期刊
ANTIBIOTICS-BASEL
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics12111626
关键词
drug-resistant bacteria; extended-spectrum beta-lactamase (ESBL); sepsis; PICU; surveillance
There is an alarming increase in multidrug-resistant (MDR) sepsis among children in the pediatric intensive care unit (PICU) in Spain, mainly caused by gram-negative bacteria (ESBL-Enterobacterales), with mostly community-onset infections. Malnourished infants and children who were on antibiotics 48 hours prior to PICU admission are at increased risk and require closer surveillance.
The emergence of multidrug-resistant (MDR) bacteria in children is a growing concern, particularly among septic patients, given the need for first-right dosing. Our aim was to determine the incidence rates and factors associated with MDR-sepsis in the pediatric intensive care unit (PICU), using data from the Spanish ENVIN-HELICS PICU registry between 2013 and 2019. The rate of MDR bacteria among septic children ranged between 5.8 and 16.2% throughout this study period, with a significant increase since 2015 (p = 0.013). MDR-gram-negative bacteria (92%), particularly EBL-Enterobacterales (63.7%), were the most frequent causative microorganisms of MDR-sepsis. During this study period, sixteen MDR-sepsis (32.6%) corresponded to intrahospital infections, and 33 (67.4%) had community-onset sepsis, accounting for 10.5% of the overall community-onset sepsis. Independent risk factors associated with MDR-sepsis were antibiotics 48 h prior to PICU admission (OR 2.38) and PICU onset of sepsis (OR 2.58) in >1 year-old children, and previous malnourishment (OR 4.99) in <1 year-old children. Conclusions: There was an alarming increase in MDR among septic children in Spain, mainly by gram-negative (ESBL-Enterobacterales), mostly coming from the community setting. Malnourished infants and children on antibiotics 48 h prior to PICU are at increased risk and therefore require closer surveillance.
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