The CXCL10-CXCR3 axis plays an important role in Kawasaki disease

The precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD. In an attempt to elucidate the pathogenesis of Kawasaki disease, we comprehensively examined the changes in immune cells and various cytokines. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD. Graphical Abstract

Automated summary

We found that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of Kawasaki disease.