Occipital atrophy signature in prodromal Lewy bodies disease

Article Neurosciences

MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies

Anna Inguanzo et al.

Summary: Using MRI data, we identified three subtypes of Dementia with Lewy bodies (DLB): older subtype with reduced cortical GM volumes and worse cognition, subtype with low GM volumes in fronto-occipital regions, and a younger subtype with the highest cortical GM volumes, lower GM volumes in basal ganglia, and cognitive fluctuations. These subtypes have implications for clinical practice, research, and treatment decisions.

NPJ PARKINSONS DISEASE (2023)

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Review Clinical Neurology

Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta-analysis

Paul C. Donaghy et al.

Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.

ALZHEIMERS & DEMENTIA (2023)

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Article Clinical Neurology

Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration

Kejal Kantarci et al.

Summary: This study found that prodromal dementia with Lewy bodies is characterized by atrophy in the nucleus basalis of Meynert. Longitudinally, grey matter atrophy progresses in regions with significant cholinergic innervation, with accelerated rates of atrophy in patients who progress to dementia with Lewy bodies.

BRAIN COMMUNICATIONS (2022)

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Article Psychology, Clinical

Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer's disease

Julia Schumacher et al.

Summary: Cholinergic deficits are common in AD and LBD, with the NBM being a major source of cortical cholinergic input. Functional connectivity analysis in LBD patients revealed an imbalance between the NBM and occipital cortex, suggesting alterations in the corticopetal cholinergic system beyond structural changes.

INTERNATIONAL PSYCHOGERIATRICS (2021)

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Article Clinical Neurology

Hippocampal and insula volume in mild cognitive impairment with Lewy bodies

Michael J. Firbank et al.

Summary: The study found that hippocampal or insula volume cannot be used to identify prodromal dementia with Lewy bodies, as these volumes were significantly reduced in both MCI-AD and MCI-LB patients, but did not differ between the two conditions.

PARKINSONISM & RELATED DISORDERS (2021)

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Review Clinical Neurology