期刊
OCULAR IMMUNOLOGY AND INFLAMMATION
卷 -, 期 -, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2023.2282610
关键词
Autoinflammation; cytokine; inflammasome; inflammation; uveitis
This review examines the clinical features of monogenic autoinflammatory syndromes (MAISs), with a special focus on uveitis. It evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.
Monogenic autoinflammatory syndromes (MAISs), are caused by pathogenic genetic variants in the innate immune system, leading to dysregulation and aberrant inflammasome activation spontaneously or with minimal triggering. The diagnosis and treatment of MAISs can be intricate, relying on an increased recognition of potential differential diagnoses. This review examines the clinical features of MAIS, with a special focus on uveitis. It also evaluates treatment options and assesses the effects of activating molecular and cytokine pathways.
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