4.8 Article

Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Automated Generation of hiPSC-Derived Hepatic Progeny by Cost-Efficient Compounds

Gert Vanmarcke et al.

Summary: By using an automated liquid handling system, highly reproducible hepatocyte-like cell (HLC) differentiation from human pluripotent stem cells (hPSCs) is achieved, reducing the cost of the differentiation process and the use of expensive growth factors. Additionally, an optimized small molecule combination and recombinant extracellular matrices can generate HLCs with similar functionality and drug toxicity susceptibility as HLCs generated with growth factor cocktails. This scalable and cost-efficient hPSC-derived HLC culture can be utilized for high throughput disease modeling, drug screenings, and regenerative therapies.

STEM CELLS (2023)

Article Cell Biology

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling

Sushama Sivakumar et al.

Summary: Aneuploidy, defective differentiation, and inactivation of TP53 are common during tumorigenesis. In this study, TP53 was inactivated in hESCs to explore the links between these cancer traits. TP53-/- hESCs showed increased proliferation rates, mitotic errors, and low-grade structural aneuploidy. They also produced poorly differentiated immature teratomas in mice and failed to differentiate into NPCs in vitro. Genome-wide CRISPR screen revealed the importance of ciliogenesis and Shh pathways in hESC differentiation into NPCs. TP53 deletion resulted in abnormal ciliogenesis in neural rosettes. TP53 transcriptionally activated BBS9, which is required for proper Shh signaling and NPC formation. This developmentally regulated transcriptional program of TP53 promotes ciliogenesis, restrains Shh signaling, and commits hESCs to neural lineages.

CELL REPORTS (2022)

Review Neurosciences

From Cell States to Cell Fates: How Cell Proliferation and Neuronal Differentiation Are Coordinated During Embryonic Development

Carla Belmonte-Mateos et al.

Summary: The central nervous system exhibits a wide diversity of neurons with specific cell types and proportions in the appropriate locations. The coordination of proliferation and differentiation is crucial for generating brains with specific size and cell composition. Understanding how cell diversity arises from pluripotent progenitor cells and how progenitor potential changes over time is an important focus in developmental neurobiology.

FRONTIERS IN NEUROSCIENCE (2022)

Article Cell Biology

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Jonathan De Smedt et al.

Summary: The lack of an effective in vitro model for liver sinusoidal endothelial cells (LSECs) led to the development of a computational tool called CenTFinder to identify key transcription factors involved in LSEC fate determination. Through this tool, PU.1 was identified as a master regulator for LSEC differentiation, and its overexpression, in combination with ETV2, induced LSEC-like phenotypes in human pluripotent stem cells. This study highlights the importance of PU.1 in driving LSEC-specific immune functions and the successful generation of functional LSEC-like endothelial cells through transcription factor manipulation.

CELL DEATH & DISEASE (2021)

Article Biophysics

Differentiation of induced pluripotent stem cells to hepatocyte-like cells on cellulose nanofibril substrate

M. R. Poorna et al.

Summary: The study demonstrated that cellulose nanofibril gel can efficiently differentiate human induced pluripotent stem cells into hepatocyte-like cells. The differentiated HLCs from both CNF and matrigel substrates expressed specific hepatocyte markers and exhibited functional maturity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Cell Biology

An Efficient Method for the Differentiation of Human iPSC-Derived Endoderm toward Enterocytes and Hepatocytes

Shimeng Qiu et al.

Summary: An efficient differentiation method has been developed to induce endoderm formation from human iPSCs, resulting in the generation of differentiated HiEnts and HiHeps with pharmacokinetic functions, which could be valuable for drug development.
Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells

Hubert M. Taieb et al.

Summary: Biophysical cues such as osmotic pressure can modulate the proliferation and growth arrest of cells, with different effects on nuclear growth, cell cycle, migration, and protein expression. These effects vary depending on the level of osmotic stress, and are reversible under mild stress.

SCIENTIFIC REPORTS (2021)

Review Anesthesiology

An overview of management of intracranial hypertension in the intensive care unit

Theodoros Schizodimos et al.

JOURNAL OF ANESTHESIA (2020)

Article Multidisciplinary Sciences

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Ruben Boon et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch

Kotaro Fujimaki et al.

PHYSIOLOGICAL GENOMICS (2020)

Review Gastroenterology & Hepatology

Spatial heterogeneity in the mammalian liver

Shani Ben-Moshe et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Cell & Tissue Engineering

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes

Mihaela Zabulica et al.

STEM CELLS AND DEVELOPMENT (2019)

Article Biochemistry & Molecular Biology

Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

Chien-Hsiang Hsu et al.

Article Gastroenterology & Hepatology

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

Seon Ju Mun et al.

JOURNAL OF HEPATOLOGY (2019)

Article Multidisciplinary Sciences

Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch

Kotaro Fujimaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

Heonjong Han et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation

Claudia M. Nicolae et al.

ONCOGENE (2018)

Article Cell Biology

A quantitative FastFUCCI assay defines cell cycle dynamics at a single-cell level

Siang-Boon Koh et al.

JOURNAL OF CELL SCIENCE (2017)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Genetics & Heredity

Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus

Anchel De Jaime-Soguero et al.

PLOS GENETICS (2017)

Article Gastroenterology & Hepatology

Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes

Thomas Touboul et al.

JOURNAL OF HEPATOLOGY (2016)

Article Multidisciplinary Sciences

Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation

Deguang Yang et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Direct and Osmolarity-Dependent Effects of Glycine on Preimplantation Bovine Embryos

Jason R. Herrick et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

P21 Deficiency Delays Regeneration of Skeletal Muscular Tissue

Nobuaki Chinzei et al.

PLOS ONE (2015)

Article Cell & Tissue Engineering

Substrate Stiffness and Composition Specifically Direct Differentiation of Induced Pluripotent Stem Cells

Laura Macri-Pellizzeri et al.

TISSUE ENGINEERING PART A (2015)

Article Cell Biology

Global discovery of high-NaCl-induced changes of protein phosphorylation

Rong Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Review Biochemistry & Molecular Biology

Neurogenesis during development of the vertebrate central nervous system

Judith T. M. L. Paridaen et al.

EMBO REPORTS (2014)

Article Multidisciplinary Sciences

Geriatric muscle stem cells switch reversible quiescence into senescence

Pedro Sousa-Victor et al.

NATURE (2014)

Article Multidisciplinary Sciences

Long-Term Quiescent Fibroblast Cells Transit into Senescence

Shiva Marthandan et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states

K. Wesley Overton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Endocrinology & Metabolism

Hyperglycemia Slows Embryonic Growth and Suppresses Cell Cycle via Cyclin D1 and p21

Devon E. Scott-Drechsel et al.

DIABETES (2013)

Review Urology & Nephrology

Osmosensory Mechanisms in Cellular and Systemic Volume Regulation

Stine Falsig Pedersen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Gastroenterology & Hepatology

Highly Efficient Generation of Human Hepatocyte-Like Cells from Induced Pluripotent Stem Cells

Karim Si-Tayeb et al.

HEPATOLOGY (2010)

Article Multidisciplinary Sciences

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

Christophe Fuerer et al.

PLOS ONE (2010)

Review Cell Biology

Emerging links between CDK cell cycle regulators and Wnt signaling

Gary Davidson et al.

TRENDS IN CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Connecting Variability in Global Transcription Rate to Mitochondrial Variability

Ricardo Pires das Neves et al.

PLOS BIOLOGY (2010)

Review Endocrinology & Metabolism

Brx, a link between osmotic stress, inflammation and organ physiology/pathophysiology

Tomoshige Kino et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2010)

Article Ophthalmology

NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells

Joon H. Lee et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

Review Physiology

Cellular response to hyperosmotic stresses

Maurice B. Burg et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Cell & Tissue Engineering

Enhancement of NF-κB expression and activity upon differentiation of human embryonic stem cell line SNUhES3

Ho-Bum Kang et al.

STEM CELLS AND DEVELOPMENT (2007)

Article Urology & Nephrology

Wnt/β-catenin signaling modulates survival of high glucose-stressed mesangial cells

Chun-Liang Lin et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

Article Oncology

Enhanced G2-M arrest by nuclear factor-κB-Dependent p21waf1/cip1 induction

SM Wuerzberger-Davis et al.

MOLECULAR CANCER RESEARCH (2005)

Article Multidisciplinary Sciences

NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment

WY Go et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Physiology

MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals

D Sheikh-Hamad et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor

JC Stroud et al.

NATURE STRUCTURAL BIOLOGY (2002)

Article Endocrinology & Metabolism

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death

F Fiordaliso et al.

DIABETES (2001)

Article Multidisciplinary Sciences

Hyperosmolality in the form of elevated NaCl but not urea causes DNA damage in murine kidney cells

D Kültz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)