4.7 Article

Assessment of intestinal status in MPLW515L mutant myeloproliferative neoplasms mice model

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation

Jian Zhang et al.

Summary: This study reveals an unexpected function of GSDMD in goblet cell mucin secretion and mucus layer formation. The secretion of mucus and the formation of the mucus layer, driven by GSDMD, maintain gut mucosal homeostasis. The nonpyroptotic role of GSDMD is crucial for efficient clearance of enteric pathogens.

SCIENCE IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation

Jong Hoon Won et al.

Summary: This study reveals that the matricellular protein CCN1 is a niche factor for intestinal stem cells, regulating their proliferation and differentiation through integrin signaling. CCN1 interacts with integrins alpha(v)beta(3)/alpha(v)beta(5) to activate distinct downstream pathways, leading to Notch activation for differentiation via NF-kappaB and Wnt signaling control for proliferation via Src-mediated YAP activation and Dkk1 expression. Moreover, CCN1 and YAP amplify each other's activities in a regulatory loop.

NATURE COMMUNICATIONS (2022)

Article Microbiology

Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State

Andrew Oliver et al.

Summary: This study found significant differences in the gut microbiome between MPN patients and non-MPN controls, suggesting that specific microbial species may play a role in the chronic inflammation associated with MPNs.

MICROBIOLOGY SPECTRUM (2022)

Article Immunology

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization

Aline Ignacio et al.

Summary: This study reveals the important role of intestinal eosinophils in the mutualistic interactions between the host and microbiota. Eosinophil-deficient mice showed various abnormalities including villus blunting, altered extracellular matrix, decreased epithelial cell turnover, increased gastrointestinal motility, and decreased lipid absorption.

IMMUNITY (2022)

Article Oncology

An Abnormal Host/Microbiomes Signature of Plasma-Derived Extracellular Vesicles Is Associated to Polycythemia Vera

Monica Barone et al.

Summary: Patients with Polycythemia Vera (PV) have a lower proportion of circulating megakaryocyte-derived extracellular vesicles (EVs) and a higher proportion of platelet-derived EVs. The microbial DNA signature of EVs in PV patients differs from that of healthy counterparts, with higher diversity and distinct microbial composition. Elevated levels of lipopolysaccharide-associated EVs are observed in PV patients.

FRONTIERS IN ONCOLOGY (2021)

Article Multidisciplinary Sciences

Desulfovibrio is not always associated with adverse health effects in the Guangdong Gut Microbiome Project

Yi-ran Chen et al.

Summary: Desulfovibrio (DSV) is commonly found in the human intestine and may be associated with host health, positively correlated with beneficial genera and negatively associated with harmful genera. The relative abundance of DSV is also negatively correlated with body indicators such as BMI, waist size, and blood lipid levels.
Article Hematology

Combination of Mesenchymal Stem Cell and Endothelial Progenitor Cell Infusion Accelerates Injured Intestinal Repair by Regulating Gut Microbiota after Hematopoietic Cell Transplantation

Shengyun Zhu et al.

Summary: The combined therapy with MSC and EPC was shown to improve blood capillary distribution, enhance occludin expression in the small intestinal tract, promote intestinal epithelial cell proliferation, and stabilize gut microbial community by regulating the intestinal microenvironment.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Article Immunology

Assessment of oral ciprofloxacin impaired gut barrier integrity on gut bacteria in mice

Shengyun Zhu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

Hui Yu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Oncology

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo

Brittany Woods et al.

CLINICAL CANCER RESEARCH (2019)

Article Multidisciplinary Sciences

T cell-mediated regulation of the microbiota protects against obesity

Charisse Petersen et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Lactose drives Enterococcus expansion to promote graft-versus-host disease

C. K. Stein-Thoeringer et al.

SCIENCE (2019)

Article Clinical Neurology

A probiotic modulates the microbiome and immunity in multiple sclerosis

Stephanie K. Tankou et al.

ANNALS OF NEUROLOGY (2018)

Article Immunology

Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 Tcells

Natasja A. M. Kragten et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

Qiang Jeremy Wen et al.

NATURE MEDICINE (2015)

Review Veterinary Sciences

Regulation of the Intestinal Barrier Function by Host Defense Peptides

Kelsy Robinson et al.

FRONTIERS IN VETERINARY SCIENCE (2015)

Article Gastroenterology & Hepatology

Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis

Xiu-Qing Wei et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Hematology

MPL W515L/K Mutations in Chronic Myeloproliferative Neoplasms

Timur Selcuk Akpinar et al.

TURKISH JOURNAL OF HEMATOLOGY (2013)