期刊
NANO LETTERS
卷 23, 期 22, 页码 10608-10616出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.3c03701
关键词
near-infrared; calcium channels; conjugatedoligomer; biomimetic; blood glucose homeostasis
In this study, biomimetic conjugated oligomeric nanoparticles were developed to modulate blood glucose homeostasis by activating calcium channels with near-infrared laser. The results showed that these nanoparticles effectively regulated glucose metabolism, holding promise for diabetes treatment.
The rarity of efficient tools with spatiotemporal resolution and biocompatibility capabilities remains a major challenge for further progress and application of signaling manipulation. Herein, biomimetic conjugated oligomeric nanoparticles (CM-CONs) were developed to precisely modulate blood glucose homeostasis via the two-pronged activation of calcium channels. Under near-infrared (NIR) laser irradiation, CM-CONs efficiently generate local heat and reactive oxygen species (ROS), thereby simultaneously activating thermosensitive transient receptor potential V1 (TRPV1) and ROS-sensitive transient receptor potential A1 (TRPA1) calcium channels in small intestinal endocrine cells. The activation of the channels mediates inward calcium flow and then promotes glucagon-like peptide (GLP-1) secretion. Both in vitro and in vivo studies indicate that CM-CONs effectively regulate glucose homeostasis in diabetic model mice upon NIR light irradiation. This work develops a two-pronged attack strategy for accurately controlling blood glucose homeostasis, holding great prospects in the treatment for diabetes.
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