Preclinical models for Type 1 Diabetes Mellitus - A practical approach for research

Numerous preclinical models have been developed to advance biomedical research in type 1 diabetes mellitus (T1DM). They are essential for improving our knowledge of T1DM development and progression, allowing researchers to identify potential therapeutic targets and evaluate the effectiveness of new medications. A deeper comprehension of these models themselves is critical not only to determine the optimal strategies for their utilization but also to fully unlock their potential applications in both basic and translational research. Here, we will comprehensively summarize and discuss the applications, advantages, and limitations of the commonly used animal models for human T1DM and also overview the up-to-date human tissue bioengineering models for the investigation of T1DM. By combining these models with a better understanding of the pathophysiology of T1DM, we can enhance our insights into disease initiation and development, ultimately leading to improved therapeutic responses and outcomes.

Automated summary

This article comprehensively summarizes and discusses the applications, advantages, and limitations of commonly used animal models for human T1DM, as well as provides an overview of the latest human tissue bioengineering models for T1DM research. By combining these models with a better understanding of the pathophysiology of T1DM, we can gain deeper insights into disease development and ultimately improve therapeutic responses and outcomes.