期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 6, 期 1, 页码 293-305出版社
WILEY
DOI: 10.5966/sctm.2016-0081
关键词
Alzheimer's disease; Protein-iPSC; 5XFAD mice; Proteomic analysis; Oligodendrocyte
资金
- NRF [2015R1A2A1A05001794, 2014M3C7A1046047, 2015M3C7A1028790, 2015M3A9B4051041]
- MRC [2012R1A5A2A44671346]
- Innovative Research Institute for Cell Therapy [A062260]
- KHIDI [HI14C1541, HI14C1277]
- Korea Health Promotion Institute [HI06C0874030015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2011-0030738, 2015M3C7A1028790, 2015M3A9B4051041] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Transplantation of stem cells into the brain attenuates functional deficits in the central nervous system via cell replacement, the release of specific neurotransmitters, and the production of neurotrophic factors. To identify patient-specific and safe stem cells for treating Alzheimer's disease (AD), we generated induced pluripotent stem cells (iPSCs) derived from mouse skin fibroblasts by treating protein extracts of embryonic stem cells. These reprogrammed cells were pluripotent but nontumorigenic. Here, we report that protein-iPSCs differentiated into glial cells and decreased plaque depositions in the 5XFAD transgenic AD mouse model. We also found that transplanted protein-iPSCs mitigated the cognitive dysfunction observed in these mice. Proteomic analysis revealed that oligodendrocyte-related genes were upregulated in brains injected with protein-iPSCs, providing new insights into the potential function of protein-iPSCs. Taken together, our data indicate that protein-iPSCs might be a promising therapeutic approach for AD.
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