期刊
TOXINS
卷 8, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/toxins8060182
关键词
VacA genotypes; vacuolation; prolonged Helicobacter pylori infection; H. pylori-mediated diseases
资金
- National Institutes of Health [DK62813]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [25293104, 26640114, 15H02657]
- Grants-in-Aid for Scientific Research [15H02657, 25293104, 16H05191] Funding Source: KAKEN
The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.
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