期刊
CHEMISTRY & BIODIVERSITY
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202301683
关键词
Cryptolepis buchananii; Asclepiadaceae; triterpene glycoside; nitric oxide inhibitor; Cryptolepis dubia
Four undescribed pentacyclic triterpenene glycosides and five known pentacyclic triterpenenes were isolated from the methanol extract of Cryptolepis buchananii fruits. Their structures were determined through various spectroscopic analyses. These compounds showed significant inhibition of NO production in LPS-activated RAW264.7 cells.
From the methanol extract of the Cryptolepis buchananii fruits, four undescribed pentacyclic triterpenene glycosides (1-4) and five known pentacyclic triterpenenes (5-9) were isolated. Their structures were determined to be uncargenin C 28-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (1), 3-O-beta-D-glucopyranosyluncargenin C 28-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (2), 3-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl-6 beta,23-dihydroxyursolic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (3), 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosylasiatic acid 28-O-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranosyl ester (4), asiatic acid (5), 2 alpha,3 beta,23-trihydroxyoleana-11,13(18)-dien-28-oic acid (6), arjunolic acid (7), 6 beta-hydroxyarjunolic acid (8), and actinidic acid (9) based on analyses of their HR-ESI-MS, 1D and 2D NMR spectra. All the isolates showed significantly NO production inhibition in LPS-activated RAW264.7 cells with the IC50 values ranging from 18.79 to 37.57 mu M, compared to that of the positive control compound, dexamethasone, which showed IC50 value of 14.05 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据