期刊
STEM CELLS TRANSLATIONAL MEDICINE
卷 5, 期 5, 页码 683-693出版社
ALPHAMED PRESS
DOI: 10.5966/sctm.2015-0231
关键词
Mesenchymal stem cell; Tissue-specific stem cells; Stem cell transplantation; Osteoporosis; Sca-1
资金
- Canadian Institute of Heath Research, Training Program in Regenerative Medicine
- Canadian Institutes of Health Research Grant [FRN 62788]
- Natural Sciences and Engineering Research Council of Canada Grant [RGPIN 293170-11]
- Canada Research Chair in Integrative Stem Cell Biology
Age-related osteoporosis is driven by defects in the tissue-resident mesenchymal stromal cells (MSCs), a heterogeneous population of musculoskeletal progenitors that includes skeletal stem cells. MSC decline leads to reduced bone formation, causing loss of bone volume and the breakdown of bony microarchitecture crucial to trabecular strength. Furthermore, the low-turnover state precipitated by MSC loss leads to low-quality bone that is unable to perform remodeling-mediated maintenance replacing old damaged bone with new healthy tissue. Using minimally expanded exogenous MSCs injected systemically into a mouse model of human age-related osteoporosis, we show long-term engraftment and markedly increased bone formation. This led to improved bone quality and turnover and, importantly, sustained microarchitectural competence. These data establish proof of concept that MSC transplantation may be used to prevent or treat human age-related osteoporosis.
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