

SMALL (2022)

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Review Chemistry, Multidisciplinary

Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials

Letao Yang et al.

Summary: Extracellular vesicles (e.g., exosomes) carrying various biomolecules have great potential in biomedical applications, but their heterogeneity and inefficient uptake by recipient cells are critical barriers. Multifunctional nanomaterials, such as magnetic nanomaterials, can play crucial roles in addressing these issues and enhancing the applications of extracellular vesicles.

SMALL (2022)

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Article Biotechnology & Applied Microbiology

Peptide-based semiconducting polymer nanoparticles for osteosarcoma-targeted NIR-II fluorescence/NIR-I photoacoustic dual-model imaging and photothermal/photodynamic therapies

Ying Yuan et al.

Summary: This study developed semiconductor polymer nanoparticles for targeted photothermal therapy and photodynamic therapy in osteosarcoma. The nanoparticles showed efficient cellular uptake and enhanced therapeutic effects, leading to significant anti-tumor activities both in vitro and in vivo.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms

Yang Wang et al.

Summary: This study constructed a theranostic nanoplatform with homologous targeting ability and photoacoustic/fluorescence imaging ability, and demonstrated its potential application in osteosarcoma treatment through in vitro and in vivo experiments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging

Ramar Thangam et al.

Summary: Functionalized nanomaterials play a crucial role in nano-theranostics for brain diseases. Metal nanomaterials with functional tags have unique properties that improve their functionality and imaging applications. These multifunctional nanomaterials can be synthesized through chemical modifications, and their primary criteria for brain application is zero toxicity. The advantages of nano-theranostics include the integration of diagnostic and therapeutic functions in a single biodegradable nanomaterial for personalized disease management.

NANOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1

Jung Min Shin et al.

Summary: Sulfisoxazole significantly decreases exosomal PD-L1 levels and reinvigorates exhausted T cells when orally administered, showing potential to improve the response rate of anti-PD-1 antibodies in cancer treatment.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy

Fei Gong et al.

Summary: In this study, CaH2 nanoparticles were prepared through liquid-phase exfoliation and used as an antitumor therapeutic agent. When injected into the tumor, the nano-CaH2 reacts with water to produce hydrogen gas, calcium ions, and hydroxyl ions, which enable hydrogen therapy, tumor calcification, and neutralization of the acidic tumor microenvironment. The results showed that the injectable nano-CaH2 dispersion significantly inhibited tumor growth and activated the immune system to promote immune cell infiltration into the tumor, resulting in robust immune responses to inhibit distant tumors. Furthermore, nano-CaH2 dispersed in lipiodol showed improved therapeutic outcomes in interventional transarterial embolization therapy compared to lipiodol alone in a liver cancer model.

CHEM (2022)

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Review Oncology

Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy

Shengxian Li et al.

Summary: Ferroptosis is a novel form of iron-dependent programmed cell death characterized by increased iron loading and lipid peroxidation leading to cell death. Research reviewed the mechanism of ferroptosis, its relationship with common diseases and immune status, and summarized inhibitors and inducers for targeted medicine exploration and future research.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

A Biodegradable Iridium(III) Coordination Polymer for Enhanced Two-Photon Photodynamic Therapy Using an Apoptosis-Ferroptosis Hybrid Pathway

Libing Ke et al.

Summary: This study presents the formulation of a promising Ir-III complex into a biodegradable coordination polymer, which can selectively accumulate in the mitochondria and trigger cell death through hybrid apoptosis and ferroptosis pathways upon irradiation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Biomedical

Nano-enabled photosynthesis in tumours to activate lipid peroxidation for overcoming cancer resistances

Jun Jiang et al.

Summary: This study developed a tumor treatment method that can overcome melanoma resistance by activating cell death mechanisms through controlled photosynthesis. The experimental results showed that this treatment method can effectively inhibit the spread of melanoma and improve patients' survival rate.

BIOMATERIALS (2022)

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Article Engineering, Biomedical

Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework

Wei-Lun Pan et al.

Summary: In this study, a nanomedicine based on the tumor microenvironment (TME) was designed and developed for effective cancer treatment. The nanocomposite with a cancer cell membrane (CM) coating can evade the immune clearance and accumulate at the tumor site. Activation of the nanocomposite in the TME triggers a series of reactions, promoting cancer cell death and enhancing photodynamic therapy (PDT) efficacy. This sequential synergistic therapy has demonstrated the ability to inhibit cancer cell proliferation effectively.

BIOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

Manipulating Nanoparticle Aggregates Regulates Receptor-Ligand Binding in Macrophages

Yuri Kim et al.

Summary: In this study, the modulation of receptor-ligand interactions in cells using magnetic nanoparticle aggregates is investigated. Manipulating the accessible ligand dispersity can either promote macrophage adhesion and healing or suppress it depending on the ligand accessibility. This study presents accessible ligand dispersity as a novel parameter that regulates receptor-ligand binding and polarization of macrophages.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

A mitochondria-localized oxygen self-sufficient two-photon nano-photosensitizer for ferroptosis-boosted photodynamic therapy under hypoxia

Fangmian Wei et al.

Summary: Photodynamic therapy (PDT) is a medical technique used for the treatment of cancer that has gained attention for its selectivity and non-invasiveness. However, the hypoxic environment in solid tumors limits its effectiveness. In this study, graphitic carbon nitride nanosheets functionalized with mitochondria-targeting iridium complexes were used to achieve oxygen self-sufficient two-photon PDT, effectively treating hypoxic tumors in a mouse model. This is the first example of using iridium complex functionalized graphitic carbon nitride nanosheets for the treatment of hypoxic tumors under clinically relevant two-photon irradiation.

NANO TODAY (2022)

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Article Chemistry, Multidisciplinary

Bonsai-inspired AIE nanohybrid photosensitizer based on vermiculite nanosheets for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy

Xinghua Yu et al.

Summary: A bonsai-inspired oxygen self-sufficient photodynamic cancer therapeutic system was developed using AIEgen/vermiculite nanohybrid, which effectively improved the efficiency of radiation therapy in the hypoxic tumor microenvironment and induced ferroptosis for enhanced therapeutic effect.

NANO TODAY (2022)

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Review Oncology

The emerging role of photoacoustic imaging in clinical oncology

Li Lin et al.

Summary: Photoacoustic imaging is a novel imaging modality that offers high spatial resolution and rapid acquisition speed without the need for radiation or exogenous contrast agents. This technology is playing an increasingly important role in the screening, diagnosis, and management of cancer patients, with potential for future implementation.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Multidisciplinary Sciences

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Yuqi Zhang et al.

Summary: The authors report the design of a H2S-responsive and -depleting nanoplatform that can be used for H2S imaging and cancer therapy, which shows great potential in studying the vital impacts of H2S in related diseases.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer

Fuqiang Shao et al.

Summary: The study found that Nectin-4 is highly expressed in TNBC, and therefore developed a theranostic pair based on anti-Nectin-4 monoclonal antibodies, Tc-99m-HYNIC-mAb(Nectin-4) and mAb(Nectin-4)-ICG, for TNBC diagnosis and photothermal therapy. The results demonstrated that this strategy provides a simple and effective approach for the diagnosis and treatment of TNBC.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Ultrasound and nanomaterial: an efficient pair to fight cancer

Edouard Alphandery

Summary: Ultrasound combined with nano-systems shows great potential in improving cancer treatment by enhancing ultrasound imaging, specific tumor targeting, and more moderate tumor heating. These combined treatments can potentially improve the benefit/risk ratio of current cancer treatments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Static and Dynamic Biomaterial Engineering for Cell Modulation

Hyung-Joon Park et al.

Summary: Cells in the biological microenvironment interact with the extracellular matrix (ECM) and are influenced by its physical and chemical properties. Efficient strategies for modulating cellular responses have become crucial in various scientific fields. Biomaterials have been extensively studied due to their ability to mimic cellular modulation. Recent research focuses on dynamic biomimetic modulation, considering both physical and chemical factors.

NANOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

Renye Yue et al.

Summary: A tumor-microenvironment-targeted and co-activated catalytic nanoplatform (CACN) has been developed for specific ferroptosis treatment of cancer cells or tumors. The catalytic activity of CACN can be turned on by dual stimuli of ATP and slight acidity in the tumor microenvironment. The switchable MRI signal of CACN is correlated with reactive oxygen species generation and drug release, allowing for monitoring the therapeutic process.

CHEM (2022)

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Article Chemistry, Multidisciplinary

Submolecular Ligand Size and Spacing for Cell Adhesion (Adv. Mater. 27/2022)

Yuri Kim et al.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Tongue cancer tailored photosensitizers for NIR-II fluorescence imaging guided precise treatment

Baoli Yin et al.

Summary: The study developed a novel NIR-II molecule with improved activation efficiency and targeted therapy for tongue cancer through rational design of the molecular structure.

NANO TODAY (2022)

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Article Multidisciplinary Sciences

Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy

Yang Yang et al.

Summary: Phototheranostics based on upconversion nanoparticles can integrate imaging diagnostics and phototherapeutics. This study demonstrates a method to switch from imaging to therapy using upconversion nanoparticles by modulating the irradiation laser, enabling programmable control with minimal side effects. The approach allows for orthogonal activation of in vivo photoacoustic imaging and photodynamic therapy.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma

Guihong Lu et al.

Summary: The use of cancer cell-membrane encapsulated nanoparticles for targeted therapy in lactate-high cancer cells shows promising results in reducing tumorigenesis in glioblastoma.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

Yiyi Zhang et al.

Summary: Researchers have developed a ROS-responsive hydrogel that can protect ICB antibodies and allow for sustained co-delivery of photosensitizers and ICB antibodies. The hydrogel not only inhibits long-term tumor recurrence and metastasis, but also effectively restrains the growth of re-challenged tumors.

NATURE COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

Synthesis of magnesium nanoparticle for NIR-II-photoacoustic-imaging-guided synergistic burst-like and H2 cancer therapy

Luntao Liu et al.

Summary: In this study, diameter- and shape-controlled magnesium nanoparticles were synthesized and applied in near infrared-II photoacoustic and bubble-enhanced ultrasound imaging and cancer therapy. These nanoparticles continuously generated H-2 in the tumor to induce cancer cell death, exhibiting superior synergistic tumor inhibition effects.

CHEM (2022)

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Article Chemistry, Multidisciplinary

Nanoplatforms with synergistic redox cycles and rich defects for activatable image-guided tumor-specific therapy

Hui Zhu et al.

Summary: In this study, a nanoplatform consisting of CMC NFs and F-19 probes has been developed, which can enhance therapeutic efficiency and activate F-19 MRI capability within the tumor microenvironment. The nanoplatforms can effectively disrupt redox homeostasis and perform tumor-specific chemodynamic therapy, offering great potential for deep-seated tumor diagnosis and treatment.

CHEM (2022)

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Article Chemistry, Multidisciplinary

Overcoming Hypoxia-Induced Ferroptosis Resistance via a 19F/1H-MRI Traceable Core-Shell Nanostructure

Zhe Dong et al.

Summary: In this study, a novel nanoplatform was designed to enhance the effectiveness of ferroptosis-based cancer therapy. The nanoplatform successfully overcame the hypoxia-induced resistance of ferroptosis by providing oxygen supply and breaking down lipid droplets. The results showed that the nanoplatform induced higher levels of oxidative stress, lipid peroxidation, and GSH depletion, leading to effective inhibition of tumor growth. Furthermore, the release of manganese from the nanoplatform could be monitored using imaging techniques.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

NIR-II Ratiometric Chemiluminescent/Fluorescent Reporters for Real-Time Monitoring and Evaluating Cancer Photodynamic Therapy Efficacy

Lichao Su et al.

Summary: A novel therapeutic monitoring platform has been developed in this study to monitor the efficacy of photodynamic therapy in real time and evaluate the treatment effect in vivo. This probe can effectively quantify and monitor the concentration and consumption of reactants using chemiluminescence and fluorescence signal changes generated by light excitation, providing strong support for achieving more precise treatment.

SMALL (2022)

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Article Biotechnology & Applied Microbiology

Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer

Kwang-Soo Kim et al.

Summary: This study investigated the interaction between ferroptosis of cancer cells and natural killer (NK) cells, and explored the potential anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer using ferumoxytol, a clinical grade iron oxide nanoparticle. The results showed that ferumoxytol-mediated ferroptosis enhances the cytotoxic function of NK cells and leads to significant tumor regression in a prostate cancer mice model. These findings suggest that ferumoxytol-mediated ferroptosis can enhance the function of NK cells and overcome therapeutic resistance in cancer cells.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Medicine, Research & Experimental

A novel afterglow nanoreporter for monitoring cancer therapy

Shiyi Liao et al.

Summary: A novel near-infrared organic afterglow nanoparticle was developed to visualize reactive oxygen species (ROS) during immunogenic cell death, with high signal to noise ratio. The nanoparticle induced immunogenic cell death of cancer cells and caused immune responses, providing a non-invasive tool for predicting the degree of immunogenic cell death during ROS-mediated cancer therapy.

THERANOSTICS (2022)

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Review Engineering, Biomedical

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Min Jun Ko et al.

Summary: This article reviews recent advances in multifunctional magnetic nanoparticles (MNPs) with unique characteristics for therapeutic applications, including remote motion control, degradability, and imaging-guided targeting. The dynamic motion, iron ion degradation, and imaging-guided targeting of MNPs under different magnetic field modes enable spatial and temporal regulation of cells and molecules, as well as thermal energy generation. Furthermore, the iron-based MNPs can be used for targeted ferroptosis therapy with medical imaging guidance. The article highlights the state-of-the-art imaging-guided dynamic therapy using MNPs, which can provide in situ feedback at each therapeutic stage. Potential challenges in translating magnetic dynamic imaging and therapy into clinical practice are also discussed.

ADVANCED NANOBIOMED RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Cancer therapeutics based on diverse energy sources

Subin Son et al.

Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Degradable FeCuS-Lipid Nanoparticles Confer Ultrasound-Activated CO Release and O2-Independent Radical Production for Synergistic Therapy

Yidan Sun et al.

Summary: The US-activated hybrid FeCuS-lipid nanoparticles showed promising therapeutic efficacy in deep-located orthotopic gastric tumors in living mice, enhancing tumor uptake and promoting hydroxyl radical production to induce tumor ferroptosis. The addition of disulfiram further synergized the therapeutic effect by chelating with liberated Cu2+ and yielding toxic chelates to ablate deep-seated orthotopic gastric tumors.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Jingchao Li et al.

Summary: This study introduces a novel semiconducting polymer nanoadjuvant for second NIR-II photothermal immunotherapy, which effectively inhibits tumor growth and eliminates metastasis through a combination of photothermal conversion and TLR agonist release.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

Jingke Fu et al.

Summary: Hypoxia is closely related to drug resistance in solid tumors. A developed nanomedicine can sensitize apoptosis and ferroptosis, effectively inhibiting tumor growth by overcoming hypoxia-induced resistance to chemotherapy.

BIOMATERIALS (2021)

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Review Chemistry, Inorganic & Nuclear

Anion binding in metal-organic frameworks

Xin Wu et al.

Summary: This review discusses the development of metal-organic frameworks (MOFs) as supramolecular anion binding hosts with various environmental and biological applications, categorized based on different design strategies. The advantages of using MOF scaffold for anion binding compared with small-molecules anion receptors are also explored.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

NIR-Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron-Chelated Biopolymer Nanoplatform

Chencheng Xue et al.

Summary: A polydopamine-based nanoplatform was developed for efficient loading of Fe2+ and beta-lapachone, which could trigger ferroptosis in tumor cells under near-infrared light. The platform could generate mild hyperthermia under NIR irritation, activate cellular heat shock response, and enhance intracellular H2O2 formation, promoting Fe2+-mediated lipid peroxidation and beta-lapachone release.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Pan Zheng et al.

Summary: This study developed an acid-sensitive nanoparticle ((CaCUR)-Ca-PEG) that induces mitochondrial Ca2+ overload and acts as an ICD inducer in improved cancer therapy. Combination with ultrasound (US) enhances the ICD effect, showing promising therapeutic and diagnostic properties.

NANO LETTERS (2021)

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Article Multidisciplinary Sciences

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang et al.

Summary: Cystine uptake promotes GPX4 synthesis by activating mTORC1, sensitizing cancer cells to ferroptosis. Inhibiting mTORC1 decreases GPX4 protein levels and enhances the effectiveness of ferroptosis inducers in cancer treatment.

NATURE COMMUNICATIONS (2021)

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Article Engineering, Biomedical

High-resolution T1 MRI via renally clearable dextran nanoparticles with an iron oxide shell

Tae-Hyun Shin et al.

Summary: A new type of nanoparticle with strong T-1 MRI contrast has been developed, showing better imaging performance than traditional gadolinium-based MRI contrast agents. The nanoparticle's biocompatibility and ability to enhance imaging of microvessels make it promising for a wide range of preclinical and clinical MRI applications.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

Single-Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy

Mengyu Chang et al.

Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy

Yingchun Yang et al.

Summary: The study demonstrated the synthesis of monodispersed ferrihydrite nanoparticles inspired by natural biomineral, which triggered Fe2+ generation on tumor sites and showed good efficacy in inhibiting cancer cell proliferation. This method induced tumor cell apoptosis and ferroptosis by promoting DNA fragmentation and GPX4 inhibition, while also causing tumor-associated macrophage polarization.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Synergistic ferroptosis and macrophage re-polarization using engineering exosome-mimic M1 nanovesicles for cancer metastasis suppression

Ping Li et al.

Summary: Ferroptosis has shown effectiveness in cancer metastasis treatment, but limitations in internal ferric aggregation and catalysis at desired sites hinder further therapeutic applications. Modified M1 macrophages with up-regulated CCR2 expression serve as Fe3O4 nanoparticles carrier, which are extruded into exosome-mimic nanovesicles for preferential delivery. This approach demonstrates promising modification efficiency and large-scale production, with potential for inducing macrophage repolarization and tumor-specific immune response in cancer metastasis management.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Gastroenterology & Hepatology

Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses

Xianda Zhao et al.

Summary: This study reveals the critical role of tumor-secreted extracellular vesicles (EVs) containing microRNA miR-424 in suppressing antitumor immune response and leading to resistance to immune checkpoint blockade therapies in colorectal cancer. Modified tumor-secreted EVs with miR-424 knocked down enhance T-cell-mediated antitumor immune response and increase the efficacy of immune checkpoint blockade. Intravenous injections of modified tumor-secreted EVs induce tumor antigen-specific immune responses and boost the immune checkpoint blockade efficacy in late-stage colorectal cancer models.

GASTROENTEROLOGY (2021)

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Article Materials Science, Multidisciplinary

Biomimetic gold nanocages for overcoming chemoresistance of osteosarcoma by ferroptosis and immunogenic cell death

Chong Zhang et al.

Summary: Nrf2/xCT pathway contributes to chemoresistance in osteosarcoma by enhancing antioxidative stress, while ferroptosis and immunogenic cell death can overcome chemoresistance. The use of C-R-AuNC achieves excellent outcomes for treating chemoresistance in osteosarcoma, showing promise for future clinical treatment.

MATERIALS & DESIGN (2021)

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Article Chemistry, Multidisciplinary

Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles

Yongjun Lim et al.

Summary: A single nanoparticle coating method is reported to form 1 nm polymeric shells with various chemical functional groups and surface charges. Nanosecond thermal energy pulses triggered polymerization in the region only a few nanometers from the surface of magnetic nanoparticles under exposure to alternating magnetic field. Modular coatings with different functional groups and surface charges can be achieved by selecting appropriate monomers.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Manipulation of the Nanoscale Presentation of Integrin Ligand Produces Cancer Cells with Enhanced Stemness and Robust Tumorigenicity

Siu Hong Dexter Wong et al.

Summary: The use of a magnetic nanoplatform was found to efficiently culture cancer cells with stem cell-like features, aiding in understanding tumor development mechanisms and establishing tumor models. Substrates with high ligand mobility suppressed integrin-mediated mechanotransduction, enhancing cancer cell stemness.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

A Highly Specific Multiple Enhancement Theranostic Nanoprobe for PET/MRI/PAI Image-Guided Radioisotope Combined Photothermal Therapy in Prostate Cancer

Lei Xia et al.

Summary: A novel biocompatible melanin nanoprobe coupled with a specific inhibitor is developed for targeted multimodal diagnosis and treatment of prostate cancer, demonstrating functionalities for photoacoustic imaging and photothermal therapy. The nanoparticles also have the capability for radioisotope therapy and photothermal therapy, showing a significant inhibitory effect on prostate cancer growth.

SMALL (2021)

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Article Nanoscience & Nanotechnology

Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy

Xiao Cui et al.

Summary: The study prepared an iron self-boosting polymer nanoenzyme FePPy NPs which can decompose H2O2 to induce a nonapoptotic ferroptosis pathway, and also showed impressive photothermal properties to accelerate Fenton reactions for enhanced ferroptosis efficacy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Biocompatible Superparamagnetic Europium-Doped Iron Oxide Nanoparticle Clusters as Multifunctional Nanoprobes for Multimodal In Vivo Imaging

Tingting Zhang et al.

Summary: This study successfully synthesized water-soluble and biocompatible EuIO NCs with enhanced contrast enhancement in MRI, as well as functionalized EuIO NCs exhibiting excellent fluorescence imaging performance in vivo. The research provides a simple strategy for the design and construction of a novel multifunctional magnetic nanoplatform, offering solutions for the development of multimodal imaging probes and disease diagnosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Catalytically Active CoFe2O4 Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

Shiyan Fu et al.

Summary: The PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities are synthesized as bioreactors responsive to TME cues for augmented sonodynamic therapy (SDT) and chemodynamic therapy (CDT), eliciting a strong immune response.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

T-Cell-Derived Nanovesicles for Cancer Immunotherapy

Jihye Hong et al.

Summary: While T-cell therapy is a significant breakthrough in cancer immunotherapy, its efficacy against solid tumors is limited due to T-cell exhaustion caused by immunosuppressive mechanisms. T-cell-derived nanovesicles (TCNVs) produced by extrusion through membranes with micro/nanosized pores show promising anti-tumoral activity in the immunosuppressive tumor microenvironment. TCNVs express programmed cell death protein 1 and TGF-beta receptor on their surface, which helps block PD-L1 on cancer cells and scavenge TGF-beta in the TME, preventing T-cell exhaustion and directly killing cancer cells. These findings suggest TCNVs as an effective strategy for cancer immunotherapy to overcome tumor's immunosuppressive mechanisms.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Rundi Song et al.

Summary: Researchers have developed a immunotherapy method that enhances the immunogenicity of tumor cells by inducing ferroptosis, thereby improving the efficacy of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanocomplex-Mediated In Vivo Programming to Chimeric Antigen Receptor-M1 Macrophages for Cancer Therapy

Mikyung Kang et al.

Summary: The study proposes a simple method to transform macrophages that can naturally infiltrate solid tumors into CAR-M1 macrophages with enhanced cancer-directed phagocytosis and anti-tumor activity. Injected nanocomplexes of macrophage-targeting nanocarriers and CAR-interferon-gamma-encoding plasmid DNA induce CAR-M1 macrophages capable of CAR-mediated cancer phagocytosis, tumor immunomodulation, and inhibiting solid tumor growth, providing an effective off-the-shelf CAR-macrophage therapy for solid tumors without the need for complex and costly ex vivo CAR-cell manufacturing processes.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Ruthenium(II) complexes coordinated to graphitic carbon nitride: Oxygen self-sufficient photosensitizers which produce multiple ROS for photodynamic therapy in hypoxia

Fangmian Wei et al.

Summary: The novel oxygen self-sufficient photosensitizer Ru-g-C3N4, designed to overcome tumor hypoxia-induced resistance in photodynamic therapy, shows enhanced water solubility, visible light absorption, and biocompatibility. Through catalyzing decomposition of H2O2 and H2O to generate O2, Ru-g-C3N4 significantly improves PDT efficacy by producing multiple reactive oxygen species and alleviating tumor hypoxia. This metal complex-grafted g-C3N4 photosensitizer represents a groundbreaking development in oxygen-producing photodynamic therapy agents.

BIOMATERIALS (2021)

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Review Cell Biology

The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury

Yang Sun et al.

Summary: Immune dysfunction plays a critical role in hypoxia-induced multiple organ injury, with PD-L1 being a significant factor. PD-L1 not only contributes to tumor immune evasion but also mediates the progression of immune dysfunction in hypoxia-induced injuries.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Engineering, Environmental

Ferroptosis-apoptosis combined anti-melanoma immunotherapy with a NIR-responsive upconverting mSiO2 photodynamic platform

Danqi Li et al.

Summary: The study developed a nanotechnology-based PDT strategy for melanoma treatment, utilizing mesoporous coated upconverting nanoparticles to convert NIR light to UV-vis light, enabling deep tissue destruction and enhancing anti-tumor immunity. By elevating levels of hydroxyl radicals and inducing apoptosis, the strategy aimed to ease tumor burden and amplify intratumoral oxidative stress.

CHEMICAL ENGINEERING JOURNAL (2021)

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Letter Oncology

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Xing-chen Ding et al.

Summary: The study showed a positive correlation between PD-L1 and HIF-1α in glioma, with their overexpression associated with poor survival. HIF-1α was found to induce PD-L1 expression under hypoxic conditions, which could be abrogated by inhibiting HIF-1α. Combination therapy of HIF-1α inhibitor and anti-PD-L1 antibody demonstrated enhanced tumor growth suppression and improved immune activation.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanostructured Phthalocyanine Assemblies with Efficient Synergistic Effect of Type I Photoreaction and Photothermal Action to Overcome Tumor Hypoxia in Photodynamic Therapy

Yuan-Yuan Zhao et al.

Summary: A novel design is introduced to enhance the efficacy of photodynamic therapy for solid tumors, demonstrating excellent phototherapeutic effects under both normoxic and hypoxic conditions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Magnetic Control and Real-Time Monitoring of Stem Cell Differentiation by the Ligand Nanoassembly

Sungkyu Lee et al.

Summary: The density of ligand nanoassembly on Fe3O4 nanoparticle can be dynamically changed to control stem cell differentiation. Magnetic control of rising and falling ligand movements influences adhesion and differentiation processes through intermolecular interactions.

SMALL (2021)

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Article Multidisciplinary Sciences

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Ann-Na Cho et al.

Summary: This study demonstrates the use of human brain extracellular matrix and a microfluidic device to improve human brain organoid culture, resulting in enhanced neurogenesis and structural and functional maturation of the organoids.

NATURE COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

Xiaoyan Wang et al.

Summary: BCFe@SRF is a novel hypoxia-responsive nanoreactor with great therapeutic efficacy, suitable for high-efficient PDT and ferroptosis synergistic therapy, promoting intracellular ROS accumulation.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

Advances in Engineered Polymer Nanoparticle Tracking Platforms towards Cancer Immunotherapy-Current Status and Future Perspectives

Ramar Thangam et al.

Summary: Engineering polymeric nanoparticles with various targeting molecules has shown improved biomedical applications, especially in cancer chemo- and immunotherapies. Immunoengineering offers solutions for vaccine development by functionalizing nanoparticles and encouraging biological systems to accept engineered materials.

VACCINES (2021)

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Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Xueze Zhao et al.

Summary: This review summarizes recent progress in developing photosensitizers (PSs) for photodynamic therapy, including enhanced tolerance, improved selectivity, and deep tissue applicability. PSs are classified based on molecular design and application, with strategies for designing and future perspectives briefly outlined.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Medicine, Research & Experimental

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Tareq Anani et al.

Summary: Multifunctional nanotheranostic systems integrating MRI-based imaging and therapy functions offer more accurate tumor identification and anti-cancer treatment guidance. This review summarizes the latest developments in hybrid treatment options, unique imaging and targeting strategies, as well as tumor microenvironment-responsive drug release in nanotheranostic systems.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS-Mediated Anticancer Therapy

Ling Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Advanced Photoresponsive Materials Using the Metal-Organic Framework Approach

Ritesh Haldar et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Near-infrared light and glucose dual-responsive cascading hydroxyl radical generation for in situ gelation and effective breast cancer treatment

Yu Hao et al.

BIOMATERIALS (2020)

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Article Cell Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei et al.

CELL RESEARCH (2020)

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Article Cell Biology

Ferroptotic agent-induced endoplasmic reticulum stress response plays a pivotal role in the autophagic process outcome

Young-Sun Lee et al.

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Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

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Article Nanoscience & Nanotechnology

Effective Phototheranostics of Brain Tumor Assisted by Near-Infrared-II Light-Responsive Semiconducting Polymer Nanoparticles

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Remote Manipulation of Slidable Nano-Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

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Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

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Upconverting Nanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer

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NANO LETTERS (2020)

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Large and Externally Positioned Ligand-Coated Nanopatches Facilitate the Adhesion-Dependent Regenerative Polarization of Host Macrophages

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GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

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Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer

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Defect-Rich Adhesive Molybdenum Disulfide/rGO Vertical Heterostructures with Enhanced Nanozyme Activity for Smart Bacterial Killing Application

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Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

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Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5

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JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Poly(amidoamine) Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis

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NANO LETTERS (2019)

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Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors

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Melanin-like nanoparticles decorated with an autophagy-inducing peptide for efficient targeted photothermal therapy

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Targeting Ferroptosis to Iron Out Cancer

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

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Autofluorescence-free chemo/biosensing in complex matrixes based on persistent luminescence nanoparticles

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TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis

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Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles

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Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11

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Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

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Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR-II Light

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Photonic/magnetic hyperthermia-synergistic nanocatalytic cancer therapy enabled by zero-valence iron nanocatalysts

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BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

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MOLECULAR CANCER (2019)

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Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

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NANO LETTERS (2019)

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Programmed degradation of a hierarchical nanoparticle with redox and light responsivity for self-activated photo-chemical enhanced chemodynamic therapy

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Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

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NANO TODAY (2019)

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Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics

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NATURE REVIEWS IMMUNOLOGY (2019)

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Ferroptosis promotes photodynamic therapy: supramolecular photosentizer-inducer nanodrug for enhanced cancer treatment

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Mitochondrial membrane anchored photosensitive nano-device for lipid hydroperoxides burst and inducing ferroptosis to surmount therapy-resistant cancer

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Oxygenic Hybrid Semiconducting Nanoparticles for Enhanced Photodynamic Therapy

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NANO LETTERS (2018)

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Near-Infrared-Light-Activatable Nanomaterial-Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

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Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

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BIOMATERIALS (2018)

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Perfluorohexane-cored nanodroplets for stimulations-responsive ultrasonography and O2-potentiated photodynamic therapy

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Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

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CHEMICAL SOCIETY REVIEWS (2018)

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Review Cell Biology

Glutathione metabolism in cancer progression and treatment resistance

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JOURNAL OF CELL BIOLOGY (2018)

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Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose

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Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

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Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

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Review Pharmacology & Pharmacy

Modulating ROS to overcome multidrug resistance in cancer

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DRUG RESISTANCE UPDATES (2018)

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Light-Responsive Biodegradable Nanorattles for Cancer Theranostics

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ADVANCED MATERIALS (2018)

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Switching Apoptosis to Ferroptosis: Metal-Organic Network for High-Efficiency Anticancer Therapy

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NANO LETTERS (2017)

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Review Chemistry, Multidisciplinary

Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: Challenges and outcomes

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JOURNAL OF CONTROLLED RELEASE (2017)

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Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy

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Regulating Near-Infrared Photodynamic Properties of Semiconducting Polymer Nanotheranostics for Optimized Cancer Therapy

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ACS NANO (2017)

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Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

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CELL (2017)

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Review Pharmacology & Pharmacy

Bioengineered protein-based nanocage for drug delivery

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ADVANCED DRUG DELIVERY REVIEWS (2016)

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Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment

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ADVANCED FUNCTIONAL MATERIALS (2016)

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Cu(II) doped polyaniline nanoshuttles for multimodal tumor diagnosis and therapy

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BIOMATERIALS (2016)

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Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy

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Targeted iron oxide nanoparticles for the enhancement of radiation therapy

Anastasia K. Hauser et al.

BIOMATERIALS (2016)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

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CELL DEATH AND DIFFERENTIATION (2016)

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Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

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CHEMICAL SOCIETY REVIEWS (2016)

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Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

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NANO LETTERS (2016)

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Article Nanoscience & Nanotechnology

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

Saeid Zanganeh et al.

NATURE NANOTECHNOLOGY (2016)

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Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

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CELL REPORTS (2016)

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Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

NATURE REVIEWS MATERIALS (2016)

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Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy

Jilian R. Melamed et al.

ACS NANO (2015)

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Review Pharmacology & Pharmacy

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

Hiroshi Maeda

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Oncology

The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

Holly E. Barker et al.

NATURE REVIEWS CANCER (2015)

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Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

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Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice

Kanyi Pu et al.

NATURE NANOTECHNOLOGY (2014)

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Regulation of immune responses by extracellular vesicles

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NATURE REVIEWS IMMUNOLOGY (2014)

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Nanometre-scale thermometry in a living cell

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NATURE (2013)

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Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

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Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells

Kai Liu et al.

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Perfluorohexane-Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU)

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ADVANCED MATERIALS (2012)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Review Oncology

Immunogenic cell death and DAMPs in cancer therapy

Dmitri V. Krysko et al.

NATURE REVIEWS CANCER (2012)

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Review Oncology

Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

Oliver Kepp et al.

CANCER AND METASTASIS REVIEWS (2011)

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Article Biochemistry & Molecular Biology

Calreticulin exposure dictates the immunogenicity of cancer cell death

Michel Obeid et al.

NATURE MEDICINE (2007)

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Review Oncology

Photodynamic therapy and anti-tumour immunity

Ana P. Castano et al.

NATURE REVIEWS CANCER (2006)

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Antioxidant activity, lipid peroxidation and skin diseases. What's new

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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2003)

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