4.8 Article

Single-Cell Atlas of Human Ovaries Reveals The Role Of The Pyroptotic Macrophage in Ovarian Aging

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Tzu-Chiao Lu et al.

Summary: This study presents the Aging Fly Cell Atlas, which is a single-nucleus transcriptomic map of the whole aging Drosophila. It reveals changes in tissue cell composition, gene expression, and cell identities during aging, and develops aging clock models that predict fly age based on ribosomal gene expression. The atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.

SCIENCE (2023)

Article Microbiology

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer

Ji-Xuan Han et al.

Summary: Statins have shown anti-cancer effects in mice and humans, which are controlled by the gut commensal Lactobacillus reuteri and the metabolite indole-3-lactic acid. Epidemiological studies have indicated a relationship between statin use and reduced colorectal cancer (CRC) incidence, and preclinical models have demonstrated the potential for chemoprevention. Statins also reduce dysbiosis in the gut microbiome, but the role of the gut microbiome in the protective effect of statins in CRC is unclear. This study validates the chemopreventive role of statins through analysis of patient cohorts and preclinical models, and highlights the significance of Lactobacillus reuteri and indole-3-lactic acid in reducing tumour burden.

NATURE MICROBIOLOGY (2023)

Review Cell Biology

Unraveling female reproductive senescence to enhance healthy longevity

Lu Dong et al.

Summary: In a society where women strive for successful careers and equal opportunities, the early onset of ovarian aging forces women to make difficult decisions between career and family development. Research on reproductive longevity is underexplored, but efforts to maintain the quality and quantity of follicles in animals may potentially prolong female reproductive lifespan and healthspan. Solutions to female reproductive senescence can contribute to enhancing overall healthy longevity for both men and women.

CELL RESEARCH (2023)

Article Cell Biology

Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling

Xiaodan Zhang et al.

Summary: Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling.

CELL DEATH & DISEASE (2022)

Review Genetics & Heredity

The process of ovarian aging: it is not just about oocytes and granulosa cells

Antonella Camaioni et al.

Summary: Ovarian age is the main cause of female reproductive infertility, leading to reduced fertility and irregular menstruation, and eventually menopause. Ovarian aging is a complex process involving factors such as mitochondria, oxidative stress, and immune cells. Understanding these processes is crucial for designing treatments to slow down ovarian aging and alleviate the side effects of menopause.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

Article Cell & Tissue Engineering

Workflow Optimization for Identification of Female Germline or Oogonial Stem Cells in Human Ovarian Cortex Using Single-Cell RNA Sequence Analysis

Hannah Alberico et al.

Summary: This article reports a study on the existence of ovarian stem cells in adult human ovaries. By optimizing the parameters of analytical workflow and using single-cell RNA sequencing analysis, rare germ cells matched to the gene expression profile of ovarian stem cells were identified, and evidence of meiosis-I in human ovaries was found. The study also highlighted the issue of mistaking perivascular cells for germ cells during stem cell sorting and proposed a solution.

STEM CELLS (2022)

Article Cell & Tissue Engineering

UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system

Wenjuan Xu et al.

Summary: This study established an in vitro ovarian culture system to restore frozen-thawed ovarian function before transplantation using UC-MSCs and explored the effects of UC-MSCs on angiogenesis in frozen-thawed ovaries. The results showed that UC-MSCs effectively improved follicular development and microvascular number, alleviated follicular apoptosis, and activated the Wnt/beta-catenin pathway in the presence of Matrigel. The in vitro culture system using Matrigel and UC-MSCs may provide a potential treatment strategy for improving the success rate of thawed ovaries transplantation.

STEM CELL RESEARCH & THERAPY (2022)

Article Multidisciplinary Sciences

Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

Takashi Umehara et al.

Summary: Ovarian fibrosis is identified as the underlying mechanism for impaired oocyte release, with antifibrosis drugs potentially restoring ovulation function in reproductively old or obese mice. Targeting mitochondrial metabolism with such drugs could be a viable therapeutic strategy for women with metabolic disorders or advancing age.

SCIENCE ADVANCES (2022)

Article Multidisciplinary Sciences

Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice

David A. Landry et al.

Summary: The study found that metformin treatment can prevent age-related ovarian fibrosis by regulating the proportion of immune cells and fibroblast populations. In aged mice, a unique metformin-responsive subpopulation of macrophages emerged. This study offers a new strategy for preventing ovarian fibrosis.

SCIENCE ADVANCES (2022)

Review Geriatrics & Gerontology

Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness

Natalia Llarena et al.

Summary: As delayed childbearing becomes more prevalent worldwide, understanding the biological basis and implications of age-related infertility has become increasingly important. Women aged 35 and older face significantly higher incidences of infertility, aneuploidy, and birth defects due to age-related declines in ovarian reserve and oocyte quality. Various pathways related to aging and nutrient-sensing in the mammalian ovary regulate primordial follicle maintenance and follicular growth, ultimately impacting reproductive longevity.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

Review Reproductive Biology

Macrophages: an indispensable piece of ovarian health

Zijing Zhang et al.

Summary: Macrophages are the most abundant immune cells in the ovary and play important roles in maintaining tissue homeostasis, adapting to tissue environment, and responding to tissue-derived signals. Research has shown a strong link between macrophages and ovarian health, despite limited understanding of their heterogeneity in the past.

BIOLOGY OF REPRODUCTION (2021)

Article Multidisciplinary Sciences

Evaluation of inflammation and follicle depletion during ovarian ageing in mice

Carolina Lliberos et al.

Summary: The decline in follicle numbers with reproductive aging in females is associated with an increase in intra-ovarian inflammatory markers and immune cell populations, while fibrosis levels remain unchanged. This suggests that inflammation may play a role in regulating follicle number as females age, but the role of fibrosis is unclear and further studies are needed to determine causative relationships.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Inhibition of the NLRP3 inflammasome prevents ovarian aging

Jose M. Navarro-Pando et al.

Summary: The study demonstrates that the NLRP3 inflammasome plays a crucial role in ovarian aging and female fertility, showing potential as a new therapeutic target for infertility treatment.

SCIENCE ADVANCES (2021)

Article Cell Biology

The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice

Carolina Lliberos et al.

Summary: This study investigated the impact of chronic low-grade systemic inflammation mediated by the inflammasome on ovarian aging, finding that by suppressing the inflammatory processes, the depletion of follicles could be delayed and the fertile window extended.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Metformin Abrogates Age-Associated Ovarian Fibrosis

Curtis W. McCloskey et al.

CLINICAL CANCER RESEARCH (2020)

Article Biochemistry & Molecular Biology

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

Si Wang et al.

Article Medicine, Research & Experimental

Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis

Daojuan Wang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Multidisciplinary Sciences

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Magdalena Wagner et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang et al.

Article Cell Biology

Disulfiram Treatment Normalizes Body Weight in Obese Mice

Michel Bernier et al.

CELL METABOLISM (2020)

Review Developmental Biology

The ovarian stroma as a new frontier

Hadrian M. Kinnear et al.

REPRODUCTION (2020)

Article Environmental Sciences

Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice

Daojuan Wang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Biotechnology & Applied Microbiology

A multidimensional systems biology analysis of cellular senescence in aging and disease

Roberto A. Avelar et al.

GENOME BIOLOGY (2020)

Article Medicine, Research & Experimental

Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Jun Wei et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Double-slit photoelectron interference in strong-field ionization of the neon dimer

Maksim Kunitski et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency

Yaoqi Huang et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

Editorial Material Cell Biology

The stromal fibrosis in aging ovary

Takashi Umehara et al.

AGING-US (2018)

Article Oncology

Ovarian Cancer Statistics, 2018

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

Article Medicine, Research & Experimental

Mucosal-associated invariant and gamma delta T cell subsets respond to initial Mycobacterium tuberculosis infection

Charles Kyriakos Vorkas et al.

JCI INSIGHT (2018)

Article Immunology

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Abdulraouf Ramadan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Endocrinology & Metabolism

Long-term melatonin treatment delays ovarian aging

Hiroshi Tamura et al.

JOURNAL OF PINEAL RESEARCH (2017)

Article Biochemical Research Methods

SCENIC: single-cell regulatory network inference and clustering

Sara Aibar et al.

NATURE METHODS (2017)

Article Gastroenterology & Hepatology

A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation

David Padua et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

Article Developmental Biology

Reproductive age-associated fibrosis in the stroma of the mammalian ovary

Shawn M. Briley et al.

REPRODUCTION (2016)

Review Biology

Current understanding of ovarian aging

Li Qian et al.

SCIENCE CHINA-LIFE SCIENCES (2012)

Review Endocrinology & Metabolism

Ovarian Aging: Mechanisms and Clinical Consequences

F. J. Broekmans et al.

ENDOCRINE REVIEWS (2009)

Review Obstetrics & Gynecology

Macrophage contributions to ovarian function

RJ Wu et al.

HUMAN REPRODUCTION UPDATE (2004)

Review Obstetrics & Gynecology

The variability of female reproductive ageing

ERT Velde et al.

HUMAN REPRODUCTION UPDATE (2002)