☆ 4.7 Review

Environmental Enrichment in Cancer as a Possible Tool to Combat Tumor Development: A Systematic Review

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Summary: Cancer initiation, progression, and recurrence are complex mechanisms that involve various components such as genetics, psychophysiology, and environment. Chronic exposure to stress, including fear of recurrence, can impact biological processes, increase cancer risk, and influence survival rates. Psychological interventions have been shown to influence cortisol levels, a biomarker for stress. This meta-analysis aimed to quantify the effect of psychosocial interventions on cortisol levels in saliva or blood, and its potential impact on breast cancer progression.

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Effects of maternal deprivation and environmental enrichment on anxiety-like and depression-like behaviors correlate with oxytocin system and CRH level in the medial-lateral habenula

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Review Biochemistry & Molecular Biology

Cytokines and Immune Cells Profile in Different Tissues of Rodents Induced by Environmental Enrichment: Systematic Review

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

The Molecular Effects of Environmental Enrichment on Alzheimer's Disease

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Summary: This article summarizes the evidence for environmental enrichment (EE) as a neuroprotective strategy and discusses the potential molecular pathways that explain its effects from a biochemical perspective. It also explores the differences in early and late life EE exposure and its potential application in humans.

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Sympathetic and parasympathetic innervation in cancer: therapeutic implications

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Enriched environment enhances NK cell maturation through hypothalamic BDNF in male mice

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B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

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Mechanical Aspects of Angiogenesis

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Environmental Enrichment Mitigates Age-Related Metabolic Decline and Lewis Lung Carcinoma Growth in Aged Female Mice

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Summary: Aging is a complex physiological process that can lead to the decline of metabolic and immune functions. Environmental enrichment (EE) is a model that helps understand the effects of the environment on aging dynamics, including antiobesity and anticancer phenotypes. The study validates EE as an anticancer intervention paradigm and highlights the importance of understanding environmental influences on cancer malignancy in aged populations.

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A simplified enriched environment increases body temperature and suppresses cancer progression in mice

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Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling

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Minimum environmental enrichment is effective in activating antitumor immunity to transplanted tumor cells in mice

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Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumor Model

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Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition

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