期刊
ADVANCED FUNCTIONAL MATERIALS
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202310260
关键词
temperature sensing; hydrogel coating; infection; in situ monitoring; medical catheter
A temperature-sensing hydrogel coating has been developed for medical surgical catheters, allowing real-time infection monitoring. The hydrogel coating has a high temperature coefficient of resistance and remains stable in vivo. It forms a mechanically compatible catheter-tissue interface and reduces the risk of inflammatory responses. By using this coated catheter for early detection of infections in the brain, the individual survival rate has increased to 90%.
Medical surgical catheters are widely used in the medical field for drug delivery or postoperative drainage. However, infections associated with local temperature rise often occur at the catheter-tissue interface, resulting in irreversible pathological damage, cognitive behavioral abnormalities, or even an increased risk of mortality if not monitored in time. Herein, an in situ temperature-sensing hydrogel coating on the outer surface of medical surgical catheters for real-time infection monitoring is developed. The hydrogel coating exhibits a record temperature coefficient of resistance of 2.90% degrees C-1 and maintains stable in vivo. Besides, the hydrogel layer forms a mechanically compatible catheter-tissue interface and minimizes the risk of inflammatory responses due to its tissue-like softness (Young's modulus of 4.24 kPa). By applying it in the early detection of infections in the brain of SD rats, the individual survival rate has increased to 90% with timely intervention. A temperature-sensing hydrogel, with a high-temperature coefficient of resistance (2.90% degrees C-1), is coated on the medical catheter for real-time infection monitoring and maintains stability in vivo. It forms a mechanically compatible catheter-tissue interface and minimizes the risk of inflammatory responses. The hydrogel-coated catheter achieves early detection of infections in the brain, elevating the individual survival rate to 90%.image
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