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Article
Chemistry, Multidisciplinary
Desheng Liu et al.
Summary: In this study, a novel tactic of salting-out-after-syneresis of PVA is proposed to create mechanically robust and highly transparent slippery PVA hydrogels. These hydrogels exhibit excellent mechanical properties and have the potential for various applications in biomedicine and wearable devices.
Review
Materials Science, Biomaterials
Enni Chen et al.
Summary: Periodontitis is a chronic inflammatory disease characterized by the continuous activation of oxidative stress. This review highlights the relationship between reactive oxygen species (ROS) and periodontitis, the application of ROS-scavenging biomaterials in periodontitis, and the different forms of fabricated materials used for periodontal therapy. The current situation and future prospects of ROS-scavenging biomaterials in periodontal applications are also summarized.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Hengli Lu et al.
Summary: A dual-functional medication has been developed to protect cartilage and repair subchondral bone simultaneously. Black phosphorus nanosheets (BPNSs) effectively eliminate intracellular reactive oxygen species (ROS), restore chondrocyte function, and regulate inflammation, providing disease-modifying effects on osteoarthritis (OA). In vivo assessments confirm that BPNSs inhibit cartilage degradation and prevent OA progression, making them a competitive candidate for OA treatment.
Review
Chemistry, Multidisciplinary
Qi Jiang et al.
Summary: Osteoarthritis (OA) is a common age-related degenerative disease that poses economic and societal burdens, especially with the increasing aging population. Stimulus-responsive nanoplatforms offer improved therapeutic strategies for OA, with potential benefits such as enhanced control, longer retention time, higher loading rates, and increased sensitivity. This review summarizes the advanced application of stimulus-responsive drug delivery nanoplatforms, categorized by endogenous and exogenous stimuli, and discusses the opportunities, restrictions, and limitations of these systems.
Article
Engineering, Biomedical
Fang Chen et al.
Summary: This study introduces reversible boronic bonds to create an intelligent antioxidant hydrogel scaffold for efficient delivery of antioxidants to diabetic wounds. The hydrogel responds to changes in glucose levels, releasing more antioxidants as glucose level increases. The hydrogel shows good biocompatibility, biodegradability, and mechanical properties similar to skin tissue. In vitro and in vivo experiments demonstrate that the hydrogel effectively eliminates reactive oxygen species, reduces inflammation, promotes angiogenesis, and improves tissue remodeling during diabetic wound healing. This strategy offers new insight into glucose-responsive scaffolds and holds great potential for the treatment of chronic diabetic wounds.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Wenjing Zhang et al.
Summary: This study developed an injectable calcium boride nanosheets (CBN) loaded hydrogel platform (CBN@GelDA hydrogel) as a high-payload and sustainable hydrogen (H2) precursor for osteoarthritis (OA) treatment. The CBN@GelDA hydrogel maintained constant physiological pH conditions, released more H2 than CBN alone, and lasted for more than one week. The hydrogel had ROS scavenging ability, reduced inflammatory cytokine expression, stimulated M2 macrophages, and decreased chondrocyte apoptosis, effectively alleviating the progression of OA.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Chemical
Elisa Belluzzi et al.
Summary: Articular cartilage is a complex connective tissue that provides load bearing, shock absorption, and lubrication functions in joints. However, traumatic events, aging, and degenerative pathologies can impact its structure and function, leading to pain and long-term disability. Osteoarthritis, a global health concern, has been found to affect the mechanical behavior of articular cartilage. This review explores the physiological aspects influencing cartilage microstructure and biomechanics, with a focus on the pathological changes caused by osteoarthritis. Experimental data on human articular cartilage and different mechanical testing techniques are presented, along with a discussion on theoretical mechanical models commonly used for articular cartilage.
Article
Chemistry, Multidisciplinary
Peng Yu et al.
Summary: A photothermal dual-bionic nanozyme, mimicking antioxidases and hyaluronan synthase, has been developed for effective osteoarthritis (OA) therapy. It can produce heat, scavenge free radicals, and promote chondrogenesis even under inflammatory conditions. This nanozyme regulates anabolic and catabolic processes simultaneously, thereby effectively restoring joint homeostasis and demonstrating an admirable photothermally therapeutic effect on OA.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Yuan Zhang et al.
Summary: To address the challenging issue of healing diabetic foot, researchers developed multifunctional hydrogels by incorporating 3-aminophenylboronic acid modified oxidized chondroitin sulfate (APBA-g-OCS), polyvinyl alcohol (PVA), and black phosphorus/bismuth oxide/e-polylysine (BP/Bi2O3/e-PL) as precursors. These hydrogels demonstrated multiple stimulus responsiveness, strong adhesion, and rapid self-healing ability, thanks to dynamic borate ester bonds, hydrogen bonds, and 7C-7C conjugation crosslink points. Moreover, the hydrogels exhibited synergistic chemo-photothermal antibacterial effect, anti-biofilm formation ability, antioxidation, and inflammatory chemokine adsorption due to the presence of APBA-g-OCS. Importantly, the hydrogels responded to the wound microenvironment, conducting combined photothermal therapy and chemotherapy for efficient anti-inflammation, while also improving the wound microenvironment by scavenging ROS and regulating cytokine expression, ultimately promoting the healing of infected wounds in diabetic rats.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Qiming Zhai et al.
Summary: Chronic inflammation leads to mitochondrial dysfunction in tissue-specific mesenchymal stem cells (MSCs), but nanotechnology can be utilized to restore their function, providing an effective treatment for periodontitis and osteoarthritis.
Article
Engineering, Biomedical
Yiting Lei et al.
Summary: A shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating liposomes and a dynamic cross-linked hyaluronic acid hydrogel, which provides stable lubrication and helps maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
T. Zhou et al.
Summary: This study developed a multifunctional injectable hydrogel system for treating osteoarthritis by depleting ROS and suppressing inflammation, significantly alleviating OA symptoms and preventing degradation of cartilage extracellular matrix.
MATERIALS TODAY NANO
(2022)
Article
Nanoscience & Nanotechnology
Weiwei Zhao et al.
Summary: This study developed self-assembled drug-free nanospheres with pharmaceutical-active functions for the treatment of TMJ osteoarthritis, providing enhanced lubrication, anti-inflammatory effects, and anti-aging effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Zahra Karimzadeh et al.
Summary: This review provides an up-to-date and comprehensive summary of the research progress of PVA hydrogel based wearable sensors, including their properties, strain sensory efficiency, and potential applications. The review specifically highlights the probes using metallic/non-metallic, liquid metal, 2D materials, bio-nanomaterials, and polymer nanofillers. The flexible electrodes and strain/pressure sensing performance of designed PVA hydrogels are described. The review also discusses the necessity and requirements for future advances of conductive and stretchable hydrogels engaged in wearable strain sensors, as well as the opportunities and challenges.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Adriano P. Pontes et al.
Summary: This review examines the use of polymeric nanoparticles (PNPs) as drug carriers for the treatment of osteoarthritis (OA). PNPs have shown promise due to their biodegradability, nanoscale structure, functional versatility, and reproducible manufacturing. The article discusses the current development of natural and synthetic PNPs for drug delivery and OA treatment, providing evidence from in vitro and pre-clinical in vivo studies on how these nanoparticle-based therapies modulate disease pathology and key cellular pathways. Additionally, the biodegradability and surface modification of the nanocarriers are compared in relation to drug release profile and tissue targeting, and the challenges of delivering nanoparticles to the cartilage are discussed.
Article
Nanoscience & Nanotechnology
Y. Chen et al.
Summary: The development of novel nanoenzymes with excellent ROS scavenging ability and biosafety shows great potentials for improving osteoarthritis (OA) treatment. This study developed a novel functional polydopamine (P) loaded with ultrasmall Pt and Cu nanoparticles (P@Pt@Cu) as nanoenzymes, which exhibited remarkable antioxidant and anti-inflammatory activities for OA therapy.
MATERIALS TODAY NANO
(2022)
Article
Nanoscience & Nanotechnology
Han Yu et al.
Summary: In this study, cartilage-targeting hydrogel microspheres with ROS-responsive ability were developed using a combination of microfluidic and photopolymerization processes. These microspheres showed better retention in the joint cavity and enhanced cellular uptake of nanoparticles. The ROS-responsive nanoparticles could react with intracellular ROS induced by OA, leading to effective OA therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zuhao Li et al.
Summary: This study introduces a biological metabolism-inspired hydrogel for ameliorating the unfavorable microenvironment of diabetic wounds. The hydrogel has the ability to capture reactive oxygen species (ROS) and generate oxygen to promote wound healing, protecting skin cells from death and proliferation inhibition. Treatment with the hydrogel accelerates wound healing and induces macrophage polarization from pro-inflammatory to anti-inflammatory phenotype.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Zhi Peng et al.
Summary: Osteoarthritis (OA) is a leading cause of disability and socioeconomic loss globally, with current pharmacological treatments mainly palliative. Focus is shifting towards targeting cartilage extracellular matrix (ECM) destruction and abnormal homeostasis in OA for regenerative therapies, using potential biomarkers and preclinical studies to identify pathological stages.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon et al.
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Engineering, Environmental
Khandmaa Dashnyam et al.
Summary: The proper administration of nanoceria has shown significant therapeutic effects in treating osteoarthritis, protecting cartilage and bone structure, reducing tissue degeneration, and decreasing inflammatory symptoms while promoting joint regeneration.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Hui Wang et al.
Summary: The study showed that HLC gel can improve the rheological properties of the gel, enhance joint protection by increasing mechanical strength, elasticity, and lubrication, prolong drug release and retention in the joint cavity for over 4 weeks, and provide a combined effect of kartogenin and hyaluronic acid for cartilage repair. Pharmacodynamic studies demonstrated that HLC gel was the most effective in promoting chondrogenesis and protecting subchondral bone.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Environmental
Xiangyu Wang et al.
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Ying Han et al.
Summary: In this study, injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment were developed by bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the microspheres. Intra-articular injection of the functionalized microspheres into rat knee joint with an OA model provided significant therapeutic effect against the development of OA.
BIOACTIVE MATERIALS
(2021)
Article
Rheumatology
Yoshihiro Nishida et al.
Summary: Intraarticular injection of diclofenac covalently linked to hyaluronic acid (DF-HA) showed significant improvement in pain subscale scores compared to placebo over 12 weeks in patients with knee osteoarthritis, although anaphylactic reactions were observed, requiring further safety evaluation.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Taejeong Kim et al.
Summary: The study introduces a novel M-NO gel platform for the treatment of rheumatoid arthritis, which combines NO scavenging and sequential drug release to effectively alleviate symptoms in animal models, showing promising prospects for future use in combating inflammation and NO-related diseases.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Sean K. Bedingfield et al.
Summary: In this study, intra-articular injection of nanoparticles targeting collagen and delivering small interfering RNA for matrix metalloproteinase 13 effectively protected cartilage integrity and reduced disease progression in mice with osteoarthritis. The inhibition of MMP13 suppressed genes associated with tissue restructuring, angiogenesis, innate immune responses, and proteolysis. Targeting collagen in damaged extracellular matrix of arthritic cartilage may be an effective strategy for treating osteoarthritis.
NATURE BIOMEDICAL ENGINEERING
(2021)
Review
Materials Science, Biomaterials
Zhonglei He et al.
Summary: Reactive oxygen species (ROS) have dual effects on living organisms, playing essential roles in cellular functions but also contributing to pathological conditions. Proper regulation of ROS levels is crucial in maintaining cellular health and preventing diseases.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Cong-Rui Liao et al.
Article
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Sana Khalid et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Review
Chemistry, Multidisciplinary
Jianhua Zhang et al.
ADVANCED MATERIALS INTERFACES
(2020)
Article
Multidisciplinary Sciences
Manoj Arra et al.
NATURE COMMUNICATIONS
(2020)
Review
Pharmacology & Pharmacy
Marianna A. Tryfonidou et al.
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Wan-Su Choi et al.
Article
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Feng Zhou et al.
ACTA PHARMACEUTICA SINICA B
(2019)
Review
Medicine, General & Internal
David J. Hunter et al.
Review
Veterinary Sciences
Ramesh C. Gupta et al.
FRONTIERS IN VETERINARY SCIENCE
(2019)
Article
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Lang Li et al.
SCIENTIFIC REPORTS
(2018)
Article
Rheumatology
Do Young Park et al.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
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Chemistry, Physical
Ovijit Chaudhuri et al.
Review
Rheumatology
Emmanuel Maheu et al.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2016)
Article
Rheumatology
Jennifer M. Hootman et al.
ARTHRITIS & RHEUMATOLOGY
(2016)
Review
Chemistry, Physical
Murat Guvendiren et al.
Review
Biochemistry & Molecular Biology
Christine C. Winterbourn
NATURE CHEMICAL BIOLOGY
(2008)
Article
Biochemical Research Methods
Jiexun Li et al.
Review
Biochemistry & Molecular Biology
Peter F. Bove et al.
FREE RADICAL BIOLOGY AND MEDICINE
(2006)
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Orthopedics
KPH Pritzker et al.
OSTEOARTHRITIS AND CARTILAGE
(2006)
