Novel Gold Nanorods@Thiolated Pectin on the Killing of HeLa Cells by Photothermal Ablation

Article Chemistry, Analytical

Fabrication and evaluation of optical nanobiosensor based on localized surface plasmon resonance (LSPR) of gold nanorod for detection of CRP

Sam Hosseinniay et al.

Summary: C-reactive protein is a biomarker for inflammatory disorders, and a nanobiosensor has been developed to monitor and quantify its levels using gold nanorods.

ANALYTICA CHIMICA ACTA (2023)

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Review Chemistry, Inorganic & Nuclear

A review of the role of carbon nanotubes for cancer treatment based on photothermal and photodynamic therapy techniques

Mohammed Faiad Naief et al.

Summary: Carbon nanostructures have unique optical characteristics and can convert light into heat effectively. By activating surface plasmons, they can increase the local temperature and enable localized treatment of nanoscale carbon catalysts. Nanotheranostic platforms combining multiple antitumour therapies under multimodal imaging guidance have become a research hotspot in cancer therapy due to their improved therapeutic effect, tumour specificity, decreased drug resistance, convenient detection and monitoring of tumour lesions, and enhanced therapeutic effect.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2023)

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Article Biochemical Research Methods

In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy

Andre Q. Figueiredo et al.

Summary: This study developed a novel and simpler methodology for producing gold-polymer hybrid structures for cancer photothermal therapy applications. The Au-Alg-NH nanohybrids were synthesized through a straightforward and faster process, using ascorbic acid to promote the in situ reduction and nucleation of gold on a crosslinked alginic acid polymeric matrix. This synthesis process avoids the use of toxic stability agents and the laborious washing and purification steps commonly used in the production of gold-based nanoparticles.

BIOTECHNOLOGY JOURNAL (2023)

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Review Biochemistry & Molecular Biology

Cancer Therapy by Silver Nanoparticles: Fiction or Reality?

David Kovacs et al.

Summary: This review highlights the potential of silver nanoparticles in cancer treatment, including their cancer-specific targeting, reduced side effects, and strong anti-cancer properties. It also discusses the critical hurdles in their clinical utilization.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

Zhijing Yang et al.

Summary: Gastrointestinal cancer remains a significant health issue with high morbidity and mortality rates in China. The deep location and lack of obvious early symptoms make it difficult to diagnose and cure at an advanced stage. The use of gold nanoparticles as nanocarriers shows promise in delivering drugs and nucleic acids to cancer cells and tissues, thereby influencing the fate of cancer. Gold nanoparticles can also serve as a safe and effective visualization agent, allowing for accurate tracking and indication of cancer location and boundaries, opening up new possibilities for treatment and diagnosis of gastrointestinal cancer.

FRONTIERS IN ONCOLOGY (2022)

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Article Nutrition & Dietetics

Structural Characterization of a Low Molecular Weight HG-Type Pectin From Gougunao Green Tea

Tao Hong et al.

Summary: In this study, an acidic polysaccharide Gougunao tea polysaccharide (GPS) was isolated from Gougunao green tea, and its structural characteristics were analyzed. GPS2b was identified as a low molecular weight acidic pectic polysaccharide composed of specific glycosidic bonds, and a minor branched RG-I structure was also found.

FRONTIERS IN NUTRITION (2022)

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Review Pharmacology & Pharmacy

Surface modifications of gold nanoparticles: stabilization and recent applications in cancer therapy

Kartik Hariharan et al.

Summary: Gold nanoparticles (GNPs) are noble metal nanocarriers that have been extensively studied for their pharmaceutical applications, imaging, and diagnosis. The surface of GNPs can be easily modified using chemical reduction techniques, and various stabilizers can be used to enhance their stability. This review discusses the different surface modification techniques and molecular level interactions involved in stabilizing GNPs. Factors such as stabilizer concentration, characteristics, and pH of the surrounding media have a significant impact on the stability of GNPs. Furthermore, the review highlights the recent applications of surface-modified GNPs in tumor microenvironment management and cancer therapy.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Application of Mesoporous Silica Nanoparticles in Cancer Therapy and Delivery of Repurposed Anthelmintics for Cancer Therapy

Maedeh Koohi Moftakhari Esfahani et al.

Summary: This review discusses the biomedical application of mesoporous silica nanoparticles (MSNs) as drug carriers for cancer therapy. MSNs, with their unique properties, show great potential for improving drug solubility and delivery. The development of multimodal anticancer therapeutics and chemical modifications can further enhance the applications of MSNs. Safety issues related to these nanoparticles are also discussed.

PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy

Lilia Arellano-Galindo et al.

Summary: The study optimized a metal-based nanoplatform for targeted drug delivery and achieved good pharmacodynamics through the release of drugs in response to dual stimuli. The platform demonstrated stability and excellent therapeutic effects in in vitro experiments under various physiological conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Nanocomposite based on gold nanoparticles and carboxymethyl cellulose: Synthesis, characterization, antimicrobial, and anticancer activities

Ahmed S. Doghish et al.

Summary: In this study, a nanocomposite based on gold nanoparticles and carboxy methyl cellulose (CMC-AuNPs) was fabricated and exhibited antibacterial, antifungal, and anticancer activities.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Gold Nanorod-Assisted Photothermal Therapy and Improvement Strategies

Mitchell Lee Taylor et al.

Summary: Noble metal nanoparticles, especially gold nanorods, have been widely used in cancer photothermal therapy due to their unique optical properties and long blood circulation half-life. This review summarizes the optical properties of gold nanorods and their applications in photothermal therapy, as well as recent strategies to improve the therapy through combination with chemotherapy and photodynamic therapy.

BIOENGINEERING-BASEL (2022)

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Article Materials Science, Multidisciplinary

Optimization of Carvacrol Nanoemulsion for the Incorporation in Pectin Membranes: Influence on Their Load Capacity, Microstructure and Antibacterial Properties

O. Beltran et al.

Summary: In this study, a pectin membrane incorporated with a Tween-80-stabilized carvacrol emulsion was developed for wound dressing. The membrane showed good antibacterial activity against Escherichia coli and Staphylococcus aureus.

MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS (2022)

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Article Polymer Science

Hybrid Acrylated Chitosan and Thiolated Pectin Cross-Linked Hydrogels with Tunable Properties

Shaked Eliyahu et al.

Summary: A new hydrogel system based on modified pectin with thiol groups and modified chitosan with acrylate end groups was developed and characterized. The cross-linking mechanisms of the hydrogel were investigated through various analyses, revealing the importance of controlling the acrylated chitosan concentration for gel properties. The hydrogel showed different behaviors at varying pH values, leading to the formation of unique properties and applications in biomedical fields.

POLYMERS (2021)

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Article Acoustics

Lipid-stabilized hydrophobically modified silica-coated gold nanorods generate enhanced photoacoustic signal from cavitation with nonlinear dependence on laser fluence

Andrew Goodwin

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA (2021)

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Article Chemistry, Medicinal

Hyaluronic Acid-Modified and Doxorubicin-Loaded Gold Nanoparticles and Evaluation of Their Bioactivity

Lin-Song Li et al.

Summary: Functionalized gold nanoparticles modified with hyaluronic acid successfully delivered the antitumor drug doxorubicin to cancer cells. The nanoparticles were more readily ingested by cells with CD44 receptors, leading to inhibition of cell proliferation through apoptosis.

PHARMACEUTICALS (2021)

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Review Pharmacology & Pharmacy

Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy

Tianqi Wang et al.

Summary: Nanomedicines have shown great potential in cancer therapy, particularly in revolutionizing cancer treatment through the combination of chemotherapy and immunotherapy. Lipid-based nanoparticles, as the most promising delivery platform for chemoimmunotherapy, are under preclinical and clinical trials. Challenges in clinical translation and future perspectives are discussed in this review.

PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Pectin-Coated Plasmonic Nanoparticles for Photodynamic Therapy: Inspecting the Role of Serum Proteins

Jose S. Cisneros et al.

Summary: Plasmonic metal nanoparticles can enhance the efficiency of photodynamic therapy. The protein corona formed around the nanoparticles in contact with biological fluids greatly affects the therapy's efficiency. The study shows that pectin-coated gold nanoparticles can improve the efficacy of riboflavin-based PDT in HeLa cells under standard serum conditions, while preincubation with serum may have negative effects.

ACS OMEGA (2021)

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Article Engineering, Biomedical

Thiolated pectins: In vitro and ex vivo evaluation of three generations of thiomers

Patrick Knoll et al.

Summary: Three generations of thiolated polymers have been developed with different thiol ligands to enhance mucus interactions. This study synthesized all three generations on a pectin backbone for the first time, with third generation showing superior mucoadhesive properties. Additionally, the polymers did not exhibit cytotoxicity, indicating potential applications in drug delivery systems.

ACTA BIOMATERIALIA (2021)

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Article Biochemistry & Molecular Biology

Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas

Jenifer P. Goncalves et al.

Summary: Researchers investigated the efficacy and safety of gum arabic-functionalized gold nanorods (GA-AuNRs) against triple wild-type melanoma, finding that GA-AuNRs significantly reduced primary tumor growth and induced histological features associated with better prognosis, while also lowering the depth of superficial lung metastasis and the incidence of intrapulmonary metastasis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Pectin in biomedical and drug delivery applications: A review

De-qiang Li et al.

Summary: Natural macromolecules, such as pectin, are attracting attention for their biocompatibility, low toxicity, and biodegradability in biomedical and drug delivery applications. Components like rhamnogalacturonan-II in pectin play a crucial role in biomedical activities. The presence of hydroxyl and carboxyl groups in pectin contributes to its favorable properties for these applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Oncology

Nanomaterials for cancer therapy: current progress and perspectives

Zhe Cheng et al.

Summary: Nanomaterials play an important role in cancer therapy by targeting cancer cells, tumor microenvironment, and the immune system. However, despite an increasing number of studies, the approval of nano-drugs has not significantly increased, requiring further research to improve clinical translation efficiency.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Pectin-capped gold nanoparticles synthesis in-situ for producing durable, cytocompatible, and superabsorbent hydrogel composites with chitosan

Debora A. de Almeida et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Nanoscience & Nanotechnology

Gold Nanoparticle-Coated Starch Magnetic Beads for the Separation, Concentration, and SERS-Based Detection of E. coli O157:H7

Sang-Mook You et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications

Jianuo Fan et al.

CHEMICAL RECORD (2020)

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Review Chemistry, Multidisciplinary

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Humaira Idrees et al.

NANOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Effective replacement of cetyltrimethylammonium bromide (CTAB) by mercaptoalkanoic acids on gold nanorod (AuNR) surfaces in aqueous solutions

Rafael del Cano et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Iron oxide nanoparticles: synthesis, functionalization, and applications in diagnosis and treatment of cancer

Aldahir A. Hernandez-Hernandez et al.

CHEMICAL PAPERS (2020)

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Article Chemistry, Physical

Effects of Cetyltrimethylammonium Bromide on the Toxicity of Gold Nanorods Both In Vitro and In Vivo: Molecular Origin of Cytotoxicity and Inflammation

Yan Peng Jia et al.

SMALL METHODS (2020)

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Article Materials Science, Biomaterials

Simple and rapid method for synthesis of porous gold nanoparticles and its application in improving DNA loading capacity

Fatemeh Hakimian et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biochemical Research Methods

Multifunctional Nanomaterial-alginate Drug Delivery and Imaging System for Cancer Therapy

Seokyoung Yoon et al.

BIOCHIP JOURNAL (2019)

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Article Nanoscience & Nanotechnology

Functional design of pH-responsive folate- targeted polymer-coated gold nanoparticles for drug delivery and in vivo therapy in breast cancer

Sneha Mahalunkar et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Polymer Science

The Use of Chitosan, Alginate, and Pectin in the Biomedical and Food Sector-Biocompatibility, Bioadhesiveness, and Biodegradability

Gheorghe Adrian Martau et al.

POLYMERS (2019)

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Article Oncology

ROS as a novel indicator to predict anticancer drug efficacy

Tarek Zaidieh et al.

BMC CANCER (2019)

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Article Materials Science, Biomaterials

Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma

Yu-Te Liao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Environmental Sciences

Assessment of pectin-coated magnetite nanoparticles in low-energy water desalination applications

Olivia A. Attallah et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Engineering of pectin-capped gold nanoparticles for delivery of doxorubicin to hepatocarcinoma cells: an insight into mechanism of cellular uptake

Shaivee Borker et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Pharmacology & Pharmacy

Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles

Fatemeh Madani et al.

ADVANCED PHARMACEUTICAL BULLETIN (2018)

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Article Chemistry, Physical

Selected Standard Protocols for the Synthesis, Phase Transfer, and Characterization of Inorganic Colloidal Nanoparticles

Jonas Huehn et al.

CHEMISTRY OF MATERIALS (2017)

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Review Chemistry, Inorganic & Nuclear

Functionalized gold nanorods for nanomedicine: Past, present and future

Jie Zhou et al.

COORDINATION CHEMISTRY REVIEWS (2017)

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Article Nanoscience & Nanotechnology

Hyaluronic Acid-Functionalized Gold Nanorods with pH/NIR Dual Responsive Drug Release for Synergetic Targeted Photothermal Chemotherapy of Breast Cancer

Weijun Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Chemistry, Applied

Surface interactions of gold nanorods and polysaccharides: From clusters to individual nanoparticles

Heloise Ribeiro de Barrosa et al.

CARBOHYDRATE POLYMERS (2016)

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Article Chemistry, Multidisciplinary

Growth Kinetics of Gold Nanorods Synthesized by a Seed-Mediated Method Under pH Acidic Conditions

M. Almada et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2016)

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Review Chemistry, Analytical

Localized surface plasmon resonance of gold nanorods and assemblies in the view of biomedical analysis

Jian Wang et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2016)

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Article Chemistry, Applied

Synthesis and characterization of pectin derivative with antitumor property against Caco-2 colon cancer cells

Elizangela A. M. S. Almeida et al.

CARBOHYDRATE POLYMERS (2015)

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Article Chemistry, Multidisciplinary

BSA modification to reduce CTAB induced nonspecificity and cytotoxicity of aptamer-conjugated gold nanorods

Emir Yasun et al.

NANOSCALE (2015)

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Article Medicine, Research & Experimental

Combined Cancer Photothermal-Chemotherapy Based on Doxorubicin/Gold Nanorod-Loaded Polymersomes

JinFeng Liao et al.

THERANOSTICS (2015)

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Article Toxicology

Synthesis and in vivo toxicity assessment of CdSe: ZnS quantum dots functionalized with EDTA-Bis-Cysteamine

Narmada Bag et al.

TOXICOLOGY RESEARCH (2015)

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Article Chemistry, Multidisciplinary

Fast loading of PEG-SH on CTAB-protected gold nanorods

Zhong Zhang et al.

RSC ADVANCES (2014)

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Article Chemistry, Multidisciplinary

Charge Density Quantification of Polyelectrolyte Polysaccharides by Conductometric Titration: An Analytical Chemistry Experiment

Stefano Farris et al.

JOURNAL OF CHEMICAL EDUCATION (2012)

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Article Chemistry, Physical

Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles

D. Keith Roper et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2007)

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Article Chemistry, Physical

Gelation of aqueous pectin solutions: A dynamic light scattering study

J Narayanan et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2002)

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Novel Gold Nanorods@Thiolated Pectin on the Killing of HeLa Cells by Photothermal Ablation

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