期刊
TOXINS
卷 8, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/toxins8050152
关键词
vacuolating cytotoxin (VacA); receptors; receptor-like protein tyrosine phosphatase (RPTP); RPTP; low-density lipoprotein receptor-related protein-1 (LRP1)
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Science and Technology Agency
- Institute of Tropical Medicine, Nagasaki University
- National Institutes of Health, National Heart, Lung, and Blood Institute
Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration. The C-terminal domain of VacA plays a crucial role in receptor recognition on target cells. We have previously identified three proteins (i.e., RPTP, RPTP, and LRP1) that serve as VacA receptors. These receptors contribute to the internalization of VacA into epithelial cells, activate signal transduction pathways, and contribute to cell death and gastric ulceration. In addition, other factors (e.g., CD18, sphingomyelin) have also been identified as cell-surface, VacA-binding proteins. Since we believe that, following interactions with its host cell receptors, VacA participates in events leading to disease, a better understanding of the cellular function of VacA receptors may provide valuable information regarding the mechanisms underlying the pleiotropic actions of VacA and the pathogenesis of H. pylori-mediated disease. In this review, we focus on VacA receptors and their role in events leading to cell damage.
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