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Review
Chemistry, Multidisciplinary
Qun Guan et al.
Summary: Multicomponent reactions (MCRs) combine multiple reactants to efficiently synthesize a desired product, and can be applied in both organic synthesis and materials chemistry. This includes the synthesis of covalent organic frameworks (COFs), crystalline porous materials with diverse properties and applications. MCRs offer advantages for COF synthesis, such as improved structural stability and increased crystallization driving forces, resulting in the preparation of robust COFs with diverse applications. This perspective article provides an overview of MCRs, discusses their application in COF synthesis, and addresses critical challenges and future perspectives for the design of new robust COFs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hao Yang et al.
Summary: Covalent organic frameworks (COFs) are promising crystalline porous materials that can be finely adjusted in terms of structure and function. Recent research has focused on designing and preparing functional COF films using surface and interfacial chemistry. This Perspective outlines the recent advances in this area and discusses the current obstacles and opportunities in scaling up the preparation of functional COF films for industrial applications. The goal is to inspire the development of COF films with tailored structures and functionalities for diverse molecular separation processes.
Article
Chemistry, Physical
Yue Yu et al.
Summary: Developing agents that specifically target cancer cells is crucial for safe cancer therapy. In this study, a folate-functionalized nanoscale covalent organic framework (FATD nCOF) was developed for active targeting of cancer cells through their enriched folate receptors (FRs). The FATD nCOF showed excellent dispersion in water and high loading capacity for anticancer drugs. It was selectively internalized by FR-harboring cancer cells and enhanced the efficacy of the loaded drug for targeted cancer cell killing. The results suggest that FATD nCOF holds great promise for active targeting of tumors in vivo.
Article
Gastroenterology & Hepatology
Luc J. W. van der Laan et al.
Summary: A new report from the World Health Organization assesses the risks of dietary exposure to nanoplastic and microplastic particles. Although detecting these particles in food and beverages remains challenging, human exposure is evident. So far, there is no convincing evidence of adverse health effects, but significant knowledge gaps remain.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wen-Yan Li et al.
Summary: Stimulus-responsive biodegradable nanocarriers based on a redox-responsive disulfide-linked porphyrin covalent organic framework (COF) were developed for tumor-selective targeted drug delivery. The nanoscale COF-based multifunctional nanoagent could be effectively dissociated by endogenous glutathione (GSH) in tumor cells, achieving selective chemotherapy and enhancing photodynamic therapy (PDT) for breast cancer. The therapeutic efficacy was significantly improved by responding to the high concentrations of GSH in the tumor microenvironment (TME).
Article
Chemistry, Multidisciplinary
Shanshan Zhang et al.
Summary: In this study, COF nanobowls were synthesized and utilized as activatable nanosensitizers with tumor-specific sonodynamic activity. The high crystallinity of the COF nanobowls enables efficient loading of the sonosensitizer and the in situ growth of manganese oxide inhibits non-specific damage to normal tissues. When reacting with tumor-overexpressed glutathione, the gatekeeper manganese oxide is decomposed to restore the ROS generation capability, leading to increased intracellular ROS stress and enhanced sonodynamic efficacy.
Article
Materials Science, Multidisciplinary
Xiuyan Wan et al.
Summary: In this study, a donor-acceptor covalent organic framework (COF), TB-COF, was developed as an effective photothermal agent for photothermal therapy (PTT). Laser-induced photoinduced electron transfer (PET) between the donor and acceptor in TB-COF converts optical energy to thermal energy, resulting in tumor ablation. The addition of hyaluronic acid (HA) improves biocompatibility and tumor targeting. In vitro and in vivo experiments confirm the satisfactory photothermal anticancer efficacy of TB-COF-HA.
SCIENCE CHINA-MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Mary Kate M. Lane et al.
Summary: Due to the chemical nature of environmental injustices, green chemistry can help advance environmental justice for a more equitable future. Environmental injustices have highlighted the unsustainability and disproportionate burden of relying on polluting and toxic chemicals. Green chemistry and related approaches offer powerful solutions by changing the fundamental molecular basis of our economy and society, reducing the need for procedural systems that can either enable progress or maintain the status quo.
NATURE SUSTAINABILITY
(2023)
Article
Oncology
Daniel J. Zabransky et al.
Summary: Immune checkpoint inhibitors can achieve significant and lasting treatment responses in around 20% of all cancers, but there is a natural resistance in many patients to current immunotherapies. Technological advancements in the past decade have allowed for the profiling of numerous cancers and their tumor microenvironments, which has significantly improved our understanding of the mechanisms tumors use to create immune-resistant microenvironments. This review discusses the key factors that contribute to immune resistance, introduces emerging concepts that reshape our understanding of immune resistance, and highlights novel strategies that aim to convert immune-resistant tumors into immune-sensitive ones.
ANNUAL REVIEW OF CANCER BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Chao Zhong et al.
Summary: Enzyme immobilization is crucial for its application in various fields. Covalent organic frameworks (COFs) are ideal for enzyme immobilization due to their controlled porous structures. However, constructing COFs-based enzyme immobilization systems with high activity using existing methods is still challenging.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Bishal Boro et al.
Summary: In this study, a unique metalated porous organic polymer was synthesized using a cost-effective approach, and it exhibited superior catalytic performance for low-temperature reactions in water. The polymer addressed some drawbacks of conventional catalytic systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Yusuke Asakura et al.
Summary: Hollow covalent organic frameworks (COFs) have attracted significant attention due to their unique properties, such as enhanced surface-to-volume ratio, large surface area, hierarchical structure, highly ordered nanostructures, and excellent chemical stability. These intrinsic characteristics make hollow COFs highly attractive for various applications, including catalysis, energy storage, drug delivery, therapy, sensing, and environmental remediation. This review focuses on the recent advancements in the synthesis of hollow COFs and their derivatives, as well as their practical applications in different fields. The challenges, future opportunities, and the importance of hollow COFs in the future of materials science are also discussed.
Review
Chemistry, Multidisciplinary
Jingyi Sheng et al.
Summary: Multienzymic nanozymes, with multiple enzyme-like activities, offer various advantages including synergistic effects, cascaded reactions, and environmentally responsive selectivity. However, the catalytic mechanism and rational design of multienzymic nanozymes are more complex compared to single-enzymic nanozymes. This review systematically discusses the classification, regulation, and design strategies of multienzymic nanozymes, as well as recent progress in their applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Varun Sridhar et al.
Summary: Tailored micromachines enable therapeutic applications in biological environments, but require sophisticated designs for controlled motion and targeted drug delivery. Covalent organic frameworks (COFs) offer new perspectives for light-driven microswimmers in biological media, such as intraocular fluids, for applications like retinal drug delivery. Two types of COFs, spherical TABP-PDA-COF sub-micrometer particles and nanoporous TpAzo-COF micrometer particles, are described as efficient visible-light-driven drug carriers in aqueous ionic and cellular media, with biocompatibility and the ability to load insoluble drugs for on-demand release. ICG dye loading in the COF pores enables real-time imaging and heat therapy for therapeutic applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Mingyan Sun et al.
Summary: Patients with triple-negative breast cancer (TNBC) have poor prognoses due to the lack of therapeutic targets and susceptibility to lymph node (LN) metastasis. In this study, a magnetic resonance imaging (MRI) contrast agent (Mn-iCOF) was developed based on a Mn-(II)-chelated ionic covalent organic framework (iCOF). The Mn-iCOF demonstrated excellent MRI properties, including high longitudinal relaxivity and longer retention time, allowing for accurate evaluation and dissection of LNs. These findings may lead to the design of more biocompatible MRI contrast agents with higher resolutions for the diagnosis of TNBC.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jieying Liang et al.
Summary: Selecting an appropriate support material for enzyme immobilization is crucial in the development of functional biosystems. Covalent-organic frameworks (COFs) with metal-free and highly stable properties are found to be ideal supports. COF-LZU1, among three COFs developed in this study, is found to retain the highest activity when horseradish peroxidase (HRP) is incorporated. The structural analysis reveals that COF-LZU1 has the weakest interaction with the hydrated enzyme, easiest accessibility to the substrate, and optimal conformation of enzyme, which promote the bioactivity of HRP-COF-LZU1. COF-LZU1 also serves as a versatile nanoplatform for encapsulating multiple enzymes, providing superior protection under harsh conditions and during recycling. The understanding of interfacial interactions, substrate diffusion, and enzyme conformation alteration within COF matrices opens up possibilities for designing ideal biocatalysts and broad applications of these nanosystems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Ting He et al.
Summary: The intensifying energy crises and environmental issues have sparked the research on renewable energy sources, sustainable energy conversion, and storage technologies. Photocatalysis, a green technology, converts eco-friendly solar energy into high-energy chemicals. Covalent organic frameworks (COFs), with their pre-designable structures, high crystallinity, and porosity, show promising potential for converting solar energy into chemicals. This Review highlights recent progress in COF-based photocatalysts synthesis and their applications in water splitting, CO2 reduction, and H2O2 production, while discussing the challenges and future opportunities for their rational design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Mengchu Feng et al.
Summary: Porous microcapsules with selective mass transfer and mechanical robustness for enzyme encapsulation were fabricated using covalent organic framework (COF) spheres. The COF microcapsules provided an enclosed aqueous environment for enzymes, with size-selective porous shells that allowed for fast diffusion of substrates and products. The crosslinking of COF spheres enhanced the structural stability of the capsules and imparted enrichment effects. The enzymes encapsulated in the COF microcapsules showed enhanced activity and durability in organic media.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yanqiu Duan et al.
Summary: The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. In this study, a COF-based sonosensitizer (TPE-NN) is synthesized using reticular chemistry-based synthesis from two inert monomers. The sonodynamic activity of TPE-NN is enhanced by embedding copper (Cu)-coordinated sites, and ultrasound (US) irradiation augments the chemodynamic efficacy of TPE-NN-Cu. This study demonstrates the potential of COF-based sonosensitizers for nanodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Rui Yan et al.
Summary: In this study, a synthetic method for crystalline and porous covalent organic frameworks (COFs) was reported, which incorporate high-density redox sites. When applied as a cathode material in a Li-S battery, the THZ-DMTD COF exhibited high capacity and long-term stability due to its high crystallinity, porosity, and the presence of redox-active moieties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Jiyun Hu et al.
Summary: Covalent organic frameworks (COFs) are crystalline porous organic materials with potential applications in various fields. However, the development of COFs is hindered by the lack of efficient synthetic methods. The traditional solvothermal approach faces challenges such as complicated processes, excessive energy consumption, long reaction times, and limited scalability, making it unsuitable for practical applications. This Review provides an overview of recent advances in alternative COF synthetic methods, focusing on energy input. Examples of COF synthesis using microwave, ultrasound, mechanic force, light, plasma, electric field, and electron beam are discussed, highlighting the advantages and limitations of these methods compared to the traditional solvothermal approach.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xinxin Wang et al.
Summary: Rationally regulating the electronic structures and functionalities of framework materials is still a challenging task. A copper organic framework USTB-11(Cu) is synthesized by reacting 4,4',4''-nitrilotribenzhydraznide with tris(mu(2)-4-carboxaldehyde-pyrazolato-N,N')-tricopper (Cu3Py3), and post-modification with divalent nickel ions results in the heterometallic framework USTB-11(Cu,Ni). The two-dimensional hexagonal structure geometry of these frameworks is revealed by powder X-ray diffraction and theoretical simulations. The mixed Cu-I/Cu-II state nature of Cu3Py3 in USTB-11(Cu,Ni) and the significantly improved charge-separation state formation efficiency contribute to the outstanding photocatalytic CO2 to CO performance of USTB-11(Cu,Ni), with a conversion rate of 22,130 mu mol g(-1) h(-1) and selectivity of 98%.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Sainan Liu et al.
Summary: The special structural morphology of hollow covalent organic frameworks (HCOFs) has a significant impact on their applications. However, the precise control of morphology for HCOFs remains challenging. In this study, a two-step strategy based on solvent evaporation and oxidation of imine bond is presented, enabling the controllable synthesis of HCOFs. The oxidation of imine bond via hydroxyl radicals (.OH) generated from Fenton reaction results in the construction of seven kinds of HCOFs with diverse nanostructures, including bowl-like, yolk-shell, capsule-like, and flower-like morphologies. The obtained HCOFs, with their large cavities, are ideal candidates for drug delivery and have been successfully used for enhanced sonodynamic cancer therapy in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Chun Lin et al.
Summary: Due to the high demand for primary alcohols, finding effective catalysts with high regioselectivity is important. However, obtaining primary alcohols with high yields and regioselectivity from terminal alkenes or alkynes is challenging. In this study, a photosensitizing metal-organic framework (MOF) was synthesized and showed excellent catalytic properties for the production of primary alcohols from terminal alkenes and alkynes via a one-pot tandem reaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Meng Lu et al.
Summary: In this work, dual photosensitizer-based three-dimensional metal-covalent organic frameworks (3D MCOFs) were successfully assembled by covalently linking pyridine ruthenium/ferrum (Ru(bpy)(3)(2+)/Fe(bpy)(3)(2+)) and porphyrin/metalloporphyrin complex (2HPor/ZnPor). These MCOFs demonstrated strong visible light-absorbing ability, efficient electron transfer, and suitable band gap, leading to highly efficient photocatalytic hydrogen (H-2) evolution. The Rubpy-ZnPor COF showed the highest H-2 yield (30,338 μmol g(-1) h(-1)) with an apparent quantum efficiency (AQE) of 9.68% at 420 nm, which is one of the best performances among all reported COF-based photocatalysts. Theoretical calculations revealed that both photosensitizer units in MCOFs can contribute to the optimal photocatalytic activity. This work establishes a general strategy and demonstrates the great potential of utilizing multiple photosensitive materials in the field of photocatalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Peng Gao et al.
Summary: This study proposes a nanozyme bridging strategy for the functionalization of covalent organic frameworks (COFs). Platinum nanoparticles were grown on the surface of COF nanoparticles as catalase mimics, and thiol-terminated aptamers were densely decorated onto the particles via a stable Pt-S bond. The nanoplatform exhibited excellent photothermal conversion, tumor targeting, and catalytic performances.
Review
Chemistry, Multidisciplinary
Xinyu Guan et al.
Summary: Three-dimensional covalent organic frameworks (3D COFs) with spatially periodic networks have significant advantages over their 2D counterparts, such as larger specific surface areas, interconnected channels, and more exposed active sites. However, the research on these materials faces challenges in crystallization and stability, which need to be addressed for practical applications. In this Minireview, strategies for preparing functional 3D COFs, including crystallization techniques and functionalization methods, are summarized. Applications of these functional materials in adsorption, separation, catalysis, fluorescence, sensing, and batteries are presented. Finally, the future challenges and perspectives for the development of 3D COFs are discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Pengfei Dong et al.
Summary: In this study, three kinds of nanoscale covalent organic frameworks (COFs) with tunable local polarization were designed to accelerate the generation of O2 center dot- in type I photodynamic therapy. The tetrakis-(4-formylphenyl)benzene-based COF (TB-COF) exhibited highly aggravated local polarization and matched with the energy level required for the photoinduced e- reduction of O2/O2 center dot-. The elongated charge-separated state of TB-COF was identified and the inhibited electron-hole recombination of COFs improved the O2 center dot- production efficiency in the acidic microenvironment of tumor cells or in vivo, enhancing the anti-cancer effect. The reticular polarization engineering of COFs provides a new paradigm for type I PDT in biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jianping Zhao et al.
Summary: A boron-dipyrromethene (BODIPY) based COF, JNM-12, was synthesized via Schiff-base condensation reaction and exhibited strong visible-light harvesting abilities. JNM-12 showed efficient photocatalytic activity in the oxidative coupling of amines and aerobic oxidation of enamines under visible light irradiation. This work provides a new approach for the synthesis of efficient, economical, and green photocatalysts for organic synthesis.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Haifeng Ji et al.
Summary: A facile and general method for constructing ionic vinylene-linked thiopyrylium-based covalent organic frameworks (COFs) has been reported in this study, using acid-catalyzed Aldol condensation. The COFs exhibited uniform nanofibrous morphologies with excellent crystallinities, special ionic structures, well-defined nanochannels, and high specific surface areas.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Oncology
Ronnie H. Fang et al.
Summary: Cell membrane-coated nanoparticles (CNPs) are emerging nanocarriers that have the potential to improve cancer therapy by overcoming limitations of traditional nanoparticles. CNPs, consisting of a synthetic nanoparticulate core surrounded by a layer of naturally derived cell membranes, offer improved biocompatibility, immune evasion, and tumor targeting. They have been used for drug delivery, phototherapy, and immunotherapy.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lars Grunenberg et al.
Summary: We present a facile method for synthesizing nitrone-linked covalent organic frameworks (COFs) from imine- and amine-linked COFs. The resulting nitrone-linked COFs exhibit high crystallinity, large surface areas, and improved water adsorption properties compared to their imine- or amine-linked precursors.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Alexander Volkov et al.
Summary: The library of imine-linked covalent organic frameworks (COFs) has significantly expanded in the past two decades, offering a wide range of morphologies, pore sizes, and applications. While various synthetic methods have been developed to enhance COF functionalities, most of them are specific to certain applications. This study presents a general strategy to introduce functional group handles in COFs through the Ugi multicomponent reaction, enabling the functionalization of any COFs containing imine linkages.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Sattwick Haldar et al.
Summary: Redox-active covalent organic frameworks (COFs) have recently emerged as advanced electrodes in polymer batteries. COFs provide molecular precision for understanding redox mechanisms and increasing the charge-storage capacities. The functional groups on COFs' pore surface provide easily accessible interaction sites and can be used to establish structure-property relationships, combining experimental and computational methods.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mengyu Sun et al.
Summary: By designing and screening a series of biocompatible covalent organic framework (COF)-based catalysts, a bioorthogonal-activated in situ cancer vaccine can be established efficiently and safely. The activation strategy minimizes drug side effects and maximizes treatment effects, while also catalytically activating immune agonists to enhance antitumor immunity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Guang-Bo Wang et al.
Summary: Photocatalytic multicomponent reactions can be used for the synthesis of covalent organic frameworks (COFs), and photoredox-catalyzed multicomponent Petasis reaction can successfully synthesize COFs with excellent crystallinity, stability, and permanent porosity. The obtained Cy-N3-COF exhibits excellent photoactivity and recyclability for the visible-light-driven oxidative hydroxylation of arylboronic acids. The concept of photocatalytic multicomponent polymerization not only enriches the methodology for COF synthesis but also opens a new avenue for the construction of COFs that might not be possible with the existing synthetic methods based on thermally driven MCRs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Tong Li et al.
Summary: Increasing infiltration of CD8(+) T cells can enhance the response rate to immune checkpoint blockade therapies. In this study, cuproptosis, induced by a newly defined Cu-coordinated covalent organic framework (COF), was shown to effectively increase CD8(+) T cell infiltration. The COF exhibited two functions: Cu2+ acted as a Fenton-like reagent to generate cytotoxicity by catalyzing the production of reactive oxygen species (ROS), and residual Cu2+ depleted cellular glutathione to enhance intracellular oxidative stress, further enhancing the Fenton-like effect. The synergy of these two functions achieved immunogenic cell death and improved anti-tumor effects.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Luis A. Rojas et al.
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a high mortality rate, but it can be targeted using mutation-derived T cell neoantigens as vaccines. In this phase I trial, researchers synthesized individualized mRNA neoantigen vaccines from PDAC tumors and administered them to patients along with atezolizumab, autogene cevumeran, and mFOLFIRINOX chemotherapy. The results showed that the autogene cevumeran vaccine induced neoantigen-specific T cells in patients, and those with vaccine-expanded T cells had a longer recurrence-free survival.
Review
Oncology
Kailin Yang et al.
Summary: Immune-checkpoint inhibitors and other immunotherapies have revolutionized cancer treatment, but most patients do not derive durable benefit, indicating a need for biomarkers. This review explores the role of antigen presentation and molecular/genomic alterations affecting it in response to these therapies. Understanding the mechanisms of clinical response and resistance is essential for maximizing the clinical benefits of immunotherapies.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Li Chen et al.
Summary: This study presents a simple and efficient method for the synthesis of well-dispersed, uniformly morphological, and amine-functionalized 2D imine-linked COFs, which are incorporated into thin-film nanocomposite membranes for the recycling of pharmaceutical synthetic organic solvents. The optimized membrane exhibits high rejection rate and favorable solvent flux, making it a reliable method for efficient organic recovery and concentration of active pharmaceutical ingredients.
Article
Multidisciplinary Sciences
Yaxin Shi et al.
Summary: Boron neutron capture therapy (BNCT) is a clinically approved radiotherapy that selectively deposits deadly particles within cancer cells, but its abscopal anti-tumour effect has been limited. In this study, a boron capsule was engineered to synergize BNCT with controlled immune adjuvants release, promoting a potent anti-tumour immune response. The study revealed that the nuclear reaction in the boron capsule enhances drug release and uncovered the mechanism of BNCT-induced heat on anti-tumour immunity. In preclinical cancer models, BNCT and controlled drug release led to significant regression of both primary and distant tumour grafts.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Qian Li et al.
Summary: This review summarizes the methods and applications of engineering advanced nano-bio-platforms (NBPFs) using emerging 2D materials, including antitumor, antipathogen, tissue regeneration, bioimaging, and biosensing applications. The synthetic strategies for designing 2D-NBPFs are discussed, as well as the recent achievements in tuning the biofunctionalities of these platforms via molecularly programmed microenvironments. The therapeutic and diagnostic applications of 2D-NBPFs are also discussed, along with current challenges and future research directions.
Article
Chemistry, Multidisciplinary
Baohong Sun et al.
Summary: This study reports an effective strategy to induce nonferrous ferroptosis-like in bacteria by incorporating single-atom metal sites (e.g., Ir and Ru) into a sp(2)-carbon-linked covalent organic framework. This strategy can activate intracellular oxidative stress and disrupt cellular metabolisms, resulting in lipid peroxidation-driven ferroptotic damage. The single-atom catalysts show potent antibacterial activity, as well as strong biocompatibility, in MRSA-infected wounds and abscesses. This nonferrous ferroptosis-like strategy may provide new insights into the treatment of drug-resistant pathogen infections.
Article
Chemistry, Multidisciplinary
Chenjie Yang et al.
Summary: In this study, a method using UiO-66@HCOF assisted serum metabolic analysis was developed for the early diagnosis and risk stratification of ACS. Early diagnosis of ACS was achieved with high accuracy using machine learning algorithms, and a comprehensive ACS risk stratification method was established. This study provides new insights into the progress of ACS through metabolic molecular diagnosis.
Review
Nanoscience & Nanotechnology
Morteza Mahmoudi et al.
Summary: The protein corona is a spontaneous formation and evolution of proteins on the surface of nanoscale materials in biological environments, altering their properties and interactions with biosystems. This Review provides an overview of protein corona research in nanomedicine, discusses challenges in characterization and research methodology, and explores how artificial intelligence can aid in advancing this field. It also highlights emerging opportunities in healthcare and environmental sciences.
NATURE REVIEWS MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Asmaa Jrad et al.
Summary: Seawater desalination is facing growing global water scarcity. Traditional materials hinder the improvement of desalination components, but covalent organic frameworks (COFs) offer breakthrough molecular design possibilities for highly efficient desalination materials. This review explores the desalination technologies that have been investigated using COFs. The properties of COFs are introduced, and each desalination technology is comprehensively surveyed, including the process, salt removal mechanism, conventional materials, and technological challenges. The molecular design strategies of COFs are then discussed, highlighting their potential to optimize desalination performance. The advancements in COFs' molecular design for desalination in each technology are reviewed, and the conclusion highlights key research and development gaps that could be addressed with COFs. This review serves as a guide to harnessing the power of molecular design to address industrial challenges in desalination, one of the most important applications.
Article
Chemistry, Multidisciplinary
Yongqiang Shi et al.
Summary: Covalent organic frameworks (COFs) are crystalline organic porous materials with porosity, large surface area, and biocompatibility, making them excellent candidates for various applications. Recent research has shown that COFs have great potential for biomedical applications such as photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. This review covers the recent progress of COF materials in these applications and discusses the challenges and future perspectives for using COFs in biology-facing applications.
Article
Chemistry, Multidisciplinary
Yite Li et al.
Summary: An ionic ZIF-8@iCOF nanocomposite was designed as a sunlight-driven photocatalytic filter, which achieved improved visible light absorption and enhanced ROS generation, resulting in antibacterial efficiency of 99.99999%. Furthermore, the combination of the material with a commercial polymer formed fibrous membranes with high interception efficiency, good biocompatibility, and strong bacteria elimination under sunlight conditions.
Article
Chemistry, Multidisciplinary
Yanhui Qin et al.
Summary: A multifunctional core-shell nanoparticle, OPCPT, was constructed by coating PEGylated COF on photothermal carbon nanospheres. The COF shell dissociates in the acidic tumor microenvironment, leading to tumor-specific photothermal therapy and enhanced apoptosis of cancer cells. This study reveals the potential of COF-based nanomaterials for extended biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Lu Zhang et al.
Summary: Nanozymes with intrinsic enzyme-mimicking activities have the potential to become surrogates of natural enzymes. However, their catalytic efficacy and practical application under physiological conditions are inferior to that of natural enzymes. Recent studies have introduced biosystem-inspired strategies to optimize the functions of nanozymes in biomedical settings. This review introduces the engineering of biosystem-inspired nanozymes and discusses their biomedical applications, as well as the opportunities and challenges in their design and application.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yingjie Fan et al.
Summary: We report the first example of COF-based energy transfer Ni catalysis, where a pyrene-based COF was synthesized and used to coordinate Ni-II centers for efficient borylation and trifluoromethylation reactions of aryl halides under light irradiation. The COF showed two orders of magnitude higher efficiency than its homogeneous control and could be reused without significant loss of catalytic activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhao et al.
Summary: The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) make them promising platforms for various functional applications. In this study, we successfully designed and synthesized a 3D non-interpenetrated stp net COF named TUS-64 with the largest pore size and record-low density. TUS-64 exhibits high stability and a highly interconnected mesoporous structure, enabling efficient drug loading and controlled release in a simulated body fluid environment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Can Guo et al.
Summary: Electrospray was used to fabricate hetero-metallic cluster covalent-organic-frameworks (MCOF-Ti6Cu3) nanosheet-coating (MNC) with integrated micro space electrostatic field for ZMBs anode protection. The MNC@Zn symmetric cell exhibited ultralow overpotential of approximately 72.8 mV over 10,000 cycles at 1 mAh cm(-2) with 20 mA cm(-2), outperforming bare Zn and state-of-the-art porous crystalline materials. Theoretical calculations revealed that MNC with integrated micro space electrostatic field promoted the deposition-kinetic and homogenized the electric field of anode, significantly prolonging the lifespan of ZMBs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Engineering, Biomedical
Nem Singh et al.
Summary: Nanomedicines based on nanoscale covalent organic frameworks (nCOFs) have potential in cancer therapy due to their unique properties and enhanced biocompatibility. This review summarizes the recent applications of nCOFs in various cancer treatments and highlights the modifications of nCOFs to improve their efficacy and clinical translation.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Environmental
Shao-Shuai Zhao et al.
Summary: A covalent organic framework named Tph-BDP-COF, based on porphyrin and boron dipyrromethenes (bodipy), is synthesized to achieve excellent synergetic antibacterial phototherapy by manipulating the excitation energy dissipation pathway. The Tph-BDP-COF exhibited a narrow optical bandgap and fast energy and electron transfer, resulting in superior generation of reactive oxygen species and photothermal conversion, leading to efficient antibacterial activities.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Shuangling Wang et al.
Summary: This study developed a multifunctional nanoplatform based on copper sulfide nanoparticles for synergistic photothermal therapy, chemotherapy, and chemodynamic therapy. The nanoplatform exhibited pH-dependent fluorescence behavior, mesoporous structure, and cancer-targeting efficiency, making it suitable for cancer cell imaging and drug delivery. The nanoplatform achieved a synergistic effect in PTT/chemotherapy/CDT and showed excellent therapeutic efficacy with negligible systemic toxicity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Zhaoyu Han et al.
Summary: In recent years, laser-mediated photodynamic therapy and photothermal therapy have received significant attention due to their minimally invasive characteristics and high specificity. However, traditional photodynamic or photothermal therapy has certain limitations such as the hypoxic microenvironment and complex operation. This study developed a drug delivery system using covalent organic framework (COF) as a carrier for the photosensitizer indocyanine green (ICG) and the hypoxia-activating prodrug AQ4N, with hyaluronic acid (HA) modified on the surface of COF. The HA-COF@ICG/AQ4N system can target tumor cells through recognizing CD44, which is overexpressed in the surface of tumor cells membrane. Under the irradiation of a single NIR laser, the nanoplatform simultaneously produces a combined effect of photodynamic and photothermal, enhancing the antitumor effect.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Inorganic & Nuclear
Zi-Wei Yang et al.
Summary: The use of metal/covalent-organic frameworks (MOFs/COFs) as biosensors for nucleic acid detection offers advantages such as adsorption, fluorescence quenching/emission, and electrocatalysis. This review provides an overview of the design and construction of these biosensors, discussing the interaction between MOFs/COFs and nucleic acids, and comprehensively covering the detection of various nucleic acid molecules. The focus is on rational design to improve sensitivity and selectivity by leveraging the unique structures and optical properties of MOFs/COFs.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Jie Feng et al.
Summary: This article introduces the method of enzyme immobilization using covalent organic frameworks (COFs) and discusses its potential and advantages in improving enzyme stability, recyclability, reducing enzyme contamination, and expanding enzyme applications in the biomedical field. The article summarizes the preparation methods, performances, and latest research applications of various COF-enzyme composites, and also explores the future opportunities and challenges of COF enzyme immobilization technology.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Wei-Chun Chou et al.
Summary: An AI-assisted PBPK model was established to simulate the delivery efficiency and biodistribution of nanoparticles (NPs) in tumor-targeted therapy. The AI-based QSAR model, developed with machine learning and deep neural network algorithms, predicted critical input parameters of the PBPK model. The predictions of the AI-PBPK model correlated well with experimentally-measured pharmacokinetic profiles of NPs in tumor.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Dayong Wang et al.
Summary: We propose a strategy to predict the band-edge positions of two-dimensional covalent organic frameworks (COFs) by combining first-principles calculations with machine learning (ML). The root-mean-square error (RMSE) between ML prediction and first-principles calculated values for the valence band maximum (VBM) and conduction band minimum (CBM) is 0.229 and 0.247 eV, respectively, in the test data set. Additionally, a linear relationship is established between the PBE and HSE06 results with RMSE values of 0.089 and 0.042 eV for VBMs and CBMs in the test data set. Finally, a workflow is developed to determine the band-edge positions of the 2D COFs.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Fangyuan Kang et al.
Summary: Developing diverse synthetic routes to prepare various crystalline covalent organic frameworks (COFs) and enriching the COFs family is crucial. In this research, the Kro''hnke oxidation method was used to construct two crystalline nitrone-linked COFs (CityU-1 and CityU-2) through the ingenious design of precursors and careful control of polymerization conditions. The as-obtained crystalline COFs were characterized and showed potential applications, such as high specific surface area and I-2 capture capacity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: Covalent organic frameworks (COFs) have shown potential as porous materials for cancer phototherapy due to their unique characteristics. However, the aggregation-caused quenching effect and apoptosis resistance limit their effectiveness. This study demonstrated that linking AIEgens into COF networks was an effective strategy for inducing pyroptosis and enhancing antitumor immunity. The synergized system of AIE COF and αPD-1 effectively eradicated tumors and inhibited recurrence and metastasis in a tumor model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Wei Li et al.
Summary: A one-pot and one-step strategy of using dynamic combinatorial chemistry is reported to construct imine-based hollow COFs with hierarchical pores. The resulting particles possess high crystallinity and hierarchical pores, making them useful nanocarriers for catalysis applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Zhifang Wang et al.
Summary: This study presents the design and synthesis of a chemically robust olefin-linked covalent organic framework material, NKCOF-62, which demonstrates remarkable selectivity in adsorbing and separating acetylene and ethane, enabling the one-step purification of ethylene.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Youxing Liu et al.
Summary: Using fluorinated covalent organic frameworks (COFs) to strongly confine Pd ICs greatly enhances the photocatalytic activity and stability of H2O2 photosynthesis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Qiu-Jin Wu et al.
Summary: Introducing an external visible-light field is a promising strategy to improve the activity of the electrocatalytic CO2 reduction reaction. In this study, Ru(bpy)(3)Cl-2 donors were immobilized into Co-porphyrin-based covalent organic frameworks via coordination bonds for photo-coupled CO2RR to produce CO. The incorporation of Ru(bpy)(3)Cl-2 donors with long excited-state lifetime and giant built-in electric field significantly enhanced the activity of the Co-Bpy-COF-Ru-1/2 catalyst, making it the first work of porphyrin-based COFs for photo-coupled CO2RR.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Linlin Deng et al.
Summary: In this study, an environmentally friendly, efficient, and general synthetic strategy was developed to synthesize imine-linked covalent organic frameworks (COFs) with high yield and high crystallinity using Choline Chloride (ChCl)-Hexafluoro-Isopropanol (HFIP) deep eutectic solvents (DESs) as solvents. The results showed that various imine-linked COFs can be synthesized by changing the molar ratio of ChCl and HFIP in DES.
Article
Multidisciplinary Sciences
Anand V. R. Kornepati et al.
Summary: Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected cancers, but its efficacy mechanisms are not fully understood. DNA damage repair (DDR) and ICB are closely linked, as faulty DDR can produce immunogenic cancer neoantigens that enhance ICB therapy. However, the immunogenic effects of nucleic acids generated from DNA damage can complicate ICB efficacy independently of neoantigens. Targets of immunotherapy can also interact with DDR to influence the response to DNA-damaging agents. Understanding the interfaces between DDR, nucleic acid immunogenicity, and ICB efficacy is important for explaining treatment failures and identifying new therapeutic vulnerabilities.
Article
Materials Science, Multidisciplinary
Qin Wang et al.
Nature Nanotechnology
(2023)
Article
Nanoscience & Nanotechnology
Wen-Jing Li et al.
Summary: De novo encapsulation of enzymes within COFs significantly enhances their catalytic performance and stability compared to MOFs. This study highlights the advantages of COFs as an enzyme host, including large channels, low diffusion barriers, superior stability, and metal-free nature, and provides insights into the interfacial interactions between reticular supports and enzymes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Shuncheng Yao et al.
Summary: Ultrasound-triggered sonodynamic therapy (SDT) is a promising method for cancer treatment due to its non-invasive nature and high tissue penetration ability. However, current sonosensitizers have low yields of free radicals. In this study, organic semiconductor π-conjugated covalent organic framework nanocages (COFNs) were developed as efficient sonosensitizers to enhance free radical production and improve cancer therapy. The COFNs exhibited significantly improved SDT performance through enhanced electron utilization and cavitation effect, resulting in increased ultrasound pressure and O-1(2) production. In vitro and in vivo experiments confirmed the elevated SDT performance, demonstrating high tumor suppression in refractory breast cancer. This work provides a promising strategy to develop high-performance sonosensitizers for cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Tao Meng et al.
Summary: This study utilizes covalent organic frameworks (COFs) to construct advanced drug delivery systems for co-delivery of protein and small-molecule drugs in lung cancer treatment, paving the way for more effective and targeted therapeutic treatments.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Qiran Chen et al.
Summary: This study presents an updated version of Nano-Tumor Database, which includes more concentration data sets for nanoparticles in tumors and provides data on nanoparticle accumulation in healthy organs. The results reveal a low tumor delivery efficiency, but consistent with previous studies. By employing the best regression model, hypothetical scenarios with potential higher delivery efficiency are generated by varying the nanoparticle factors.
Article
Chemistry, Multidisciplinary
Le-Le Zhou et al.
Summary: This study reports a iodine- and ferrocene-loaded covalent organic framework (COF) nanozyme that enhances the efficacy of radiotherapy for radioresistant esophageal cancer. The nanozyme increases X-ray absorption and reactive oxygen species production, while disrupting redox homeostasis. Both in vitro and in vivo experiments demonstrate the excellent radiotherapeutic response of the nanozyme.
Article
Chemistry, Analytical
Xiang-Lan Mao et al.
Summary: The isomerism of a covalent organic framework (COF) greatly affects its electrochemiluminescence (ECL) performance. In this study, two isomeric COFs, TFPB-BD(OMe)(2)-H and TAPB-BD(OMe)(2)-H, were synthesized based on different imine linkages and conversion to the quinoline structure. Despite having the same composition and similar structures, the two COFs exhibited significant differences in photoelectrochemical and ECL fields. TFPB-BD(OMe)(2)-H showed a superior ECL emission compared to TAPB-BD(OMe)(2)-H due to stronger polar interaction and enhanced electron interactions.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Dali Wei et al.
Summary: The cooperation of biocatalysis and chemocatalysis in a catalytic cascade reaction has been widely studied. However, practical applications are hindered by enzyme fragility, poor compatibility between carriers and enzymes, and limited catalytic efficiency. In this study, a biomimetic cascade nanoreactor (GOx@COFs@Os) was developed, integrating glucose oxidase (GOx) and Os nanozyme with covalent organic framework (COF) capsules. The GOx@COFs@Os capsule provided a spacious microenvironment to retain GOx activity and protect it from incompatible environments. The COF capsule also improved substrate affinity and mass transfer efficiency, resulting in significantly improved catalytic efficiency compared to the free cascade system. Moreover, the biomimetic cascade capsule was successfully used for glucose monitoring, glutathione sensing, and bisphenol S detection. This strategy provides a new avenue for improving biocatalytic cascade performance and expanding its applications in various fields.
ANALYTICAL CHEMISTRY
(2023)
Article
Polymer Science
Rajeshkumar Anbazhagan et al.
Summary: Interlayer hydrogen-bonded, uniform, and spherical covalent organic frameworks (USCOFs) and non-hydrogen bonded, and spherical covalent organic polymers (USCOPs) were synthesized in different solvents at room temperature. USCOFs showed well-ordered molecular arrangements due to the presence of interlayer hydrogen bonds, while USCOPs exhibited amorphous structures. The synthesized USCOFs were used for protein loading and drug delivery, showing selective cytotoxicity against cancer cells.
Article
Chemistry, Multidisciplinary
Daria Kurandina et al.
Summary: In this study, a nitrone-linked covalent organic framework, COF-115, was synthesized by polycondensation reaction of N, N', N'', N'''-(ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis(hydroxylamine) and terephthaladehyde. The formation of nitrone functionality was confirmed through spectroscopic analysis. The porous nature of COF-115 was evaluated through sorption experiments and showed potential for water harvesting and CO2 capture applications. Additionally, the photoinduced rearrangement of COF-115 to an associated amide-linked material was successfully demonstrated.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuan-Zhe Cheng et al.
Summary: Constructing a powerful photocatalytic system that can simultaneously achieve the carbon dioxide (CO2) reduction half-reaction and the water (H2O) oxidation half-reaction is a challenging task with significant meaning. A porous material named viCOF-bpy-Re, with rhenium complexes as reductive sites and triazine ring structures as oxidative sites, was synthesized through robust -C=C- bond linkages. The viCOF-bpy-Re exhibited excellent charge-separation ability, enabling the generation of photogenerated electrons for CO2 reduction and photogenerated holes for H2O oxidation. It achieved the highest catalytic CO production rate (190.6 μmol g(-1) h(-1) with 100% selectivity) and oxygen evolution (90.2 μmol g(-1) h(-1)) among all the porous catalysts. It also showed excellent stability during the catalysis process for 50 hours. The structure-function relationship was confirmed by femtosecond transient absorption spectroscopy and density functional theory calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Xue Xia et al.
Summary: This paper reviews the construction methods, mechanisms, and potential applications of chemotactic micro/nanomotors in biomedicine. It focuses on the construction of chemotactic micro/nanomotors based on natural cells and synthetic materials, as well as the mechanism of chemotaxis. The applications of chemotactic micro/nanomotors in cancer and cardiovascular disease are summarized, and future developments are discussed.
Article
Chemistry, Multidisciplinary
Yuxin Wang et al.
Summary: A high-efficiency MW sensitizer TM is designed for MW thermo-dynamic therapy, and the mechanism of COF coating to enhance the MW dynamic sensitization of TM is explored. This provides a new idea for the further development of MW sensitizer.
Review
Chemistry, Multidisciplinary
Shi-peng Qi et al.
Summary: This paper summarizes the latest research progress on COF-based materials in photocatalytic systems. The typical structures and preparation methods of COFs are analyzed and compared. The essential principles of photocatalytic reactions over COFs-based materials and the latest research developments in various applications are indicated. The outlook and challenges of COF-based materials in photocatalysis are also discussed.
Article
Biochemistry & Molecular Biology
Pan Li et al.
Summary: DTIC/ICG-Fe3O4@TpBDBSP/HA microneedles were designed and fabricated to enhance the targeting of melanoma and perform photothermal therapy and chemotherapy concurrently. The results showed that this microneedle combination could effectively inhibit the growth of melanoma without tumor recurrence or significant weight loss.
Article
Multidisciplinary Sciences
Gobinda Das et al.
Summary: Controlling the number and positioning of molecular switches in porous materials is crucial for their functionality and properties. In this study, a synthetic strategy involving mixed linkers was used to control the distribution of spiropyran-functionalized linkers in a covalent organic framework. The resulting spiropyran-COF exhibited excellent reversible photoswitching behavior and morphological transitions in response to UV light. The merocyanine-equipped COFs were stable and had a more ordered structure with enhanced photoluminescence.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Liang Zhang et al.
Summary: This study presents a dual-inducer called COF-919, based on non-metallic AIEgen-based covalent organic frameworks, capable of triggering both pyroptosis and ferroptosis, resulting in enhanced anti-tumor immunity and inhibition of tumor growth and metastasis.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Xiongli Liu et al.
Nature Communications
(2023)
Article
Engineering, Biomedical
Jie Feng et al.
Summary: Developing efficient integrated diagnosis and treatment agents based on fuel-free self-movement nanomotors remains challenging in antitumor therapy. This study reports a COF-based biomimetic nanomotor composed of a PPy core, porphyrin-COF shell, and HCT116 cancer cell membrane coating. The nanomotor achieves directional motion through self-thermophoretic force and has good mobility due to the cancer cell membrane coating. The COF-based nanomotor shows promising results for cancer treatment with combined imaging and therapy modalities.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Shuang Liang et al.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Wanqin Wang et al.
Summary: In this study, a novel synthetic strategy for fabricating amide-linked COFs (Am-COFs) was introduced through N-heterocyclic carbene-mediated aerobic oxidation of C=N bonds in the corresponding imine-linked COFs. This method not only featured mild reaction conditions, high crystallinity retention, quantitative conversion efficiency, and generality, but also delivered great compatibility with functional groups due to the umpolung of imine. The discovery of this strategy is expected to expedite the application of amide-linked COFs.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyu Zhao et al.
Summary: A new drug delivery system, GDMCN2, has been developed for pancreatic cancer treatment. It consists of Fe-MOF nanocages enclosed in a COF and modified with NRP2 antibody. GDMCN2 releases DVDMS and gemcitabine while generating ROS under US irradiation, overcoming drug resistance and reducing toxicity.
Article
Materials Science, Multidisciplinary
Jie Feng et al.
Summary: In this study, an H2O2-responsive nanozyme, ABTS@Fe-DhaTph, was developed for combination therapy of catalytic therapy, photothermal therapy, and photodynamic therapy. It can catalyze the decomposition of H2O2 to produce cytotoxic hydroxyl radicals for in situ tumor catalytic therapy. Additionally, it can enable H2O2-dependent photothermal therapy and synergistically enhance reactive oxygen species generation, thereby improving catalytic therapy and photodynamic therapy.
SCIENCE CHINA-MATERIALS
(2023)
Article
Multidisciplinary Sciences
Shengnan Zhou et al.
Summary: This study reports a biomimetic multifunctional COF nanozyme composed of AIEgen-based COF (TPE-s COF) and encapsulated gold nanoparticles (Au NPs). By co-culturing the nanozyme with HepG2 cells, an inactivated form of the TPE-s COF-Au@Cisplatin nanozyme (M@TPE-s COF-Au@Cisplatin) was fabricated, which lost its proliferative ability and pathogenicity. Laser irradiation resulted in the cleavage of M@TPE-s COF-Au@Cisplatin nanozymes, releasing TPE-s COF-Au nanozyme and Cisplatin for photothermal and drug therapeutic effects.
Article
Materials Science, Multidisciplinary
Hongjie Yang et al.
Summary: Covalent organic frameworks (COFs) have shown great potential in photocatalysis due to their customizability and targeted functionalization. This study explored a new approach to regulate exciton dissociation on COFs by introducing localized defects through the synthesis of monoaldehyde electron donors. The formation of D-A configuration defects changed the local electronic structure and charge distribution, enhancing dipole polarization, and promoting exciton dissociation and photocatalytic activity.
ACS MATERIALS LETTERS
(2023)
Review
Chemistry, Physical
Jinhui Lin et al.
Summary: Cancer poses a significant threat to human health, and traditional treatments such as chemotherapy and radiotherapy are suboptimal and cause significant side effects. Gene therapy offers improved targeting and reduced side effects, and the use of nanocarriers like liposomes enables effective delivery of gene therapy agents. However, combining gene therapy with other therapies using nanocarriers can lead to synergistic therapeutic effects. This review highlights various ways to combine gene therapy with other therapies and emphasizes the role of nanoplatforms in mediating these combined therapies.
Article
Chemistry, Multidisciplinary
Qiu-Jin Wu et al.
Summary: Researchers immobilized Ru(bpy)3Cl2 as powerful photosensitive donors into Co-porphyrin-based covalent organic frameworks (Co-Bpy-COF-Ru x) via coordination bonds to enhance the electrocatalytic CO2 reduction reaction (CO2RR). The optimal Co-Bpy-COF-Ru1/2 showed a high CO Faradaic efficiency of 96.7% and a CO partial current density of 16.27 mA cm-2 under light assistance, surpassing the values observed in the dark. The enhanced activity is mainly attributed to the incorporation of a Ru(bpy)3Cl2 donor with long excited-state lifetime and concomitantly giant built-in electric field in Co-Bpy-COF-Ru1/2.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Shuying Chen et al.
Summary: mRNA vaccines have revolutionized the field of infectious disease and cancer research, offering rapid and precise immune responses. This study discusses the development and evaluation of biomaterials and nanotechnology in mRNA vaccines, highlighting their advantages over traditional vaccines. The use of nanoparticles and nanotechnology provides innovative solutions to overcome challenges in mRNA delivery and enhance the potency of vaccines.
NATURE REVIEWS METHODS PRIMERS
(2023)
Article
Chemistry, Multidisciplinary
Satyadip Paul et al.
Summary: In this study, a hierarchical TpAzo COF-foam with micro-, meso-, and macroporosity was synthesized using an in situ CO2 gas effervescence technique. The resulting TpAzo foam matrix showed higher immobilization efficiency for enzymes compared to the COF. The enzyme-immobilized TpAzo foam exhibited activity and stability, and was successfully utilized for a one-pot tandem conversion reaction with high recyclability.
Review
Biochemistry & Molecular Biology
Shanze Chen et al.
Summary: Macrophages are vital to the innate immune system and play a central role in various immune tasks. They possess polarization settings that are crucial for immune regulation, and their clinical importance in cancer and other diseases is increasingly recognized. Macrophages have a significant impact on processes such as angiogenesis, tumor cell proliferation, metastasis, and immune suppression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Multidisciplinary Sciences
Ke Tian Tan et al.
Summary: Chemical approaches play a crucial role in the design, synthesis, control and engineering of small molecules, polymers and networks, combining covalent bonds and non-covalent interactions to establish complex structures for specific functions. Covalent organic frameworks (COFs) are crystalline porous polymers that integrate organic units into highly ordered structures through polymerization using covalent bonds for primary order structures and non-covalent interactions for high order structures in a one-pot reaction system. This Primer provides a comprehensive overview of the field of COFs, covering chemistry, physics, materials and applications, aiming to present a concise yet complete picture of the field and addressing key fundamental issues with future directions in mind.
NATURE REVIEWS METHODS PRIMERS
(2023)
Article
Chemistry, Physical
Yue Yu et al.
Summary: Developing agents that can accurately differentiate tumors from normal healthy tissues is crucial for safe cancer therapy. In this study, a folate-functionalized nanoscale covalent organic framework (FATD nCOF) was developed for active targeting of cancer cells through the abundant folate receptors (FRs). The FATD nCOF showed good dispersibility in water and high loading capacity for various anticancer drugs. It was selectively internalized by FR-harboring cancer cells, leading to enhanced efficacy of the loaded drug and increased apoptosis rate. This research highlights the potential of FATD nCOF for active tumor targeting and its application in chemical and biomedical fields.
Article
Nanoscience & Nanotechnology
X. Zhang et al.
Summary: Based on the supramolecular assembly strategy, a donor-acceptor (D-A) covalent organic framework (COF) was developed, which can efficiently convert luminous energy into thermal energy for photothermal therapy. The COF was intercalated with electron-rich tetrathiafulvalene (TTF) and coated with cancer cell membranes to improve biocompatibility and tumor targeting ability. In vitro and in vivo experiments showed that the intercalated COF could effectively suppress tumor growth upon laser irradiation.
MATERIALS TODAY NANO
(2023)
Review
Chemistry, Physical
Jing Xiao et al.
Summary: Covalent organic frameworks (COFs), a new porous crystalline material constructed by covalent links between building monomers, have made significant progress in chemistry and materials fields. However, traditional synthesis methods using solvothermal methods pose challenges to the environment, leading to the exploration of facile fabrication approaches.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Nanoscience & Nanotechnology
Shuangqiao Han et al.
Summary: Covalent organic frameworks (COFs) have the potential to be a fast and efficient solution for molecular separation due to their orderly arranged pores and regulatable pore apertures. This study utilized a synthesized COF to modulate the physicochemical properties of polyamide membranes, resulting in improved water permeability and ion selectivity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of multienzyme-mimicking covalent organic frameworks (COFs) have been engineered to induce pyroptosis and remodel the tumor microenvironment, boosting cancer immunotherapy.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Shuncheng Yao et al.
Summary: This study develops a human self-driven catalysis-promoting system to improve the reactive oxygen species (ROS) generation efficiency of nanocatalysts for cancer therapy. The system demonstrates high catalytic ROS generation efficiency and offers a new therapeutic mode for self-driven at-home therapy.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bin Han et al.
Summary: Functional 3D COFs with irreversible bond were synthesized successfully, showing a large current density and high Faradaic efficiency, significantly improved compared to excellent 2D COF analogues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Li Cao et al.
Summary: Nanofluidic devices based on oriented two-dimensional covalent organic framework membranes show significantly higher ion flux and actively modulable ion transport capabilities, with a high pH-gating on/off ratio of approximately 100. The customisable structure and rich chemistry of COF materials provide a promising platform for manufacturing nanofluidic devices with modifiable ion/molecular transport features.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Anthony Letai et al.
Summary: Functional precision medicine is a strategy that provides personalized treatment guidance based on the immediate response of live tumor cells. The heterogeneity of human cancer requires personalized approaches for improved treatment outcomes. Traditional precision oncology relies on static tumor features, but only a small proportion of individuals benefit from this approach. Functional precision medicine can provide additional information on tumor vulnerabilities.
Article
Chemistry, Multidisciplinary
Xiao-Jie Dong et al.
Summary: In this study, a composite nanoscale COF material loaded with an inorganic photothermal agent, CuS, and an organic photosensitizer, BODIPY, was synthesized via stepwise post-synthetic modification. The resulting CuS@COF-BDP showed efficient singlet oxygen generation and photothermal conversion abilities, making it a promising dual-modal therapeutic agent for highly inhibiting MCF-7 tumor cell proliferation.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Austin M. Evans et al.
Summary: Synthetic chemists have developed various methods to synthesize molecules, polymers, and networks, but have long lacked the ability to prepare two-dimensional polymers from designed monomers. Recent advances in polymerization strategies and characterization methods have enabled the realization of covalently linked macromolecular sheets. Three predominant 2D polymerization strategies have emerged, producing 2DPs as either monolayers or multilayer assemblies.
Review
Chemistry, Inorganic & Nuclear
Sara Abednatanzi et al.
Summary: Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as two emerging classes of highly porous compounds have shown great potential for various applications due to their distinctive properties. These materials are being extensively studied by both academic and industrial scientists, but there is still a need for further exploration into their structural design and advanced applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yize Zhang et al.
Summary: The study demonstrates the synthesis of silver nanoparticles using two pyridine-based covalent organic frameworks (COFs) with rich porosity, showing outstanding catalytic activity for the carboxylative cyclization of propargylic amines with CO2. By regulating the position of pyridinic-N in the frameworks, selective confinement of silver sites to specific sizes in different pores is achieved, influencing catalytic activity and stability. The ultrasmall nanoparticles in Ag@2,6-FPP-TAPT exhibit enhanced catalytic activity due to synergistic effects among particle size, mass transfer, adsorption and activation for propargylic amines and CO2, supporting scalable preparative ability with full conversion and high TOF value in continuous-flow conditions.
Article
Chemistry, Multidisciplinary
Zhi-Bei Zhou et al.
Summary: Amide-linked covalent organic frameworks (amide COFs) have great potential in practical applications due to their high stability and polyamide structures. However, their accessibility is limited. In this study, a new linkage conversion method using KHSO5 as an oxidant was developed to rapidly synthesize crystalline amide COFs under mild conditions. This approach is general, facile, efficient, and scalable, allowing for easy production of amide COFs from widely available imine-linked COFs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yan Yue et al.
Summary: A new kind of piperazine-linked covalent organic framework (COF) was successfully synthesized through nucleophilic substitution reaction. The COF exhibits excellent chemical stability and permanent porosity, and possesses high conductivity and carrier mobility.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Rui Ren et al.
Summary: A novel synthetic approach was used to construct chemically stable CQ linkages in COFs, achieving dual-mode sensing of strongly acidic environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Immunology
Guido Kroemer et al.
Summary: Immunogenic cell death (ICD) plays an important role in therapy and disease, as dying mammalian cells release signals that interact with the host to determine the immunological correlates of cellular stress and death. ICD is crucial in immunosurveillance and is related to strategies evolved by pathogens and cancer cells. Additionally, normal cell death can also initiate antigen-specific immune responses.
Article
Chemistry, Multidisciplinary
Xueji Ma et al.
Summary: We present a facile and environmentally friendly method for the synthesis of chemically stable covalent organic frameworks with diversified structures in an aqueous medium at low temperatures. This method is also applicable for the gram-scale synthesis of highly crystalline COFs (>1 g).
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sarah E. Hickman et al.
Summary: Machine learning algorithms demonstrate a stand-alone application in mammographic screening workflows, achieving or even exceeding human reader detection performance and improving efficiency.
Article
Chemistry, Analytical
Lei Chen et al.
Summary: By tuning the surface charges of COFs, two solution-dispersible nanoparticle COFs with improved subcellular targeting ability and enhanced ROS generation ability were prepared and successfully applied for imaging-guided type I PDT, providing a promising strategy to expand the biomedical applications of COFs.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Biomedical
Sukanya Bhunia et al.
Summary: A new class of hydrolytically stable 2D COFs for sustained drug delivery to direct stem cell fate has been reported. Loading an osteogenic agent dexamethasone within the COFs enhances their osteoinductive ability, demonstrating their potential biomedical applications.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Biomaterials
Wenxin Wang et al.
Summary: Photothermal therapy (PTT) is one of the most effective methods for tumor treatment, and heteropoly blue (HPB) is an ideal photothermal therapy agent (PTA) with decent photothermal conversion efficiency. Covalent organic frameworks (COFs) are considered as good carriers with excellent biocompatibility. In this study, HPB was successfully loaded into a COF, resulting in a platform with desirable biocompatibility, pH-responsive release properties, and high tumor inhibition efficiency for PTT.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Multidisciplinary
Jie Feng et al.
Summary: The development of photothermal strategies with excellent therapeutic efficiencies under low-temperature conditions is crucial for tumor treatments. By using a multimodal therapeutic agent GA@PCOF@PDA, which combines photodynamic therapy, heat-shock protein down-regulation, and chemotherapy, this study illustrates an efficient approach to design high-performance nanoagents for improved cancer theranostics at low temperatures.
SCIENCE CHINA-MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xinxi Li et al.
Summary: The synthesis of organic polymers from COFs by changing the unit molecule can enhance photocatalytic activity. In this study, the exfoliation of metalloporphyrin-based COFs and adjustment of the layer thickness were found to enhance photocatalytic activity.
Review
Chemistry, Multidisciplinary
Pengfei She et al.
Summary: This review summarizes the recent progress of smart 2D COFs that show reversible changes in conformation, color, and luminescence in response to external stimuli. The responsive mechanisms, design strategies, and applications in chemical sensors and photoelectronic devices are discussed, providing guidelines for designing novel stimulus-responsive 2D COFs for advanced photoelectronic applications.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Fanglin Tan et al.
Summary: A liquid crystal-directed synthesis method was proposed for the production of highly crystalline COFs in water and air. The synthesized COFs are organic semiconductors with macropores and mesopores, making them attractive catalysts. The yield reached up to 94%, demonstrating the generality of the method.
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A novel porphyrin-based staggered stacking covalent organic framework, COF-618-Cu, is designed to overcome the photobleaching and aggregation-caused quench defects of photosensitizers and the intrinsic antioxidant tumor microenvironment. COF-618-Cu exhibits excellent catalase-like activity and glutathione peroxidase mimic activity, which can alleviate tumor hypoxia by consuming hydrogen peroxide and decrease ROS scavenging by depleting intracellular glutathione. The unique staggered stacking mode of COF-618-Cu effectively relieves both photobleaching and aggregation-caused quench effects. Additionally, COF-618-Cu shows great potential for inducing immunogenic cell death and remodeling the tumor microenvironment to boost antitumor immunity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Shimei Li et al.
Summary: This study proposes an integrated strategy derived from MOF@COF for remarkably augmenting single MWTT to reduce tumor recurrence.
Article
Chemistry, Multidisciplinary
Li Liao et al.
Summary: In this study, novel three-dimensional sp(2) carbon-linked COFs were synthesized through the formation reaction of C=C bonds and their application in fluorescence imaging was investigated. The results showed that these COFs exhibited high stability and excellent light-emitting properties, making them potential drug carriers and cell fluorescent stains.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Liuxiao Li et al.
Summary: This study synthesizes a series of 2D COFs with the kgd topology and controllable pore size, achieving one of the smallest reported pore sizes for 2D COFs at 6.7 A. The in-plane network and stacking sequence of these COFs can be clearly observed by low-dose electron microscopy. With the unique combination of kgd topology and small rhombic micropores, these 2D COFs exhibit potential for drug delivery with high loading and good release control of ibuprofen.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jie Feng et al.
Summary: The development of linkage chemistry in covalent organic frameworks (COFs) is crucial for creating stable and highly crystalline structures with diversified functionality. By synthesizing fused-ring-linked COFs, researchers have achieved a new level of complexity and controllability in linkage chemistry, opening up new possibilities for the construction of sophisticated COF structures with high controllability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zhenwu Lu et al.
Summary: The reversibility of imine bonds in COFs can be locked through the asymmetric hydrophosphonylation reaction, resulting in improved chemical and thermal stabilities, as well as intrinsic proton conductivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zhenjie Mu et al.
Summary: In this study, a series of COFs with different pore apertures were successfully constructed using designed building blocks, demonstrating their potential applications in enzyme separation and protection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jiayu Ren et al.
Summary: The protein corona is a challenge in the field of nanomedicine, as it can both improve and compromise the properties of nanoparticles. This is determined by the chemistry of the nanoparticles and the spatiotemporal variation in biological environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Liang Yao et al.
Summary: Researchers have successfully synthesized crystalline covalent organic framework (COF) nanoplates with uniform distribution. These nanoplates were used to create smooth, homogeneous, and tunable COF nanofilms by spin coating and applied in photoelectrochemical solar-to-hydrogen conversion. By designing the photoelectrode structure, charge recombination in COFs was reduced, leading to high photocurrent density and efficient photoelectric conversion. This study provides experimental basis for the application of large-scale COF nanofilms and heterojunction architectures in solar energy conversion devices.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Zeshan Xiong et al.
Summary: This study reports a versatile and efficient strategy of amorphous-to-crystalline transformation for the fabrication of highly crystalline HCOFs. The approach allows for the control of hollowing process and crystallization process by regulating the dynamic imine exchange reaction. Various HCOFs with ultrahigh surface areas and uniform morphologies were successfully synthesized, and COF-based yolk-shell nanostructures with functional interior cores were also fabricated. The obtained metal@HCOFs catalysts showed enhanced catalytic activity and size-selectivity, highlighting the significance of nucleation-growth kinetics of COFs in tuning their morphologies, structures, and applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xuan Kan et al.
Summary: In this study, a novel type of chiral covalent organic frameworks (CCOFs) was reported for the first time, which can achieve enantioselective photocatalytic reactions. The researchers successfully applied this framework to the photooxidation reaction of sulfides to sulfoxides and the synthesis of (R)-modafinil.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Sizhuo Yang et al.
Summary: Covalent organic frameworks (COFs) have shown great potential for various advanced applications due to their unique structure. Researchers have developed a synthetic approach that introduces nitrogen-containing heterocycles into COFs, leading to the introduction of new functionalities. This general strategy opens up possibilities for a broader range of functional porous crystalline materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Kevin Maik Jablonka et al.
Summary: Large amounts of data generated in chemistry labs are often inaccessible to digital tools due to non-digitally captured and reported data. A modular open-science platform for chemistry would benefit data-mining studies and the chemistry community as a whole. Existing technologies, such as electronic lab notebooks, have made progress in addressing data-management concerns, but further integration and optimization are needed.
Article
Biochemistry & Molecular Biology
Oliver Lester Saldanha et al.
Summary: This study demonstrates the importance of using a decentralized, privacy-preserving machine learning framework for histopathology image analysis. By utilizing swarm learning, AI models can be trained on routine histopathology slides collected in real-world settings to predict molecular alterations in patients. The results show that AI models trained with swarm learning outperform most locally trained models and perform on par with models trained on merged datasets.
Article
Multidisciplinary Sciences
Zhi-Bei Zhou et al.
Summary: Exploring new linkage chemistry for covalent organic frameworks (COFs) is a strong driving force for promoting the development of this class of porous materials. The authors report a strategy to synthesize COFs with azo linkages and explore their unique properties.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yimeng Li et al.
Summary: Porous covalent organic frameworks have been engineered with co-catalyst binding sites to improve photocatalytic hydrogen evolution performances. Photodeposited platinum clusters as cocatalyst on the framework make it an efficient photocatalyst for light-driven hydrogen production. This work provides a direction for structural design on covalent organic frameworks to develop efficient photocatalysts.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Miao Guo et al.
Summary: The utilization of weak interactions to improve the catalytic performance is crucial but challenging. This study demonstrates that by using imine-linked covalent organic frameworks, the weak interactions near Pd nanoparticles can be finely tuned. The pi-pi interaction between the organic frameworks and the substrate significantly reduces the activation barrier, thus enhancing the catalytic activity.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yongliang Yang et al.
Summary: Covalent linkages are crucial for covalent organic frameworks (COFs). This study focuses on the synthesis of crystalline and ultrastable 4-carboxyl-quinoline linked COFs via Doebner reactions using both one-pot and post-synthetic modification methods. The authors demonstrate the application of these COFs in nanofiltration, showing desirable separation capacity, high water permeance, and tolerance of extreme conditions. This work opens up new possibilities for constructing robust and functional COFs materials for practical applications.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Jianan Zhang et al.
Summary: A novel nanoscale porphyrin-containing covalent organic polymer was designed with enhanced synergistic effects of photodynamic therapy, chemodynamic therapy, and energy starvation by loading glucose oxidase, leading to effective tumor growth inhibition upon near-infrared light irradiation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Taotao Huo et al.
Summary: In this study, a space-time conversion vehicle based on covalent organic framework (COF)-coated mesoporous silica nanospheres (MSN) with a sandwiched polyethyleneimine (PEI) layer (MPCP) is designed to overcome the biological barriers in the pharmacotherapy of pancreatic carcinoma. The programmed drug delivery achieved by the ordered degradation from COF shell to MSN core contributes to the enhanced chemotherapeutic outcomes by overcoming extracellular matrix and drug reflux barriers.
Article
Nanoscience & Nanotechnology
Xia Zhang et al.
Summary: A multiple ROS-based cancer immunotherapy synergistic strategy has been developed in this study to enhance the therapeutic effect of cancer. By embedding copper ions into a three-dimensional covalent organic framework, multifunctional nanomaterial 3D Cu@COF-TATB is prepared. The generated multiple types of ROS can induce immunogenic cell death and activate an immune response to attack the tumor.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Gui-Ping Yang et al.
Summary: A covalent organic framework called TAPP-BDP with a conjugated donor-acceptor structure has been developed for efficient photoinduced bacteriostasis. It demonstrates triple and synergistic bacterial inhibition through integration of photodynamic, photothermal, and peroxidase-like enzymatic activities under irradiation with near-infrared light. TAPP-BDP exhibits excellent antibacterial efficiency against both Gram-negative and Gram-positive bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Feng Qiu et al.
Summary: A stable and conductive two-dimensional phthalocyanine-based covalent-organic framework (COF) was shown as an electrocatalyst for the reduction of CO2 to acetate with high efficiency and stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yunlong Zheng et al.
Summary: Enzyme immobilization is crucial for large-scale biocatalytic processes. This study presents a green and scalable approach to prepare high-performance biocatalysts through the assembly of enzymes with covalent organic frameworks. These biocatalysts have exceptional reusability and stability, making them efficient catalysts for important industrial reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Qian-You Wang et al.
Summary: A novel aminal-linked porphyrinic COF, Por-Aminal-COF, was synthesized and characterized. It exhibited excellent photocatalytic activity for the detoxification of sulfur mustard simulant with a much shorter half-life compared to the traditional imine-linked Por-COF. The superior photocatalytic performance of Por-Aminal-COF was attributed to its aminal linkages, which facilitated the intersystem crossing process and enhanced triplet-state generation efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Jia You et al.
Summary: This study presents a novel AIEgen-based carbon-conjugated COF with high stability and fluorescence. Through modification and activation, the COF can be used for tumor cell imaging and ferroptosis.
CHEMISTRY OF MATERIALS
(2022)
Article
Engineering, Environmental
Wen-Xiu Wu et al.
Summary: Providing safe and clean domestic water is a global issue, and heavy metal ions and pathogens are the main pollutants. This research introduces a multifunctional material, APCOF-1, and demonstrates its potential for water treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hao Lyu et al.
Summary: This study reports the covalent incorporation of reactive aliphatic amine species into covalent organic frameworks (COFs) for the first time. Through crystallization and chemical reactions, tris(3-aminopropyl)amine was successfully incorporated into COF-609, resulting in a significant enhancement in CO2 uptake capacity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Peng Wang et al.
Summary: Bioorthogonal cleavage reaction-triggered prodrug activation by the pretargeted methods can achieve accurate cancer therapy. In this study, we successfully realized the synchronous delivery of prodrugs and triggers through the creation of a nanovoid-confinement and click-activated core-shell nanoreactor, resulting in efficient and safe tumor treatment.
Review
Chemistry, Multidisciplinary
Cheng Qian et al.
Summary: This article reviews the chemistry of modifying and preparing imine derivatives in 2D COFs. The derivation of imine bonds through covalent and noncovalent bonding, as well as the properties and potential applications of the resulting materials, are discussed to gain a better understanding of the relationship between covalent linkages and overall performance in 2D COF materials.
NATURE REVIEWS CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jie Zhou et al.
Summary: This study reports the development of a crystalline hetero-metallic cluster catalyst, MCOF-Ti6Cu3, based on the cooperation between MOF and COF. The catalyst exhibits efficient coupling of photocatalytic CO2 reduction and H2O oxidation by utilizing dynamic covalent bonds between clusters to promote photo-induced charge separation and transfer. The MCOF-Ti6Cu3 catalyst shows fine activity in the conversion of CO2 and water into HCOOH.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Chaonan Jin et al.
Summary: This study developed a photoenzymatic platform for asymmetric catalysis by immobilizing wheat germ lipase (WGL) onto rationally designed photocatalytic porphyrinic covalent organic frameworks (COFs). The WGL@COFs photobiocatalysts demonstrated high enzymatic activity and good operational stability, and exhibited excellent performance for an enantioselective Mannich reaction under visible light irradiation. This work provides a general and efficient strategy for fabricating photobiocatalysts that enable highly efficient photoenzymatic asymmetric catalysis using COFs as photocatalytic platforms for enzyme immobilization.
Review
Nanoscience & Nanotechnology
Arindam Mal et al.
Summary: Covalent organic frameworks (COFs) are functional nanoporous materials with potential applications in biomedical research, such as drug delivery, bioimaging, phototherapy, and antibacterial properties, due to their robust covalent connectivity and chromophoric networks.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
X. Wan et al.
Summary: This study reported a porphyrin-based three-dimensional covalent organic framework as an enzyme nanoprotector to maintain the activity of catalase under acidic tumor microenvironment. The nanoprotector can efficiently generate reactive oxygen species and realize photodynamic therapy of cancer, greatly enhancing the efficacy of cancer therapy.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Multidisciplinary
Rui Gao et al.
Summary: In this study, we stabilize enzymes by wrapping them with covalent organic frameworks using a mild mechanochemistry-guided assembly. The covalent organic framework not only stabilizes enzymes, but also outperforms enzyme-zeolite imidazole frameworks in terms of catalytic efficiency, functional diversity, and structural stability.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Saikat Das et al.
Summary: Three-dimensional covalent organic frameworks (COFs) are a new type of crystalline solids with intriguing structures and porosity. Synthesizing 3D COFs from pre-designed building units remains challenging due to the lack of suitable units and reversible linkages. In this study, a new 3D COF, TUS-84, was reported by linking a tetragonal prism node with a square planar node, exhibiting a two-fold interpenetrated structure, well-defined porosity, and high surface area. TUS-84 also demonstrated efficient drug loading and sustained release profile in drug delivery applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xiao Wang et al.
Summary: This study developed a core-shell dye/MOFs@COFs gas-sensing material with excellent humidity resistance and sub-ppm level sensitivity, which is applicable for early and accurate detection of wheat scab.
Review
Chemistry, Multidisciplinary
Chendi Ding et al.
Summary: Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Article
Chemistry, Multidisciplinary
Shuncheng Yao et al.
Summary: In this work, a human self-driven electrical stimulation enhanced catalytic system based on wearable triboelectric nanogenerator (TENG) and fully pi-conjugated covalent organic framework nanocages (hCOF) for improving cancer therapy is created.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chao Wang et al.
Summary: In this study, a highly efficient laser-ignitable primary explosive was prepared by constructing a core-shell hetero-framework. The explosive showed lower laser energy thresholds and higher detonation ability compared to traditional metal complex-based primary explosives. The study also demonstrated successful laser initiation and detonation of secondary explosives. This research provides a unique method for constructing high-performance laser-ignitable primary explosives for micro-detonator applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhixiang Lu et al.
Summary: This study presents the synthesis of a covalent organic framework with sonosensitive properties for the efficient loading of MnO2 and Poly(I:C). The developed nanomaterial is capable of reversing the reductive tumor microenvironment, generating magnetic resonance imaging signals, promoting reactive oxygen species production, inducing immunogenic cell death, and boosting the immune response. This multifunctional nanosystem represents a promising strategy for cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dianwei Wang et al.
Summary: A covalent organic framework (COF) sonosensitizer is developed using a new nanoscale COF preparation strategy, which improves the therapeutic effect of sonodynamic therapy (SDT). The COF structure prevents aggregation of the sonosensitizer molecules and enhances their chemical stability. Additionally, the coordination of Fe3+ to COF enables chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and alpha-PD-L1 antibody achieves effective antitumor effects.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Penghui Zhang et al.
Summary: This research successfully synthesized a series of highly crystalline covalent organic frameworks (COFs) using a melt polymerization method and demonstrated the kilogram-scale fabrication of robust foams. The resulting COFs are low-cost and can be conveniently transformed into ionic COFs, exhibiting highly efficient ion-exchange adsorption capacity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xiaodong Zhao et al.
Summary: A new strategy for constructing nonsubstituted quinoline-linked COFs through rhodium-catalyzed [4+2] annulation has been developed, which shows high conversion efficiency and stability, and can be applied to the synthesis of various compounds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Wei Wang et al.
Summary: This study presents a porous-shell/core hybrid to improve the performance of photoresponsive batteries. The hybrid ensures long-lived separated charges through electron transfer relay and allows high-rate redox reactions. Batteries equipped with this photoelectrochemical cathode show significant enhancement in energy storage efficiency and have the potential application in solar cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Engineering, Environmental
Shimei Li et al.
Summary: In this article, we provide a detailed review of covalent organic frameworks (COFs) as an emerging class of crystal materials with unique properties. We summarize the different types of chemical linkages used in the formation of COFs and classify them. The biomedical applications of COFs, such as cargo carriers, cancer therapy, biosensing, and biocatalysis, are outlined. The prospects and challenges for further expanding the application value of COFs are also discussed.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Lei Ran et al.
Summary: This study presents a novel method to enhance the catalytic performance of CO2 reduction by anchoring different metal single-atom sites on a triazine-based covalent organic framework. The synthesized catalyst shows superior CO generation rate and selectivity, achieving efficient CO2 conversion under visible light irradiation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yizhou Yang et al.
Summary: In this study, a highly crystalline electroactive two-dimensional covalent organic framework (2D COF) was designed and synthesized. By interfacial doping, the conductivity of an organic semiconductor was significantly increased. Encapsulating a photoswitchable molecule into the COF layer enabled the devices to respond differently to light of different wavelengths, effectively creating on and off states.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Rong-Jia Wei et al.
Summary: This study reports the synthesis of two-dimensional metal-organic framework nanosheets with high aspect ratio and ultrathin thickness through interfacial polymerization. The nanosheets exhibit superior thermal and chemical stability, as well as exceptional catalytic activity and reusability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Juan Wu et al.
Summary: This study reports the first-ever synthesis of COF using natural sunlight and demonstrates its application as a reusable photocatalyst for promoting light-driven oxidation reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Shahriar Sharifi et al.
Summary: Understanding the interaction between biological structures and nanoscale technologies is crucial for the development of safe and efficient nanomedicine products. However, the lack of a universal reporting system and standardized methods for nanomaterial characterization has resulted in low reliability and reproducibility in nanomedicine literature. It is necessary to establish a characterization system to support reproducibility of nanoscience data, especially for studies seeking clinical translation. Implementation of standard protocols in experimental laboratories requires long-term planning and collaboration among stakeholders.
NANO-MICRO LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Fazheng Jin et al.
Summary: In this study, two highly crystalline three-dimensional COFs were synthesized and their topological structures were determined. These COFs exhibit good photoelectric activity and structural stability, making them highly efficient photocatalysts for various reactions.
Article
Chemistry, Multidisciplinary
Tian-Xiang Luan et al.
Summary: This study presents a new covalent organic framework (COF) named PyPor-COF, which is a highly efficient photosensitizer. The COF combines photoactive porphyrin moieties through in situ-formed imidazole groups and exhibits high crystallinity, permanent porosity, robust stability, and semiconductive photo response activity. It can effectively initiate the generation of singlet oxygen (1O2) under visible-light irradiation, surpassing the efficiency of other porphyrin-based reactants and commercially available photosensitizing agents. The COF also shows potential in triggering 1O2 production in a physiological environment, making it a promising candidate for photodynamic therapy.
Review
Chemistry, Inorganic & Nuclear
Guang-Bo Wang et al.
Summary: Light-involved catalysis, especially photocatalysis and photothermal catalysis, is a promising alternative to traditional thermocatalysis. Highly efficient photocatalysts are crucial for the development of light-mediated catalysis. Covalent organic frameworks (COFs) are crystalline molecular solids with designable structures, light-harvesting, and semiconducting properties. The recent development of COFs has brought opportunities for visible-light induced organic transformations. This review comprehensively summarizes and discusses the applications of COFs in selective light-initiated organic transformations, provides an overview of COF-based photocatalysts, and discusses the limitations, challenges, and future perspectives of COF photocatalysis and photothermal catalysis.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Physical
Meng Sha et al.
Summary: This review focuses on intelligent strategies for Metal-organic frameworks (MOFs) as carriers to modulate the activity of biocatalysts and as biomimetic catalysts with precise design and regulation in the field of nanobiocatalysis. MOFs not only can adjust the activity of biocatalysts, but also can enhance enzyme-mimetic catalytic activity and selectivity, thus opening up various potential biomedical applications.
Article
Chemistry, Multidisciplinary
Yingying Guo et al.
Summary: A green, high-yield, and scalable method for stripping two-dimensional imine-linked covalent organic framework powders in water using bi-functional ionic liquids has been reported, achieving a record exfoliation yield of up to 66.6%. The acid-base and hydrogen bond interactions between CONs and cations of the ILs play critical roles in the delamination and stability of the nanosheets. The liquid phase stripping approach has shown tremendous potential in mass production of CONs for high efficiency photocatalysis of CO2 reduction in the gas phase.
Article
Materials Science, Biomaterials
Qun Guan et al.
Summary: This study presents a vinyl-decorated nanoscale covalent organic framework (COF) that consumes cysteine through a light-promoted thiol-ene click reaction, showing powerful therapeutic activity against colon cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Xiuyan Wan et al.
Summary: A porphyrin-based material with covalent organic framework (COF) was developed as a nitric oxide (NO) donor delivery nanoplatform responsive to glutathione for synergistic cancer therapy involving NO mediated therapy and photodynamic therapy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Peng Wang et al.
Summary: A new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, are reported. The nanoreactor, consisting of a ZIF-90 core, COF shells, and an aptamer polymer coating, induces a nanoconfined bioorthogonal reaction, enhancing the activation efficiency of CA4V and its therapeutic effects in vivo.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Fei Lu et al.
Summary: A porphyrin-based COF material was modified with a dialkylnaphthalene derivative to deliver extracellular singlet oxygen to cancer cells, enabling light- and oxygen-independent oxidative damage for cancer therapy.
CHEMICAL COMMUNICATIONS
(2022)
Review
Oncology
Matthew J. Lin et al.
Summary: The article discusses the current status and potential of cancer vaccines, emphasizing the need for accurate immune monitoring of early trials to advance the most promising vaccines. It also classifies cancer vaccines based on the included antigens and their colocalization with antigen-presenting cells, highlighting the challenges and opportunities in advancing these vaccines to the clinic.
Article
Chemistry, Inorganic & Nuclear
Jianping Zhao et al.
Summary: In this study, four novel 2D chiral CMOFs were successfully synthesized and demonstrated their potential applications in dye adsorption, degradation, and chiral separation.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Pharmacology & Pharmacy
Xinyue Wang et al.
Summary: With the development of the biotherapeutic field, biomacromolecules with definite curative effects and small side effects have become a hot topic in the research and development of new drugs. However, there are technical difficulties in using biomacromolecules as drug candidates, mainly related to drug stability and in vivo transport and delivery. To address these challenges, diverse nanodrug delivery systems have been used to deliver biomacromolecules, offering improved stability, bioavailability, and targeted distribution.
ADVANCED THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Qun Guan et al.
Summary: Covalent organic frameworks (COFs) are a class of organic crystalline porous materials with high crystallinity and intrinsic porosity. Metalated COFs formed by combining COFs with metal ions not only retain the advantages of COFs but also have additional properties and applications, thus attracting considerable attention.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Dawid Pakulski et al.
Summary: The tunable physicochemical properties and high stability of covalent organic frameworks (COFs) make them promising candidates for the next generation of energy storage systems. This study focuses on the integration of redox-active moieties (thiols) into COFs and demonstrates their enhanced performance as electrochemical supercapacitors. The researchers synthesized two thiol-decorated COFs (SH-COF-1 and SH-COF-2) and found that SH-COF-1 exhibited higher surface area and improved electrochemical performance compared to previous COFs without redox-active units. Additionally, the presence of thiol groups in the COFs allowed for the in situ growth of gold nanoparticles, which were utilized as heterogeneous catalysts with excellent catalytic activity and long-term performance.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Subhajit Bhunia et al.
Summary: Solid porous and crystalline covalent organic frameworks have high specific surface areas and functional pore walls, allowing adsorption of bioactive molecules. A perylene-based COF was developed as a reservoir for an anticancer drug and the intracellular release of the drug was achieved using serum albumin.
Article
Chemistry, Multidisciplinary
Le-Le Zhou et al.
Summary: The study highlights the ambient synthesis of a positively charged iminium-linked covalent organic framework for adsorption of siRNA, showing potential for therapeutic applications in antitumor activity.
Review
Immunology
Phineas T. Hamilton et al.
Summary: This article introduces the application of predator-prey theory to the interaction between immune cells and cancer cells. By revealing the fundamental mechanisms by which antitumour immunity might fail in sometimes counterintuitive ways, it provides a new evidence-based framework to better understand and therapeutically target the immune-cancer interface.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sabuj Kanti Das et al.
Summary: In this research, a novel biocompatible COF material, TRIPTA, is used as a drug delivery carrier for cisplatin to combat the proliferation and migration of TNBC cells. The study demonstrates that TRIPTA-COF can serve as a potent nanocarrier, showing higher detrimental effects on TNBC cells by increasing the cytotoxicity of cisplatin and minimizing epithelial-mesenchymal transition.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Xiuyan Wan et al.
Summary: In this study, a well-designed three-dimensional covalent organic framework was constructed as a nanocapsule for encapsulating horseradish peroxidase. This novel approach enables sustained release of horseradish peroxidase, prolonging the therapeutic effects of the encapsulated enzymes and promoting long-term enzyme prodrug therapy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Wen-Xiu Ren et al.
Summary: External light-independent antitumor photodynamic therapy has been successfully achieved using a covalent organic framework (COF)-based host-guest nanosystem. Its highly effective antitumor behavior is fully demonstrated in both H2O2-overexpressed 4T1 and H2O2-less expressed HCT116 and MCF-7 xenograft models.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Qun Guan et al.
Summary: A method for constructing imine-linked COFs through photocatalytic oxidation and imine condensation steps is reported, which can be easily scaled up and results in uniform particle size COFs suitable for biomedical applications. The concept of photocatalytic-cascade COF synthesis enriches the nanoscale COF synthetic methodology.
ADVANCED THERAPEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Lihan Cai et al.
Summary: Utilizing COFs as a template, Au nanoparticles grown on the surface, coated with MnO2, and introducing HA, the COF-Au-MnO2 product can perform cascade reactions in the tumor microenvironment, demonstrating excellent cancer cell killing effects and antitumor efficacy via a cycle-like process.
SCIENCE CHINA-MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Sainan Liu et al.
Summary: In this research, a cubic porphyrin-based COF named CTP with excellent hydrophilicity was prepared for the first time using a simple method. By linking the porphyrin monomer into the COF, solubility and biocompatibility issues were overcome, and the band gap was narrowed. The resulting CTP showed enhanced sonodynamic effect and photothermal conversion under external irradiation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Cuie Wang et al.
Summary: Enzyme catalysis can be mimicked using biomimetic approaches, with metal-organic frameworks and covalent-organic frameworks being popular enzyme carrier platforms due to their tunability and surface modification capabilities. These platforms protect enzymes under harsh conditions and enhance selective diffusion of guest molecules.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Mi Zhang et al.
Summary: In this study, a strategy called metal organic framework-sacrificed in situ acid-etching (MSISAE) was developed for the continuous synthesis of COF-based nanocomposites, including core-shell, yolk-shell, and hollow-sphere structures. One of the obtained samples with special three components showed high photocatalytic CO2-to-CO conversion efficiency in the gas-solid mode. This strategy allows for precise morphology design and control of multicomponent hybrid composites based on COFs, potentially leading to the development of porous crystalline materials with powerful superstructures for multifunctional catalytic reactions.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Luca Cusin et al.
Summary: Imine-based COFs are functional, crystalline, and porous nanostructures with relatively easy crystallization, but the stability of the imine bond is limited, making it unsuitable for harsh conditions. Solutions are needed to increase the potential of these materials, potentially through chemical conversion and locking of the imine bond to enhance framework robustness and functionality.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Lu Zhang et al.
Summary: The study presents a high-efficiency peroxidase mimic MOF@COF nanozyme, utilizing the interaction between MOFs and COFs to achieve enhanced bacterial inhibition.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Meng Lu et al.
Summary: This study designed a series of stable metallophthalocyanine COFs as novel single-site catalysts with outstanding activity and selectivity for electrocatalytic CO2 reduction. Coupled with light, these COFs showed improved efficiency and potential for applications in the field of electrocatalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Medicine, Research & Experimental
Sreya Bagchi et al.
Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Chemistry, Multidisciplinary
Weibin Liang et al.
Summary: Enzymes play a crucial role in chemical synthesis and biotechnology, but their activity can be easily affected by external stressors. Metal-organic frameworks (MOFs) offer protection to enzymes through encapsulation or infiltration, allowing them to maintain activity under challenging conditions.
Review
Medicine, General & Internal
Shrey Sindhwani et al.
Summary: Nanomedicine has been a significant research focus in the last thirty years, with researchers developing methods to synthesize and characterize nanomaterials. The current focus is on translating nanotechnologies to benefit patients and addressing the challenges of clinical translation. Building partnerships between engineers and clinicians to create a feedback loop between bench and bedside is crucial for advancing fundamental studies and addressing clinical challenges in this field.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Chemistry, Organic
Bing-Jian Yao et al.
Summary: A quinoline-linked and ionic liquid-decorated covalent organic framework, COF-IM-SO3H, was synthesized and demonstrated to be an efficient catalyst for promoting the Biginelli reaction. A scaled-up Biginelli reaction was successfully achieved using the COF-IM-SO3H@chitosan aerogel-based cup reactor.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Kelvin Li et al.
Summary: The study introduces a novel two-dimensional covalent organic framework that allows for post-synthetic modification through easily implementable chemical reactions, enabling quantitative decoration of the COF lattice with ligands without the need for exogenous species. Functionalization can lead to the spontaneous delamination of COF materials into solution-stable sheets, demonstrating the utility of this technique.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Engineering, Biomedical
Arezoo Esrafili et al.
Summary: Covalent organic frameworks (COFs) are porous organic polymeric materials with desirable properties like high stability, low density, and large surface area, making them suitable for applications in the energy sector and drug delivery. This review discusses different types of COFs, synthesis methods, and their potential applications in the biomedical field, highlighting the specific advantages that can be utilized for specialized biomedical applications such as immune engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemical Research Methods
Lihan Cai et al.
Summary: The study successfully synthesized a new sonodynamic therapy material COF-TiO2 NPs and demonstrated its significantly improved anti-tumor effect compared to conventional TiO2 NPs.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Weiwen Xin et al.
Summary: Researchers have fabricated a series of nanochannel membranes composed of uniform spherical COFs, which have different diameters and surface charge distribution, allowing for tunable water permeation and efficient separation of charged dyes.
Article
Chemistry, Multidisciplinary
Lars Grunenberg et al.
Summary: Covalent organic frameworks with amine linkages can be directly accessed using a novel synthetic strategy, enabling further postsynthetic functionalization for increased hydrolytic stability and potential use as heterogeneous catalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Nanoscience & Nanotechnology
Joshua J. Rennick et al.
Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Li Zhang et al.
Summary: 2D COFs have been recognized as novel photoactive materials with extended pi-electron conjugation and high chemical stabilities. In this study, a new COF (TphBDP) was synthesized using a porphyrin derivative and BODIPY derivative as monomers, showing excellent simulated oxidase activity under 635 nm laser irradiation. The presence of uranium (UO22+) modulated the charge transfer process of colored products, leading to intense aggregation and remarkable color fading.
Review
Pharmacology & Pharmacy
Lucas M. Bush et al.
Summary: Live cells have innate targeting mechanisms and can be used as drug-delivery vehicles to increase drug accumulation efficiency. In cases where native cell types do not exhibit the desired therapeutic phenotype, preferred outcomes can be achieved by genetically modifying and reprogramming cells. Recent advances in using cells like red blood cells, platelets, neutrophils, mesenchymal stem cells, and bacteria for drug delivery have been highlighted in this review.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Mandana T. Manzari et al.
Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.
NATURE REVIEWS MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jie Feng et al.
Summary: The study introduced a COF-based nanocomposite Fe3O4@COF-DhaTph as a multifunctional nanoagent for cancer theranostics under single 660 nm NIR irradiation. Apart from photothermal and photodynamic effects, this nanoagent also allows triple-modal magnetic resonance/photoacoustic/near-infrared thermal imaging, potentially advancing the application of COF-based multifunctional nanomaterials in cancer theranostics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Rui Xia et al.
Summary: This study successfully developed a series of COFs based on the electron donor-acceptor strategy with excellent colloidal stability and adjustable sizes, as well as varying absorption spectra. By altering the electron-donating ability of the monomers, these COFs exhibit a wide range of absorption spectra and potent photothermal activity, effectively inhibiting tumor growth.
Article
Biochemical Research Methods
Yijing Zhang et al.
Summary: A nanoscale PEG-COF-Ag material was developed with high radiolabeling rate and stability, which rapidly captured radioiodine and exhibited long tumor retention time, showing excellent cancer cell killing performance. Radioiodine-labeled PEG-COF-Ag could potentially be applied in brachytherapy with promising therapeutic effects, as confirmed by radiotherapy experiments.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Bin Han et al.
Summary: The study presents the design and synthesis of two-dimensional polyimide-linked phthalocyanine COFs with stable properties, showing potential applications in electrocatalysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Lei Ge et al.
Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.
Article
Nanoscience & Nanotechnology
Caiping Ding et al.
Summary: By studying the energy band structure of NCOF and its matching with the redox potential of Fe3+/Fe2+, a fluorescent probe based on NCOF was successfully designed for sensing Fe3+ and ATP in cells, achieving ultralow detection limits and a broad linear response range. The excellent fluorescence properties and good biocompatibility of NCOF allowed for sensitive imaging of Fe3+ and real-time monitoring of ATP in cells, showing promising potential for the development of fluorescent nanoprobes in biosensor and bioimaging applications.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Hao Zhang et al.
Summary: Asymmetric catalysis is essential due to the increasing demand for optically pure substances. Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) show great potential for heterogeneous asymmetric catalysis. The unique properties of MOFs and COFs make them highly active and enantioselective for a wide range of asymmetric catalytic organic transformations.
Article
Nanoscience & Nanotechnology
Imann Mosleh et al.
Summary: The study explored the use of ionic COF Py-BPy+-COF as an ion exchange material for biomolecule separation, demonstrating high adsorption capacities and selectivity for different amino acids and proteins. Desorption experiments showed successful separation of proteins based on isoelectric point, hydrophobicity, and ability to penetrate the crystalline material, suggesting Py-BPy2+-COF can be a robust anion exchange biomolecule separation material.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Lei-Lei Yang et al.
Summary: The combination of immune checkpoint blockade therapy and photodynamic therapy shows promising potential in inducing efficient immunogenic cell death and immune response, offering new hope for cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Peng Gao et al.
Summary: The development of new structures in spherical nucleic acids offers great potential in nanomedicine and bioanalytical fields. A strategy known as bonding defect-amplified modification (BDAM) was identified for the facile preparation of functionalized COFs and applied to create COF-based spherical nucleic acid probes. This innovative SNAP showed successful application in specifically lighting up RNA biomarkers in living cells for cancer diagnostic imaging.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Qiang Dang et al.
Summary: Yolk-shell-structured COF@MOF nanocomposites were successfully synthesized through a rational design, with COF as the external shell and MOF as the inner yolk, forming a hollow cavity under specific conditions. The study integrates the structural tunability and functionality of both COFs and MOFs, which can be regulated and optimized by metal ions and organic building blocks.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Liang Zhang et al.
Summary: A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
Article
Chemistry, Physical
Irene de Lazaro et al.
Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.
Review
Nanoscience & Nanotechnology
Korin E. Wheeler et al.
Summary: This review discusses the importance of dynamic protein corona composition in mediating the fate of nanomaterials in the environment, as well as future steps in eco-corona studies. The formation of the biomolecular coating on nanomaterials entering the environment, known as the eco-corona, is still an emerging area of research. Proteins within the eco-corona play a crucial role in defining the biological identity of nanomaterials and their impacts on the environment.
NATURE NANOTECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Jayesh A. Kulkarni et al.
Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kai Hao et al.
Summary: COF nanoparticles with uniform size and good dispersion were successfully prepared with microwave assistance. By adding cationic polymers or small amine molecules, the dispersibility of COF could be further improved, leading to excellent gene transfection ability and good biocompatibility. This COF-based gene vector offers a new direction for gene carrier design in the field of gene therapy.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Le-Le Zhou et al.
Summary: A nanodrug, RSL3@COF-Fc (2b), based on covalent organic framework (COF) has been fabricated to enhance cellular damage induced by CDT through promoting Fenton-like reactions and inhibiting GPX4 irreversibly. This approach synergistically results in massive lipid peroxide accumulation, subsequent cell damage, and ultimately ferroptosis, not being limited by intracellular glutathione, providing new insights for developing COF-based nanomedicine.
Article
Chemistry, Multidisciplinary
Wenjuan Zhao et al.
Summary: This study introduces the first case of 3D hydrazone-decorated COFs as pH-triggered molecular switches and explores their application in stimuli-responsive drug delivery systems. These functionalized COFs show intelligent sustained-release effects under pH changes, which could be important for improving drug targeting.
Article
Multidisciplinary Sciences
Liang Chen et al.
Summary: A universal strategy for the synthesis of monodisperse core-shell structured COF nanocomposites remains challenging. The authors have developed a versatile dual-ligand assistant strategy for interfacial growth of COFs on functional nanoparticles with various properties for potential applications in PDT and chemotherapeutic drug delivery. The core@shell structured nanocomposites exhibit controllable shell-thickness and uniformity without agglomeration, making them promising for NIR-activated PDT with deep tissue penetration.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Ha L. Nguyen et al.
Summary: Covalent organic frameworks (COFs) are a new class of porous crystalline materials with semiconductor properties, showing promising performance in CO2 photoreduction catalysis. Principles of design and recent advancements in using COFs for CO2 photoreduction can serve as a reference for developing CO2 reduction catalysts.
Article
Chemistry, Multidisciplinary
Myeongsang Lee et al.
Summary: This study comprehensively examined the characteristics of NanoEL phenomenon, revealing the nano-scale interactions between nanoparticles and VE-cadherin and its intra/extracellular cofactors. Utilizing computational simulation methods, it also revealed the molecular and statistical mechanics of cadherin disruption by the smallest size and highest concentration of AuNPs for the first time.
Article
Chemistry, Multidisciplinary
Peng Gao et al.
Summary: COF(Fe) is a catalytically active nano covalent organic framework that can reverse tumor multidrug resistance. By converting H2O2 into OH to induce oxidation stress and down-regulate MDR protein, COF(Fe) enhances intracellular drug accumulation to overcome MDR.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Zheng Meng et al.
Summary: COFs, as a new class of materials, show great potential in advancing chemical detection with high sensitivity and selectivity. By harnessing the unique properties of COFs, different types of chemical detection systems can be developed for various analytes under different mechanisms.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Materials Science, Biomaterials
Qiaoqiao Sun et al.
Summary: A nanoagent called COF-GA was designed to enhance photothermal therapy against cancer at low temperatures by inhibiting HSP90, effectively killing tumor cells. The agent can increase the temperature of tumor tissue under laser irradiation, leading to significant suppression of tumor growth.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Minghao Zhang et al.
Summary: This study reported two 3D COFs for reversible singlet oxygen capture and release, achieved through chemical transformation of excited oxygen molecules. Control of singlet oxygen capture and release was confirmed by switching UV-vis irradiation. This research broadens the potential applications of 3D functionalized COFs in biology and organic synthesis.
Review
Chemistry, Multidisciplinary
Nem Singh et al.
Summary: Finding a personalized nano theranostics solution for cancer diagnosis and therapy is a top challenge in current medicinal science. Porous organic polymers (POPs) show remarkable advantages for cancer theranostics due to their specific physicochemical characteristics. Both crystalline and non-crystalline POPs, such as covalent organic frameworks (COFs), have shown potential applications across various research areas. Early research on nanoscale POPs for theranostics has demonstrated promising applications in drug loading, targeted delivery, stimuli-responsive release, cancer imaging, and combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Materials Science, Biomaterials
Chunyang Liao et al.
Summary: The biomedical applications of COFs, based on diverse crystalline porous structures and well-customized functionalities, have become increasingly attractive. However, clinical translation faces challenges such as low biocompatibility and poor selectivity. Tailored engineering of COFs could provide a promising solution to overcome these obstacles and open up new possibilities for their clinical use.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Sainan Liu et al.
Summary: Porphyrin-incorporating covalent organic frameworks were synthesized with uniform morphology and excellent crystallinity, showing good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated significant antitumor efficiency via sonodynamic therapy.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jie Feng et al.
Summary: In this study, a Cu(ii)-porphyrin-derived nanoscale COF was developed for PDT against H2S-enriched colon tumors, with controllable singlet oxygen release. The in situ generated CuS can also be used synchronously as a photothermal agent for PTT.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Peng Gao et al.
Summary: A modification-facilitated exfoliation strategy was developed for the preparation of ultrathin 2D functionalized covalent organic framework nanosheets (COF NSs) in a single step. The hyaluronic acid-functionalized ultrathin porphyrin COF NSs with enhanced reactive oxygen species (ROS) generation effect were prepared for tumor-targeted photodynamic therapy.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Peng Gao et al.
Summary: A polydopamine core-shell nanoplatform engineered with a covalent organic framework (COF) was developed, benefiting from the ultrasmall pores and abundant functional sites of COF. The nanoplatform exhibited enhanced drug loading capacity and reduced drug leakage effect, enabling multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy after rational functionalization. This work contributes to the development of COF-based multifunctional theranostic systems.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiuyan Wan et al.
Summary: A novel porphyrin-containing covalent organic framework (COF) was synthesized for decorating selenium nanoparticles (Se NPs) via in situ reduction. Selenium nanoparticle-mediated therapy (SeT) was combined with photodynamic therapy (PDT) to enhance anticancer effects and address the limitations of PDT.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Xiuyan Wan et al.
Summary: A new enzyme nanopocket was developed from a porphyrin-based covalent organic framework (COF) for co-loading glucose oxidase (GOx) and catalase (CAT) to achieve long-term starvation therapy and enhanced photodynamic therapy (PDT).
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Yan Chen et al.
Summary: The synthesis of COFs has traditionally relied on the solvothermal method using a large amount of organic solvents, but there is a growing interest in green synthesis methods. This Feature Article summarizes the green COF synthesis strategies that aim to reduce or avoid the use of organic solvents and facilitate large-scale synthesis, discussing basic operations, yields, key factors, product qualities, advantageous applications, and limitations.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Ming Li et al.
Summary: Cage-COF-TT, a novel cage-based crystalline covalent organic framework, exhibits excellent structure and porosity for efficient drug delivery. Its superior cell viability and high drug loading capacity with efficient release profile in simulated body fluid environment make it a promising candidate for biomedical applications and inspire the development of versatile tools in this field.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Rajeshkumar Anbazhagan et al.
Summary: A novel TCOF was constructed for dual-sensitive anticancer drug delivery systems by click chemistry, showing high drug release in GSH and lysosomal pH conditions. The flexible nature of TCOF allowed for PEG modification, leading to stable colloidal solutions. The TCOF-PEG system demonstrated time-dependent release of DOX in HeLa cells, suggesting potential as a sensitive drug carrier system in COF research.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Pharmacology & Pharmacy
Peng Mi et al.
Summary: Nanomedicines are effective in delivering probes and anticancer agents to tumors selectively, reducing side effects. Current clinically used self-assembled nanomedicines and recent candidates in clinical trials show advancements in cancer treatment.
ADVANCED THERAPEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Xinyi Chen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Applied
Lalehan Akyuz
MICROPOROUS AND MESOPOROUS MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Hafeesudeen Sahabudeen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Yanming Zhao et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Engineering, Biomedical
Shi-Bo Wang et al.
Review
Chemistry, Multidisciplinary
Keyu Geng et al.
Review
Chemistry, Multidisciplinary
Qun Guan et al.
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Physical
Cleverson J. F. Oliveira et al.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Engineering, Chemical
Jin Yao et al.
JOURNAL OF MEMBRANE SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Carlos Franco et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Polymer Science
Shuai Liu et al.
MACROMOLECULAR RAPID COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Shrey Sindhwani et al.
Letter
Nanoscience & Nanotechnology
Steffen Foss Hansen et al.
NATURE NANOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Rao Tao et al.
Review
Chemistry, Multidisciplinary
Sukanya Bhunia et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Haiwang Lai et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Review
Chemistry, Multidisciplinary
Frederik Haase et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Ignacio Romero-Muniz et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Ji-Long Shi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Hui-Chao Ma et al.
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Yanan Shi et al.
Review
Chemistry, Multidisciplinary
Yongfeng Zhi et al.
Article
Chemistry, Multidisciplinary
Yuancheng Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Xue-Tian Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Mingmin Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Kewei Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Physical
Lifei Liu et al.
Review
Oncology
Won Jin Ho et al.
NATURE REVIEWS CLINICAL ONCOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Yusran Yusran et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Su-Yun Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Qun Guan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Hai-Long Qian et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Haijun Peng et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Multidisciplinary Sciences
Lauren S. L. Price et al.
Article
Nanoscience & Nanotechnology
Sainan Liu et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Duxin Sun et al.
Article
Chemistry, Multidisciplinary
Yongwu Peng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Physical
Alberto Lopez-Magano et al.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2020)
Article
Chemistry, Multidisciplinary
Xing Kang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Jian-Cheng Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Cheng Qian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Farah Benyettou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Chemistry, Multidisciplinary
Hao Lyu et al.
Article
Nanoscience & Nanotechnology
Yaxin Shi et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Jiao Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Yunyang Qan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
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