Palmatine treats urticaria by reducing inflammation and increasing autophagy

Article Plant Sciences

Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis

Gaoxiang Ai et al.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Article Plant Sciences

Jingfang Granules improve glucose metabolism disturbance and inflammation in mice with urticaria by up-regulating LKB1/AMPK/ SIRT1 axis

Chenghong Sun et al.

Summary: JFG effectively treats OVA/aluminum hydroxide-induced skin lesions and inflammation in mice through modulating the LKB1/AMPK/SIRT1 axis.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Chemistry, Medicinal

Myricetin alleviated immunologic contact urticaria and mast cell degranulation via the PI3K/Akt/NF-κB pathway

Shiting Hu et al.

Summary: Immunologic contact urticaria (ICU) is a type I hypersensitivity reaction mediated by allergen-specific immunoglobulin E (sIgE). Myricetin (Myr), a flavonoid, has anti-inflammatory properties. Myr treatment alleviated ICU symptoms, reduced IgE levels and inflammatory markers in mice. Myr inhibited mast cell activation and reduced calcium influx and degranulation in human mast cells. Myr exerted its effects through the PI3K/Akt/NF-kappa B signaling pathway.

PHYTOTHERAPY RESEARCH (2023)

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Article Medicine, General & Internal

IgG and IgE Autoantibodies to IgE Receptors in Chronic Spontaneous Urticaria and Their Role in the Response to Omalizumab

Carlo Alberto Maronese et al.

Summary: This study investigated potential predictors of response to omalizumab in patients with chronic spontaneous urticaria (CSU). It was found that CSU patients had higher levels of anti-Fc epsilon RI IgE autoantibodies, and the co-occurrence of anti-Fc epsilon RI IgG and IgE autoantibodies was associated with a poorer response to omalizumab.

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Nanoscience & Nanotechnology

Autophagy-Modulated Biomaterial: A Robust Weapon for Modulating the Wound Environment to Promote Skin Wound Healing

Jin Zhang et al.

Summary: Autophagy is a self-renewal mechanism that helps maintain cellular homeostasis and is closely related to various diseases. Biomaterials can regulate autophagy to influence the process of skin wound healing and promote tissue regeneration. Polymeric materials, cellular materials, metal nanomaterials, and carbon-based materials are used to target autophagy and improve therapeutic approaches for clinical applications.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2023)

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Article

Sleep Quality as a Predictor of Quality-of-Life and Emotional Status Impairment in Patients with Chronic Spontaneous Urticaria: A Cross-Sectional Study

Manuel Sánchez-Díaz et al.

International Journal of Environmental Research and Public Health (2023)

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Review Allergy

Chronic urticaria and the pathogenic role of mast cells

Daniel Elieh-Ali-Komi et al.

Summary: The signs and symptoms of chronic urticaria (CU) are caused by the activation and degranulation of skin mast cells (MCs). Recent studies have contributed to our understanding of the involvement and differences of skin MCs in CU. Moreover, novel mechanisms of MC activation in CU have been identified and characterized. The use of MC-targeted and MC mediator-specific treatments has also provided insights into the role of the skin environment and the relevance of MC crosstalk in CU pathogenesis. This review summarizes these recent findings and their impact on our understanding of CU, specifically focusing on chronic spontaneous urticaria (CSU). It also highlights unresolved questions, controversial issues, and future research directions.

ALLERGOLOGY INTERNATIONAL (2023)

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Letter Allergy

Anti-IL-23 treatment with tildrakizumab can be effective in omalizumab- refractory chronic spontaneous urticaria: A case series

Hanna Bonnekoh et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2023)

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Review Allergy

Interleukin-6 and cytokine release syndrome A new understanding in drug hypersensitivity reactions

Erika Yue Lee et al.

Summary: Immediate drug hypersensitivity reactions (DHRs) are traditionally attributed to immunoglobulin E (IgE) cross-linking and mast cell degranulation, but the emergence of cytokine release syndrome (CRS) has revealed atypical features such as initial exposure reaction, absence of urticaria and angioedema, and predominance of fever, chills, rigors, and musculoskeletal pain. Desensitization can be a life-saving option for patients with immediate DHRs, and interleukin 6 shows promise as a novel biomarker for distinguishing different types of DHRs. Phenotyping and endotyping hypersensitivity reactions using validated biomarkers are important in the era of precision medicine.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

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Article Plant Sciences

Integrating metabonomics and metagenomics sequencing to study the anti-liver fibrosis effects of palmatine in Corydalis saxicola Bunting

Jinghua Qin et al.

Summary: This study aimed to identify the main anti-liver fibrosis ingredients in Corydalis saxicola Bunting (CS) and its underlying mechanism. The results showed that palmatine (PAL) was the most important active ingredient in CS and it could reverse the abnormal levels of gut microbial-mediated metabolites and improve intestinal flora metabolism and energy metabolism. PAL also improved the intestinal barrier function and the levels of hepatic inflammation factors, demonstrating its therapeutic efficiency in liver fibrosis.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Medicine, Research & Experimental

IL-17A-targeting fenofibrate attenuates inflammation in psoriasis by inducing autophagy

Aeri Park et al.

Summary: IL-17A is a crucial pro-inflammatory cytokine in autoimmune diseases, which can be inhibited by fenofibrate, a small molecule drug. Fenofibrate regulates autophagy and exerts anti-inflammatory effects, suggesting its potential as a therapeutic for psoriasis and other autoimmune diseases.

LIFE SCIENCES (2023)

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Article Cell Biology

Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells

Yuanyuan Ding et al.

Summary: This study investigates the therapeutic effect of Paeonol on chronic urticaria and its mechanism of action in mast cells. The results indicate that Paeonol can alleviate the symptoms of chronic urticaria by inhibiting the release of cytokines and chemokines.

CELLULAR IMMUNOLOGY (2023)

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Review Immunology

IL-17 and IL-17-producing cells in protection versus pathology

Kingston H. G. Mills

Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.

NATURE REVIEWS IMMUNOLOGY (2023)

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Article Dermatology

Analysis of clinical features and inflammatory-related molecules with the disease in acute infectious urticaria

Zhezhang Liu et al.

Summary: Acute infectious urticaria, a subset of acute urticaria, presents with severe persistence wheals, systemic symptoms, and responds well to combined corticosteroids and antibiotics treatment. This study aimed to analyze the clinical features, neutrophil activation, and expression of inflammatory cytokines in patients with acute urticaria and acute infectious urticaria. Patients with acute infectious urticaria showed significantly higher levels of pro-inflammatory factors, including CRP, D-dimer, IL-6, IL-8, and CCL8, compared to acute urticaria. Treatment of acute infectious urticaria resulted in a significant decrease in CCL8 levels and a positive correlation between CRP levels and IL-6. Neutrophil infiltration was not observed by HE stains, but positive expression of MPO was found in acute infectious urticaria lesions by IHC stains. Elevated neutrophil levels, associated with IL-8 and CCL8, and positive expression of MPO in lesions may be involved in the pathogenic mechanism of acute infectious urticaria.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2023)

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Article Plant Sciences

TMT-based proteomics analysis reveals the protective effect of Jueyin granules on imiquimod-induced psoriasis mouse model by causing autophagy

Jiankun Song et al.

Summary: Jueyin granules (JYG) may induce autophagy by up-regulating ApoA1 and inhibit the infiltration of CD4+ T cells and macrophages, thereby alleviating psoriatic inflammation.

PHYTOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity

Wenxian Ma et al.

Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Allergy

The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Torsten Zuberbier et al.

Summary: The updated international guideline for urticaria was developed jointly by multiple international organizations, with participants from 50 countries and international societies, aiming to provide expert guidance on diagnostic and therapeutic approaches for different subtypes of urticaria.

ALLERGY (2022)

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Review Allergy

Autoimmune chronic spontaneous urticaria

Pavel Kolkhir et al.

Summary: Chronic spontaneous urticaria (CSU) is a mast cell-driven disease characterized by recurrent wheals and/or angioedema, with two main autoimmune mechanisms: type I autoallergic CSU and type IIb autoimmune CSU. The latter is less common but more severe, and new targeted therapies are under development for CSU treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Allergy

Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis

Angelo Valerio Marzano et al.

Summary: Urticarial vasculitis (UV) is a rare skin disease characterized by recurrent episodes of wheal-like lesions, lasting for a long period of time, and with specific histopathological features. The pathogenesis of UV is mainly related to immune complexes and the complement cascade. It can be divided into two types, one of which is associated with antibodies and may have systemic symptoms. This article summarizes the clinical features, pathophysiological mechanisms, and other similar diseases of UV.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Pharmacology & Pharmacy

Autophagy and Skin Diseases

Kim Klapan et al.

Summary: This review provides an overview of the principles of autophagy and highlights recent research on the role of autophagy in skin disorders and therapeutic modulation strategies.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Palmatine alleviates LPS-induced acute lung injury via interfering the interaction of TAK1 and TAB1

Yunduan Song et al.

Summary: Palmatine (PAL) can alleviate acute lung injury (ALI) by inhibiting macrophage activation and attenuating the inflammatory response. PAL has inhibitory effects on the production of inflammatory mediators in cells and fluids. Additionally, PAL regulates macrophage function by inhibiting the activation of NF-KB and p38 MAPK signaling pathways.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Cell Biology

High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells

Paulina Hennig et al.

Summary: This study identified p62 as a negative regulator of the NLRP1 inflammasome in human cutaneous SCC cells, where increased p62 levels suppress NLRP1 and support stress resistance of skin cancer cells.

CELL DEATH & DISEASE (2022)

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Article Chemistry, Medicinal

Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-?B/NLRP3 and Nrf2 Pathways

Juan -Juan Cheng et al.

Summary: This study found that palmatine can inhibit the inflammatory response and oxidative stress in gouty arthritis by regulating the activity of the NF-Kappa B / NLRP3 and Nrf2 pathways. Palmatine may be a potential candidate for the treatment of gouty arthritis.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Review Immunology

Interleukin-6 inhibition in the treatment of autoinflammatory diseases

Tomohiro Koga et al.

Summary: IL-6 plays an important role in autoinflammatory diseases and is considered a promising therapeutic target.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria

Bingjing Zhou et al.

Summary: This article summarizes the latest research progress on the crosstalk between mast cells and other immune cells, providing impetus for the development of treatment strategies for chronic spontaneous urticaria.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Autophagy: Guardian of Skin Barrier

Hyun Jee Kim et al.

Summary: Autophagy is a crucial cellular degradation pathway that plays a role in immune-related skin diseases by maintaining skin homeostasis and eliminating pathogens.

BIOMEDICINES (2022)

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Article Chemistry, Medicinal

Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease

Guo-Shuai Lin et al.

Summary: Palmatine has a protective effect against alcohol-induced liver injury by promoting autophagy, reducing hepatocyte damage, and inhibiting apoptosis.

DRUG DEVELOPMENT RESEARCH (2022)

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Review Pharmacology & Pharmacy

Autophagy plays an essential role in ultraviolet radiation-driven skin photoaging

Jingwen Ma et al.

Summary: This article discusses the characteristics of photoaging and the protective role of autophagy in skin cells damaged by UV radiation. Autophagy is a crucial cellular process that clears or recycles damaged components in cells, playing a key role in cell survival and adaptive responses.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Medicine, General & Internal

Adult-onset Still's disease: A disease at the crossroad of innate immunity and autoimmunity

Shijia Rao et al.

Summary: Adult-onset Still's disease is a rare disease with diverse clinical symptoms and laboratory indicators. The diagnosis is challenging and requires ruling out other diseases. The pathogenesis of AOSD is complex and involves various factors and immune mechanisms. Further research and collaboration are needed for the treatment options and efficacy.

FRONTIERS IN MEDICINE (2022)

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Article Pediatrics

Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria

Anna Gora et al.

Summary: This study aimed to evaluate the levels of various cytokines and chemokines in the serum of children with acute and chronic urticaria and compare them with healthy volunteers. The results showed significant differences in the concentrations of certain cytokines and chemokines between patients with urticaria and the control group. IL-6 and IP-10 may be useful in distinguishing children with acute urticaria from healthy ones.

ITALIAN JOURNAL OF PEDIATRICS (2022)

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Article Medicine, Research & Experimental

Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway

Ge Peng et al.

Summary: A study found that autophagy in keratinocytes is restrained in patients with atopic dermatitis (AD) and mouse models of AD. Human β-defensin-3 (hBD-3) alleviates the impairment of the tight junction barrier through activation of keratinocyte autophagy, and reduces skin inflammation. This suggests that autophagy contributes to the pathogenesis of AD, and hBD-3 could be used therapeutically.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Dermatology

The global burden of chronic urticaria for the patient and society

M. Goncalo et al.

Summary: Chronic urticaria (CU) affects about 1% of the global population, predominantly young and middle-aged women. It presents as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU), or a combination of both. CU has a significant impact on patients' health-related quality of life, with comorbidities such as anxiety and depression aggravating the impairment. Severe pruritus and unpredictable occurrences of weals and angio-oedema contribute to sleep disorders, sexual dysfunction, and limitations in daily life, work, and social activities.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Engineering, Biomedical

Palmatine-loaded electrospun poly(ε-caprolactone)/gelatin nanofibrous scaffolds accelerate wound healing and inhibit hypertrophic scar formation in a rabbit ear model

Zhimin Jiang et al.

Summary: The study demonstrated that palmatine-loaded electrospun nanofibrous scaffold could accelerate wound healing and inhibit hypertrophic scar formation effectively. Both in vitro and in vivo experiments confirmed the significant inhibitory effect of PCL/GE/PAL scaffold on hypertrophic scar formation, showing promising potential for wound healing and scar prevention.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

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Review Chemistry, Medicinal

The regulatory factors and pathological roles of autophagy-related protein 4 in diverse diseases: Recent research advances

Fan Xia et al.

Summary: This paper summarizes the regulation of ATG4 activity, including factors such as micro-RNAs, posttranslational modifications, and small molecules. It also explores the roles of ATG4 in various diseases, such as cancer, neurodegeneration, microbial infection, and provides insight into potential therapeutic opportunities targeting ATG4 for future research and human health.

MEDICINAL RESEARCH REVIEWS (2021)

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Review Dermatology

Autophagy in skin barrier and immune-related skin diseases

Chi Liu et al.

Summary: Autophagy is a vital cellular process involved in cell apoptosis, inflammation, and immunity. It plays a crucial role in maintaining skin homeostasis as the largest organ of the body. Dysregulation of autophagy is linked to various skin diseases.

JOURNAL OF DERMATOLOGY (2021)

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Article Medicine, Research & Experimental

Paeoniflorin suppresses allergic and inflammatory responses by promoting autophagy in rats with urticaria

Jing Guo et al.

Summary: Paeoniflorin (PF) was found to improve urticarial lesions by inhibiting inflammatory cytokine IL-23 and enhancing autophagic activity.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Dermatology

Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis

Kim Klapan et al.

Summary: Atopic dermatitis and psoriasis are common chronic inflammatory skin diseases. Autophagy dysfunction may be associated with the pathogenesis of these diseases, in which the cytokine TNF-alpha may play a dual role in regulating autophagy.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Allergy

Presence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis

Jorge Sanchez et al.

Summary: The study found that IgE responses against eosinophil proteins may contribute to chronic inflammation in patients with atopic dermatitis and chronic spontaneous urticaria. Cross-reactivity between EPX and TPO could explain thyroid problems in CSU patients.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2021)

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Article Dermatology

IFN-γ/IL-6 and related cytokines in chronic spontaneous urticaria: evaluation of their pathogenetic role and changes during omalizumab therapy

Teresa Grieco et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2020)

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Review Immunology

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

Stephen J. Galli et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

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Article Biotechnology & Applied Microbiology

Autophagy Suppresses Toll-Like Receptor 3-Mediated Inflammatory Reaction in Human Epidermal Keratinocytes

Xue Mei Li et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Medicine, General & Internal

Anxiety, depression, and stress in Korean patients with chronic urticaria

Gil-Soon Choi et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2020)

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Article Immunology

IL-37 Ameliorating Allergic Inflammation in Atopic Dermatitis Through Regulating Microbiota and AMPK-mTOR Signaling Pathway-Modulated Autophagy Mechanism

Tianheng Hou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

The strategies and techniques of drug discovery from natural products

Li Zhang et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Biochemistry & Molecular Biology

A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders

Ji-Eun Chang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Plant Sciences

Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion

Hui Wang et al.

PHARMACEUTICAL BIOLOGY (2020)

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Review Dermatology

Autophagy in Skin Diseases

Yeye Guo et al.

DERMATOLOGY (2019)

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Article Multidisciplinary Sciences

LC3-positive structures are prominent in autophagy-deficient cells

Gautam Runwal et al.

SCIENTIFIC REPORTS (2019)

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Article Immunology

MiR-135-5p-p62 Axis Regulates Autophagic Flux, Tumorigenic Potential, and Cellular Interactions Mediated by Extracellular Vesicles During Allergic Inflammation

Misun Kim et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Allergy

The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis

Fansi Jin et al.

ALLERGY (2019)

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Review Biochemistry & Molecular Biology

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

Sandra M. Hill et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Biology

Beclin 1 regulates recycling endosome and is required for skin development in mice

Saori Noguchi et al.

COMMUNICATIONS BIOLOGY (2019)

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Article Allergy

The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

T. Zuberbier et al.

ALLERGY (2018)

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Review Immunology

The role and relevance of mast cells in urticaria

Martin K. Church et al.

IMMUNOLOGICAL REVIEWS (2018)

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Review Allergy

Chronic Spontaneous Urticaria: The Devil's Itch

Sarbjit S. Saini et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

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Article Dermatology

Seasonality of the hospitalizations at a dermatologic ward (2007-2017)

Leonardo de Andrade Rodrigues Brito et al.

ANAIS BRASILEIROS DE DERMATOLOGIA (2018)

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Review Immunology

Autoreactive IgE in Chronic Spontaneous/Idiopathic Urticaria and Basophil/Mastocyte Priming Phenomenon, as a Feature of Autoimmune Nature of the Syndrome

Bernard Panaszek et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2017)

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Article Medicine, Research & Experimental

Immunoregulatory effects of the traditional Dai prescription Yajieshaba on food allergic mice

Guangyuan Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

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Article Allergy

Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children

Seung Jin Lee et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2017)

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Article Cell Biology

Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy

Lei-Lei Chen et al.

AUTOPHAGY (2017)

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Review Allergy

Justification for IgE as a therapeutic target in chronic spontaneous urticaria

M. Sanchez-Borges et al.

EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Immunology

Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses

Rachel Ettinger et al.

AUTOIMMUNITY (2017)

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Article Allergy

Co-Occurrence of Chronic Spontaneous Urticaria with Immunoglobulin A Deficiency and Autoimmune Diseases

Barbara Frossi et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)

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Article Dermatology

Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes

Xingqi Wang et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

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Article Cell Biology

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

Tao Liu et al.

CELL REPORTS (2016)

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Article Integrative & Complementary Medicine

Agarwood Inhibits Histamine Release from Rat Mast Cells and Reduces Scratching Behavior in Mice -Effect of Agarwood on Histamine Release and Scratching Behavior

Eiji Inoue et al.

JOURNAL OF PHARMACOPUNCTURE (2016)

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Article Cell Biology

Atg41/Icy2 regulates autophagosome formation

Zhiyuan Yao et al.

AUTOPHAGY (2015)

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Review Genetics & Heredity

Autophagy in autoimmune disease

Zhen Yang et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Review Genetics & Heredity

Targeting autophagy in skin diseases

Teng Yu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Article Integrative & Complementary Medicine

Effect of Yajieshaba, a preparation of Dai indigenous medicine, on enhanced liver detoxification

Duan Xiaohua et al.

Journal of Traditional Chinese Medicine (2015)

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Review Allergy

Mast Cells and IgE: From History to Today

Hirohisa Saito et al.

ALLERGOLOGY INTERNATIONAL (2013)

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Article Biochemistry & Molecular Biology

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

Julia Romanov et al.

EMBO JOURNAL (2012)

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Editorial Material Cell Biology

An unexpected role for autophagy in degranulation of mast cells

Hiroyasu Nakano et al.

AUTOPHAGY (2011)

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Article Allergy

Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils

Ying Song et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Dermatology

Multiple H1-antihistamine-induced urticaria

Naoko Inomata et al.

JOURNAL OF DERMATOLOGY (2009)

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Review Cell Biology

How to interpret LC3 immunoblotting

Noboru Mizushima et al.

AUTOPHAGY (2007)

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Review Anesthesiology

Mast cell tryptase: a review of its physiology and clinical significance

V Payne et al.

ANAESTHESIA (2004)

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Review Pharmacology & Pharmacy

Chronic urticaria - Aetiology, management and current and future treatment options

MMA Kozel et al.

DRUGS (2004)

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Palmatine treats urticaria by reducing inflammation and increasing autophagy

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