☆ 4.6 Article

Elasticity tunes mechanical stress localization around active topological defects

SOFT MATTER (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Physics, Multidisciplinary

Mechanical stress driven by rigidity sensing governs epithelial stability

Surabhi Sonam et al.

Summary: Epithelial cells are influenced by mechanical stress and abrasion, impacting their integrity. Culturing epithelial cells on two-dimensional hydrogels showed that soft substrates resulted in a loss of epithelial monolayer integrity through hole formation. This rupture was associated with cellular stretching and cell division events.

NATURE PHYSICS (2023)

添加到收藏夹

Article Biology

Active morphogenesis of patterned epithelial shells

Diana Khoromskaia et al.

Summary: This study investigates the shape transformations of epithelial tissues in three dimensions and identifies the active forces generated by the cytoskeleton as crucial. The interplay between local differential tensions, tissue geometry, and external forces is explored, revealing the mechanical equilibrium shapes and dynamic deformations of epithelial sheets.

ELIFE (2023)

添加到收藏夹

Article Biology

Mechanical basis and topological routes to cell elimination

Siavash Monfared et al.

Summary: Cell layers eliminate unwanted cells through the extrusion process, and the underlying mechanical basis of cellular extrusion remains largely unexplored. By using a phase-field model, the study reveals that the forces involved in cell extrusion are linked to defects in cellular arrangements, and increasing cell-cell adhesion forces can switch the behavior of the cell monolayer for extrusion. An extrusion event acts as a mechanism to relieve localized stress concentration by accessing three-dimensional mechanical stress fields.

ELIFE (2023)

添加到收藏夹

Article Physics, Fluids & Plasmas

Fluctuations of cell geometry and their nonequilibrium thermodynamics in living epithelial tissue

M. Olenik et al.

Summary: We have measured the contributions to entropy production in a living functional epithelial tissue by studying its functional dynamics and quantifying fluctuations. Using high-resolution live imaging of the translucent Drosophila melanogaster pupal epithelium, we measured the entropy associated with the stochastic geometry of cells. Our analysis of the shape and orientation dynamics of individual cells allowed us to separate local and global aspects of tissue behavior. Interestingly, we observed irreversible dynamics in cell geometries without a change in the entropy associated with those degrees of freedom, indicating a flow of energy into those degrees of freedom and the control of entropy production by the living system.

PHYSICAL REVIEW E (2023)

添加到收藏夹

Article Cell Biology

The role of tissue maturity and mechanical state in controlling cell extrusion

Teresa Zulueta-Coarasa et al.

Summary: Epithelia remove dying or excess cells through a process called extrusion, which is influenced by tissue mechanics and development. New studies highlight the significance of tissue mechanics as a whole, rather than individual cell mechanics, in controlling extrusion. Factors such as tissue compaction, stiffness, and cell-cell adhesion can affect the efficiency of cell extrusion and the mechanisms involved in adapting to different developmental or disease conditions.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2022)

添加到收藏夹

Article Chemistry, Physical

Integer topological defects organize stresses driving tissue morphogenesis

Pau Guillamat et al.

Summary: Integer topological defects promote cellular self-organization and regulate cell differentiation and tissue morphogenesis. The self-organization of cells around these defects can establish complex multicellular structures and trigger localized cell differentiation or the growth of swirling cellular pillars. These processes require specific stress patterns.

NATURE MATERIALS (2022)

添加到收藏夹

Article Physics, Multidisciplinary

Polar Fluctuations Lead to Extensile Nematic Behavior in Confluent Tissues

Andrew Killeen et al.

Summary: A collection of motile cells, each generating contractile nematic stresses in isolation, can exhibit extensile nematic behavior at the tissue level, which seems contradictory. Understanding this phenomenon is crucial in biology and has fundamental significance in soft matter and many body physics.

PHYSICAL REVIEW LETTERS (2022)

添加到收藏夹

Article Physics, Fluids & Plasmas

Fluctuation-induced dynamics of nematic topological defects

Lasse Bonn et al.

Summary: Topological defects in biological systems have been increasingly studied. Numerical simulations show that even without specific forms of active stresses, fluctuations in orientation or hydrodynamics can result in flow patterns similar to those observed in active systems around topological defects. Additionally, fluctuation-induced defects can exhibit extensile or contractile motion.

PHYSICAL REVIEW E (2022)

添加到收藏夹

Article Chemistry, Physical

Catapulting of topological defects through elasticity bands in active nematics

Nitin Kumar et al.

Summary: Active materials are those in which local stresses drive the material out of equilibrium on a global scale. Active nematic liquid crystals (LCs) are a system of particular interest, and increasing the bend elasticity drives the material into an exotic steady state dominated by elasticity bands that strongly influence defect dynamics.

SOFT MATTER (2022)

添加到收藏夹

Review Physics, Applied

Topological active matter

Suraj Shankar et al.

Summary: This review focuses on topological defects and topologically protected edge modes in active matter, highlighting their distinctive properties in non-equilibrium systems. The review also emphasizes the significance of topological excitations in non-equilibrium settings.

NATURE REVIEWS PHYSICS (2022)

添加到收藏夹

Article Physics, Multidisciplinary

Topological defects in the nematic order of actin fibres as organization centres of Hydra morphogenesis

Yonit Maroudas-Sacks et al.

Summary: The study reveals that the nematic order of actin fibers in Hydra regeneration plays a crucial role in morphogenesis, with topological defects acting as organization centers for morphological feature development. Fibre alignment sets the regenerated body axis and defect sites form organizing centers for the developing body plan.

NATURE PHYSICS (2021)

添加到收藏夹

Article Physics, Multidisciplinary

Bacteria solve the problem of crowding by moving slowly

O. J. Meacock et al.

Summary: The study demonstrates that slow movement of Pseudomonas aeruginosa is vital for its collective migration across surfaces, as it avoids being trapped by topological defects resulting from faster cell movements. In contrast, faster mutant cells are overtaken and outcompeted by slower wild-type cells at high cell densities, leading to faster collective behavior and migration. The physics of liquid crystals helps explain how bacteria can outcompete each other in the race for new territory by generating topological defects that trap fast-moving cells.

NATURE PHYSICS (2021)

添加到收藏夹

Review Cell Biology

Tissue mechanics in stem cell fate, development, and cancer

Mary-Kate Hayward et al.

Summary: Cells sense mechanical cues and modulate their behavior through mechanotransduction. Loss of tensional homeostasis can increase cancer risk and promote tumor aggressiveness and metastasis. Therefore, strategies that regulate tumor mechanics may be effective in preventing aggressive tumor behavior.

DEVELOPMENTAL CELL (2021)

添加到收藏夹

Review Cell Biology

Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression

Xiaomin Cai et al.

Summary: Biophysical cues, such as mechanical properties, play a critical role in tissue growth and homeostasis. YAP and TAZ are key mechanotransducers that control transcriptional programs for cell proliferation, differentiation, and transformation. However, the regulatory mechanisms and downstream transcriptome responses of YAP/TAZ signaling remain largely unknown.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Microbiology

Mechanomicrobiology: how bacteria sense and respond to forces

Yves F. Dufrene et al.

NATURE REVIEWS MICROBIOLOGY (2020)

添加到收藏夹

Article Physics, Multidisciplinary

Flow States and Transitions of an Active Nematic in a Three-Dimensional Channel

Santhan Chandragiri et al.

PHYSICAL REVIEW LETTERS (2020)

添加到收藏夹

Article Chemistry, Physical

Active nematics with anisotropic friction: the decisive role of the flow aligning parameter

Kristian Thijssen et al.

SOFT MATTER (2020)

添加到收藏夹

Review Cell Biology

Intracellular mechanics: connecting rheology and mechanotransduction

Samuel Mathieu et al.

CURRENT OPINION IN CELL BIOLOGY (2019)

添加到收藏夹

Article Chemistry, Physical

Active transport in a channel: stabilisation by flow or thermodynamics

Santhan Chandragiri et al.

SOFT MATTER (2019)

添加到收藏夹

Article Chemistry, Physical

The interplay between activity and filament flexibility determines the emergent properties of active nematics

Abhijeet Joshi et al.

SOFT MATTER (2019)

添加到收藏夹

Review Multidisciplinary Sciences

Active nematics

Amin Doostmohammadi et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Tunable structure and dynamics of active liquid crystals

Nitin Kumar et al.

SCIENCE ADVANCES (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Elastic constants, viscosity and dielectric properties of bent-core nematic liquid crystals doped with single-walled carbon nanotubes

Srikanth Turlapati et al.

LIQUID CRYSTALS (2017)

添加到收藏夹

Article Physics, Multidisciplinary

Topological defects in confined populations of spindle-shaped cells

Guillaume Duclos et al.

NATURE PHYSICS (2017)

添加到收藏夹

Review Physics, Applied

Review of cellular mechanotransduction

Ning Wang

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Topological defects control collective dynamics in neural progenitor cell cultures

Kyogo Kawaguchi et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Topological defects in epithelia govern cell death and extrusion

Thuan Beng Saw et al.

NATURE (2017)

添加到收藏夹

Review Cell Biology

Mechanobiology of collective cell behaviours

Benoit Ladoux et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

添加到收藏夹

Review Cell Biology

Mechanobiology of YAP and TAZ in physiology and disease

Tito Panciera et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

添加到收藏夹

Review Cell Biology

Mechanical forces direct stem cell behaviour in development and regeneration

Kyle H. Vining et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

添加到收藏夹

Article Physics, Multidisciplinary

Vortex formation and dynamics of defects in active nematic shells

Diana Khoromskaia et al.

NEW JOURNAL OF PHYSICS (2017)

添加到收藏夹

Article Biophysics

Cell Volume Fluctuations in MDCK Monolayers

Steven M. Zehnder et al.

BIOPHYSICAL JOURNAL (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Mechanical World of Bacteria

Alexandre Persat et al.

CELL (2015)

添加到收藏夹

Article Physics, Multidisciplinary

Intrinsic free energy in active nematics

Sumesh P. Thampi et al.

EPL (2015)

添加到收藏夹

Article Physics, Multidisciplinary

Instabilities and topological defects in active nematics

Sumesh P. Thampi et al.

EPL (2014)

添加到收藏夹

Article Physics, Multidisciplinary

Forces driving epithelial wound healing

Agusti Brugues et al.

NATURE PHYSICS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Defect dynamics in active nematics

Luca Giomi et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

Sergey V. Plotnikov et al.

CELL (2012)

添加到收藏夹

Article Cell Biology

Force transduction and strain dynamics in actin stress fibres in response to nanonewton forces

Louise Guolla et al.

JOURNAL OF CELL SCIENCE (2012)

添加到收藏夹

Article Physics, Multidisciplinary

Spontaneous flow states in active nematics: A unified picture

S. A. Edwards et al.

EPL (2009)

添加到收藏夹

Article Physics, Fluids & Plasmas

Steady-state hydrodynamic instabilities of active liquid crystals: Hybrid lattice Boltzmann simulations

D. Marenduzzo et al.

PHYSICAL REVIEW E (2007)

添加到收藏夹

Review Cell Biology

Myosin II and mechanotransduction: a balancing act

Kristopher Clark et al.

TRENDS IN CELL BIOLOGY (2007)

添加到收藏夹

Review Materials Science, Multidisciplinary

Topological point defects in nematic liquid crystals

M. Kleman et al.

PHILOSOPHICAL MAGAZINE (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Force mapping in epithelial cell migration

O du Roure et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Physics, Multidisciplinary

Hydrodynamics of topological defects in nematic liquid crystals -: art. no. 105504

G Tóth et al.

PHYSICAL REVIEW LETTERS (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.