期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 6, 期 1, 页码 316-329出版社
WILEY
DOI: 10.5966/sctm.2016-0087
关键词
Mesenchymal stem cells; Magnetic resonance imaging; Stem cell therapy; Proton magnetic resonance spectroscopy; Traumatic brain injury
资金
- Defence Research and Development Organization, Ministry of Defence, Government of India [INM-311, 4.1]
- Council of Medical Research
Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-indicator of the recovery mechanism. This study used in vivo magnetic resonance imaging and1H-MRSto evaluate the therapeutic prospects of implanted MSCsat injury site in experimental mice longitudinally up to 21 days. Negative tissue contrast and cytotoxic edema formation were observed in susceptibility-based contrast (T2*) and an apparent diffusion coefficient map, respectively. Lesion site showed decreased N-acetylaspartate, total choline, myo-inositol, total creatine, glutamate-glutamine complex, and taurine neurometabolic concentrations by 1H-MRS investigation. There was a considerable decrease in locomotor activity, depression index, and cognitive index after TBI. It may, therefore, be inferred that MSC transplantation prompted recovery by decreasing negative signals and edema, restoring metabolites to baseline concentrations, and enhancing behavioral activity. Overall findings support the potential of MSC transplantation for the enhancement of endogenous neuroprotective responses, which may provide future clinical applications for translating laboratory research into therapeutic clinical advances.
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