Administrative coding of frailty: Its association with clinical outcomes and resource use in kidney transplantation

IntroductionAlthough not formalized into current risk assessment models, frailty has been associated with negative postoperative outcomes in many specialties. However, national analyses of the association between frailty and post-transplant outcomes following kidney transplantation (KT) are lacking.MethodsThis was a retrospective cohort study of adults undergoing KT from 2016 to 2020 in the Nationwide Readmissions Databases. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups frailty indicator.ResultsOf an estimated 95 765 patients undergoing KT during the study period, 4918 (5.1%) were frail. After risk adjustment, frail patients were associated with significantly higher odds of in-hospital mortality (AOR 2.17, 95% CI: 1.33-3.57) compared to their non-frail counterparts. Our findings indicate that frail patients had an average increase in postoperative hospital stay of 1.44 days, a $2300 increase in hospitalization costs, as well as higher odds of developing a major perioperative complication as compared to their non-frail counterparts. Frailty was also associated with greater adjusted risk of non-home discharge.ConclusionsFrailty, as identified by administrative coding, is independently associated with worse surgical outcomes, including increased mortality and resource use, in adults undergoing KT. Given the already limited donor organ pool, novel efforts are needed to ensure adequate optimization and timely post-transplantation care of the growing frail cohort undergoing KT.

Automated summary

Frail patients undergoing kidney transplantation were found to have significantly higher odds of in-hospital mortality, longer hospital stays, increased hospitalization costs, greater risk of major perioperative complications, and higher likelihood of non-home discharge compared to their non-frail counterparts. These findings highlight the importance of identifying and addressing frailty in this patient population to improve surgical outcomes post-transplantation.