4.6 Article

Exosomes derived from adipose stem cells in combination with hyaluronic acid promote diabetic wound healing

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Aref Jafari et al.

Summary: This study investigated the combined effect of exosomes derived from human placental mesenchymal stem cells (hpMSCs-Exos) and hyperbaric oxygen (HBO) on spinal cord ischemia-reperfusion injury (IR) in rats. The results showed that this combined treatment improved neurological function, increased levels of antioxidative and anti-inflammatory factors, and decreased levels of oxidative and inflammatory factors, thereby providing synergistic neuroprotection in rats undergoing IR.

REGENERATIVE THERAPY (2023)

Review Endocrinology & Metabolism

Mechanism and application of exosomes in the wound healing process in diabetes mellitus

Danyang Li et al.

Summary: This article reviews the mechanism of exosomes in diabetic wound healing, including promoting angiogenesis, collagen synthesis, and inhibiting inflammation. It also discusses the combined use of exosomes and hydrogels or dressings to prolong their presence in the wound. These studies contribute to a better understanding of diabetic wound treatment.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

Article Biotechnology & Applied Microbiology

SDF-1α loaded bioengineered human amniotic membrane-derived scaffold transplantation in combination with hyperbaric oxygen improved diabetic wound healing

Davood Nasiry et al.

Summary: Combining bioengineered scaffold transplantation, hyperbaric oxygen treatment, and SDF-1 alpha loading can accelerate wound healing in rats with type 1 diabetes mellitus. The results showed that the combined HBO+HAMS-D and HBO+SHAMS-D treatments led to significant improvements in wound closure, new tissue formation, and cellular density compared to the untreated and HBO-treated groups. Moreover, the expression of key genes was upregulated, while inflammation-related genes were downregulated in the HBO+SHAMS-D group.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2022)

Article Dermatology

Decellularized human amniotic membrane engraftment in combination with adipose-derived stem cells transplantation, synergistically improved diabetic wound healing

Sima Davoodi et al.

Summary: The study demonstrated that the concurrent use of dHAM and ADS can effectively accelerate the healing of diabetic wounds and improve the quality of wound repair. The treated groups showed increased volumes of newly formed epidermis and dermis, density of fibroblasts and blood vessels, collagen deposition, density of proliferation cells, expression levels of genes, and improved biomechanical characteristics.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

Article Integrative & Complementary Medicine

Topical administration of Juglans regia L. leaf extract accelerates diabetic wound healing

Davood Nasiry et al.

Summary: This study demonstrates that topical administration of Juglans regia L. leaf extract significantly accelerates diabetic wound healing, especially at a concentration of 5%.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

Review Cell Biology

Exosomes from adipose-derived stem cells and application to skin wound healing

Yang An et al.

Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.

CELL PROLIFERATION (2021)

Article Cell & Tissue Engineering

Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing

Shune Xiao et al.

Summary: The study demonstrated that hAAM scaffolds incorporated with ADSC-Exos can promote diabetic skin wound healing by regulating inflammation, stimulating vascularization, and promoting the production of extracellular matrix.

STEM CELL RESEARCH & THERAPY (2021)

Article Chemistry, Medicinal

Wound Healing Promotion by Hyaluronic Acid: Effect of Molecular Weight on Gene Expression and In Vivo Wound Closure

Yayoi Kawano et al.

Summary: The study found that the molecular weight and concentration of hyaluronic acid can enhance the proliferation and migration ability of epidermal cells, especially high molecular weight hyaluronic acid has a significant impact on gene expression in keratinocytes, which may help improve the re-epithelialization process of chronic wounds.

PHARMACEUTICALS (2021)

Review Biotechnology & Applied Microbiology

Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing

Antonio Casado-Diaz et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Engineering, Biomedical

Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration

Lei Hong et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2018)

Article Dermatology

Stem Cell-Containing Hyaluronic Acid-Based Spongy Hydrogels for Integrated Diabetic Wound Healing

Lucilia Pereira da Silva et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Article Cell & Tissue Engineering

Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing

Sean V. Murphy et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Review Medicine, Research & Experimental

Chronic Wound Healing: A Review of Current Management and Treatments

George Han et al.

ADVANCES IN THERAPY (2017)

Review Pharmacology & Pharmacy

Hyaluronic Acid and Wound Healing

Manuela G. Neuman et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2015)

Review Surgery

Chronic wounds

K Izadi et al.

CLINICS IN PLASTIC SURGERY (2005)