期刊
TOXINS
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/toxins8070227
关键词
clinical; pathogens; Toxin-Antitoxin; plasmids; chromosome; resistance; persistance; virulence
资金
- integrated National Plan for Scientific Research, Development and Technological Innovation
- ISCIII-General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) A way of making Europe
- Spanish Network for the Research in Infectious Diseases [REIPI RD12/0015]
- Spanish Ministry of Health
- Miguel Servet II Programme (SERGAS)
- Miguel Servet II Programme (ISCIII)
- SEP-CONACyT Grant [152794]
- UNAM-PAPIIT [IA201116]
- Army Research Office [W911NF-14-1-0279]
- [PI13/02390]
Toxin-antitoxin (TA) systems are prevalent in bacteria and archaea. Although not essential for normal cell growth, TA systems are implicated in multiple cellular functions associated with survival under stress conditions. Clinical strains of bacteria are currently causing major human health problems as a result of their multidrug resistance, persistence and strong pathogenicity. Here, we present a review of the TA systems described to date and their biological role in human pathogens belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) and others of clinical relevance (Escherichia coli, Burkholderia spp., Streptococcus spp. and Mycobacterium tuberculosis). Better understanding of the mechanisms of action of TA systems will enable the development of new lines of treatment for infections caused by the above-mentioned pathogens.
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