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Photoacid Generators for Biomedical Applications

ADVANCED SCIENCE (2023)

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Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial

Dion Morton et al.

Summary: Neoadjuvant chemotherapy shows potential benefits for locally advanced colon cancer compared to postoperative chemotherapy. In this study, patients with radiologically staged T3-4, N0-2, M0 colon cancer were randomly assigned to receive 6 weeks of preoperative oxaliplatin-fluoropyrimidine chemotherapy followed by either 18 or 24 weeks postoperatively. Results indicate that neoadjuvant chemotherapy results in marked downstaging of tumors and lower rates of incomplete resections and disease recurrence within 2 years.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Review Medicine, Research & Experimental

Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications

Shilang Liao et al.

Summary: Chlorin e6 (Ce6), a highly effective photosensitizer and sonosensitizer, has been extensively researched and developed for antitumor therapy. It shows promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and light therapy for tumors. Ce6 is also being studied for other applications such as fluorescence navigation, antibacterials, and plant growth regulation. Despite the challenges in clinical applications, Ce6 offers significant advantages in photodynamic therapy/sonodynamic therapy against cancer and has potential clinical utility.

MOLECULAR PHARMACEUTICS (2023)

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Review Pharmacology & Pharmacy

Current Challenges and Opportunities of Photodynamic Therapy against Cancer

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Summary: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. It generates reactive oxygen species (ROS) that induce cell death and disrupt the tumor area. PDT can also damage the tumor vasculature and release or expose damage-associated molecular patterns (DAMPs) to initiate an antitumor immune response. However, there are challenges that limit its widespread clinical application. A literature study has identified these challenges and discussed opportunities for improvement.

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Article Oncology

Oxygen (and lack thereof) in photodynamic therapy

Santi NONELL

Photodiagnosis and Photodynamic Therapy (2023)

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Article Engineering, Biomedical

Long-Lived Photoacid-Doped Conducting Composites Induce Photocurrent for Efficient Wound Healing

Haiyan Yin et al.

Summary: In this study, a light-powered dressing based on long-lived photoacid generator (PAG)-doped polyaniline composites is developed to facilitate wound healing. The dressing generates a photocurrent under visible light irradiation, which interacts with the endogenous electric field to promote skin growth. The PAG-induced acidic environment protects the wound from microbial infection. This simple and effective therapeutic strategy has great potential for wound treatment.

ADVANCED HEALTHCARE MATERIALS (2023)

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Review Engineering, Environmental

Emerging nanotherapeutics for facilitating photodynamic therapy

Shumeng Li et al.

Summary: Photodynamic therapy (PDT) is a promising therapeutic option for cancer treatment, and nanotherapeutics have made great progress in facilitating PDT. This article outlines the latest updates in nanotherapeutics, including trends in light transmitting in deep tumors, methods for reversing tumor hypoxia, and strategies for enhancing photosensitizers delivery efficiency. The design rationale, advantages, and challenges of nanosystems for clinical therapy are also highlighted.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Chemistry, Physical

Cyclopentylmalononitrile dye as an efficient photosensitizer for combined photodynamic and water-dependent reversible photoacidity therapy

Lin Kang et al.

Summary: Photodynamic therapy (PDT) is widely used for clinical treatment of tumors, however, its high oxygen dependency limits its therapeutic efficacy for hypoxic tumors. A water-dependent reversible photoacidity (W-RPA) mechanism has been discovered as an oxygen-independent therapy with potential for tumor treatment. By designing and synthesizing a cyclopentylmalononitrile dye (BN-PEG5) with enhanced absorption in the red region, the advantages of combined PDT and W-RPA therapy in hypoxic tumor treatment have been demonstrated.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2023)

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Uttpal Anand et al.

Summary: Cancer is a deadly disease characterized by uncontrolled cell proliferation and the formation of aggressive malignancies. In recent years, advances in molecular understanding have led to the development of new therapeutic approaches such as targeted drug therapy and immunotherapy. Despite the potential of these treatments, chemotherapy remains a commonly used option due to its effectiveness in advanced-stage malignancies. This report reviews the current advancements in chemotherapy and discusses the emerging role of targeted therapies in improving clinical outcomes for cancer patients.

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Review Oncology

Photodynamic therapy in oral cancer: a review of clinical studies

Seyed Ali Mosaddad et al.

Summary: Oral cancer has a high mortality rate, especially when diagnosed at a late stage. Despite advances in treatment, the survival rates for oral cancer have only gradually improved. This poor success rate is mainly due to the development of secondary tumors, local recurrence, and regional failure. Invasive treatments often have negative effects on the appearance and function of survivors. Therefore, there is a need for novel approaches to manage this deadly disease based on these statistics.

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Article Chemistry, Multidisciplinary

Photoresponsive Vaccine-Like CAR-M System with High-Efficiency Central Immune Regulation for Inflammation-Related Depression

Yu Liu et al.

Summary: Microglia-induced neuroinflammation is crucial in the development of depression. Researchers have developed a light-responsive system called UZPM, which can be introduced into macrophages and targeted to centrally activated microglia. Experimental results show that the CAR-M-UZPM drug delivery system can efficiently penetrate the blood-brain barrier, inhibit the M1 polarization of microglia, and prevent the occurrence and development of inflammation-related depression.

ADVANCED MATERIALS (2022)

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Reversible photo control of proton chemistry

Yi Liao

Summary: This article introduces the concept of photoacids and their applications in spatial, temporal, and remote control of proton chemistry. It compares the advantages of mPAHs with excited-state photoacid and common acids, and discusses their mechanisms, advantages, and applications in various fields.

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Lu Zhang et al.

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Thiruchelvi Pulingam et al.

Summary: Antibiotic resistance is a major global health concern that could result in millions of deaths if the current trend of inappropriate and excessive antibiotic use continues. This review highlights the economic burden of antibiotic resistance, recent cases linked to various bacteria, and potential strategies to overcome resistance.

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The effect of postmortem pH decline rate on caspase-3 activation and tenderness of bovine skeletal muscle during aging

Jibing Ma et al.

Summary: The fast postmortem pH decline enhances caspase-3 activation and improves beef tenderness by inducing mitochondrial dysfunction-induced apoptosis during aging.

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Photoenergy Harvesting by Photoacid Solution (Adv. Mater. 24/2022)

Jaehyeong Bae et al.

ADVANCED MATERIALS (2022)

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A water-dependent reversible photoacidity strategy for cancer treatment

Lin Kang et al.

Summary: A water-dependent reversible photoacidity (W-RPA) mechanism has been discovered, in which the proton is dissociated from water locked by a thiadiazoloquinoxaline compound (TQs-Th-PEG5) under laser irradiation. This mechanism has been applied for cancer treatment and shows promising antitumor effects.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Regulating Mitochondrial pH with Light and Implications for Chemoresistance

Tinghan Zhao et al.

Summary: Targeting mitochondria with BD-PAG can regulate mitochondrial pH and significantly impact mitochondrial membrane depolarization, reducing chemoresistance. BD-PAG shows high biocompatibility in the dark and accumulates greatly in mitochondria. Therapeutic tests with chlorambucil combined with BD-PAG reveal a novel strategy in suppressing chemoresistance.

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Yaofeng Zhou et al.

Summary: Various strategies have been developed to increase the efficiency of the intratumoral Fenton reaction in chemodynamic therapy (CDT), enhancing the therapeutic efficacy. The introduction of reinforcement strategies can improve treatment efficiency and promote the development of enhanced CDT-based multimodal anticancer therapies.

ADVANCED MATERIALS (2021)

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A Fluorescent Visual Proton Donor and Photoacid Sterilant Based on Sulfonate-conjugated BODIPY

Abbas Mohammed Ali et al.

Summary: Increasing acidity is an effective method to inhibit bacterial growth by suppressing intracellular protein synthesis. A photo-driven proton release probe can be utilized to measure protons in hydrophobic conditions. The study suggests that BDP-S is a promising fluorescent proton donor which can efficiently inhibit the growth of E. coli.

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Recent Advances in Nanomaterial-Based Nanoplatforms for Chemodynamic Cancer Therapy

Shu-Lan Li et al.

Summary: Chemodynamic therapy (CDT) uses endogenous chemical energy in the tumor microenvironment for treatment, converting hydrogen peroxide into reactive oxygen species for oncotherapy. However, limitations in the tumor microenvironment hinder CDT efficacy, and the development of nanotechnology offers potential solutions to improve CDT efficiency.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Multidisciplinary Sciences

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Weier Bao et al.

Summary: A novel nanoagent combining upconversion nanoparticles and metal-organic frameworks was developed for near-infrared light-triggered synergistic oxidative stress and calcium overload, resulting in multilevel damage to mitochondria and showing therapeutic potency in tumor cells.

NATURE COMMUNICATIONS (2021)

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Review Materials Science, Biomaterials

Recent advances in in situ oxygen-generating and oxygen-replenishing strategies for hypoxic-enhanced photodynamic therapy

Shuheng Qin et al.

Summary: Hypoxia poses a significant challenge to the efficacy of photodynamic therapy for tumors due to increased oxygen consumption, limiting its potential application. Various strategies to alleviate tumor hypoxia are being explored to improve the effectiveness of PDT therapy in treating cancer.

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Review Materials Science, Multidisciplinary

Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

Zijun Shen et al.

Summary: Photodynamic therapy is a promising tumor treatment technology, but tumor hypoxia hinders its effectiveness. Various strategies, including oxygen carriers and multimodal therapy, have been explored to overcome the limitations caused by hypoxia and improve therapeutic outcomes.

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Upconverted Metal-Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy

Zhao Wang et al.

Summary: A biocatalytic Janus nanocomposite, UPFB, was fabricated for ultrasound-driven SDT and 808 nm NIR light-mediated PDT by combining UCNPs and a ferric zirconium porphyrin MOF. UPFB not only promotes ROS generation via GSH depletion and oxygen supply from Fe3+ ions but also achieves CDT performance under acidic conditions. Additionally, UPFB linked with biotin exhibits a good targeting ability to rapidly accumulate in the tumor region, making it suitable for cancer therapeutics.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Chemistry, Multidisciplinary

Recent Progress on NIR-II Photothermal Therapy

Yunguang Zhang et al.

Summary: Photothermal therapy is a promising treatment for cancer, with photothermal nanomaterials in the NIR-I region attracting attention. The use of light in the NIR-II region allows for deeper tissue penetration, higher radiation limits, and greater tissue tolerance, showing greater potential in photothermal conversion. This review highlights the photothermal properties of various nanomaterials in the NIR-II region and their application prospects in photothermal therapy, sparking interest in the field of cancer treatment and nanomedicine.

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Review Oncology

Photodynamic Therapy: A Compendium of Latest Reviews

Jose Francisco Algorri et al.

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Woo Tak Lee et al.

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Xiaolin Liu et al.

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Zhao Wang et al.

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Xiaoyu Xu et al.

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Jiating Xu et al.

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Nano MOF Entrapping Hydrophobic Photosensitizer for Dual-Stimuli-Responsive Unprecedented Therapeutic Action against Drug-Resistant Bacteria

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pH-Triggered Pinpointed Cascading Charge-Conversion and Redox-Controlled Gene Release Design: Modularized Fabrication for Nonviral Gene Transfection

Qian Jiang et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Review Biochemistry & Molecular Biology

Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)

Rama Rathore et al.

APOPTOSIS (2017)

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Article Biochemistry & Molecular Biology

Relationship between intracellular pH, metabolic co-factors and caspase-3 activation in cancer cells during apoptosis

Tatiana F. Sergeeva et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

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Review Oncology

Photodynamic therapy: Inception to application in breast cancer

S. M. Banerjee et al.

BREAST (2017)

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Article Chemistry, Multidisciplinary

Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

Hyung Woo Choi et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications

Wenyan Yin et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Engineering Gram Selectivity of Mixed-Charge Gold Nanoparticles by Tuning the Balance of Surface Charges

Pramod P. Pillai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Review Biochemistry & Molecular Biology

New photosensitizers for photodynamic therapy

Heidi Abrahamse et al.

BIOCHEMICAL JOURNAL (2016)

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Article Nanoscience & Nanotechnology

Pegylated and nanoparticle-conjugated sulfonium salt photo triggers necrotic cell death

Alaa A. Fadhel et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

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Review Polymer Science

Polymer-Based Drug Delivery Systems for Cancer Treatment

Xing Guo et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2016)

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Article Chemistry, Multidisciplinary

Highly active, stable and self-antimicrobial enzyme catalysts prepared by biomimetic mineralization of copper hydroxysulfate

Zhixian Li et al.

NANOSCALE (2016)

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Article Polymer Science

A photo, temperature, and pH responsive spiropyran-functionalized polymer: Synthesis, self-assembly and controlled release

Fengjuan Jiang et al.

POLYMER (2016)

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Article Chemistry, Multidisciplinary

Self-strengthening hybrid dental adhesive via visible-light irradiation triple polymerization

Linyong Song et al.

RSC ADVANCES (2016)

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Article Biochemistry & Molecular Biology

Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity

Ji Hoon Jeon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

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Article Nanoscience & Nanotechnology

Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery

Yan Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Engineering, Biomedical

Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium

Junnan Li et al.

BIOMATERIALS (2015)

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Review Chemistry, Multidisciplinary

Development of individualized anti-metastasis strategies by engineering nanomedicines

Qianjun He et al.

CHEMICAL SOCIETY REVIEWS (2015)

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Article Chemistry, Physical

Excited-State Dynamics of a D-pi-A Type Sulfonium-Based Alkoxystilbene Photoacid Generator

Vincent De Waele et al.

CHEMISTRY OF MATERIALS (2015)

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Article Polymer Science

Independent temperature and pH dual-stimuli responsive yolk/shell polymer microspheres for controlled release: Structural effect

Lei Liu et al.

EUROPEAN POLYMER JOURNAL (2015)

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Review Biochemistry & Molecular Biology

Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer

Silvia Rocio Lucena et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Article Chemistry, Physical

Proton Transfer in Ionic and Neutral Reverse Micelles

Christian Lawler et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2015)

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Article Chemistry, Physical

pH-Jump Induced Leucine Zipper Folding beyond the Diffusion Limit

Mateusz L. Donten et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2015)

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Article Chemistry, Multidisciplinary

A Reversible Photoacid Functioning in PBS Buffer under Visible Light

Nawodi Abeyrathna et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Review Microbiology

Tackling antibiotic resistance: the environmental framework

Thomas U. Berendonk et al.

NATURE REVIEWS MICROBIOLOGY (2015)

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Editorial Material Surgery

Low-Level Light/Laser Therapy Versus Photobiomodulation Therapy

Juanita J. Anders et al.

PHOTOMEDICINE AND LASER SURGERY (2015)

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Article Chemistry, Physical

Photo-induced dynamic association of coumarin pendants within amphiphilic random copolymer micelles

Huan Chang et al.

COLLOID AND POLYMER SCIENCE (2015)

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Article Nanoscience & Nanotechnology

Superior Antibacterial Activity of Zinc Oxide/Graphene Oxide Composites Localized around Bacteria

Yan-Wen Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Review Pharmacology & Pharmacy

Movers and shakers: cell cytoskeleton in cancer metastasis

C. M. Fife et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

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Article Chemistry, Multidisciplinary

Remote-Controlled Drug Release from Graphene Oxide-Capped Mesoporous Silica to Cancer Cells by Photoinduced pH-Jump Activation

Dinggeng He et al.

LANGMUIR (2014)

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Review Chemistry, Multidisciplinary

Photo-responsive block copolymer micelles: design and behavior

Jean-Francois Gohy et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes

Hui Wei et al.

CHEMICAL SOCIETY REVIEWS (2013)

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Review Biochemistry & Molecular Biology

Operation mechanism of FoF1-adenosine triphosphate synthase revealed by its structure and dynamics

Ryota Iino et al.

IUBMB LIFE (2013)

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Article Chemistry, Multidisciplinary

Photoswitching of Enzyme Activity by Laser-Induced pH-Jump

Stefanie Kohse et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Multidisciplinary

Selective Cell Death by Photochemically Induced pH Imbalance in Cancer Cells

Xiling Yue et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Multidisciplinary

Photoswitchable Particles for On-Demand Degradation and Triggered Release

Tae-Hong Park et al.

SMALL (2013)

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Review Chemistry, Physical

Dye Sensitizers for Photodynamic Therapy

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MATERIALS (2013)

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Article Materials Science, Biomaterials

Visible light mediated killing of multidrug-resistant bacteria using photoacids

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JOURNAL OF MATERIALS CHEMISTRY B (2013)

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Biographical-Item Dermatology

From patient to discoverer-Niels Ryberg Finsen (1860-1904)-the founder of phototherapy in dermatology

Andrzej Grzybowski et al.

CLINICS IN DERMATOLOGY (2012)

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Review Multidisciplinary Sciences

The Protein-Folding Problem, 50 Years On

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SCIENCE (2012)

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Article Materials Science, Multidisciplinary

A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Prapatsorn Techawanitchai et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2012)

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Article Chemistry, Physical

Photo-switchable control of pH-responsive actuators via pH jump reaction

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SOFT MATTER (2012)

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Article Chemistry, Physical

Photoswitching of Enzyme Activity of Horseradish Peroxidase Intercalated into Semiconducting Layers

Kai Kamada et al.

CHEMISTRY OF MATERIALS (2011)

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Review Chemistry, Inorganic & Nuclear

Photochemical reagents for the study of metalloproteins by flash photolysis

Federico I. Rosell et al.

COORDINATION CHEMISTRY REVIEWS (2011)

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Review Biochemistry & Molecular Biology

Taming the complexity of protein folding

Gregory R. Bowman et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

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Review Biochemistry & Molecular Biology

Rotation and structure of FoF1-ATP synthase

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JOURNAL OF BIOCHEMISTRY (2011)

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Article Chemistry, Multidisciplinary

Long-Lived Photoacid Based upon a Photochromic Reaction

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Review Microbiology

Tackling antibiotic resistance

Karen Bush et al.

NATURE REVIEWS MICROBIOLOGY (2011)

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Article Microbiology

Impact of pH on bacterial growth and activity of recent fluoroquinolones in pooled urine

Zeynep Erdogan-Yildirim et al.

RESEARCH IN MICROBIOLOGY (2011)

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Review Biophysics

Biodegradable polymeric nanoparticles based drug delivery systems

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COLLOIDS AND SURFACES B-BIOINTERFACES (2010)

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Article Chemistry, Applied

Colorimetric properties of reversible thermochromic printing inks

Rahela Kulcar et al.

DYES AND PIGMENTS (2010)

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Article Infectious Diseases

Colistin therapy for microbiologically documented multidrug-resistant Gram-negative bacterial infections: a retrospective cohort study of 258 patients

Matthew E. Falagas et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2010)

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Article Infectious Diseases

Safety and efficacy of intravenous colistin (colistin methanesulphonate) for severe multidrug-resistant Gram-negative bacterial infections

Chien-Yu Cheng et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2010)

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Article Polymer Science

Cationic Polymerization of L,L-Lactide

Malgorzata Basko et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2010)

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Article Oncology

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

Curtis B. Thompson et al.

MOLECULAR CANCER THERAPEUTICS (2010)

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Review Cell Biology

ADF/Cofilin: a functional node in cell biology

Barbara W. Bernstein et al.

TRENDS IN CELL BIOLOGY (2010)

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Article Microbiology

In Vitro Activity of Colistin (Polymyxin E) against 3,480 Isolates of Gram-Negative Bacilli Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007-2008

A. Walkty et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

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Article Biochemistry & Molecular Biology

Designed Human Serum Hyaluronidase 1 Variant, HYAL1ΔL, Exhibits Activity up to pH 5.9

Stephan Reitinger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Multidisciplinary Sciences

Real-Time Observation of Carbonic Acid Formation in Aqueous Solution

Katrin Adamczyk et al.

SCIENCE (2009)

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Review Oncology

Photodynamic therapy in the therapy for recurrent/persistent nasopharyngeal cancer

Maarten A. M. Wildeman et al.

HEAD & NECK ONCOLOGY (2009)

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Article Chemistry, Physical

Charge Transfer in Photoacids Observed by Stark Spectroscopy

Lisa N. Silverman et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2008)

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Article Chemistry, Multidisciplinary

Acetal-derivatized dextran:: An acid-responsive biodegradable material for therapeutic applications

Eric M. Bachelder et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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Article Microbiology

Bacterial killing in gastric juice -: effect of pH and pepsin on Escherichia coli and Helicobacter pylori

H. Zhu et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2006)

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Review Chemistry, Multidisciplinary

Advances in time-resolved approaches to characterize the dynamical nature of enzymatic catalysis

Robert Callender et al.

CHEMICAL REVIEWS (2006)

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Article Biochemistry & Molecular Biology

FOLD-RATE: prediction of protein folding rates from amino acid sequence

M. Michael Gromiha et al.

NUCLEIC ACIDS RESEARCH (2006)

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Review Multidisciplinary Sciences

Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouyssegur et al.

NATURE (2006)

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Article Nanoscience & Nanotechnology

Effects of different reconstitution procedures on membrane protein activities in proteopolymersomes

Hyo-Jick Choi et al.

NANOTECHNOLOGY (2006)

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Article Chemistry, Physical

Nonequilibrium protein folding dynamics: laser-induced pH-jump studies of the-helix-coil transition

TP Causgrove et al.

CHEMICAL PHYSICS (2006)

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Article Chemistry, Multidisciplinary

Distance-dependent fluorescence quenching on gold nanoparticles ensheathed with layer-by-layer assembled polyelectrolytes

G Schneider et al.

NANO LETTERS (2006)

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Article Biotechnology & Applied Microbiology

Engineering and characterization of a superfolder green fluorescent protein

JD Pedelacq et al.

NATURE BIOTECHNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Acid-induced unfolding of myoglobin triggered by a laser pH jump method

Stefania Abbruzzetti et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2006)

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Review Oncology

Metastasis: a question of life or death

P Mehlen et al.

NATURE REVIEWS CANCER (2006)

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Article Chemistry, Multidisciplinary

Artificial organelle: ATP synthesis from cellular mimetic polymersomes

HJ Choi et al.

NANO LETTERS (2005)

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Article Medicine, Research & Experimental

Drug delivery systems improve pharmaceutical profile and facilitate medication adherence

AI Wertheimer et al.

ADVANCES IN THERAPY (2005)

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Review Cell Biology

Mechanisms of cancer cell invasion

E Sahai

CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)

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Article Biochemistry & Molecular Biology

Impact of pH on Bax α conformation, oligomerisation and mitochondrial integration

PF Cartron et al.

FEBS LETTERS (2004)

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Review Biochemistry & Molecular Biology

Antibacterial resistance worldwide: causes, challenges and responses

SB Levy et al.

NATURE MEDICINE (2004)

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Article Biochemistry & Molecular Biology

Deprotonation yields, pK(a), and aci-nitro decay rates in some substituted o-nitrobenzaldehydes

S Abbruzzetti et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2003)

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Article Biophysics

Characterization of a new caged proton capable of inducing large pH jumps

A Barth et al.

BIOPHYSICAL JOURNAL (2002)

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Review Biochemistry & Molecular Biology

Photoremovable protecting groups: reaction mechanisms and applications

AP Pelliccioli et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2002)

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Article Chemistry, Multidisciplinary

Kinetics of histidine deligation from the heme in GuHCl-unfolded Fe(III) cytochrome c studied by a laser-induced pH-jump technique

S Abbruzzetti et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)

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Review Oncology

Tumor hypoxia:: Definitions and current clinical, biologic, and molecular aspects

M Höckel et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)

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Article Engineering, Environmental

Effects of reaction conditions on the oxidation efficiency in the Fenton process

YW Kang et al.

WATER RESEARCH (2000)

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Article Biophysics

Fast events in protein folding: Structural volume changes accompanying the early events in the N -> I transition of apomyoglobin induced by ultrafast pH jump

S Abbruzzetti et al.

BIOPHYSICAL JOURNAL (2000)

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