Sensitization to alpha-gal as a cause of idiopathic anaphylaxis

Article Allergy

Anaphylaxis in Brazil between 2011 and 2019

Luciana Kase Tanno et al.

Summary: This study is the first national population-based study of anaphylaxis hospital admissions in Brazil, using data from a low- or middle-income country. Hospital admissions and fatalities from anaphylaxis in Brazil appear to be increasing.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

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Article Allergy

Idiopathic anaphylaxis: Diagnosis and management

Alyssa G. Burrows et al.

Summary: Idiopathic anaphylaxis is a challenging diagnosis characterized by the inability to identify a causal relationship between a trigger and an anaphylactic event. Comorbid atopic conditions are common, and differential diagnoses such as alpha-gal allergy and hereditary alpha-tryptasemia should be considered. Management involves acute epinephrine administration and long-term use of antihistamines, with potential for biologics as steroid-sparing agents. More research is needed to advance therapeutic options for patients with IA.

ALLERGY AND ASTHMA PROCEEDINGS (2021)

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Article Allergy

Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome

Marija Perusko et al.

Summary: BGG, LF, and LPO were identified as relevant milk alpha-Gal-containing glycoproteins that bound AGS patients' IgE antibodies and activated their basophils. These proteins are likely involved in allergic reactions to milk in AGS patients. LPO was also shown to be an allergen for the first time.

ALLERGY (2021)

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Letter Allergy

Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients

Danijela Apostolovic et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2021)

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Article Allergy

Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome

Paul Schmidle et al.

Summary: Patients with AGS showed strong positive results for basophil activation tests after vaccination with gelatin-containing vaccines, indicating a high risk for anaphylaxis. BAT is a useful additional tool for screening potentially high-risk alpha-gal-containing drugs.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

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Review Allergy