4.6 Article

Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Gastroenterology & Hepatology

Endoplasmic reticulum stress in liver diseases

Amir Ajoolabady et al.

Summary: The endoplasmic reticulum stress and unfolded protein response play important roles in the pathophysiology of liver diseases. Understanding this process is crucial for developing interventions for the treatment of nonmalignant liver diseases.

HEPATOLOGY (2023)

Article Gastroenterology & Hepatology

NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression

Muhammad Umair Latif et al.

Summary: NFATc1 stimulates NAFLD progression through chronic ER stress sensing and subsequent activation of terminal UPR signaling in hepatocytes. Interfering with ER stress-responses, for example, by TUDCA, protects fatty livers from progression towards manifest NASH.
Review Biochemistry & Molecular Biology

Reshaping endoplasmic reticulum quality control through the unfolded protein response

R. Luke Wiseman et al.

Summary: Cells adapt endoplasmic reticulum quality control (ERQC) to match the diverse demands encountered during normal physiology and in disease through the unfolded protein response (UPR), which plays a crucial role in maintaining ER function.

MOLECULAR CELL (2022)

Article Immunology

Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain

Wei Gao et al.

Summary: This study revealed a beneficial role of AT(2)R activation in alleviating primary and secondary hyperalgesia in joint inflammatory pain, potentially through modulation of synovial macrophage and spinal microglial activity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Article Endocrinology & Metabolism

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Yong Chen et al.

Summary: Chen et al. discovered that the IRE1 alpha endoplasmic reticulum stress sensor inhibits beige adipocyte activation in white and beige adipocytes by regulating lipolysis and Pgc1 alpha messenger RNA levels. The research shows the therapeutic potential of blocking IRE1 alpha in unlocking adipocytes' thermogenic capacity to combat obesity and metabolic disorders.

NATURE METABOLISM (2022)

Article Medicine, Research & Experimental

AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel Gonzalez-Blazquez et al.

Summary: The study found that AT2R stimulation by C21 in obesity can preserve NO availability, prevent unhealthy vascular remodeling, and protect the abdominal aorta in HF mice against the development of endothelial dysfunction, ECM remodeling, and arterial stiffness.

CLINICAL SCIENCE (2021)

Review Cell Biology

The Power of Plasticity?Metabolic Regulation of Hepatic Stellate Cells

Parth Trivedi et al.

Summary: Hepatic stellate cells play a crucial role in regulating physiological and pathological responses in the liver, particularly in chronic liver injury. They drive hepatic fibrosis and are involved in inflammation and cancer by adapting metabolic pathways to meet increased energy demands.

CELL METABOLISM (2021)

Article Biochemistry & Molecular Biology

Delayed Administration of Angiotensin Receptor (AT2R) Agonist C21 Improves Survival and Preserves Sensorimotor Outcomes in Female Diabetic Rats Post-Stroke through Modulation of Microglial Activation

LaDonya Jackson-Cowan et al.

Summary: The study demonstrates that administration of C21 compound can improve neuro-inflammation in diabetic animals post-stroke by modulating inflammatory properties of microglia/macrophages. Furthermore, delayed administration of C21 can also reduce chronic inflammation post-stroke in female diabetic rats.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate

Natalia Siwecka et al.

Summary: IRE1 is a key protein in the UPR signaling pathway, with implications for cell survival and apoptosis in various human pathologies. Its increased activity in conditions such as cancer, neurodegeneration, inflammation, and metabolic disorders suggests that modulation of IRE1 could provide promising therapeutic strategies. Understanding the molecular characteristics and activation of IRE1 may lead to the design of specific modulators for drug development.

BIOMEDICINES (2021)

Article Pharmacology & Pharmacy

Update on Angiotensin II Subtype 2 Receptor: Focus on Peptide and Non-peptide Agonists

Arina Ranjit et al.

MOLECULAR PHARMACOLOGY (2021)

Article Cell Biology

Renin-angiotensin system and inflammation update

Elena Cantero-Navarro et al.

Summary: The classical view of the renin-angiotensin system highlights its role in regulating sodium balance and blood pressure, but it is now recognized that RAS also plays a crucial role in organ damage and inflammation. Angiotensin II and its receptors can promote inflammatory responses, while other RAS components may have anti-inflammatory properties. Recent research has revealed new insights into the complex interactions between RAS and inflammation, shedding light on potential therapeutic targets for kidney and heart diseases.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

Review Cell Biology

Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis

Beatrice Foglia et al.

Summary: Liver fibrosis is a potentially reversible pathophysiological event characterized by excess deposition of extracellular matrix components, which is primarily driven by activated myofibroblasts and other hepatic cell populations involved in chronic liver disease progression. The emerging pathogenic role of hypoxia, hypoxia-inducible factors, and related mediators in the fibrogenic progression of chronic liver diseases is a key focus of research.
Review Pharmacology & Pharmacy

Endoplasmic reticulum stress and protein degradation in chronic liver disease

Si-Wei Xia et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Gastroenterology & Hepatology

Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases

Yun Seok Kim et al.

CLINICAL AND MOLECULAR HEPATOLOGY (2020)

Review Biochemistry & Molecular Biology

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Maurizio Parola et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

Review Gastroenterology & Hepatology

Human hepatic stellate cell isolation and characterization

Linshan Shang et al.

JOURNAL OF GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

Liver diseases: A major, neglected global public health problem requiring urgent actions and large-scale screening

Patrick Marcellin et al.

LIVER INTERNATIONAL (2018)

Review Biochemistry & Molecular Biology

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

Jiwon Hwang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

Review Gastroenterology & Hepatology

Mechanisms of hepatic stellate cell activation

Takuma Tsuchida et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Multidisciplinary Sciences

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium

Riccardo Terenzi et al.

SCIENTIFIC REPORTS (2017)

Review Pharmacology & Pharmacy

Hepatic stellate cells as key target in liver fibrosis

Takaaki Higashi et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Review Biochemistry & Molecular Biology

Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer

Juan R. Cubillos-Ruiz et al.

Article Medicine, Research & Experimental

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

Bryna S. M. Chow et al.

CLINICAL SCIENCE (2016)

Article Oncology

Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence

Akihiro Yoneda et al.

EXPERIMENTAL CELL RESEARCH (2016)

Article Urology & Nephrology

AT2R activation counteracts hypertension

Andrea Aguilar

Nature Reviews Nephrology (2016)

Article Multidisciplinary Sciences

Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress

Chen Wang et al.

SCIENTIFIC REPORTS (2016)

Review Pathology

The Role of Endoplasmic Reticulum Stress in Human Pathology

Scott A. Oakes et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10 (2015)

Article Gastroenterology & Hepatology

Pathobiology of liver fibrosis: a translational success story

Youngmin A. Lee et al.

Article Peripheral Vascular Disease

AT2R Autoantibodies Block Angiotensin II and AT1R Autoantibody-Induced Vasoconstriction

Campbell Liles et al.

HYPERTENSION (2015)

Article Peripheral Vascular Disease

AT2R Agonist, Compound 21, Is Reno-Protective Against Type 1 Diabetic Nephropathy

Christine Koulis et al.

HYPERTENSION (2015)

Article Gastroenterology & Hepatology

Angiotensin-II Type 1 Receptor-Mediated Janus Kinase 2 Activation Induces Liver Fibrosis

Michaela Granzow et al.

HEPATOLOGY (2014)

Article Urology & Nephrology

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Bryna S. Man Chow et al.

KIDNEY INTERNATIONAL (2014)

Article Cell Biology

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

Arvin B. Tam et al.

CELL REPORTS (2014)

Review Pharmacology & Pharmacy

Angiotensin II type 2 receptor agonists: where should they be applied?

Koen Verdonk et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)

Article Biochemistry & Molecular Biology

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks

Diego Acosta-Alvear et al.

MOLECULAR CELL (2007)

Review Biochemistry & Molecular Biology

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

SB Cullinan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Review Medicine, General & Internal

Current concepts -: Management of cirrhosis and ascites

P Ginès et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)