4.8 Article

Exosome-tuned MOF signal amplifier boosting tumor exosome phenotyping with high-affinity nanostars

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Bioorthogonal Microbubbles with Antifouling Nanofilm for Instant and Suspended Enrichment of Circulating Tumor Cells

Yuanhang Xiang et al.

Summary: This study presents a biomimetic, self-powered bioorthogonal micro-bubble called cells-on-a-bubble (click bubble). It utilizes a clickable antifouling nanointerface and a DNA-assembled polyvalent cell surface to achieve rapid and suspended isolation of circulating tumor cells (CTCs) with a capture efficiency of up to 98%. The buoyancy-activated bubble also allows for self-separation, 3D suspension culture, and in situ phenotyping of captured single cancer cells, demonstrating its potential for single-cell analysis and 3D organoid culture.

ACS NANO (2023)

Article Nanoscience & Nanotechnology

DNA-framework-based multidimensional molecular classifiers for cancer diagnosis

Fangfei Yin et al.

Summary: The article introduces a DNA-encoded molecular classifier that can classify multidimensional molecular clinical data and has been tested in prostate cancer patients.

NATURE NANOTECHNOLOGY (2023)

Article Chemistry, Multidisciplinary

Bottom-Up Signal Boosting with Fractal Nanostructuring and Primer Exchange Reaction for Ultrasensitive Detection of Cancerous Exosomes

Minmin Huang et al.

Summary: Researchers have developed an ultrasensitive exosome sensor (NPExo) that utilizes hierarchical nanostructuring array and primer exchange reaction (PER) to accurately quantify cancerous exosomes. The sensor captures the target exosomes using a high-curvature nanostructuring array and amplifies the signal through PER-based DNA extension. The NPExo demonstrates high sensitivity and accuracy in detecting exosomes, making it a promising diagnostic tool in clinical settings.

ACS SENSORS (2023)

Review Pharmacology & Pharmacy

Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles

Duanping Sun et al.

Summary: Liquid biopsy is a promising technology for early cancer detection, therapy monitoring, and prognosis prediction. Circulating tumor cells (CTCs) and extracellular vesicles (EVs) are crucial components in liquid biopsy, carrying important molecular information. Aptamer-based microfluidic platforms combine the advantages of microfluidic chips and aptamers to improve the purity and capture efficiency of CTCs and EVs. This review provides an overview of aptamer-based microfluidics for CTC and EV detection, as well as future challenges in clinical applications.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2023)

Review Chemistry, Analytical

Trends in Paper-Based Sensing Devices for Clinical and Environmental Monitoring

Shekher Kummari et al.

Summary: Environmental toxic pollutants and pathogens are global issues. Traditional detection methods have drawbacks such as tedious sample preparation and dependence on large instruments. Paper-based biosensors are cost-effective alternatives that improve accessibility to testing, especially in developing countries.

BIOSENSORS-BASEL (2023)

Review Chemistry, Analytical

Recent Trends in Biosensing and Diagnostic Methods for Novel Cancer Biomarkers

Jagadeeswara Rao Bommi et al.

Summary: Cancer is a significant global public health issue, accounting for the second highest number of deaths, especially in low- and middle-income countries. It has a huge economic burden of over a trillion dollars annually. Early detection plays a crucial role in effective treatment and improved survival rates, as a large percentage of cancers are diagnosed at late stages. Biosensors offer promise in the early screening of cancer biomarkers. This review highlights recent findings of novel cancer biomarkers, their advantages over traditional biomarkers, and innovative biosensing and diagnostic methods, aiding in early recognition and treatment monitoring of various human cancers.

BIOSENSORS-BASEL (2023)

Article Multidisciplinary Sciences

Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors

Yan Zhang et al.

Summary: Current technologies to subtype glioblastoma (GBM) rely on invasive brain biopsies. In this study, the authors develop a digital platform called EZ-READ to detect and characterize GBM using circulating RNAs in extracellular vesicles. The platform utilizes an RNA-responsive transducer to convert and enhance signals from rare RNA targets, allowing for programmable and reliable RNA detection directly in blood samples. When evaluated clinically, the EZ-READ platform shows promising results for accurate blood-based diagnosis and subtyping of GBM.

NATURE COMMUNICATIONS (2023)

Review Chemistry, Analytical

Advances in nucleic acids-scaffolded electrical sensing of extracellular vesicle biomarkers

Ting-Ting Liang et al.

Summary: This review summarizes the recent advances in nucleic acids-mediated extracellular vesicles (EVs) detection, with a focus on electrochemical strategies. It highlights the contribution of nucleic acids, particularly DNA self-assembly structures, in analyzing EVs with high sensitivity. Furthermore, it discusses the challenges and future perspectives of electric EVs detection strategies in clinical applications.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

Review Chemistry, Analytical

Metal-Organic Frameworks-Mediated Assembly of Gold Nanoclusters for Sensing Applications

Zi-Jian Wang et al.

Summary: This review systematically summarizes the recent progress on sensing applications of MOFs-mediated AuNCs assemblies, along with a brief outlook on future developments.

JOURNAL OF ANALYSIS AND TESTING (2022)

Article Chemistry, Multidisciplinary

Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles Size-Coded Microbeads

Jiacheng Wu et al.

Summary: In this study, a highly sensitive method for tEV phenotyping using microbeads and a microfluidic chip was developed. This method enables the simultaneous detection of multiple tEV phenotypes and overcomes the limitation of spectral overlap with fluorescence spectroscopy. Clinical cohort studies suggest that this strategy may provide new ideas for the precise diagnosis and personalized treatment of cancer patients.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Chemistry, Analytical

Ultracentrifugation-Free Enrichment and Quantification of Small Extracellular Vesicles

Xingle Yu et al.

Summary: This study proposed a DNAzyme-triggered assembly and disassembly system for the conversion of single nano-sized sEVs into clusters, which could be enriched by centrifugation and then broken into single sEVs in the presence of magnesium ions. The quantification of sEVs was achieved by recording the increase in fluorescence upon nucleic acid cleavage, with a detection limit as low as 54 particles/μL. The entire process could be completed in 1.5 hours without the need for ultracentrifugation.

ANALYTICAL CHEMISTRY (2022)

Review Chemistry, Inorganic & Nuclear

Bioprobes-regulated precision biosensing of exosomes: From the nanovesicle surface to the inside

Xin-Xin Peng et al.

Summary: This review summarizes recent progress in bioprobes-mediated exosomal biosensing, covering the transition from extravesicular to intravesicular analysis, from solid sensor surface to solution phase, and from simplex to multiplexing detection. The review highlights the use of bioprobes, including one-dimensional to three-dimensional structures and antibodies to functional nucleic acids, for the recognition, capture, and detection of exosomal biomarkers.

COORDINATION CHEMISTRY REVIEWS (2022)

Article Engineering, Biomedical

Nanomaterials assisted exosomes isolation and analysis towards liquid biopsy

Xiaoni Fang et al.

Summary: Exosomes have attracted significant research interest as a new paradigm of liquid biopsy. However, the efficient isolation and sensitive molecular quantification of exosomes is still a major obstacle, and nanomaterials have been identified as powerful tools for effective purification and molecular analysis of exosomes.

MATERIALS TODAY BIO (2022)

Review Chemistry, Multidisciplinary

Metal-Organic Framework-Based Enzyme Biocomposites

Weibin Liang et al.

Summary: Enzymes play a crucial role in chemical synthesis and biotechnology, but their activity can be easily affected by external stressors. Metal-organic frameworks (MOFs) offer protection to enzymes through encapsulation or infiltration, allowing them to maintain activity under challenging conditions.

CHEMICAL REVIEWS (2021)

Article Chemistry, Multidisciplinary

pH-Mediated Clustering of Exosomes: Breaking Through the Size Limit of Exosome Analysis in Conventional Flow Cytometry

Xinzhuo Liu et al.

Summary: Exosomes have emerged as promising biomarkers for disease diagnosis. A pH-mediated assembly system was developed to convert nanosized exosomes into microsized clusters, allowing for analysis beyond the size limit of exosomes. The combination of MUC-1 and PD-L1 was identified as a new biomarker panel for early diagnosis of liver cancer.

NANO LETTERS (2021)

Article Chemistry, Analytical

Metal-Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay

Xiaojuan Liu et al.

Summary: The combination of a metal-organic framework-functionalized paper and a screen-printed electrode has enabled the development of a simple and cost-efficient electrochemical biosensor for detecting cancer-derived exosomes with high sensitivity and a low detection limit. This label-free paper-based biosensor offers advantages such as low cost, ease of operation, and high sensitivity, making it suitable for point-of-care diagnosis in resource-limited settings.

ANALYTICAL CHEMISTRY (2021)

Article Engineering, Biomedical

An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma

Jongmin Park et al.

Summary: The device described in the study efficiently integrates enrichment and electrochemical detection of tumor extracellular vesicles, accurately classifying colorectal cancer patients in less than an hour. The device showed high accuracy in classifying patients, with potential for aiding in cancer detection and monitoring.

NATURE BIOMEDICAL ENGINEERING (2021)

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma

Jing Wang et al.

SCIENCE ADVANCES (2020)

Article Multidisciplinary Sciences

Encoding quantized fluorescence states with fractal DNA frameworks

Jiang Li et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

Ning Zhang et al.

CHEMICAL COMMUNICATIONS (2020)

Article Engineering, Biomedical

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Peng Zhang et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Chemistry, Multidisciplinary

Peptide-induced super-assembly of biocatalytic metal-organic frameworks for programmed enzyme cascades

Jieying Liang et al.

CHEMICAL SCIENCE (2019)

Review Chemistry, Multidisciplinary

New Technologies for Analysis of Extracellular Vesicles

Huilin Shao et al.

CHEMICAL REVIEWS (2018)

Article Chemistry, Multidisciplinary

General and Direct Method for Preparing Oligonucleotide-Functionalized Metal-Organic Framework Nanoparticles

Shunzhi Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Physical

Exosome-Coated Metal-Organic Framework Nanoparticles: An Efficient Drug Delivery Platform

Bernhard Illes et al.

CHEMISTRY OF MATERIALS (2017)

Article Chemistry, Multidisciplinary

Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins

Ying Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Chemistry, Multidisciplinary

Zr-based metal-organic frameworks: design, synthesis, structure, and applications

Yan Bai et al.

CHEMICAL SOCIETY REVIEWS (2016)

Article Nanoscience & Nanotechnology

Modular assembly of superstructures from polyphenol-functionalized building blocks

Junling Guo et al.

NATURE NANOTECHNOLOGY (2016)

Article Chemistry, Multidisciplinary

Multifunctional Phosphate-Based Inorganic-Organic Hybrid Nanoparticles

Joachim G. Heck et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

Article Chemistry, Multidisciplinary

Modulated Synthesis of Zr-Based Metal-Organic Frameworks: From Nano to Single Crystals

Andreas Schaate et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Review Oncology

5-Fluorouracil: Mechanisms of action and clinical strategies

DB Longley et al.

NATURE REVIEWS CANCER (2003)