期刊
JOURNAL OF HOSPITAL INFECTION
卷 142, 期 -, 页码 88-95出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2023.09.017
关键词
Bacteraemia; Cephalosporin; Escherichia coli; Extended-spectrum beta; lactamase; Quinolone; Urinary catheter
This review evaluated 10 observational studies and found that previous antibiotic therapy, especially with cephalosporins and quinolones, as well as urinary catheter use, were predictive factors for ESBL-producing E. coli-induced bacteraemia.
Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bacteraemia can induce unfavourable clinical outcomes due to delay in appropriate antimicrobial treatment and limited therapeutic options. Therefore, elucidating the predictors of ESBLproducing E. coli-induced bacteraemia is crucial to improve clinical outcomes. However, a literature search did not reveal any studies that incorporate a meta-analysis of the predictors of ESBL-producing E. coli-induced bacteraemia. As such, this review was undertaken to assess current evidence on the predictors of ESBL-producing E. coli-induced bacteraemia. PubMed, Web of Science and Cochrane Library databases were searched for all relevant publications from January 2000 to September 2021. This systematic review evaluated 10 observational studies, comprising a total of 2325 patients with E. coliinduced bacteraemia and 850 (36.6%) ESBL-producing strains. In the meta-analysis, previous antibiotic therapy [pooled risk ratio (RR) 2.72; P<0.001], especially with cephalosporins (pooled RR 4.66; P<0.001) and quinolones (pooled RR 5.47; P<0.001), and urinary catheter use (pooled RR 3.79; P<0.001) were predictive of ESBL-producing E. coliinduced bacteraemia. Antibiotic therapy for patients with the above-mentioned risk factors should be selected considering the possibility of ESBL-producing E. coli-induced bacteraemia compared with non-ESBL-producing E. coli-induced bacteraemia. It is important to elucidate whether appropriate modulation of the identified risk factors can potentially mitigate the risk of ESBL-producing E. coli-induced bacteraemia compared with non-ESBL-producing E. coli-induced bacteraemia.(c) 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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