期刊
TOXINS
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/toxins8070207
关键词
C. perfringens; regulatory network
资金
- KAKENHI on Priority Areas Applied Genomics from the Ministry of Education, Culture, Sports, Science [17019021, 17790284, 22390081, 15390140]
- Ministry of Technology of Japan
- Health and Labor Sciences Research Grants (Research on Food Safety)
- Grants-in-Aid for Scientific Research [15390140, 17790284, 22390081, 17019021] Funding Source: KAKEN
The Gram-positive anaerobic bacterium Clostridium perfringens is widely distributed in nature, especially in soil and the gastrointestinal tracts of humans and animals. C. perfringens causes gas gangrene and food poisoning, and it produces extracellular enzymes and toxins that are thought to act synergistically and contribute to its pathogenesis. A complicated regulatory network of toxin genes has been reported that includes a two-component system for regulatory RNA and cell-cell communication. It is necessary to clarify the global regulatory system of these genes in order to understand and treat the virulence of C. perfringens. We summarize the existing knowledge about the regulatory mechanisms here.
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