☆ 4.2 Review

Potential therapies targeting nuclear metabolic regulation in cancer

MEDCOMM (2023)

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Article Biochemistry & Molecular Biology

Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer

Yanjie Chen et al.

Summary: LRRC8A is upregulated in cervical cancer and associated with poor prognosis. It maintains cell survivals under hypotonic condition and promotes tumorigenesis through apoptosis suppression. NSUN2-mediated m(5)C modification upregulates LRRC8A expression, and loss of NSUN2 suppresses the proliferation and metastasis of cervical cancer cells. The NSUN2-m(5)C-LRRC8A axis is crucial and could be a potential therapeutic target for cervical cancer.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2023)

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Article Oncology

Multicenter Phase II Clinical Trial of Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Patients With High-Grade Upper Tract Urothelial Carcinoma

Jonathan A. Coleman et al.

Summary: Neoadjuvant chemotherapy with split-dose GC has positive effects on pathologic response and favorable survival outcomes for patients with high-risk UTUC.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Gastroenterology & Hepatology

Methionine deficiency facilitates antitumour immunity by altering m6A methylation of immune checkpoint transcripts

Ting Li et al.

Summary: Methionine and YTHDF1 play a critical role in anticancer immunity through regulating the functions of T cells. Targeting methionine metabolism or YTHDF1 could be a potential new strategy for cancer immunotherapy.

GUT (2023)

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Review Pharmacology & Pharmacy

LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials

Beatrice Noce et al.

Summary: Histone lysine-specific demethylase 1 (LSD1/KDM1A) is an epigenetic enzyme that demethylates specific lysine residues of histone H3. Its overexpression is associated with various cancers and leads to cellular-level effects such as differentiation block and increased proliferation, migration, and invasiveness. There are covalent and non-covalent LSD1 inhibitors, some of which are currently in clinical trials for cancer treatment. This review summarizes the structure and functions of LSD1, its pathological implications, and the development of LSD1 inhibitors as potential anticancer agents.

FRONTIERS IN PHARMACOLOGY (2023)

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Article Oncology

Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells

Xueran Chen et al.

Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.

NEURO-ONCOLOGY (2023)

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Article Cell Biology

Nuclear SPHK2/S1P induces oxidative stress and NLRP3 inflammasome activation via promoting p53 acetylation in lipopolysaccharide-induced acute lung injury

Linjing Gong et al.

Cell Death Discovery (2023)

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Review Oncology

GSK-J4: An H3K27 histone demethylase inhibitor, as a potential anti-cancer agent

Nidhi Dalpatraj et al.

Summary: Aberrant epigenetic modifications are important drivers of tumor progression. The deregulation of H3K27me3 marks is involved in cancer progression. GSK-J4, a histone demethylase inhibitor, upregulates H3K27me3 levels and shows potential as an anti-cancer agent alone or in combination with other drugs. In this review, the anti-cancer properties of GSK-J4, targeted molecular pathways, in-vivo studies, and drug combination studies are summarized.

INTERNATIONAL JOURNAL OF CANCER (2023)

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Article Oncology

Pembrolizumab Plus Pemetrexed and Platinum in Nonsquamous Non-Small-Cell Lung Cancer: 5-Year Outcomes From the Phase 3 KEYNOTE-189 Study

Marina C. Garassino et al.

Summary: This study presents the 5-year outcomes of the KEYNOTE-189 study, which included previously untreated metastatic nonsquamous non-small-cell lung cancer patients. The results show that treatment with pembrolizumab plus pemetrexed-platinum significantly improves overall survival and progression-free survival compared to placebo plus pemetrexed-platinum. These data continue to support pembrolizumab plus pemetrexed-platinum as a standard of care for previously untreated metastatic non-small-cell lung cancer patients.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Biochemistry & Molecular Biology

Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification

Kanghui Liu et al.

Summary: Peritoneal metastasis (PM) is a significant mode of metastasis in gastric cancer (GC), associated with poor prognosis. However, the molecular mechanism of PM remains unclear. This study revealed that NSUN2, an RNA modifier, is upregulated in PM and patients with high NSUN2 expression have a worse prognosis. Mechanistically, NSUN2 regulates ORAI2 mRNA stability through m5C modification, promoting ORAI2 expression and resulting in peritoneal metastasis and colonization in GC.

ONCOGENE (2023)

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Review Biochemistry & Molecular Biology

N6-methyladenosine-mediated gene regulation and therapeutic implications

Yujiao Liu et al.

Summary: N6-methyladenosine (m6A) RNA methylation is the most common form of mRNA modification in eukaryotes, playing a crucial role in biological and biomedical research. This dynamic and reversible modification affects the fate of RNA molecules and is involved in various important biological processes. Dysregulation of m6A modification is linked to diseases, especially cancer. This review provides an overview of post-transcriptional and transcriptional regulatory mechanisms involving m6A modification and discusses its implications in disease development, as well as potential targets for therapeutics and diagnostics.

TRENDS IN MOLECULAR MEDICINE (2023)

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Editorial Material Cell Biology

Editorial: Tumor metabolism: From molecular mechanisms to clinical application

Chunming Cheng et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

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Article Biochemistry & Molecular Biology

PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription

Can Balaban et al.

Summary: In this study, Myosin Phosphatase Rho-Interacting Protein (MPRIP) was identified as a novel regulator of RNA polymerase II (RNAPII) transcription. MPRIP recruits Tyr1-phosphorylated CTD (Tyr1P-CTD) to nuclear PIP2-containing structures, affecting transcription and condensation. These findings shed light on the role of PIP2 in RNAPII transcription.

BIOMOLECULES (2023)

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Review Biochemistry & Molecular Biology

Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer

Weijing He et al.

Summary: Acetyl-CoA is an important molecule that participates in multiple intracellular metabolic reactions and affects protein post-translational modification, playing a key role in cell metabolism and epigenetic inheritance. In cancer, extensive lipid metabolism and histone acetylation are required for cancer cell growth and expression of cancer-promoting genes. Acetyl-CoA, as a raw material for lipid synthesis and histone acetylation, has a major impact on lipid metabolism and histone acetylation in cancer. Moreover, acetyl-CoA connects lipid metabolism with histone acetylation, forming a complex regulatory mechanism that influences cancer growth, proliferation, and metastasis.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2023)

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Article Oncology

mTOR inhibitor, gemcitabine and PD-L1 antibody blockade combination therapy suppresses pancreatic cancer progression via metabolic reprogramming and immune microenvironment remodeling in Trp53flox/+LSL-KrasG12D/+Pdx-1-Cre murine models

Jiangdong Qiu et al.

Summary: The combination of mTOR inhibitor sirolimus and gemcitabine can effectively inhibit tumor growth, alter the subpopulations of immune cells, and enhance the efficacy of anti-PD-L1 therapy in pancreatic cancer.

CANCER LETTERS (2023)

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Article Medicine, Research & Experimental

Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B

Na Sang et al.

Summary: In this study, it was found that LSD1 plays an important role in the development of hepatocellular carcinoma (HCC) and is associated with poor prognosis. ZY0511, a specific LSD1 inhibitor, can suppress HCC cell proliferation and tumor growth. Mechanistically, ZY0511 increases the expression of GADD45B by inducing H3K4 methylation, which is a novel target gene of LSD1. Combination therapy of ZY0511 and DTP3 effectively inhibits HCC cell proliferation.

MEDCOMM (2023)

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Article Medicine, Research & Experimental

Enhanced nuclear translation is associated with proliferation and progression across multiple cancers

Sailan Zou et al.

Summary: Recent advances in technology have sparked renewed interest in nuclear translation (NT), which remains poorly understood. However, researchers have now discovered that NT is enhanced in malignant cancer cells and is associated with rapid cell growth. This novel link between NT and malignancy suggests that cancer cells may utilize NT as a mechanism to support their need for rapid growth, opening up new possibilities for therapeutic targeting.

MEDCOMM (2023)

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Article Oncology

Risk stratification and adjuvant chemotherapy after radical resection based on the clinical risk scores of patients with stage IB-IIA non-small cell lung cancer

Wenyu Zhai et al.

Summary: In this study, a model for risk stratification and individualized application of adjuvant chemotherapy (ACT) was developed for patients with stage IB-IIA non-small cell lung cancer (NSCLC). The model predicted the prognosis of patients and identified those most suitable for receiving ACT. The study also found that ACT improved the outcome of patients with a high clinical risk score (CRS). Patients with non-squamous cell histology may benefit more from pemetrexed plus platinum, but those with EGFR-activating mutations are not suitable for ACT.

EJSO (2022)

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Article Biochemistry & Molecular Biology

Trichostatin A inhibits dendritic cell maturation through down-regulating NF-kappa B (p65) pathway

Ying Yu et al.

Summary: TSA inhibits the maturation of DCs by down-regulating NF-kappa B (p65) pathway, leading to inhibition of T cell proliferation and cytokine secretion.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Oncology

Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer

Yi Wang et al.

Summary: Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) or programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1)-based immune checkpoint inhibitors (ICIs) have shown significant improvements in overall survival of certain cancer patients, but resistance to immunotherapy remains a challenge. This article examines the metabolic modulation of tumor immunity and immune checkpoints in the tumor microenvironment (TME) and discusses potential metabolism-based therapeutic strategies. Understanding the link between tumor metabolism and immunotherapy is crucial for cancer treatment and research.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

Wen Li et al.

Summary: Aerobic glycolysis, also known as the Warburg effect, is a key characteristic of cancer cell metabolism. GAPDH, an important enzyme in glycolysis, is a potential therapeutic target for cancer treatment. PGG has been identified as a novel reversible inhibitor of GAPDH, suggesting potential for future therapeutic applications.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Biochemistry & Molecular Biology

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Jia Xiong et al.

Summary: The lactylation-driven METTL3-mediated RNA m(6)A modification plays an important role in promoting the immunosuppressive capacity of tumor-infiltrating myeloid cells (TIMs).

MOLECULAR CELL (2022)

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Article Multidisciplinary Sciences

DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development

Li He et al.

Summary: DNA methylation plays a crucial role in plant development and gene regulation, and is essential for multiple biological processes.

NATURE COMMUNICATIONS (2022)

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Article Genetics & Heredity

Recent Development of Prodrugs of Gemcitabine

Bhoomika Pandit et al.

Summary: Gemcitabine, widely used as an anticancer drug, has limitations such as enzymatic deamination, fast systemic clearance, and emerging chemoresistance. Recent developments in prodrug strategies and drug delivery methods aim to improve the pharmacokinetic properties and effectiveness of gemcitabine in treating cancerous tumors.

GENES (2022)

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Article Cell Biology

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer

Jie Xu et al.

Summary: This study identifies distinct m(5)C modification patterns in ovarian cancer patients, leading to metabolic heterogeneity, differences in chemotherapy sensitivity, and ultimately affecting overall survival.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Multidisciplinary Sciences

Active DNA demethylation promotes cell fate specification and the DNA damage response

Dongpeng Wang et al.

Summary: Neurons have high levels of single-strand DNA breaks, which may be caused by the excision of methylcytosines and can lead to DNA damage response and neuronal cell death.

SCIENCE (2022)

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Review Pharmacology & Pharmacy

The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications

Philippe Icard et al.

Summary: NSCLC is the main cause of cancer mortality and poses a significant challenge in cancer therapy. Resistance to anticancer drugs is promoted by hypoxia and HIF-1?? in tumor cells. Chemoresistance is also influenced by the activation of various oncogenic signaling pathways.

DRUG RESISTANCE UPDATES (2022)

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Article Cell Biology

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Geethu Emily Thomas et al.

Summary: The mitochondrial enzyme hexokinase 2 (HK2) localizes to the nucleus of leukaemic and normal haematopoietic stem cells, where it interacts with nuclear proteins to regulate chromatin accessibility. This nuclear localization and regulation are independent of the enzymatic activity of HK2. It influences stem cell properties, differentiation, and chemoresistance.

NATURE CELL BIOLOGY (2022)

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Article Oncology

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Hengyou Weng et al.

Summary: This study reveals the oncogenic role of IGF2BP2 and the critical role of m(6)A modification in AML. Inhibiting IGF2BP2 may be a promising therapeutic strategy for AML.

CANCER CELL (2022)

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Article Endocrinology & Metabolism

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth

Chunming Cheng et al.

Summary: In this study, researchers found that ammonia released from glutaminolysis activates SREBP-1 and promotes lipogenesis, thus supporting tumor growth. The study reveals the role of ammonia as a key activator in promoting lipid synthesis through dissociation of SCAP-Insig and activation of SREBP-1. It also demonstrates the critical role of SCAP as a sensor for glutamine, glucose, and sterol levels in precise control of lipid synthesis.

NATURE METABOLISM (2022)

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Article Oncology

Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Katelyn D. Miller et al.

Summary: ACSS2 is a crucial enzyme in cancer cells that helps them use acetate as an alternative nutrient source under stress. Inhibiting ACSS2 has been shown to effectively inhibit tumor growth.

CANCER RESEARCH (2021)

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Article Cell Biology

Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

Zongwei Li et al.

Summary: The study indicates that acetyl-CoA synthetase 2 (ACSS2) plays an important role in obesity-related myeloma progression, interacting with oncoprotein interferon regulatory factor 4 (IRF4) to enhance tumor growth. Overexpression of ACSS2 contributes to IRF4 stability and gene transcription, reducing myeloma growth in an obese mouse model.

CELL METABOLISM (2021)

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Review Cell Biology

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

Daqian Xu et al.

Summary: Key pathological signaling pathways regulate metabolic enzymes, giving them nonmetabolic functions. These aberrantly regulated metabolic enzymes play critical roles in governing cellular activities, promoting disease progression.

CELL METABOLISM (2021)

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Review Pharmacology & Pharmacy

Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

Chengcan Yang et al.

Summary: Folate-mediated one-carbon metabolism plays a vital role in cancer development, with folate-metabolizing enzymes SHMT2 and MTHFD2 being associated with the progression of cancers and showing potential for tumor-targeted therapy.

DRUG DISCOVERY TODAY (2021)

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Review Cell Biology

Metabolism of Amino Acids in Cancer

Zhen Wei et al.

Summary: Metabolic reprogramming involving amino acid metabolism is a recognized hallmark of malignancy, with potential therapeutic implications in targeting this pathway for cancer treatment. Amino acids play a crucial role in supporting survival and proliferation of cancer cells under various stress conditions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis

Mengzhu Zheng et al.

Summary: The novel selective HK2 inhibitor BNBZ was reported to directly bind to HK2, induce cancer cell apoptosis, and inhibit glycolysis of cancer cells. BNBZ significantly inhibited cancer cell proliferation in vitro and in vivo by targeting HK2 with high potency and low toxicity.

PHARMACOLOGICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

Youhua Liu et al.

Summary: This study revealed an important role of m(5)C modification in adipogenesis by controlling cell cycle progression, providing a potential therapeutic target for preventing obesity.

RNA BIOLOGY (2021)

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Review Oncology

Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets

Krzysztof Kotowski et al.

Summary: Glycolysis is a crucial metabolic process in rapidly proliferating cells, such as cancer cells, with PFK-1 being a key rate-limiting enzyme regulated primarily by F-2,6-BP. PFK-2/FBPase-2 is a bifunctional enzyme responsible for F-2,6-BP synthesis and degradation, and alterations in PFKFB isozymes play important roles in various diseases, particularly in cancer.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition

Jie Gao et al.

Summary: The PRMT5/Snail complex plays a crucial role in promoting invasion and metastasis of cervical cancer by targeting genes related to EMT, while the PRMT5 inhibitor EPZ015666 suppresses the invasion potential of cervical cancer cells by disinhibiting the expression of TET1 and increasing 5hmC levels, suggesting PRMT5 as a potential target for cancer therapy.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Cell Biology

A methionine-Mettl3-N-6-methyladenosine axis promotes polycystic kidney disease

Harini Ramalingam et al.

Summary: Mettl3 and m(6)A levels are increased in ADPKD, and Mettl3 deletion slows cyst growth, while methionine and SAM are associated with ADPKD development. Furthermore, Mettl3 activates cyst-promoting pathways in ADPKD through epitranscriptional modifications.

CELL METABOLISM (2021)

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Article Cell Biology

Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

Yi Liu et al.

Summary: Research has identified the m(6)A demethylase FTO as a key regulator in tumors, impacting immune surveillance through glycolytic metabolism regulation. Knockdown of FTO impairs tumor cell glycolytic activity, restores CD8(+) T cell function, and inhibits tumor growth. Additionally, the development of the small-molecule compound Dac51 can block FTO-mediated immune evasion and synergize with checkpoint blockade for improved tumor control.

CELL METABOLISM (2021)

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Review Chemistry, Multidisciplinary

A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications

Kiall F. Suazo et al.

Summary: This review discusses the attachment of hydrophobic groups to proteins through different chemical linkages, as well as the use of click chemistry in studying protein lipid modification. It also explores the various types of protein lipid modifications in biology, and the role of click chemistry in identifying lipid-modified proteins, studying their regulation, and their involvement in diseases. Additionally, the review covers the use of protein-lipid modifying enzymes for specific labeling applications.

CHEMICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The interplay between DNA and histone methylation: molecular mechanisms and disease implications

Yinglu Li et al.

Summary: Methylation of CpG dinucleotides and histone residues plays a crucial role in genome regulation; there is a strong correlation between DNA and histone methylation; complex molecular crosstalk exists between DNA and histone methylation.

EMBO REPORTS (2021)

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Article Multidisciplinary Sciences

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova et al.

Summary: The study identified a highly potent and selective catalytic inhibitor of METTL3, STM2457, which shows potential therapeutic value in treating AML. Treatment with this inhibitor leads to reduced AML growth, increased differentiation and apoptosis, and decreased m(6)A levels on leukemogenic mRNAs. In vivo pharmacological inhibition of METTL3 results in impaired engraftment and prolonged survival in mouse models of AML.

NATURE (2021)

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Article Cell Biology

HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes

Xin Lv et al.

Aging-US (2021)

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Article Oncology

Myristoylation-mediated phase separation of EZH2 compartmentalizes STAT3 to promote lung cancer growth

Jie Zhang et al.

Summary: The study demonstrated that myristoylation of EZH2 in lung cancer cells modulates liquid-liquid phase separation (LLPS) and activates the STAT3 signaling pathway, resulting in accelerated lung cancer cell growth. Targeting EZH2 myristoylation may have therapeutic efficacy in the treatment of lung cancer, providing a novel approach to induce or maintain LLPS.

CANCER LETTERS (2021)

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Article Biochemistry & Molecular Biology

Selective activation of PFKL suppresses the phagocytic oxidative burst

Neri Amara et al.

Summary: The study demonstrates that small-molecule LDC7559 and its potent analog NA-11 inhibit the NOX2-dependent oxidative burst in neutrophils by activating PFKL, reducing inflammation and tissue damage. This provides a potential tool for selectively activating PFKL, the main isoform expressed in immune cells.

CELL (2021)

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Review Biochemistry & Molecular Biology

Fructose and fructose kinase in cancer and other pathologies

Hongfei Jiang et al.

Summary: This study highlights the importance of fructose metabolism and fructose kinase in the development of metabolic disorders and cancer, emphasizing the protein kinase activity of KHKeA in tumor development. It also introduces different approaches to inhibit KHK and explores the use of KHK inhibitors in clinical treatment.

JOURNAL OF GENETICS AND GENOMICS (2021)

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Article Oncology

Stereotactic body radiotherapy plus pembrolizumab and trametinib versus stereotactic body radiotherapy plus gemcitabine for locally recurrent pancreatic cancer after surgical resection: an open-label, randomised, controlled, phase 2 trial

Xiaofei Zhu et al.

Summary: This study aimed to evaluate the efficacy of SBRT plus pembrolizumab and trametinib in patients with postoperative locally recurrent pancreatic cancer. Among 198 patients, the median overall survival was significantly longer in the SBRT plus pembrolizumab and trametinib group compared to the SBRT plus gemcitabine group. The most common adverse effects were mild to moderate in severity.

LANCET ONCOLOGY (2021)

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Article Oncology

Combination atezolizumab, bevacizumab, pemetrexed and carboplatin for metastatic EGFR mutated NSCLC after TKI failure

T. C. Lam et al.

Summary: This study confirmed the promising efficacy of the combination of atezolizumab, bevacizumab, pemetrexed, and carboplatin in EGFR mutated lung cancer after TKI failure. Treatment-related adverse events were common, but quality of life measures did not change significantly.

LUNG CANCER (2021)

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Article Biochemistry & Molecular Biology

NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

Jiachun Su et al.

Summary: The study found that increased m(5)C methylation in esophageal squamous cell carcinoma is related to overexpression of NSUN2, which is positively regulated by E2F1 and predicted poor survival. Silencing NSUN2 can suppress ESCC development, and the mechanism involves m(5)C-LIN28B dependent stabilization of GRB2 transcript to enhance the initiation and progression of ESCC.

ONCOGENE (2021)

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Review Genetics & Heredity

Navigating the DNA methylation landscape of cancer

Atsuya Nishiyama et al.

Summary: DNA methylation is a chemical modification that defines cell type and lineage through controlling gene expression and genome stability. Aberrant DNA methylation in cancer cells targets CpG islands in gene expression regulatory elements. Recent studies suggest that the classical model of DNA hypermethylation in cancer needs to be reevaluated.

TRENDS IN GENETICS (2021)

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Article Chemistry, Multidisciplinary

IDH Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma

Xiao Xiang et al.

Summary: Intrahepatic cholangiocarcinoma (ICC) exhibits high heterogeneity, with the IDH mutant subgroup associated with intratumor heterogeneity (ITH) and the tumor microenvironment (TME). IDH-like tumors may benefit from IDH targeted therapies, presenting important implications for diagnosis and treatment of ICC.

ADVANCED SCIENCE (2021)

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Article Medicine, Research & Experimental

Entinostat induces antitumor immune responses through immune editing of tumor neoantigens

Andrew S. Truong et al.

Summary: The study highlights the immunomodulatory effects of entinostat on tumor neoantigens, remodeling the tumor immune microenvironment, leading to a strong antitumor response with increased neoantigen-specific T cells. Combination treatment with entinostat and PD-1 blockade results in complete responses and long-term immune memory, providing a strong preclinical rationale.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Medicine, Research & Experimental

Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia

Xueliang Gao et al.

Summary: PFKP, the major isoform of PFK1 in T-ALL, functions as a nucleocytoplasmic shuttling protein with nuclear export and localization sequences. Nuclear PFKP promotes the expression of CXCR4 to facilitate T-ALL cell invasion, which can be blocked with CXCR4 antagonists. The presence of nuclear PFKP in T cell malignancy correlates with poor survival and suggests its potential as a diagnostic marker.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

Hao Wu et al.

Summary: Previous studies have shown that LDHA and LDHB can produce hydrogen peroxide, and this activity is enhanced by superoxide. Knockout of LDHA or LDHB significantly reduces hydrogen peroxide production in cancer cells, and re-expression of LDHA partially restores it. Additionally, tumors formed by LDHA or LDHB knockout cells exhibit a significantly less oxidative state compared to control cells.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Oncology

The language of chromatin modification in human cancers

Shuai Zhao et al.

Summary: The deregulation of chromatin modification underlies numerous oncogenic processes, contributing to cancer development by inducing epigenetic, transcriptomic, and phenotypic alterations. Understanding and developing more effective drugs to target these chromatin-related vulnerabilities will enhance the treatment of human malignancies. This review synthesizes the connections between chromatin modifications and cancer, highlighting options for therapeutic targeting based on recent advances.

NATURE REVIEWS CANCER (2021)

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Article Biotechnology & Applied Microbiology

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Jie Yu et al.

Summary: The study reveals that histone lactylation is increased in tumors, promoting tumorigenesis by facilitating YTHDF2 expression and degradation of m6A-modified PER1 and TP53 mRNA. This provides new therapeutic targets and insights into epigenetic regulation in tumorigenesis.

GENOME BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Qing Li et al.

Summary: YTHDF1 plays a key role in hepatocellular carcinoma, with its expression level correlated to hypoxia-induced autophagy, tumor growth, and metastasis, serving as an independent prognostic factor. HIF-1 alpha regulates YTHDF1 transcription under hypoxia to promote translation of autophagy-related genes, contributing to autophagy and malignancy in HCC progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Endocrinology & Metabolism

The ins and outs of serine and glycine metabolism in cancer

Shauni L. Geeraerts et al.

Summary: Cancer cells reprogram their metabolism to hyperactivate serine and glycine synthesis, relying on de novo production and genetic alterations to enhance their survival and proliferation. Serine and glycine synthesis play a crucial role in cancer progression, contributing to macromolecule synthesis, oxidative stress neutralization, and regulation of biological processes like methylation.

NATURE METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Cancer metabolism and intervention therapy

Huakan Zhao et al.

Summary: Metabolic reprogramming with heterogeneity is a key feature of cancer, enabling tumor cells to adapt to low nutrition and hypoxic microenvironments. By manipulating various metabolic pathways, cancer cells produce biomass for their material needs and generate ATP and antioxidants to survive stress conditions. The metabolic products of cancer cells also play a role in remodeling the tumor microenvironment to create an immunosuppressive milieu. Targeting metabolic pathways may offer new therapeutic strategies for cancer treatment.

MOLECULAR BIOMEDICINE (2021)

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Article Medicine, Research & Experimental

Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m(6)A signaling

Kaiju Sun et al.

Summary: The study revealed that SsD has broad anti-proliferation effects in AML by targeting FTO/m(6)A signaling pathway, increasing global m(6)A RNA methylation levels, and suppressing relevant pathways affecting AML cell proliferation.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

C-MET-dependent signal transduction mediates retinoblastoma growth by regulating PKM2 nuclear translocation

Hanjun Dai et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

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Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

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PHARMACOLOGY & THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

C. Martinez Calejman et al.

NATURE COMMUNICATIONS (2020)

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Editorial Material Biochemistry & Molecular Biology

Epigenetic Therapy for Epithelioid Sarcoma

Scott B. Rothbart et al.

CELL (2020)

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Correction Cell Biology

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis (vol 31, pg 174, 2020)

Peiwei Huangyang et al.

CELL METABOLISM (2020)

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Article Oncology

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su et al.

CANCER CELL (2020)

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Article Immunology

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

Luis Eduardo Alves Damasceno et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity

Lina Wang et al.

NATURE CHEMICAL BIOLOGY (2020)

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Article Multidisciplinary Sciences

ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Na Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Chemistry, Medicinal

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes

Yi-xiang Xu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Oncology

PhaseIIstudy of adjuvant chemotherapy with pemetrexed and cisplatin with a short hydration method for completely resected nonsquamous non-small cell lung cancer

Motoko Tachihara et al.

THORACIC CANCER (2020)

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Article Oncology

Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

Franck Morschhauser et al.

LANCET ONCOLOGY (2020)

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Article Oncology

Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy

Chia-Sing Lu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Biochemistry & Molecular Biology

Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma

Lifeng Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemistry & Molecular Biology

Redox Regulation of Hexokinases

Petr Heneberg

ANTIOXIDANTS & REDOX SIGNALING (2019)

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Article Oncology

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/l Deficiency Promotes Neuroendocrine Prostate Cancer

Miguel Reina-Campos et al.

CANCER CELL (2019)

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Article Oncology

EZH2 Inhibitor GSK126 Suppresses Antitumor Immunity by Driving Production of Myeloid-Derived Suppressor Cells

Shuo Huang et al.

CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4

Xiphias Ge Zhu et al.

MOLECULAR CELL (2019)

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Article Multidisciplinary Sciences

Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

Bogi Karbech Hansen et al.

NATURE COMMUNICATIONS (2019)

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Article Oncology

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

Andressa S. Laino et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang et al.

CANCER CELL (2019)

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Shikonin derivatives for cancer prevention and therapy

Joelle C. Boulos et al.

CANCER LETTERS (2019)

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Article Cell Biology

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

Shiming Peng et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Biochemistry & Molecular Biology

TET enzymes, DNA demethylation and pluripotency

Samuel E. Ross et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

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Article Biochemistry & Molecular Biology

Inositol phosphates and core subunits of the Sin3L/Rpd3L histone deacetylase (HDAC) complex up-regulate deacetylase activity

Ryan Dale Marcum et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Oncology

Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC

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JOURNAL OF THORACIC ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Xia Gao et al.

NATURE (2019)

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Article Cell Biology

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

Xin Chen et al.

NATURE CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

Nathanael H. Green et al.

ONCOGENE (2019)

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Article Multidisciplinary Sciences

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation

Richard T. Timms et al.

SCIENCE (2019)

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Article Multidisciplinary Sciences

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

Gang Cheng et al.

NATURE COMMUNICATIONS (2019)

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Editorial Material Hematology

Guadecitabine in myelodysplastic syndromes: promising but there is still progress to be made

Lionel Ades et al.

LANCET HAEMATOLOGY (2019)

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Review Biochemistry & Molecular Biology

Essential role of O-GlcNAcylation in stabilization of oncogenic factors

Vivek Makwana et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

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Article Multidisciplinary Sciences

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation

Jixiao Niu et al.

NATURE (2019)

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Article Oncology

Bladder Preservation With Twice-a-Day Radiation Plus Fluorouracil/Cisplatin or Once Daily Radiation Plus Gemcitabine for Muscle-Invasive Bladder Cancer: NRG/RTOG 0712A Randomized Phase II Trial

John J. Coen et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Pharmacology & Pharmacy

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

Ali F. Abdel-Wahab et al.

PHARMACOLOGICAL RESEARCH (2019)

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Article Medicine, Research & Experimental

Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma

Libin Yan et al.

THERANOSTICS (2019)

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Review Genetics & Heredity

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Frank Lyko

NATURE REVIEWS GENETICS (2018)

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Article Biochemistry & Molecular Biology

Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

V. L. Sodi et al.

ONCOGENE (2018)

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Article Hematology

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

Eytan M. Stein et al.

BLOOD (2018)

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Article Biochemistry & Molecular Biology

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

CELL (2018)

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Review Cell Biology

RNA N-6-methyladenosine modification in cancers: current status and perspectives

Xiaolan Deng et al.

CELL RESEARCH (2018)

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Review Chemistry, Multidisciplinary

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

Hong Jiang et al.

CHEMICAL REVIEWS (2018)

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Article Biochemistry & Molecular Biology

Detecting and interpreting DNA methylation marks

Ren Ren et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2018)

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Article Cell Biology

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling

Joyce V. Lee et al.

GENES & DEVELOPMENT (2018)

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Review Cell Biology

Phospholipids and inositol phosphates linked to the epigenome

Livia Ulicna et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2018)

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Review Biophysics

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle

John A. Hanover et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2018)

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Article Biochemistry & Molecular Biology

Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells

Touseef Sheikh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Review Oncology

Role of metabolism in cancer cell radioresistance and radiosensitization methods

Le Tang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Gastroenterology & Hepatology

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure

Rosa Ferriero et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Biochemistry & Molecular Biology

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

Jong-Ho Lee et al.

MOLECULAR CELL (2018)

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Article Genetics & Heredity

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Jingjing Chen et al.

NATURE GENETICS (2018)

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Review Cell Biology

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Xinjian Li et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

Sharanya Sivanand et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

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Article Plant Sciences

Cytosolic GAPDH as a redox-dependent regulator of energy metabolism

Markus Schneider et al.

BMC PLANT BIOLOGY (2018)

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Review Pharmacology & Pharmacy

Valproic acid as an adjunctive therapeutic agent for the treatment of breast cancer

Hayley Heers et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Article Multidisciplinary Sciences

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Subhamoy Dasgupta et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

Yuan Liu et al.

NATURE COMMUNICATIONS (2018)

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Review Oncology

Lipid metabolism reprogramming and its potential targets in cancer

Chunming Cheng et al.

CANCER COMMUNICATIONS (2018)

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Article Genetics & Heredity

Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae

Benjamin J. E. Martin et al.

GENETICS (2017)

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Review Oncology

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

Lu Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Biochemistry & Molecular Biology

A Metabolic Function for Phospholipid and Histone Methylation

Cunqi Ye et al.

MOLECULAR CELL (2017)

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Article Biochemistry & Molecular Biology

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Sharanya Sivanand et al.

MOLECULAR CELL (2017)

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Article Cell Biology

O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency

Ting Wang et al.

NATURE CELL BIOLOGY (2017)

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Review Genetics & Heredity

TET-mediated active DNA demethylation: mechanism, function and beyond

Xiaoji Wu et al.

NATURE REVIEWS GENETICS (2017)

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Review Cell Biology

Protein O-GlcNAcylation: emerging mechanisms and functions

Xiaoyong Yang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Article Multidisciplinary Sciences

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Jong-Ho Lee et al.

NATURE COMMUNICATIONS (2017)

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Article Multidisciplinary Sciences

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

Karthigayan Shanmugasundaram et al.

NATURE COMMUNICATIONS (2017)

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Article Genetics & Heredity

Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae

Benjamin J. E. Martin et al.

GENETICS (2017)

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Review Oncology

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

Lu Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Article Chemistry, Medicinal

Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2

Lin You et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

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Article Biochemistry & Molecular Biology

Blocking LDHA glycolytic pathway sensitizes glioblastoma cells to radiation and temozolomide

Michael Koukourakis et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Cell Biology

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Maria V. Liberti et al.

CELL METABOLISM (2017)

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Review Biochemistry & Molecular Biology

Protein arginine methylation: a prominent modification and its demethylation

Juste Wesche et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Article Biochemistry & Molecular Biology

Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism

Saveg Yadav et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2017)

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Article Biochemistry & Molecular Biology

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Mohammad S. Eram et al.

ACS CHEMICAL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine

Lili Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Developmental Biology

Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions

James A. Browne et al.

MOLECULAR HUMAN REPRODUCTION (2016)

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Article Biochemistry & Molecular Biology

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor

Shun Matsuda et al.

NUCLEIC ACIDS RESEARCH (2016)

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Article Cell Biology

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

Shawn M. Davidson et al.

CELL METABOLISM (2016)

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Review Biochemistry & Molecular Biology

Nutrient regulation of gene expression by O-GlcNAcylation of chromatin

Stephan Hardiville et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2016)

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Review Biochemistry & Molecular Biology

O-GIcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Christina M. Ferrer et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Oliver D. K. Maddocks et al.

MOLECULAR CELL (2016)

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Article Multidisciplinary Sciences

Tumour hypoxia causes DNA hyper-methylation by reducing TET activity

Bernard Thienpont et al.

NATURE (2016)

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Review Biochemistry & Molecular Biology

Fatty acylation of proteins: The long and the short of it

Marilyn D. Resh

PROGRESS IN LIPID RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Cameron L. Noland et al.

STRUCTURE (2016)

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Review Oncology

Metabolic control of epigenetics in cancer

Adam Kinnaird et al.

NATURE REVIEWS CANCER (2016)

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Review Medicine, General & Internal

Development of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in China

Xianping Lu et al.

INTRACTABLE & RARE DISEASES RESEARCH (2016)

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Article Oncology

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

Chunming Cheng et al.

CANCER CELL (2015)

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Review Oncology

O-GlcNAc signaling in cancer metabolism and epigenetics

Jay Prakash Singh et al.

CANCER LETTERS (2015)

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Article Cell Biology

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Samantha J. Mentch et al.

CELL METABOLISM (2015)

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Review Cell Biology

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Carles Canto et al.

CELL METABOLISM (2015)

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Article Oncology

Panobinostat for the Treatment of Multiple Myeloma

Jacob P. Laubach et al.

CLINICAL CANCER RESEARCH (2015)

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Article Cell Biology

Hexosamine pathway and (ER) protein quality control

Martin S. Denzel et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

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Article Chemistry, Multidisciplinary

Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity

Toshifumi Takeuchi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

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Article Biochemistry & Molecular Biology

AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation

Chunmei Chang et al.

MOLECULAR CELL (2015)

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Article Cell Biology

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

Yuhui Jiang et al.

NATURE CELL BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

David Peralta et al.

NATURE CHEMICAL BIOLOGY (2015)

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Article Multidisciplinary Sciences

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation

Wenjuan Li et al.

PLOS ONE (2015)

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Article Biochemical Research Methods

An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events in Arabidopsis thaliana

A. Saskia Venne et al.

PROTEOMICS (2015)

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Article Multidisciplinary Sciences

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Jihye Yun et al.

SCIENCE (2015)

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Article Cell Biology

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

Timothy H. Witney et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Oncology

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

Jason Chesney et al.

ONCOTARGET (2015)

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Review Biotechnology & Applied Microbiology

Glucose repression in Saccharomyces cerevisiae

Omur Kayikci et al.

FEMS YEAST RESEARCH (2015)

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Correction Biochemistry & Molecular Biology

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis (vol 150, pg 685, 2012)

Weiwei Yang et al.

CELL (2014)

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Article Cell Biology

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

Joyce V. Lee et al.

CELL METABOLISM (2014)

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Review Biochemistry & Molecular Biology

Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer

Moonmoon Deb et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

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Article Biochemistry & Molecular Biology

Cross-talk between Two Essential Nutrient-sensitive Enzymes O-GlcNAc TRANSFERASE ( OGT) AND AMP-ACTIVATED PROTEIN KINASE ( AMPK)

John W. Bullen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Biochemistry & Molecular Biology

PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells

Yuhui Jiang et al.

MOLECULAR CELL (2014)

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Article Biochemistry & Molecular Biology

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

Christina M. Ferrer et al.

MOLECULAR CELL (2014)

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Article Multidisciplinary Sciences

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Bo Li et al.

NATURE (2014)

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Review Cell Biology

Histone core modifications regulating nucleosome structure and dynamics

Peter Tessarz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

AMPK regulates histone H2B O-GlcNAcylation

Qiuran Xu et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Multidisciplinary Sciences

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism

Hung-Jung Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

O-GlcNAcylation regulates EZH2 protein stability and function

Chi-Shuen Chu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Chemistry, Medicinal

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

Kyle R. Brimacombe et al.

ACS MEDICINAL CHEMISTRY LETTERS (2014)

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Review Plant Sciences

The role of lipid post-translational modification in plant developmental processes

Mark P. Running

FRONTIERS IN PLANT SCIENCE (2014)

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Article Oncology

[18F]FDG and [18F]FLT positron emission tomography imaging following treatment with belinostat in human ovary cancer xenografts in mice

Mette Munk Jensen et al.

BMC CANCER (2013)

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Article Oncology

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

Chenfang Dong et al.

CANCER CELL (2013)

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Article Oncology

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

Eunhee Kim et al.

CANCER CELL (2013)

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Review Cell Biology

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

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