期刊
AUTOIMMUNITY REVIEWS
卷 22, 期 12, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.autrev.2023.103465
关键词
Neuromyelitis optica spectrum disorder; AQP4-IgG; Optic neuritis; Myelitis; Pathogenesis; Prognosis
类别
This article reviews the evolution of our understanding of NMOSD, including its pathogenesis, clinical features, disease course, treatment options, and associated symptoms. The article also addresses the gaps in current knowledge and areas for future research focus.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most cases are characterised by aquaporin-4antibody positivity and have a relapsing disease course, which is associated with accrual of disability. Although the prognosis in NMOSD has improved markedly over the past few years owing to advances in diagnosis and therapeutics, it remains a severe disease. In this article, we review the evolution of our understanding of NMOSD, its pathogenesis, clinical features, disease course, treatment options and associated symptoms. We also address the gaps in knowledge and areas for future research focus.
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