期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 5, 期 3, 页码 325-330出版社
WILEY
DOI: 10.5966/sctm.2015-0152
关键词
Organoids; Liver; Adult stem cell culture; Applications
Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, disease modeling, drug testing, and transplantation. In this review, we summarize the applications of liver-derived organoids and discuss their potential. It is likely that organoids will provide an invaluable tool to unravel disease mechanisms, design novel (personalized) treatment strategies, and generate autologous stem cells for gene editing and transplantation purposes.
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