Optical modulation of Iridium(III) complexes for enhanced ROS generation: Multi-photon absorption and near-infrared photodynamic therapy insights

Article Chemistry, Applied

Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy

A. Prieto-Castaneda et al.

Summary: We have designed and synthesized a series of Ir(III) metal complexes with different auxiliary dipyrromethene ligands, which demonstrate potential applications in inducing cell apoptosis and disrupting cellular morphology.

DYES AND PIGMENTS (2022)

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Article Chemistry, Inorganic & Nuclear

BODIPY-Tagged Platinum(II) Curcumin Complexes for Endoplasmic Reticulum-Targeted Red Light PDT

Aarti Upadhyay et al.

Summary: Three compounds were synthesized and characterized, and their anticancer activities were studied. They generated singlet oxygen under red light and showed photocytotoxicity.

INORGANIC CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

Shi Kuang et al.

Summary: A novel mitochondria-localized iridium(III) endoperoxide prodrug is reported, which releases highly cytotoxic iridium(III) complex, singlet oxygen, and alkoxy radical under two-photon irradiation in NIR. This approach shows potential for the treatment of hypoxic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Materials Science, Multidisciplinary

Benzannulation of a ditopic ligand to afford mononuclear and dinuclear Ir(III) complexes with intense phosphorescence: applications in singlet oxygen generation and bioimaging

Marsel Z. Shafikov et al.

Summary: Annulation of the additional aromatic pi-system to the ligand is an effective method of influencing the luminescence of metal complexes. The new dinuclear complex di-Ir shows drastically improved efficiency of phosphorescence compared to the previously reported complex Ir-2. The two complexes, mono-Ir and di-Ir, are promising materials for optical oxygen sensing and applications associated with singlet oxygen generation.

JOURNAL OF MATERIALS CHEMISTRY C (2022)

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Article Chemistry, Medicinal

Platinum-Based Two-Photon Photosensitizer Responsive to NIR Light in Tumor Hypoxia Microenvironment

Yanjun Wang et al.

Summary: PtPAN is a platinum-based photosensitizer that is unreactive to DNA in the dark but highly cytotoxic upon near-infrared irradiation for oxygen-independent photodynamic therapy. With its two-photon excitation property, PtPAN may be suitable for the treatment of deep solid tumors.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Inorganic & Nuclear

Isomer Engineering of Lepidine-Based Iridophosphors for Far-Red Hypoxia Imaging and Photodynamic Therapy

Peng Tao et al.

Summary: The rational molecular design greatly promotes the development of highly efficient cyclometalated phosphorescent iridium(III) complexes. In this study, a simple yet efficient strategy is proposed for the manipulation of the excited states of 2-phenyllepidine-based iridophosphors, resulting in significant tuning of phosphorescence wavelength. An oxygen-responsive iridophosphor is employed for accurate oxygen sensing and efficient photodynamic therapy, making it a promising candidate for image-guided photodynamic therapeutic agent.

INORGANIC CHEMISTRY (2022)

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Article Materials Science, Biomaterials

A cyclometallated iridium(iii) complex with multi-photon absorption properties as an imaging-guided photosensitizer

Dandan Chen et al.

Summary: A designed and synthesized photosensitizer Ir-Biotin with long excitation wavelength and effective cancer cell targeting exhibits excellent photodynamic therapy activity and biocompatibility, capable of inducing cancer cell apoptosis under laser irradiation, and demonstrates significant anti-tumor effects in vivo.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Multidisciplinary

A host-guest strategy for converting the photodynamic agents from a singlet oxygen generator to a superoxide radical generator

Kun-Xu Teng et al.

Summary: In this work, an effective strategy for converting the conventional type-II photosensitizer (PS) to a type-I PS by host-guest complexation is reported. The supramolecular PS demonstrates high photodynamic therapy efficacy even under hypoxic conditions.

CHEMICAL SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

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Article Materials Science, Biomaterials

A new near-infrared phosphorescent iridium(iii) complex conjugated to a xanthene dye for mitochondria-targeted photodynamic therapy

Yongquan Wu et al.

Summary: Iridium(iii) complexes, such as NIR-Ir-XE, conjugated with xanthene dye show promising properties for mitochondria-targeted imaging and cancer phototherapy. The generation of singlet oxygen after irradiation with visible light makes them effective in photodynamic therapy. Comparisons with xanthene-free counterparts demonstrate higher singlet oxygen generation efficiency and better therapeutic effects.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Inorganic & Nuclear