3.9 Article

SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

Yasset Perez-Riverol et al.

Summary: PRIDE is the largest data repository of mass spectrometry-based proteomics data in the world, with around 500 datasets submitted per month. In addition to continuous improvements in data pipelines and infrastructure, PRIDE has developed the Spectra Archive and MAGE-TAB file format to enhance sample metadata annotation and access to mass spectra.

NUCLEIC ACIDS RESEARCH (2022)

Article Cell Biology

S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects

Takafumi Ogawa et al.

Summary: Methionine restriction can extend lifespan and delay aging-associated pathologies. Supplementation with S-adenosyl-L-homocysteine (SAH) can mimic the effects of methionine restriction by reducing methionine levels and activating AMP-activated protein kinase (AMPK), thereby extending lifespan.

AGING CELL (2022)

Article Biochemistry & Molecular Biology

A heterotypic assembly mechanism regulates CHIP E3 ligase activity

Aniruddha Das et al.

Summary: The study revealed that UFD-2 binding enhances cooperation between CHN-1 and ubiquitin-conjugating E2 enzymes, while HSP70/HSP-1 chaperone protein restricts this cooperation, leading CHN-1 to an autoinhibited state. This finding elucidates the molecular mechanism underlying the synergistic cooperation of CHN-1 and UFD-2 in substrate ubiquitylation.

EMBO JOURNAL (2022)

Review Cell Biology

Functional and Pathological Roles of AHCY

Pedro Vizan et al.

Summary: Adenosylhomocysteinase (AHCY) is a unique and crucial enzyme in living organisms, involved in controlling methyltransferase activity. Its involvement in important cellular processes in mammals makes it a subject of widespread research. AHCY's key role in organisms has sparked significant interest and study in the scientific community.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

VRK-1 extends life span by activation of AMPK via phosphorylation

Sangsoon Park et al.

SCIENCE ADVANCES (2020)

Article Biochemical Research Methods

Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells

Samuel A. Myers et al.

MOLECULAR & CELLULAR PROTEOMICS (2019)

Article Biochemistry & Molecular Biology

The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition

Eric W. Deutsch et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Geriatrics & Gerontology

Pleiotropic responses to methionine restriction

Gene P. Ables et al.

EXPERIMENTAL GERONTOLOGY (2017)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Biochemical Research Methods

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

Stefka Tyanova et al.

NATURE PROTOCOLS (2016)

Article Multidisciplinary Sciences

Stimulating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK

Takafumi Ogawa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

Fumiaki Obata et al.

NATURE COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

S-adenosylmethionine:: nothing goes to waste

M Fontecave et al.

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Article Multidisciplinary Sciences

S-adenosylhomocysteine hydrolase deficiency in a human:: A genetic disorder of methionine metabolism

I Baric et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemical Research Methods

Genorne-wide RNAi screening in Caenorhabditis elegans

RS Kamath et al.

METHODS (2003)